Timothy Hla
@hlatim.bsky.social
560 followers
280 following
98 posts
Scientist, biochemist / molecular biologist, works on lipid mediators, sphingolipids, S1P, prostanoids, vascular biology, endothelial cells, Professor
https://research.childrenshospital.org/hlalab
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Reposted by Timothy Hla
Timothy Hla
@hlatim.bsky.social
· Aug 8
Lipid and Lipoprotein Metabolism in Microglia: Alzheimer’s Disease Mechanisms and Interventions
Alzheimer’s disease (AD) presents a significant challenge owing to its widespread
prevalence and complex neuropathogenesis, affecting millions worldwide. Current therapeutic
strategies that predominan...
www.jlr.org
Reposted by Timothy Hla
Ivan Zanoni
@lozanzi.bsky.social
· Aug 6
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis - Nature
N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal network with...
www.nature.com
Reposted by Timothy Hla
Reposted by Timothy Hla
Dr. Ahna Skop
@ahnaskop.bsky.social
· Jul 16
Timothy Hla
@hlatim.bsky.social
· Jul 4
Inflamed endothelial cells express S1PR1 inhibitor CD69 to induce vascular leak
Inflammation disrupts endothelial barrier function and causes vascular leak into the
tissue parenchyma. Sphingosine 1-phosphate receptor-1 (S1PR1) in endothelial cells
(EC) is a key inducer of endothe...
www.jbc.org
Timothy Hla
@hlatim.bsky.social
· Jul 2
HDL-bound S1P affects the subventricular niche and early neuropathological features of Alzheimer’s disease - Nature Communications
The blood ApoM-S1P complex regulates vascular functions, but its role in neurogenic niches remains unclear. Here, the authors show that the blood ApoM-S1P complex preserves V-SVZ homeostasis and prote...
www.nature.com
Reposted by Timothy Hla
Hans schoofs
@hansschoofs.bsky.social
· Mar 20
Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium - Nature
Dynamic cytoskeletal regulation of lymphatic endothelial cell shape, induced by isotropic stretch and crucial for dermal lymphatic capillary function, is identified and found to result from continuous...
www.nature.com
Timothy Hla
@hlatim.bsky.social
· Jun 24
Apolipoprotein M attenuates age-related macular degeneration phenotypes via sphingosine-1-phosphate signaling and lysosomal lipid catabolism - Nature Communications
Age-related macular degeneration (AMD) is a leading cause of blindness. Here, the authors identify a role for apolipoprotein M in AMD that may present a therapeutic target.
www.nature.com
Timothy Hla
@hlatim.bsky.social
· Jun 24
S1PR1 regulates lymphatic valve development and tertiary lymphoid organ formation in the ileum | Journal of Experimental Medicine | Rockefeller University Press
TLOs are LN-like structures that are observed in certain inflammatory diseases. Geng et al. demonstrate that S1PR1 activity in the lymphatic vasculature is
rupress.org
