Jitendra Gosai
@gosciee.bsky.social
Postdoc @ ASU Biodesign Inst,
Molecular genetics, Molecular Microbiology, Computational Biology, Host microbe interactions, Biochemistry
Father, Fixer, Photographer
Molecular genetics, Molecular Microbiology, Computational Biology, Host microbe interactions, Biochemistry
Father, Fixer, Photographer
Reposted by Jitendra Gosai
A collaborative project that began with the Osaka Expo has just been released as a preprint!
Here, we show Promethearchaeota (Asgard archaea) “moving” under anaerobic conditions.
The videos capturing this unique behavior are so fascinating you can watch endlessly.
www.biorxiv.org/content/10.1...
Here, we show Promethearchaeota (Asgard archaea) “moving” under anaerobic conditions.
The videos capturing this unique behavior are so fascinating you can watch endlessly.
www.biorxiv.org/content/10.1...
Dynamic protrusions mediate unique crawling motility in Asgard Archaea (Promethearchaeota)
Crawling motility is a hallmark of eukaryotic cells and requires a dynamic actin cytoskeleton, regulated adhesion, and spatially organized signalling pathways1–3. Asgard archaea (phylum Promethearchae...
www.biorxiv.org
December 2, 2025 at 11:52 PM
A collaborative project that began with the Osaka Expo has just been released as a preprint!
Here, we show Promethearchaeota (Asgard archaea) “moving” under anaerobic conditions.
The videos capturing this unique behavior are so fascinating you can watch endlessly.
www.biorxiv.org/content/10.1...
Here, we show Promethearchaeota (Asgard archaea) “moving” under anaerobic conditions.
The videos capturing this unique behavior are so fascinating you can watch endlessly.
www.biorxiv.org/content/10.1...
Reposted by Jitendra Gosai
A brand-new Gordon Conference on Microbiomes!🦠 The opening session (Jan 2026) dives into microbiome editing - how fundamental research and new technologies can advance human health and environmental sustainability. Super looking forward!🧪 #microsky #microbiomesky #grc
www.grc.org/microbiome-e...
www.grc.org/microbiome-e...
2026 Microbiome Editing Conference GRC
The 2026 Gordon Research Conference on Microbiome Editing will be held in Pomona, California. Apply today to reserve your spot.
www.grc.org
October 31, 2025 at 9:42 AM
A brand-new Gordon Conference on Microbiomes!🦠 The opening session (Jan 2026) dives into microbiome editing - how fundamental research and new technologies can advance human health and environmental sustainability. Super looking forward!🧪 #microsky #microbiomesky #grc
www.grc.org/microbiome-e...
www.grc.org/microbiome-e...
Reviewing an exciting manuscript. This is going to be a long night!
a pink cartoon character is surrounded by math equations on a green background
ALT: a pink cartoon character is surrounded by math equations on a green background
media.tenor.com
October 29, 2025 at 4:34 AM
Reviewing an exciting manuscript. This is going to be a long night!
Reposted by Jitendra Gosai
This morning, @isbscience.org's Dr. Mary Brunkow was awarded the 2025 Nobel Prize in Physiology or Medicine! Dr. Brunkow shares the award with Fred Ramsdell and Shimon Sakaguchi. Read the press release here: www.nobelprize.org/.../medicine....
What a tremendous honor! Congratulations!
What a tremendous honor! Congratulations!
October 6, 2025 at 4:19 PM
This morning, @isbscience.org's Dr. Mary Brunkow was awarded the 2025 Nobel Prize in Physiology or Medicine! Dr. Brunkow shares the award with Fred Ramsdell and Shimon Sakaguchi. Read the press release here: www.nobelprize.org/.../medicine....
What a tremendous honor! Congratulations!
What a tremendous honor! Congratulations!
Reposted by Jitendra Gosai
Friday Papers Club! 🍿In light of Pubmed going down, the collapse of social media, and my recent success at getting recommendations for interesting papers from those still around, I am starting a new tradition! - Recommend a good scientific manuscript! 👇
October 3, 2025 at 9:10 AM
Friday Papers Club! 🍿In light of Pubmed going down, the collapse of social media, and my recent success at getting recommendations for interesting papers from those still around, I am starting a new tradition! - Recommend a good scientific manuscript! 👇
Reposted by Jitendra Gosai
Amazing work by @hueihsuantsai.bsky.social and colleagues from @nikogeldner.bsky.social, Feng Zhou @tonnigrubeandersen.bsky.social labs in Science
Localized glutamine leakage drives the spatial structure of root microbial colonization
www.science.org/doi/10.1126/...
#chemotaxis #MicroSky
Localized glutamine leakage drives the spatial structure of root microbial colonization
www.science.org/doi/10.1126/...
#chemotaxis #MicroSky
Localized glutamine leakage drives the spatial structure of root microbial colonization
Plant roots release exudates to encourage microbiome assembly, which influences the function and stress resilience of plants. How specific exudates drive spatial colonization patterns remains largely ...
www.science.org
October 3, 2025 at 5:55 AM
Amazing work by @hueihsuantsai.bsky.social and colleagues from @nikogeldner.bsky.social, Feng Zhou @tonnigrubeandersen.bsky.social labs in Science
Localized glutamine leakage drives the spatial structure of root microbial colonization
www.science.org/doi/10.1126/...
#chemotaxis #MicroSky
Localized glutamine leakage drives the spatial structure of root microbial colonization
www.science.org/doi/10.1126/...
#chemotaxis #MicroSky
Reposted by Jitendra Gosai
Discovery of a new type of immune cell in fat tissue that promotes infllammaging (chronic inflammation with aging)
www.nature.com/articles/d41...
www.nature.com/articles/s43...
www.nature.com/articles/d41...
www.nature.com/articles/s43...
Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related inflammation - Nature Aging
Gonzalez-Hurtado, Leveau and colleagues characterize adipose resident tissue macrophages across lifespan in mice, finding that nerve-associated macrophages, which mitigate inflammation and control lip...
www.nature.com
September 4, 2025 at 5:42 PM
Discovery of a new type of immune cell in fat tissue that promotes infllammaging (chronic inflammation with aging)
www.nature.com/articles/d41...
www.nature.com/articles/s43...
www.nature.com/articles/d41...
www.nature.com/articles/s43...
Reposted by Jitendra Gosai
Join us in Arizona!
The Fourth Annual Symposium on Mechanisms of Cellular Evolution will again be held at ASU. November 5-8, 2025, in Tempe, AZ. Theme: Unicellular Diversification of Cell Types and Division Systems.
na.eventscloud.com/cmesymposium2025
The Fourth Annual Symposium on Mechanisms of Cellular Evolution will again be held at ASU. November 5-8, 2025, in Tempe, AZ. Theme: Unicellular Diversification of Cell Types and Division Systems.
na.eventscloud.com/cmesymposium2025
August 29, 2025 at 8:42 PM
Join us in Arizona!
The Fourth Annual Symposium on Mechanisms of Cellular Evolution will again be held at ASU. November 5-8, 2025, in Tempe, AZ. Theme: Unicellular Diversification of Cell Types and Division Systems.
na.eventscloud.com/cmesymposium2025
The Fourth Annual Symposium on Mechanisms of Cellular Evolution will again be held at ASU. November 5-8, 2025, in Tempe, AZ. Theme: Unicellular Diversification of Cell Types and Division Systems.
na.eventscloud.com/cmesymposium2025
Reposted by Jitendra Gosai
Out now!
🍫🦠A defined microbial community reproduces attributes of fine flavour #chocolate fermentation
By Gabriel Castrillo, David Salt & co
#microsky #microbiomesky 🧪
Read it here: www.nature.com/articles/s41...
🍫🦠A defined microbial community reproduces attributes of fine flavour #chocolate fermentation
By Gabriel Castrillo, David Salt & co
#microsky #microbiomesky 🧪
Read it here: www.nature.com/articles/s41...
A defined microbial community reproduces attributes of fine flavour chocolate fermentation - Nature Microbiology
An in-depth microbiological and metagenomic analysis of Colombian farm and fermentation facilities resulted in the design of a defined microbial community that can reproduce the flavour of fine chocol...
www.nature.com
August 18, 2025 at 3:35 PM
Out now!
🍫🦠A defined microbial community reproduces attributes of fine flavour #chocolate fermentation
By Gabriel Castrillo, David Salt & co
#microsky #microbiomesky 🧪
Read it here: www.nature.com/articles/s41...
🍫🦠A defined microbial community reproduces attributes of fine flavour #chocolate fermentation
By Gabriel Castrillo, David Salt & co
#microsky #microbiomesky 🧪
Read it here: www.nature.com/articles/s41...
Reposted by Jitendra Gosai
#phagesky
I am looking for phages infecting Streptococcus pneumoniae to test a phenotype - does anyone have some and willing to share ?
Repost appreciated :)
I am looking for phages infecting Streptococcus pneumoniae to test a phenotype - does anyone have some and willing to share ?
Repost appreciated :)
August 19, 2025 at 8:11 AM
#phagesky
I am looking for phages infecting Streptococcus pneumoniae to test a phenotype - does anyone have some and willing to share ?
Repost appreciated :)
I am looking for phages infecting Streptococcus pneumoniae to test a phenotype - does anyone have some and willing to share ?
Repost appreciated :)
On my 14th hour of troubleshooting the code while ChatGPT tells me we are close for the 280th time.
August 7, 2025 at 6:25 AM
On my 14th hour of troubleshooting the code while ChatGPT tells me we are close for the 280th time.
Reposted by Jitendra Gosai
Site-specific DNA insertion into the human genome with engineered recombinases www.biorxiv.org/content/10.1...
in other words... genome engineering to precisely insert large multi-kilobase sequences into specific sites without introducing double-strand breaks #synbio
in other words... genome engineering to precisely insert large multi-kilobase sequences into specific sites without introducing double-strand breaks #synbio
June 5, 2025 at 3:32 PM
Site-specific DNA insertion into the human genome with engineered recombinases www.biorxiv.org/content/10.1...
in other words... genome engineering to precisely insert large multi-kilobase sequences into specific sites without introducing double-strand breaks #synbio
in other words... genome engineering to precisely insert large multi-kilobase sequences into specific sites without introducing double-strand breaks #synbio
Reposted by Jitendra Gosai
Internet Roadtrip is my favorite thing on the internet right now—it’s basically Twitch Plays Google Street View. They started in Boston, spent several weeks on a quest to cross the Canadian border, and are now exploring New Brunswick. neal.fun/internet-roa...
Internet Roadtrip
Let's take a streetview roadtrip
neal.fun
May 31, 2025 at 3:27 AM
Internet Roadtrip is my favorite thing on the internet right now—it’s basically Twitch Plays Google Street View. They started in Boston, spent several weeks on a quest to cross the Canadian border, and are now exploring New Brunswick. neal.fun/internet-roa...
Started in Abhishek’s lab as a new postdoc without any coding skills, and now I've contributed to a bacterial-tracking library and debugged critical issues while at that - super happy with this.
Thanks to all my more-hardworking-coauthors on this one! Cheers and here is to many more 🥂.
Thanks to all my more-hardworking-coauthors on this one! Cheers and here is to many more 🥂.
Presenting RABiTPy, a Python package for bacterial tracking that works in a jupyter notebook format for: video/image stack import and processing, AI-based or traditional cell segmentation, cell tracking, trajectory analysis, and downstream plotting
bmcbioinformatics.biomedcentral.com/articles/10....
bmcbioinformatics.biomedcentral.com/articles/10....
RABiTPy: an open-source Python software for rapid, AI-powered bacterial tracking and analysis - BMC Bioinformatics
Bacterial tracking is crucial for understanding the mechanisms governing motility, chemotaxis, cell division, biofilm formation, and pathogenesis. Although modern microscopy and computing have enabled...
bmcbioinformatics.biomedcentral.com
May 24, 2025 at 6:38 PM
Started in Abhishek’s lab as a new postdoc without any coding skills, and now I've contributed to a bacterial-tracking library and debugged critical issues while at that - super happy with this.
Thanks to all my more-hardworking-coauthors on this one! Cheers and here is to many more 🥂.
Thanks to all my more-hardworking-coauthors on this one! Cheers and here is to many more 🥂.
Reposted by Jitendra Gosai
Interviewer: Can you explain this gap in your resume?
Me: I was waiting for the Argon laser to warm up
Me: I was waiting for the Argon laser to warm up
December 20, 2024 at 1:32 PM
Interviewer: Can you explain this gap in your resume?
Me: I was waiting for the Argon laser to warm up
Me: I was waiting for the Argon laser to warm up
Reposted by Jitendra Gosai
TaxonKit v0.20.0 is adapted to recent rank changes in NCBI Taxonomy.
github.com/shenwei356/t...
Also updated
- taxid-changelog to May, 2025 github.com/shenwei356/t...
- gtdb-taxdump to GTDB r226 github.com/shenwei356/g...
- ictv-taxdump to VMR_MSL40 github.com/shenwei356/i...
github.com/shenwei356/t...
Also updated
- taxid-changelog to May, 2025 github.com/shenwei356/t...
- gtdb-taxdump to GTDB r226 github.com/shenwei356/g...
- ictv-taxdump to VMR_MSL40 github.com/shenwei356/i...
Release TaxonKit v0.20.0 · shenwei356/taxonkit
Changes
TaxonKit v0.20.0
This version is mainly for maintaining compatibility with NCBI's recent changes(1, 2).
Please remove the ranks.txt file in ~/.taxonkit/ or other directories containing t...
github.com
May 6, 2025 at 4:13 AM
TaxonKit v0.20.0 is adapted to recent rank changes in NCBI Taxonomy.
github.com/shenwei356/t...
Also updated
- taxid-changelog to May, 2025 github.com/shenwei356/t...
- gtdb-taxdump to GTDB r226 github.com/shenwei356/g...
- ictv-taxdump to VMR_MSL40 github.com/shenwei356/i...
github.com/shenwei356/t...
Also updated
- taxid-changelog to May, 2025 github.com/shenwei356/t...
- gtdb-taxdump to GTDB r226 github.com/shenwei356/g...
- ictv-taxdump to VMR_MSL40 github.com/shenwei356/i...
Reposted by Jitendra Gosai
New 𝘕𝘢𝘵𝘶𝘳𝘦 𝘔𝘦𝘥𝘪𝘤𝘪𝘯𝘦 🦠
Personalized Nebulized Bacteriophage Therapy for MDR 𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 Infections in Cystic Fibrosis
In 9 patients, 10²–10⁴ CFU/mL drop in sputum bacteria, 6% median gain in FEV1
Post-treatment isolates showed trade-offs—reduced virulence, increased antibiotic susceptibility
Personalized Nebulized Bacteriophage Therapy for MDR 𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 Infections in Cystic Fibrosis
In 9 patients, 10²–10⁴ CFU/mL drop in sputum bacteria, 6% median gain in FEV1
Post-treatment isolates showed trade-offs—reduced virulence, increased antibiotic susceptibility
Personalized inhaled bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa in cystic fibrosis - Nature Medicine
A novel personalized phage therapy strategy that selects phages for a predicted evolutionary trade-off may represent a viable alternative approach for the treatment of antimicrobial-resistant bacteria...
www.nature.com
May 4, 2025 at 3:27 PM
New 𝘕𝘢𝘵𝘶𝘳𝘦 𝘔𝘦𝘥𝘪𝘤𝘪𝘯𝘦 🦠
Personalized Nebulized Bacteriophage Therapy for MDR 𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 Infections in Cystic Fibrosis
In 9 patients, 10²–10⁴ CFU/mL drop in sputum bacteria, 6% median gain in FEV1
Post-treatment isolates showed trade-offs—reduced virulence, increased antibiotic susceptibility
Personalized Nebulized Bacteriophage Therapy for MDR 𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 Infections in Cystic Fibrosis
In 9 patients, 10²–10⁴ CFU/mL drop in sputum bacteria, 6% median gain in FEV1
Post-treatment isolates showed trade-offs—reduced virulence, increased antibiotic susceptibility
Reposted by Jitendra Gosai
Do people in the same household share strains when they have the same species?
How many cells transmit when a strain is shared?
Can strain composition be dynamic when species composition is stable?
We answer these and related questions for the facial skin microbiome in our latest paper.
🧵[1/10]
How many cells transmit when a strain is shared?
Can strain composition be dynamic when species composition is stable?
We answer these and related questions for the facial skin microbiome in our latest paper.
🧵[1/10]
May 1, 2025 at 6:41 PM
Do people in the same household share strains when they have the same species?
How many cells transmit when a strain is shared?
Can strain composition be dynamic when species composition is stable?
We answer these and related questions for the facial skin microbiome in our latest paper.
🧵[1/10]
How many cells transmit when a strain is shared?
Can strain composition be dynamic when species composition is stable?
We answer these and related questions for the facial skin microbiome in our latest paper.
🧵[1/10]
Reposted by Jitendra Gosai
Some insect larvae have been incorporating microplastics into the casings they build to protect themselves against predators since at least the early 1970s, researchers report. scim.ag/3GD5SNx
Four decades ago, this insect built its protective shell from human garbage
Study suggests microplastics have been affecting freshwater animal communities for decades
scim.ag
April 24, 2025 at 4:14 PM
Some insect larvae have been incorporating microplastics into the casings they build to protect themselves against predators since at least the early 1970s, researchers report. scim.ag/3GD5SNx
Reposted by Jitendra Gosai
A trial has drawn links between fibromyalgia and alterations of the gut microbiome
https://go.nature.com/3EDZxkv
https://go.nature.com/3EDZxkv
Baffling chronic pain eases after doses of gut microbes
A small, preliminary trial and studies in mice draw links between fibromyalgia and alterations of the gut microbiome.
go.nature.com
April 24, 2025 at 4:13 PM
A trial has drawn links between fibromyalgia and alterations of the gut microbiome
https://go.nature.com/3EDZxkv
https://go.nature.com/3EDZxkv
Reposted by Jitendra Gosai
Fascinating innate immune evasion strategy in SCIENCE #glycotime
𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 𝘴𝘺𝘳𝘪𝘯𝘨𝘢𝘦 makes GLYCOSIRIN, a novel iminosugar that blocks plant glycosidases from degrading bacterial flagellin—hiding pathogens from plant immune sensors. New cryo-EM insights reveal exactly how this stealthy trick works
𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 𝘴𝘺𝘳𝘪𝘯𝘨𝘢𝘦 makes GLYCOSIRIN, a novel iminosugar that blocks plant glycosidases from degrading bacterial flagellin—hiding pathogens from plant immune sensors. New cryo-EM insights reveal exactly how this stealthy trick works
Bacterial pathogen deploys the iminosugar glycosyrin to manipulate plant glycobiology
The extracellular space (apoplast) in plants is a key battleground during microbial infections. To avoid recognition, the bacterial model phytopathogen Pseudomonas syringae pv. tomato DC3000 produces ...
www.science.org
April 18, 2025 at 5:00 AM
Fascinating innate immune evasion strategy in SCIENCE #glycotime
𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 𝘴𝘺𝘳𝘪𝘯𝘨𝘢𝘦 makes GLYCOSIRIN, a novel iminosugar that blocks plant glycosidases from degrading bacterial flagellin—hiding pathogens from plant immune sensors. New cryo-EM insights reveal exactly how this stealthy trick works
𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 𝘴𝘺𝘳𝘪𝘯𝘨𝘢𝘦 makes GLYCOSIRIN, a novel iminosugar that blocks plant glycosidases from degrading bacterial flagellin—hiding pathogens from plant immune sensors. New cryo-EM insights reveal exactly how this stealthy trick works
Reposted by Jitendra Gosai
Delighted to share that @asm.org has met its goal for all of its 'legacy' journals (ie favorites like J. Bact, I&I, AEM) so ALL 2025 articles will be published open access. Thanks to all institutional subscribers, this is the S2O way.
Please submit to these great journals!
asm.org/Press-Releas...
Please submit to these great journals!
asm.org/Press-Releas...
ASM Expands Open Access: 6 Journals Available in 2025 Via S2O
ASM has successfully met its sustainability target for the subscription year under its S2O publishing model. Now, articles in the 2025 volume of ASM’s 6 S2O journals will be published open access.
asm.org
April 2, 2025 at 5:30 PM
Delighted to share that @asm.org has met its goal for all of its 'legacy' journals (ie favorites like J. Bact, I&I, AEM) so ALL 2025 articles will be published open access. Thanks to all institutional subscribers, this is the S2O way.
Please submit to these great journals!
asm.org/Press-Releas...
Please submit to these great journals!
asm.org/Press-Releas...
Reposted by Jitendra Gosai
A paper in Nature presents a temporary pacemaker smaller than a grain of rice capable of mediating effective cardiac pacing in animal models and human heart tissues. https://go.nature.com/3E4Trt6 #medsky 🧪
April 2, 2025 at 10:19 PM
A paper in Nature presents a temporary pacemaker smaller than a grain of rice capable of mediating effective cardiac pacing in animal models and human heart tissues. https://go.nature.com/3E4Trt6 #medsky 🧪