Gabriel Ortega
@gabolab.bsky.social
Research lab at CIC bioGUNE (Bilbao, Spain).
Biosensors, biomolecular engineering and protein biophysics.
www.cicbiogune.es/people/gortega
Biosensors, biomolecular engineering and protein biophysics.
www.cicbiogune.es/people/gortega
Reposted by Gabriel Ortega
#bioGUNE_Seminars | 👥 Yesterday we held a new #OncoSeminar session at #CICbioGUNE @brtaeus.bsky.social under #PreMetaCan, where researchers shared recent advances and challenges. A participatory format that fostered synergies, collaboration, and new connections
@contracancerinv.bsky.social
@contracancerinv.bsky.social
November 21, 2025 at 7:43 AM
#bioGUNE_Seminars | 👥 Yesterday we held a new #OncoSeminar session at #CICbioGUNE @brtaeus.bsky.social under #PreMetaCan, where researchers shared recent advances and challenges. A participatory format that fostered synergies, collaboration, and new connections
@contracancerinv.bsky.social
@contracancerinv.bsky.social
Not only an impressive high-throughput characterization of protein stability, but so many interesting take away messages...
Arginines bad for solubility
Solubility predictors not great
Anti-correlation between aggregation and folding stability
...
Amazing work!
Arginines bad for solubility
Solubility predictors not great
Anti-correlation between aggregation and folding stability
...
Amazing work!
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
November 20, 2025 at 11:54 AM
Not only an impressive high-throughput characterization of protein stability, but so many interesting take away messages...
Arginines bad for solubility
Solubility predictors not great
Anti-correlation between aggregation and folding stability
...
Amazing work!
Arginines bad for solubility
Solubility predictors not great
Anti-correlation between aggregation and folding stability
...
Amazing work!
Reposted by Gabriel Ortega
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
November 19, 2025 at 9:16 PM
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
Reposted by Gabriel Ortega
#bioGUNE_Research | The @caixaresearch.bsky.social funds nearly €1M for #GlycoTARGET, led by June Ereño-Orbea #CICbioGUNE #Ikerbasque @brtaeus.bsky.social, to boost cancer immunotherapy with partners from Spain & Portugal
🔗 cicbiogune.es/news/la-caix...
@urv.cat @champalimaudr.bsky.social
🔗 cicbiogune.es/news/la-caix...
@urv.cat @champalimaudr.bsky.social
November 20, 2025 at 8:24 AM
#bioGUNE_Research | The @caixaresearch.bsky.social funds nearly €1M for #GlycoTARGET, led by June Ereño-Orbea #CICbioGUNE #Ikerbasque @brtaeus.bsky.social, to boost cancer immunotherapy with partners from Spain & Portugal
🔗 cicbiogune.es/news/la-caix...
@urv.cat @champalimaudr.bsky.social
🔗 cicbiogune.es/news/la-caix...
@urv.cat @champalimaudr.bsky.social
Reposted by Gabriel Ortega
Giant telescope project, long planned for Hawaii, gets cozy with Spain | Science | AAAS 🔭🧪 @science.org www.science.org/content/arti...
Giant telescope project, long planned for Hawaii, gets cozy with Spain
Spain’s €400 million offer could induce Thirty Meter Telescope to switch sites
www.science.org
November 17, 2025 at 5:50 PM
Giant telescope project, long planned for Hawaii, gets cozy with Spain | Science | AAAS 🔭🧪 @science.org www.science.org/content/arti...
Reposted by Gabriel Ortega
NEW pub in @science.org 🥳
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
November 13, 2025 at 8:34 PM
NEW pub in @science.org 🥳
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
Saw this on the other site by @smead2.bsky.social
Synuclein spreading as prions… great news for all researchers ever working with synuclein!
Synuclein spreading as prions… great news for all researchers ever working with synuclein!
November 12, 2025 at 10:14 PM
Saw this on the other site by @smead2.bsky.social
Synuclein spreading as prions… great news for all researchers ever working with synuclein!
Synuclein spreading as prions… great news for all researchers ever working with synuclein!
Reposted by Gabriel Ortega
ahem, ONE of THE chemical biology conferences of 2026:) www.janelia.org/you-janelia/...
Chemical Tools for Complex Biological Systems IV
Organizers Luke Lavis, HHMI/Janelia Research Campus Matthew Bogyo, Stanford University Zev Gartner, University of California, San Francisco Jennifer Prescher, University of California, Irvine
www.janelia.org
November 11, 2025 at 6:03 PM
ahem, ONE of THE chemical biology conferences of 2026:) www.janelia.org/you-janelia/...
Reposted by Gabriel Ortega
Registration for THE chemical biology conference of 2026 is now open! EMBO ChemBio 2026 in Heidelberg
DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social
www.embl.org/about/info/c...
DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social
www.embl.org/about/info/c...
Chemical biology 2026
www.embl.org
November 11, 2025 at 5:46 PM
Registration for THE chemical biology conference of 2026 is now open! EMBO ChemBio 2026 in Heidelberg
DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social
www.embl.org/about/info/c...
DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social
www.embl.org/about/info/c...
Reposted by Gabriel Ortega
If you believe either that Franklin discovered the double helix, and / or Watson and Crick stole her data, ask yourself how you know this. Then take a read of this article.
If I see one more stupid Rosalind Franklin take I'm going to lose my mind. Thank god for @matthewcobb.bsky.social and @nccomfort.bsky.social. www.nature.com/articles/d41...
What Rosalind Franklin truly contributed to the discovery of DNA’s structure
Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.
www.nature.com
November 8, 2025 at 7:32 AM
If you believe either that Franklin discovered the double helix, and / or Watson and Crick stole her data, ask yourself how you know this. Then take a read of this article.
Reposted by Gabriel Ortega
#bioGUNE_News | 💡 The European project #RGNcestry, awarded an #ERCSyG, brings together #CICbioGUNE and Instituto Biofisika to study CRISPR evolution and develop next-gen gene-editing and diagnostic tools
🔗 www.cicbiogune.es/news/cic-bio...
@erc.europa.eu
🔗 www.cicbiogune.es/news/cic-bio...
@erc.europa.eu
November 6, 2025 at 11:55 AM
#bioGUNE_News | 💡 The European project #RGNcestry, awarded an #ERCSyG, brings together #CICbioGUNE and Instituto Biofisika to study CRISPR evolution and develop next-gen gene-editing and diagnostic tools
🔗 www.cicbiogune.es/news/cic-bio...
@erc.europa.eu
🔗 www.cicbiogune.es/news/cic-bio...
@erc.europa.eu
Reposted by Gabriel Ortega
Nature research paper: Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites
go.nature.com/47qdigV
go.nature.com/47qdigV
Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites - Nature
A recombinant antivenom composed of eight nanobodies provides broad protection against venom-induced lethality and dermonecrosis in mice challenged with venoms from cobras, mambas and rinkhals snakes.
go.nature.com
October 29, 2025 at 6:30 PM
Nature research paper: Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites
go.nature.com/47qdigV
go.nature.com/47qdigV
Reposted by Gabriel Ortega
γδ T cells are a unique population of immune cells that can recognize and kill tumors.
A 2024 #ScienceReview explores current research efforts focused on how γδ cells naturally discriminate cancers from healthy tissues. https://scim.ag/3L4i3oU #ScienceMagArchives
A 2024 #ScienceReview explores current research efforts focused on how γδ cells naturally discriminate cancers from healthy tissues. https://scim.ag/3L4i3oU #ScienceMagArchives
Cancer immunotherapy by γδ T cells
The premise of cancer immunotherapy is that cancers are specifically visible to an immune system tolerized to healthy self. The promise of cancer immunotherapy is that immune effector mechanisms and i...
scim.ag
October 24, 2025 at 7:56 PM
γδ T cells are a unique population of immune cells that can recognize and kill tumors.
A 2024 #ScienceReview explores current research efforts focused on how γδ cells naturally discriminate cancers from healthy tissues. https://scim.ag/3L4i3oU #ScienceMagArchives
A 2024 #ScienceReview explores current research efforts focused on how γδ cells naturally discriminate cancers from healthy tissues. https://scim.ag/3L4i3oU #ScienceMagArchives
¿Qué son y para qué sirven los biosensores?
Aquí hablo de ello en #BioEnredados el podcast de divulgación científica de @cicbiogune.bsky.social
Enjoy!
Aquí hablo de ello en #BioEnredados el podcast de divulgación científica de @cicbiogune.bsky.social
Enjoy!
#bioGUNE_Outreach | 🎙️ Biosensores, el cuerpo habla y la ciencia escucha
➡️ ¿Y si la tecnología pudiera avisarte antes de que aparezcan los síntomas? Descúbrelo con @gabolab.bsky.social #Ikerbasque en #BioEnredados #CICbioGUNE @brtaeus.bsky.social
🔗 ow.ly/TJYO50XeLy0
➡️ ¿Y si la tecnología pudiera avisarte antes de que aparezcan los síntomas? Descúbrelo con @gabolab.bsky.social #Ikerbasque en #BioEnredados #CICbioGUNE @brtaeus.bsky.social
🔗 ow.ly/TJYO50XeLy0
October 21, 2025 at 9:40 AM
¿Qué son y para qué sirven los biosensores?
Aquí hablo de ello en #BioEnredados el podcast de divulgación científica de @cicbiogune.bsky.social
Enjoy!
Aquí hablo de ello en #BioEnredados el podcast de divulgación científica de @cicbiogune.bsky.social
Enjoy!
Reposted by Gabriel Ortega
📢 New preprint:
Experiment-guided AlphaFold3 resolves accurate protein ensembles.
doi.org/10.1101/2025...
AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇
Experiment-guided AlphaFold3 resolves accurate protein ensembles.
doi.org/10.1101/2025...
AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇
October 18, 2025 at 6:59 PM
📢 New preprint:
Experiment-guided AlphaFold3 resolves accurate protein ensembles.
doi.org/10.1101/2025...
AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇
Experiment-guided AlphaFold3 resolves accurate protein ensembles.
doi.org/10.1101/2025...
AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇
Reposted by Gabriel Ortega
BREAKING: The Nobel Prize in Physics has been awarded to John Clarke, Michel H. Devoret, and John M. Martinis "for the discovery of macroscopic quantum mechanical tunnelling and energy quantisation in an electric circuit"
Stay tuned for more.
Stay tuned for more.
October 7, 2025 at 9:51 AM
BREAKING: The Nobel Prize in Physics has been awarded to John Clarke, Michel H. Devoret, and John M. Martinis "for the discovery of macroscopic quantum mechanical tunnelling and energy quantisation in an electric circuit"
Stay tuned for more.
Stay tuned for more.
Reposted by Gabriel Ortega
‼️Premio Nobel de Física 2025 a los descubridores del efecto túnel cuántico macroscópico www.eldiario.es/1_c1383c?utm...
Premio Nobel de Física 2025 a los descubridores del efecto túnel cuántico macroscópico
La Real Academia Sueca de Ciencias ha otorgado el premio a a John Clarke, Michel H. Devoret y John M. Martinis “por el descubrimiento del efecto túnel mecánico cuántico macroscópico y la cuantificaci...
www.eldiario.es
October 7, 2025 at 9:54 AM
‼️Premio Nobel de Física 2025 a los descubridores del efecto túnel cuántico macroscópico www.eldiario.es/1_c1383c?utm...
Reposted by Gabriel Ortega
⚫Hoy decimos adiós a la primatóloga Jane Goodall.
Maravillosa su entrada el pasado mes de abril en @larevueltafans.bsky.social, enseñando a Broncano a hablar chimpancé.
D.E.P.
www.rtve.es/noticias/202...
Maravillosa su entrada el pasado mes de abril en @larevueltafans.bsky.social, enseñando a Broncano a hablar chimpancé.
D.E.P.
www.rtve.es/noticias/202...
October 1, 2025 at 6:39 PM
⚫Hoy decimos adiós a la primatóloga Jane Goodall.
Maravillosa su entrada el pasado mes de abril en @larevueltafans.bsky.social, enseñando a Broncano a hablar chimpancé.
D.E.P.
www.rtve.es/noticias/202...
Maravillosa su entrada el pasado mes de abril en @larevueltafans.bsky.social, enseñando a Broncano a hablar chimpancé.
D.E.P.
www.rtve.es/noticias/202...
Placental organoids, cool!
Why do we still know so little about pregnancy? Claire Richards and Lana McClements write about their Nature Communications paper, explaining why sampling early placental tissue is risky, and how the world’s first bioprinted placenta organoids can help. #Academicsky 🧪
Designer homes for mini-placentas: A bioprinted solution
Mini placentas can be grown in the lab to study pregnancy and complications like preeclampsia. Using 3D printing technology, we have bioprinted the first placental organoids and studied the impact of their environment on cell behaviour.
go.nature.com
September 25, 2025 at 7:24 PM
Placental organoids, cool!
Reposted by Gabriel Ortega
"Adapting ProteinMPNN for antibody design without retraining"
Our several-years-old fix to ProteinMPNN's tendency to make weird antibody CDR sequences is finally preprinted
Our several-years-old fix to ProteinMPNN's tendency to make weird antibody CDR sequences is finally preprinted
Adapting ProteinMPNN for antibody design without retraining
The neural network ProteinMPNN designs protein sequences capable of folding into predefined tertiary structures and quaternary assemblies. It has become widely used due to its high success rates when ...
www.biorxiv.org
May 15, 2025 at 4:30 PM
"Adapting ProteinMPNN for antibody design without retraining"
Our several-years-old fix to ProteinMPNN's tendency to make weird antibody CDR sequences is finally preprinted
Our several-years-old fix to ProteinMPNN's tendency to make weird antibody CDR sequences is finally preprinted
🚨 New paper alert!
We used AI to make nanobodies more stable, easier to produce, and just as effective at binding their targets.
🔗 Gift link here:
academic.oup.com/peds/advance...
We used AI to make nanobodies more stable, easier to produce, and just as effective at binding their targets.
🔗 Gift link here:
academic.oup.com/peds/advance...
Improving the Production and Stability of Nanobodies
Abstract. Nanobodies offer unique advantages in biomedical and biotechnological applications due to their smaller size, ability to bind challenging epitope
eur04.safelinks.protection.outlook.com
September 25, 2025 at 10:34 AM
🚨 New paper alert!
We used AI to make nanobodies more stable, easier to produce, and just as effective at binding their targets.
🔗 Gift link here:
academic.oup.com/peds/advance...
We used AI to make nanobodies more stable, easier to produce, and just as effective at binding their targets.
🔗 Gift link here:
academic.oup.com/peds/advance...
Reposted by Gabriel Ortega
Still boggles my mind that we can leave frameworks as-is and only edit CDRs and still reliably get nM binders. Complete opposite of what I would have expected given how hard it is to graft CDRs from one FW to another (such as humanizing mouse mAbs). First RFantibody and now this
In another preprint from the @brianhie.bsky.social Lab and @synbiogaolab.bsky.social, they introduce Germinal, a generative AI system for de novo antibody design.
Germinal produces functional nanobodies in just dozens of tests, making custom antibody design more accessible than ever before.
Germinal produces functional nanobodies in just dozens of tests, making custom antibody design more accessible than ever before.
September 25, 2025 at 2:07 AM
Still boggles my mind that we can leave frameworks as-is and only edit CDRs and still reliably get nM binders. Complete opposite of what I would have expected given how hard it is to graft CDRs from one FW to another (such as humanizing mouse mAbs). First RFantibody and now this
Reposted by Gabriel Ortega
In another preprint from the @brianhie.bsky.social Lab and @synbiogaolab.bsky.social, they introduce Germinal, a generative AI system for de novo antibody design.
Germinal produces functional nanobodies in just dozens of tests, making custom antibody design more accessible than ever before.
Germinal produces functional nanobodies in just dozens of tests, making custom antibody design more accessible than ever before.
September 24, 2025 at 3:07 PM
In another preprint from the @brianhie.bsky.social Lab and @synbiogaolab.bsky.social, they introduce Germinal, a generative AI system for de novo antibody design.
Germinal produces functional nanobodies in just dozens of tests, making custom antibody design more accessible than ever before.
Germinal produces functional nanobodies in just dozens of tests, making custom antibody design more accessible than ever before.
It’s gonna be a butchery.
As if the MSCA evaluation was not random enough…
As if the MSCA evaluation was not random enough…
“This represents an increase of 64.6%.”
Exciting time to be a postdoc 🙃
Exciting time to be a postdoc 🙃
September 16, 2025 at 1:19 PM
It’s gonna be a butchery.
As if the MSCA evaluation was not random enough…
As if the MSCA evaluation was not random enough…
Reposted by Gabriel Ortega
Interesting discussion between Reviewer 1 and the authors of "Redox-driven mineral and organic associations in Jezero Crater, Mars" and whether the paper will attract media attention as evidence of past Martian life
doi.org/10.1038/s415...
doi.org/10.1038/s415...
September 10, 2025 at 8:35 PM
Interesting discussion between Reviewer 1 and the authors of "Redox-driven mineral and organic associations in Jezero Crater, Mars" and whether the paper will attract media attention as evidence of past Martian life
doi.org/10.1038/s415...
doi.org/10.1038/s415...