Gabriel Ortega
@gabolab.bsky.social
Research lab at CIC bioGUNE (Bilbao, Spain).
Biosensors, biomolecular engineering and protein biophysics.
www.cicbiogune.es/people/gortega
Biosensors, biomolecular engineering and protein biophysics.
www.cicbiogune.es/people/gortega
Damn! I was just thinking it was hydrophobicity! Then what, folding reversibility? change in DCp?
November 20, 2025 at 11:49 AM
Damn! I was just thinking it was hydrophobicity! Then what, folding reversibility? change in DCp?
Yep, arginines and solubility... not a great match!
November 20, 2025 at 11:47 AM
Yep, arginines and solubility... not a great match!
Reposted by Gabriel Ortega
ahem, ONE of THE chemical biology conferences of 2026:) www.janelia.org/you-janelia/...
Chemical Tools for Complex Biological Systems IV
Organizers Luke Lavis, HHMI/Janelia Research Campus Matthew Bogyo, Stanford University Zev Gartner, University of California, San Francisco Jennifer Prescher, University of California, Irvine
www.janelia.org
November 11, 2025 at 6:03 PM
ahem, ONE of THE chemical biology conferences of 2026:) www.janelia.org/you-janelia/...
Mainly surface-exposed residues throughout the entire scaffold, lots of threonines, and some asparagines and glutamines (hydration?)
September 25, 2025 at 6:25 PM
Mainly surface-exposed residues throughout the entire scaffold, lots of threonines, and some asparagines and glutamines (hydration?)
Interesting!
Although perhaps not that surprising to me. We found that we can engineer up to 10% of the amino acids in the framework to improve their production and stability without affecting binding (granted, nanobodies are simpler...)
bsky.app/profile/gabo...
Although perhaps not that surprising to me. We found that we can engineer up to 10% of the amino acids in the framework to improve their production and stability without affecting binding (granted, nanobodies are simpler...)
bsky.app/profile/gabo...
🚨 New paper alert!
We used AI to make nanobodies more stable, easier to produce, and just as effective at binding their targets.
🔗 Gift link here:
academic.oup.com/peds/advance...
We used AI to make nanobodies more stable, easier to produce, and just as effective at binding their targets.
🔗 Gift link here:
academic.oup.com/peds/advance...
Improving the Production and Stability of Nanobodies
Abstract. Nanobodies offer unique advantages in biomedical and biotechnological applications due to their smaller size, ability to bind challenging epitope
eur04.safelinks.protection.outlook.com
September 25, 2025 at 5:01 PM
Interesting!
Although perhaps not that surprising to me. We found that we can engineer up to 10% of the amino acids in the framework to improve their production and stability without affecting binding (granted, nanobodies are simpler...)
bsky.app/profile/gabo...
Although perhaps not that surprising to me. We found that we can engineer up to 10% of the amino acids in the framework to improve their production and stability without affecting binding (granted, nanobodies are simpler...)
bsky.app/profile/gabo...