Erik Van Dis
@erikvandis.bsky.social
Immunologist and Damon Runyon fellow in the Stetson lab at UW, interested in innate immunity and cell death.
Previously at Berkeley, Carleton College and Rocky Mountain Labs
Previously at Berkeley, Carleton College and Rocky Mountain Labs
Reposted by Erik Van Dis
"Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity" spkl.io/63326Ad0f6
Ya-Chieh Hsu & colleagues
@cp-cell.bsky.social
Ya-Chieh Hsu & colleagues
@cp-cell.bsky.social
November 26, 2025 at 11:30 PM
"Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity" spkl.io/63326Ad0f6
Ya-Chieh Hsu & colleagues
@cp-cell.bsky.social
Ya-Chieh Hsu & colleagues
@cp-cell.bsky.social
Reposted by Erik Van Dis
‘Lymphotoxin alpha eradicates acute myeloid leukemia and simultaneously promotes healthy hematopoiesis in mice’
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Lymphotoxin alpha eradicates acute myeloid leukemia and simultaneously promotes healthy hematopoiesis in mice
Lymphotoxin alpha represses acute myeloid leukemia by depleting TRAF2 and triggering cell death and myeloid differentiation.
www.science.org
November 26, 2025 at 10:44 PM
‘Lymphotoxin alpha eradicates acute myeloid leukemia and simultaneously promotes healthy hematopoiesis in mice’
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Erik Van Dis
Annndddd it’s out! Here’s what came out of combining my virology background with the @brozlab.bsky.social’s cell death focus : a novel role for the cell death protein ninj1 during hsv1 infection. In brief, Ninj1 on mouse macrophages results in lower infection rates and higher cytokine secretion.
November 20, 2025 at 3:29 PM
Annndddd it’s out! Here’s what came out of combining my virology background with the @brozlab.bsky.social’s cell death focus : a novel role for the cell death protein ninj1 during hsv1 infection. In brief, Ninj1 on mouse macrophages results in lower infection rates and higher cytokine secretion.
Reposted by Erik Van Dis
November is a big month for the lab with *two* new papers by @ehartenian.bsky.social and @alexandraboegli.bsky.social ++ co authors now online.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
NINJ1 blocks HSV-1 entry into macrophages to impact viral replication and immunity | EMBO reports
imageimageNINJ1 blocks HSV-1 entry into mouse macrophages independent of its role in cell death, resulting in greater secretion of pro inflammatory cytokines downstream of infection. Mouse macrophages lacking NINJ1 are more permissive to HSV-1 ...
www.embopress.org
November 20, 2025 at 3:15 PM
November is a big month for the lab with *two* new papers by @ehartenian.bsky.social and @alexandraboegli.bsky.social ++ co authors now online.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Erik Van Dis
Dengue Virus NS1 Binds Ephrin B1 to Trigger Endothelial Dysfunction https://www.biorxiv.org/content/10.1101/2025.11.19.689067v1
November 19, 2025 at 11:16 PM
Dengue Virus NS1 Binds Ephrin B1 to Trigger Endothelial Dysfunction https://www.biorxiv.org/content/10.1101/2025.11.19.689067v1
Reposted by Erik Van Dis
@biorxivpreprint.bsky.social Regulation of lipid metabolism is a primordial function of STING @igmm-montpel.bsky.social
www.biorxiv.org/content/10.1... @nadinelaguette.bsky.social
www.biorxiv.org/content/10.1... @nadinelaguette.bsky.social
November 19, 2025 at 1:27 AM
@biorxivpreprint.bsky.social Regulation of lipid metabolism is a primordial function of STING @igmm-montpel.bsky.social
www.biorxiv.org/content/10.1... @nadinelaguette.bsky.social
www.biorxiv.org/content/10.1... @nadinelaguette.bsky.social
Reposted by Erik Van Dis
“The prohibited activities would include joint research, co-authorship on papers, and advising a foreign graduate student or postdoctoral fellow. The language is retroactive, meaning any interactions during the previous 5 years could make a scientist ineligible for future federal funding.”
U.S. Congress considers sweeping ban on Chinese collaborations
Researchers speak out against proposal that would bar funding for U.S. scientists working with Chinese partners or training Chinese students
www.science.org
November 14, 2025 at 1:03 AM
“The prohibited activities would include joint research, co-authorship on papers, and advising a foreign graduate student or postdoctoral fellow. The language is retroactive, meaning any interactions during the previous 5 years could make a scientist ineligible for future federal funding.”
Reposted by Erik Van Dis
NEW: Jenna Norton, an NIH employee who is openly critical of Trump & RFK Jr, has been put on "non-disciplinary" administrative leave. She says the administration is trying to "scare and silence me." An HHS official, asked to comment, called her a radical leftist.
www.nytimes.com/2025/11/13/u...
www.nytimes.com/2025/11/13/u...
N.I.H. Worker Who Criticized Trump Health Policies Says She Is on Administrative Leave
www.nytimes.com
November 14, 2025 at 2:56 AM
NEW: Jenna Norton, an NIH employee who is openly critical of Trump & RFK Jr, has been put on "non-disciplinary" administrative leave. She says the administration is trying to "scare and silence me." An HHS official, asked to comment, called her a radical leftist.
www.nytimes.com/2025/11/13/u...
www.nytimes.com/2025/11/13/u...
Reposted by Erik Van Dis
Termination of the integrated stress response | Science www.science.org/doi/10.1126/...
Termination of the integrated stress response
Stress responses enable cells to detect, adapt to, and survive challenges. The benefit of these signaling pathways depends on their reversibility. The integrated stress response (ISR) is elicited by p...
www.science.org
November 13, 2025 at 7:05 PM
Termination of the integrated stress response | Science www.science.org/doi/10.1126/...
Reposted by Erik Van Dis
What is the most profitable industry in the world, this side of the law? Not oil, not IT, not pharma.
It's *scientific publishing*.
We call this the Drain of Scientific Publishing.
Paper: arxiv.org/abs/2511.04820
Background: doi.org/10.1162/qss_...
Thread @markhanson.fediscience.org.ap.brid.gy 👇
It's *scientific publishing*.
We call this the Drain of Scientific Publishing.
Paper: arxiv.org/abs/2511.04820
Background: doi.org/10.1162/qss_...
Thread @markhanson.fediscience.org.ap.brid.gy 👇
November 12, 2025 at 10:31 AM
What is the most profitable industry in the world, this side of the law? Not oil, not IT, not pharma.
It's *scientific publishing*.
We call this the Drain of Scientific Publishing.
Paper: arxiv.org/abs/2511.04820
Background: doi.org/10.1162/qss_...
Thread @markhanson.fediscience.org.ap.brid.gy 👇
It's *scientific publishing*.
We call this the Drain of Scientific Publishing.
Paper: arxiv.org/abs/2511.04820
Background: doi.org/10.1162/qss_...
Thread @markhanson.fediscience.org.ap.brid.gy 👇
Reposted by Erik Van Dis
Interleukin-1β (IL-1β) is secreted primarily by dying monocytes rather than by live bystander monocytes, challenging established models.
#cryopyrin
#pyrin
#immunology
#science
buff.ly/2cBb3sk
#cryopyrin
#pyrin
#immunology
#science
buff.ly/2cBb3sk
Single-cell analysis reveals cell death as driver of NLRP3-mediated secretion of IL-1β in human monocytes - Nature Immunology
Lamkanfi, Shirasaki, Izawa and colleagues show that IL-1β release in human monocytes stimulated with lipopolysaccharide or carrying NLRP3 activatory mutations is mostly restricted to cells undergoing…
buff.ly
November 11, 2025 at 7:58 PM
Interleukin-1β (IL-1β) is secreted primarily by dying monocytes rather than by live bystander monocytes, challenging established models.
#cryopyrin
#pyrin
#immunology
#science
buff.ly/2cBb3sk
#cryopyrin
#pyrin
#immunology
#science
buff.ly/2cBb3sk
Reposted by Erik Van Dis
Reposted by Erik Van Dis
Truncating RELA variants drive autoinflammation and autoimmunity by impairing the negative feedback control of NF-kB https://www.biorxiv.org/content/10.1101/2025.11.09.687461v1
November 10, 2025 at 9:17 PM
Truncating RELA variants drive autoinflammation and autoimmunity by impairing the negative feedback control of NF-kB https://www.biorxiv.org/content/10.1101/2025.11.09.687461v1
Reposted by Erik Van Dis
Can we improve peer review? We think we can! Check out an experiment I helped with as part of @solvingforsci.bsky.social 's mission to make science better.
And if you don't want to read the whole bioRxiv manuscript, here's an overview of the main findings:
solvingfor.org/news-posts-d...
And if you don't want to read the whole bioRxiv manuscript, here's an overview of the main findings:
solvingfor.org/news-posts-d...
November 5, 2025 at 11:25 PM
Can we improve peer review? We think we can! Check out an experiment I helped with as part of @solvingforsci.bsky.social 's mission to make science better.
And if you don't want to read the whole bioRxiv manuscript, here's an overview of the main findings:
solvingfor.org/news-posts-d...
And if you don't want to read the whole bioRxiv manuscript, here's an overview of the main findings:
solvingfor.org/news-posts-d...
Very cool work from my former mentor elucidating differential control of HIV by IFN alpha subtypes 🦠🧫🧬
Differential Control of HIV-1 Replication by IFN-α14 Compared to IFN-α2 Relates to Differences in the Modulation of Host Antiretroviral Restriction Factors https://www.biorxiv.org/content/10.1101/2025.11.01.685890v1
November 4, 2025 at 3:37 AM
Very cool work from my former mentor elucidating differential control of HIV by IFN alpha subtypes 🦠🧫🧬
Reposted by Erik Van Dis
Sphingolipid sensor degrades cGAMP to suppress antiviral host defense- #virus #lipids #hostdefense #innateImmunity
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation
Wang et al. find that cell membrane stress upon viral infection induces expression
and stabilization of host sphingomyelin phosphodiesterase acid-like 3B (SMPDL3B),
which, in turn, degrades cGAMP to s...
www.cell.com
November 2, 2025 at 6:52 PM
Sphingolipid sensor degrades cGAMP to suppress antiviral host defense- #virus #lipids #hostdefense #innateImmunity
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Reposted by Erik Van Dis
#Cytokines2025 will kick off with two special symposia! Check in early, get your badges, to attend these sessions.
November 2, 2025 at 5:19 PM
#Cytokines2025 will kick off with two special symposia! Check in early, get your badges, to attend these sessions.
Reposted by Erik Van Dis
Sad day for the folks who staked their reputations on lab leak conspiracy theories.
www.telegraph.co.uk/global-healt...
www.telegraph.co.uk/global-healt...
October 31, 2025 at 3:51 PM
Sad day for the folks who staked their reputations on lab leak conspiracy theories.
www.telegraph.co.uk/global-healt...
www.telegraph.co.uk/global-healt...
Reposted by Erik Van Dis
Super excited about first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to the brilliant Chase Suiter (not here) & @greenahn.bsky.social on the work! Preprint here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 14, 2025 at 6:45 PM
Super excited about first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to the brilliant Chase Suiter (not here) & @greenahn.bsky.social on the work! Preprint here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Erik Van Dis
When 2 life science discoveries converge: solving a ~3 decade mystery of extraordinary longevity and healthspan + an essential cell danger sensor
And related ongoing clinical trials!
erictopol.substack.com/p/a-long-awa...
And related ongoing clinical trials!
erictopol.substack.com/p/a-long-awa...
A Long-Awaited Longevity Mystery Solved
Spotlighting an essential human biologic pathway targeted by drugs in clinical trials
erictopol.substack.com
October 12, 2025 at 12:32 PM
When 2 life science discoveries converge: solving a ~3 decade mystery of extraordinary longevity and healthspan + an essential cell danger sensor
And related ongoing clinical trials!
erictopol.substack.com/p/a-long-awa...
And related ongoing clinical trials!
erictopol.substack.com/p/a-long-awa...
Reposted by Erik Van Dis
Asthma is a chronic disease characterized by acute, intermittent, recurrent episodes of airway inflammation. A decade of work developing the tools, techniques and collaborations needed to figure out how CD4+ T cells in the lungs propagate disease can be found here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells
Tissue-resident memory CD4+ T cells (TRM) are key sentinels of the adaptive immune response that provide a rapid, robust inflammatory response upon reactivation in non-lymphoid tissues. While CD4+ TRM...
www.biorxiv.org
October 10, 2025 at 7:22 PM
Asthma is a chronic disease characterized by acute, intermittent, recurrent episodes of airway inflammation. A decade of work developing the tools, techniques and collaborations needed to figure out how CD4+ T cells in the lungs propagate disease can be found here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Erik Van Dis
@biorxivpreprint.bsky.social Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells @marionpepper.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 7, 2025 at 3:02 PM
@biorxivpreprint.bsky.social Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells @marionpepper.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Erik Van Dis
How does a “universal” transcription factor evolve to do species-specific jobs?
Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes.
Read it here 👉
www.biorxiv.org/content/10.1...
#MolecularEvolution #Transcription
Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes.
Read it here 👉
www.biorxiv.org/content/10.1...
#MolecularEvolution #Transcription
Molecular determinants underlying functional divergence of TBP homologs
The TATA-box binding protein (TBP) is a highly conserved basal transcription factor and a core component of the pre-initiation complex (PIC) for all three eukaryotic RNA polymerases (RNA Pols). Despit...
www.biorxiv.org
October 7, 2025 at 7:43 PM
How does a “universal” transcription factor evolve to do species-specific jobs?
Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes.
Read it here 👉
www.biorxiv.org/content/10.1...
#MolecularEvolution #Transcription
Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes.
Read it here 👉
www.biorxiv.org/content/10.1...
#MolecularEvolution #Transcription
Reposted by Erik Van Dis
Impaired IFNγ responsiveness of lung monocyte-derived cells limits immunity to Mycobacterium tuberculosis https://www.biorxiv.org/content/10.1101/2025.10.06.680719v1
October 7, 2025 at 2:16 AM
Impaired IFNγ responsiveness of lung monocyte-derived cells limits immunity to Mycobacterium tuberculosis https://www.biorxiv.org/content/10.1101/2025.10.06.680719v1
Reposted by Erik Van Dis
Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells https://www.biorxiv.org/content/10.1101/2025.10.03.680350v1
October 6, 2025 at 2:16 AM
Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells https://www.biorxiv.org/content/10.1101/2025.10.03.680350v1