Daniel Lane
@dlane345.bsky.social
32 years old | Pittsburgh, PA | Infectious disease PhD Candidate | TB and Immunometabolism | Cat dad
Wreck of Shackleton’s Endurance Tied to Culprit Other Than Ice www.nytimes.com/2025/10/06/s...
Wreck of Shackleton’s Endurance Tied to Culprit Other Than Ice
www.nytimes.com
October 11, 2025 at 2:36 AM
Wreck of Shackleton’s Endurance Tied to Culprit Other Than Ice www.nytimes.com/2025/10/06/s...
Reposted by Daniel Lane
Measuring membrane fluidity in live mycobacteria reveals subcellular lateral variation and pole-selective responses to mycomembrane perturbation https://www.biorxiv.org/content/10.1101/2025.09.08.674961v1
September 9, 2025 at 4:22 AM
Measuring membrane fluidity in live mycobacteria reveals subcellular lateral variation and pole-selective responses to mycomembrane perturbation https://www.biorxiv.org/content/10.1101/2025.09.08.674961v1
Reposted by Daniel Lane
T6SS4 is heterogeneously expressed in Y. pseudotuberculosis and is a target for transcriptional and post-transcriptional regulation https://www.biorxiv.org/content/10.1101/2025.07.10.664076v1
July 11, 2025 at 3:17 AM
T6SS4 is heterogeneously expressed in Y. pseudotuberculosis and is a target for transcriptional and post-transcriptional regulation https://www.biorxiv.org/content/10.1101/2025.07.10.664076v1
Reposted by Daniel Lane
3'UTR-derived small RNA couples acid resistance to metabolic reprogramming of Salmonella within macrophages https://www.biorxiv.org/content/10.1101/2025.06.06.658255v1
June 7, 2025 at 4:23 AM
3'UTR-derived small RNA couples acid resistance to metabolic reprogramming of Salmonella within macrophages https://www.biorxiv.org/content/10.1101/2025.06.06.658255v1
Reposted by Daniel Lane
May’s ‘Microbe of the Month’ is a novel archaeon called Methanobrevibacter intestini which was isolated from a human faecal sample taken from an individual in the United States. Find out more about M. intestini and other exciting discoveries by clicking the link in our bio 🧫🔬
May 8, 2025 at 8:09 AM
May’s ‘Microbe of the Month’ is a novel archaeon called Methanobrevibacter intestini which was isolated from a human faecal sample taken from an individual in the United States. Find out more about M. intestini and other exciting discoveries by clicking the link in our bio 🧫🔬
Reposted by Daniel Lane
Researchers are studying why mitochondria are moving between cells and whether the process can be harnessed to treat cancer and other diseases
https://go.nature.com/4cHJv5S
https://go.nature.com/4cHJv5S
Cells are swapping their mitochondria. What does this mean for our health?
Nature - Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.
go.nature.com
April 18, 2025 at 2:34 PM
Researchers are studying why mitochondria are moving between cells and whether the process can be harnessed to treat cancer and other diseases
https://go.nature.com/4cHJv5S
https://go.nature.com/4cHJv5S
Reposted by Daniel Lane
A patient with poorly controlled HIV infection was found to have two different strains of 𝘛𝘳𝘦𝘱𝘰𝘯𝘦𝘮𝘢 𝘱𝘢𝘭𝘭𝘪𝘥𝘶𝘮. Careful evaluation showed evidence for recombination between these two organisms. Read the full correspondence: nej.md/3Y03J4w
#MedSky #IDSky #Genetics
#MedSky #IDSky #Genetics
April 18, 2025 at 4:04 PM
A patient with poorly controlled HIV infection was found to have two different strains of 𝘛𝘳𝘦𝘱𝘰𝘯𝘦𝘮𝘢 𝘱𝘢𝘭𝘭𝘪𝘥𝘶𝘮. Careful evaluation showed evidence for recombination between these two organisms. Read the full correspondence: nej.md/3Y03J4w
#MedSky #IDSky #Genetics
#MedSky #IDSky #Genetics
Reposted by Daniel Lane
"This is my home - I really love my country. But a lot of my mentors have been telling me to get out, right now"
75% of US scientists who answered our poll are considering relocating. Read the full story: https://go.nature.com/3E2OocE
75% of US scientists who answered our poll are considering relocating. Read the full story: https://go.nature.com/3E2OocE
April 1, 2025 at 9:58 AM
"This is my home - I really love my country. But a lot of my mentors have been telling me to get out, right now"
75% of US scientists who answered our poll are considering relocating. Read the full story: https://go.nature.com/3E2OocE
75% of US scientists who answered our poll are considering relocating. Read the full story: https://go.nature.com/3E2OocE
Reposted by Daniel Lane
Opinion | Banning DEI Is Catastrophic for U.S. Science
An attack on DEI is an attack on science itself, Joseph L. Graves Jr., Stacy C. Farina, Parvin Shahrestani, Vaughn S. Cooper and Gilda A. Barabino write. #HigherEd #EDUSky #AcademicSky bit.ly/4l569c2
An attack on DEI is an attack on science itself, Joseph L. Graves Jr., Stacy C. Farina, Parvin Shahrestani, Vaughn S. Cooper and Gilda A. Barabino write. #HigherEd #EDUSky #AcademicSky bit.ly/4l569c2
Banning DEI Is Catastrophic for U.S. Science (opinion)
An attack on DEI is an attack on science itself, Joseph L. Graves Jr., Stacy C. Farina, Parvin Shahrestani, Vaughn S. Cooper and Gilda A. Barabino write.
bit.ly
March 26, 2025 at 6:10 PM
Opinion | Banning DEI Is Catastrophic for U.S. Science
An attack on DEI is an attack on science itself, Joseph L. Graves Jr., Stacy C. Farina, Parvin Shahrestani, Vaughn S. Cooper and Gilda A. Barabino write. #HigherEd #EDUSky #AcademicSky bit.ly/4l569c2
An attack on DEI is an attack on science itself, Joseph L. Graves Jr., Stacy C. Farina, Parvin Shahrestani, Vaughn S. Cooper and Gilda A. Barabino write. #HigherEd #EDUSky #AcademicSky bit.ly/4l569c2
Reposted by Daniel Lane
The mood was defiant at many of the rallies, where chants of “Scientists will not be silenced”, “Facts over fear” and “What do we want? Peer review! When do we want it? Now!” were heard.
https://go.nature.com/3F8T6FX
https://go.nature.com/3F8T6FX
‘Scientists will not be silenced’: thousands protest Trump research cuts
Researchers at Stand Up for Science rallies voice defiance against the policies of US President Donald Trump’s administration.
go.nature.com
March 7, 2025 at 8:50 PM
The mood was defiant at many of the rallies, where chants of “Scientists will not be silenced”, “Facts over fear” and “What do we want? Peer review! When do we want it? Now!” were heard.
https://go.nature.com/3F8T6FX
https://go.nature.com/3F8T6FX
Reposted by Daniel Lane
This isn’t going to pass, as we keep hearing from science leaders. It’s not something we just need to get to the other side of.
It’s a fundamentally new politics for US science and we need to engage differently. The old playbook won’t work. 2/
It’s a fundamentally new politics for US science and we need to engage differently. The old playbook won’t work. 2/
February 15, 2025 at 9:56 PM
This isn’t going to pass, as we keep hearing from science leaders. It’s not something we just need to get to the other side of.
It’s a fundamentally new politics for US science and we need to engage differently. The old playbook won’t work. 2/
It’s a fundamentally new politics for US science and we need to engage differently. The old playbook won’t work. 2/
Reposted by Daniel Lane
There is a lot going on right now! So much in fact that our news team at @science.org is now running a Trump tracker to keep track of it all. *sigh* 🧪
www.science.org/content/arti...
www.science.org/content/arti...
Welcome to Trump Tracker: Probationary workers at health agencies being fired today
Follow President Donald Trump’s impact on U.S. research and science globally
www.science.org
February 14, 2025 at 10:30 PM
There is a lot going on right now! So much in fact that our news team at @science.org is now running a Trump tracker to keep track of it all. *sigh* 🧪
www.science.org/content/arti...
www.science.org/content/arti...
Reposted by Daniel Lane
south korean politicians were literally scaling fences to protect their government and our senators are sending out pre-scheduled tweets about the super bowl while an unelected foreign billionaire seizes control of the treasury.
February 2, 2025 at 2:08 PM
south korean politicians were literally scaling fences to protect their government and our senators are sending out pre-scheduled tweets about the super bowl while an unelected foreign billionaire seizes control of the treasury.
Reposted by Daniel Lane
Reposted by Daniel Lane
Reposted by Daniel Lane
As this "pause" hits you and your project, institution, workplace, etc:
TELL SOMEONE ABOUT IT.
Contact your MoC, esp if they're a Dem. Contact a relevant advocacy group. Contact the press, local, regional, movement, trade - and not just for an LtE, for a story.
Tell real life stories of harm.
TELL SOMEONE ABOUT IT.
Contact your MoC, esp if they're a Dem. Contact a relevant advocacy group. Contact the press, local, regional, movement, trade - and not just for an LtE, for a story.
Tell real life stories of harm.
January 28, 2025 at 2:34 AM
As this "pause" hits you and your project, institution, workplace, etc:
TELL SOMEONE ABOUT IT.
Contact your MoC, esp if they're a Dem. Contact a relevant advocacy group. Contact the press, local, regional, movement, trade - and not just for an LtE, for a story.
Tell real life stories of harm.
TELL SOMEONE ABOUT IT.
Contact your MoC, esp if they're a Dem. Contact a relevant advocacy group. Contact the press, local, regional, movement, trade - and not just for an LtE, for a story.
Tell real life stories of harm.
Reposted by Daniel Lane
🧪Here's the script for your senators. If you're in WI, like I am, that's Johnson www.ronjohnson.senate.gov/office_locat... and Baldwin www.baldwin.senate.gov
Data by state on NIH impact: www.unitedformedicalresearch.org/nih-in-your-...
Data by state on NIH impact: www.unitedformedicalresearch.org/nih-in-your-...
![I am calling due to grave concerns with the freezing of communications at Federal agencies. Specifically, I am calling regarding HHS and the National Institutes of Health, including the indefinite suspension of council review meetings, review section, and travel. Currently, our state of [insert state here] benefits from over $654 million [WI data; insert data from your state here] in biomedical research funding from the NIH with a significant portion of that going to support jobs, innovation, and education, translating to $1.64 Billion in economic activity [WI data; insert data from your state here]. As a concerned local [citizen/resident/scientist/researcher/educator], I urge you to make sure that the money that has already been allocated for NIH extramural funding, including all training and workforce development grants remain committed. Having this funding removed would be disastrous for our local economy, important university biomedical research, and would lead to the loss of thousands of research training positions at the staff, postdoctoral, and graduate student level. NIH has always benefited from Congressional support across political ideologies, and continuing to commit to its funding and extramural projects ensures our country remains at the forefront of biomedical research efforts and innovations.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:pj7rqr7fzl2qf4v7l7ygej6w/bafkreif2irkeiikyvwoqan3aksfsatisbkobnupftulco2gjy6reu2lfoa@jpeg)
January 23, 2025 at 3:32 AM
🧪Here's the script for your senators. If you're in WI, like I am, that's Johnson www.ronjohnson.senate.gov/office_locat... and Baldwin www.baldwin.senate.gov
Data by state on NIH impact: www.unitedformedicalresearch.org/nih-in-your-...
Data by state on NIH impact: www.unitedformedicalresearch.org/nih-in-your-...
Reposted by Daniel Lane
New in @science.org: A World Less Safe & Secure
We examine how the US withdrawal from @who.int will limit US leadership to protect public health & challenge WHO governance in facing global challenges.
www.science.org/doi/10.1126/...
We examine how the US withdrawal from @who.int will limit US leadership to protect public health & challenge WHO governance in facing global challenges.
www.science.org/doi/10.1126/...
A world less safe and secure
On 20 January, President Trump announced the withdrawal of the United States from the World Health Organization (WHO). President Trump shares many of the same concerns about WHO as previous administra...
www.science.org
January 22, 2025 at 7:21 PM
New in @science.org: A World Less Safe & Secure
We examine how the US withdrawal from @who.int will limit US leadership to protect public health & challenge WHO governance in facing global challenges.
www.science.org/doi/10.1126/...
We examine how the US withdrawal from @who.int will limit US leadership to protect public health & challenge WHO governance in facing global challenges.
www.science.org/doi/10.1126/...
Reposted by Daniel Lane
The antidote for despair is action ❤️
* Dial (202) 224-3121
* Enter zip code
* Leave voicemail
* Say “My name is ___, I’m a constituent in [town]. (If clinician/scientist, say so)
“The NIH freeze harms research and patients and must be lifted immediately.”
Be brief. Staffers tally all calls. Go! ✅
* Dial (202) 224-3121
* Enter zip code
* Leave voicemail
* Say “My name is ___, I’m a constituent in [town]. (If clinician/scientist, say so)
“The NIH freeze harms research and patients and must be lifted immediately.”
Be brief. Staffers tally all calls. Go! ✅
NIH funding supports the vast majority of all biomedical research in the United States. Virtually every advance in American medicine and biological science comes from NIH. This is a blow against American science.
Call Congress, 202-224-3121.
Call Congress, 202-224-3121.
All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.
January 23, 2025 at 3:21 AM
The antidote for despair is action ❤️
* Dial (202) 224-3121
* Enter zip code
* Leave voicemail
* Say “My name is ___, I’m a constituent in [town]. (If clinician/scientist, say so)
“The NIH freeze harms research and patients and must be lifted immediately.”
Be brief. Staffers tally all calls. Go! ✅
* Dial (202) 224-3121
* Enter zip code
* Leave voicemail
* Say “My name is ___, I’m a constituent in [town]. (If clinician/scientist, say so)
“The NIH freeze harms research and patients and must be lifted immediately.”
Be brief. Staffers tally all calls. Go! ✅
Reposted by Daniel Lane
I'm really excited to see this is now available for the world to read! Are you curious about type 1 interferons, NETosing neutrophils, and macrophages in TB granulomas? This paper has it all! Congratulations to the entire team, especially the amazing scientists in the @stallingslab.bsky.social!
Very excited for this story to be out!! Check out our dissection of how type I IFN promotes NET release, which contributes to Mtb pathogenesis and is associated with granuloma necrosis. Congratulations to all authors!! www.cell.com/cell-host-mi...
Type I IFN-mediated NET release promotes Mycobacterium tuberculosis replication and is associated with granuloma caseation
Sur Chowdhury et al. report that Mycobacterium tuberculosis (Mtb) infection results in the release of neutrophil extracellular traps (NETs) that promote Mtb replication and associate with tissue damage. Blocking NET release results in better control of Mtb replication, revealing a strategy for treating these deadly infections.
www.cell.com
December 5, 2024 at 2:45 AM
I'm really excited to see this is now available for the world to read! Are you curious about type 1 interferons, NETosing neutrophils, and macrophages in TB granulomas? This paper has it all! Congratulations to the entire team, especially the amazing scientists in the @stallingslab.bsky.social!
Reposted by Daniel Lane
Introducing PiM Connections, a mentorship program by the Pride in Microbiology Network! 🌈 🔬
We will connect members based on career & scientific interests to support the next gen of queer & trans scientists. Register to be a mentor or mentee (or both!): https://buff.ly/3ZhdFGr
We will connect members based on career & scientific interests to support the next gen of queer & trans scientists. Register to be a mentor or mentee (or both!): https://buff.ly/3ZhdFGr
December 4, 2024 at 5:00 PM
Introducing PiM Connections, a mentorship program by the Pride in Microbiology Network! 🌈 🔬
We will connect members based on career & scientific interests to support the next gen of queer & trans scientists. Register to be a mentor or mentee (or both!): https://buff.ly/3ZhdFGr
We will connect members based on career & scientific interests to support the next gen of queer & trans scientists. Register to be a mentor or mentee (or both!): https://buff.ly/3ZhdFGr
Reposted by Daniel Lane
The impact of fold-dilution and diluent volume on the estimation of colony forming units in a bacterial culture https://www.biorxiv.org/content/10.1101/2024.11.28.625891v1
The impact of fold-dilution and diluent volume on the estimation of colony forming units in a bacterial culture https://www.biorxiv.org/content/10.1101/2024.11.28.625891v1
Bacteriological sampling by dilution plating is an age old fundamental microbiological procedure bei
www.biorxiv.org
November 29, 2024 at 2:17 AM
The impact of fold-dilution and diluent volume on the estimation of colony forming units in a bacterial culture https://www.biorxiv.org/content/10.1101/2024.11.28.625891v1
Reposted by Daniel Lane
The repurposed STAT3 inhibitor pyrimethamine controls mycobacterial infection-induced vascular permeability and mycobacterial burden https://www.biorxiv.org/content/10.1101/2024.11.28.625803v1
The repurposed STAT3 inhibitor pyrimethamine controls mycobacterial infection-induced vascular permeability and mycobacterial burden https://www.biorxiv.org/content/10.1101/2024.11.28.625803v1
Infection-induced vascular pathologies are a side effect of the immune response to contact with a ra
www.biorxiv.org
November 29, 2024 at 3:16 AM
The repurposed STAT3 inhibitor pyrimethamine controls mycobacterial infection-induced vascular permeability and mycobacterial burden https://www.biorxiv.org/content/10.1101/2024.11.28.625803v1