Daniel Hoces
@dhoces.bsky.social
Postdoc @Stanford. Engineering immune cells to fight cancer. Ph.D. @ETH_en | M.D. @CayetanoHeredia 🇵🇪 🇨🇭
Emma is an incredible mentor and scientist! Plus, Switzerland is a powerhouse of high-quality science. Don’t doubt to apply to this position.
1 week left to apply for a postdoc position in beautiful Switzerland doing awesome mucosal immunology. See below for details! Please re-post to spread the word!
We have an opening for a postdoctoral researcher in my group at the Botnar Institute for Immune Engineering in Basel, Switzerland. The project is aimed at developing novel mucosal adjuvants for application in oral vaccines. Deadline to apply 16.11.25! Please re-post 🔬🧬
join.com/companies/im...
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November 10, 2025 at 12:36 AM
Emma is an incredible mentor and scientist! Plus, Switzerland is a powerhouse of high-quality science. Don’t doubt to apply to this position.
Reposted by Daniel Hoces
1 week left to apply for a postdoc position in beautiful Switzerland doing awesome mucosal immunology. See below for details! Please re-post to spread the word!
We have an opening for a postdoctoral researcher in my group at the Botnar Institute for Immune Engineering in Basel, Switzerland. The project is aimed at developing novel mucosal adjuvants for application in oral vaccines. Deadline to apply 16.11.25! Please re-post 🔬🧬
join.com/companies/im...
join.com/companies/im...
Botnar Institute of Immune Engineering - BIIE (Zürich): Postdoctoral Researcher (100%): Mechanisms of action of mucosal adjuvants
Botnar Institute of Immune Engineering - BIIE has a job opening for Postdoctoral Researcher (100%): Mechanisms of action of mucosal adjuvants in Zürich (published: 30.10.2025). Apply now or check the ...
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November 9, 2025 at 10:41 PM
1 week left to apply for a postdoc position in beautiful Switzerland doing awesome mucosal immunology. See below for details! Please re-post to spread the word!
Reposted by Daniel Hoces
We are hiring! 🧫 🧬 🚀
Three PhD studentships with start dates in 2026 available in the Molecular Mucosal Immunology lab at the Botnar Institute of Immune Engineering, Basel, Switzerland.
See here for details (Deadline: 7th November 2025):
join.com/companies/im...
Three PhD studentships with start dates in 2026 available in the Molecular Mucosal Immunology lab at the Botnar Institute of Immune Engineering, Basel, Switzerland.
See here for details (Deadline: 7th November 2025):
join.com/companies/im...
Botnar Institute of Immune Engineering - BIIE (Zürich): Doctoral studentships, Molecular Mucosal Immunology Group
Botnar Institute of Immune Engineering - BIIE has a job opening for Doctoral studentships, Molecular Mucosal Immunology Group in Zürich (published: 29.10.2025). Apply now or check the other available...
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October 29, 2025 at 12:51 PM
We are hiring! 🧫 🧬 🚀
Three PhD studentships with start dates in 2026 available in the Molecular Mucosal Immunology lab at the Botnar Institute of Immune Engineering, Basel, Switzerland.
See here for details (Deadline: 7th November 2025):
join.com/companies/im...
Three PhD studentships with start dates in 2026 available in the Molecular Mucosal Immunology lab at the Botnar Institute of Immune Engineering, Basel, Switzerland.
See here for details (Deadline: 7th November 2025):
join.com/companies/im...
Reposted by Daniel Hoces
Introducing SLAE, our new framework to represent all-atom protein structures with residue local chemical environment tokens!
SLAE reasons over atomic interactions to recover structures and residue pairwise energetics, yielding a generalizable, physics-informed latent space. (1/8)
SLAE reasons over atomic interactions to recover structures and residue pairwise energetics, yielding a generalizable, physics-informed latent space. (1/8)
October 9, 2025 at 5:36 PM
Introducing SLAE, our new framework to represent all-atom protein structures with residue local chemical environment tokens!
SLAE reasons over atomic interactions to recover structures and residue pairwise energetics, yielding a generalizable, physics-informed latent space. (1/8)
SLAE reasons over atomic interactions to recover structures and residue pairwise energetics, yielding a generalizable, physics-informed latent space. (1/8)
Reposted by Daniel Hoces
Excitability as a Design Principle in the Immune System https://www.biorxiv.org/content/10.1101/2025.08.31.673412v1
September 3, 2025 at 3:16 AM
Excitability as a Design Principle in the Immune System https://www.biorxiv.org/content/10.1101/2025.08.31.673412v1
Reposted by Daniel Hoces
LCK deficiency in CD8 T cells leads to reduced proliferation and increased effector T-cell formation in mice https://www.biorxiv.org/content/10.1101/2025.08.28.672860v1
September 3, 2025 at 4:16 AM
LCK deficiency in CD8 T cells leads to reduced proliferation and increased effector T-cell formation in mice https://www.biorxiv.org/content/10.1101/2025.08.28.672860v1
Reposted by Daniel Hoces
Did you ever wonder what insights hide in the multiplets that are usually discarded in flow cytometry? 🫧 Find out in the first publication of my PhD, now out in Nature Methods! www.nature.com/articles/s41... (1/4)
August 7, 2025 at 8:48 PM
Did you ever wonder what insights hide in the multiplets that are usually discarded in flow cytometry? 🫧 Find out in the first publication of my PhD, now out in Nature Methods! www.nature.com/articles/s41... (1/4)
Reposted by Daniel Hoces
Our new review article led by Jordan Kramer:
Platforms for studying cell–cell recognition by immune cells
onlinelibrary.wiley.com/doi/10.1111/...
Platforms for studying cell–cell recognition by immune cells
onlinelibrary.wiley.com/doi/10.1111/...
May 31, 2025 at 8:54 AM
Our new review article led by Jordan Kramer:
Platforms for studying cell–cell recognition by immune cells
onlinelibrary.wiley.com/doi/10.1111/...
Platforms for studying cell–cell recognition by immune cells
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Daniel Hoces
As promised, a 'skeet' -orial on our paper published last week !
Now online! Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity
Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity
Robot-assisted analysis and theoretical modeling of TCR/CAR crosstalk enable the design of adoptive T cell therapies that maximize anti-tumor activity and minimize toxicity in healthy tissues.
dlvr.it
April 14, 2025 at 1:05 PM
As promised, a 'skeet' -orial on our paper published last week !
Reposted by Daniel Hoces
Excited to share my graduate work from the @ejohnwherry.bsky.social lab on the molecular mechanisms locking in the differentiation fate of exhausted CD8 T cells (Tex), published earlier this month in @science.org immunology. Main findings below!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Continuous expression of TOX safeguards exhausted CD8 T cell epigenetic fate
TOX safeguards exhaustion biology in established Tex cells and restrains fate conversion to Teff cells.
www.science.org
March 28, 2025 at 8:36 PM
Excited to share my graduate work from the @ejohnwherry.bsky.social lab on the molecular mechanisms locking in the differentiation fate of exhausted CD8 T cells (Tex), published earlier this month in @science.org immunology. Main findings below!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Daniel Hoces
ICYMI by First release - now in print @science.org
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.
buff.ly/3DjNQ1e
By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.
buff.ly/3DjNQ1e
By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al
March 14, 2025 at 3:25 PM
ICYMI by First release - now in print @science.org
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.
buff.ly/3DjNQ1e
By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.
buff.ly/3DjNQ1e
By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al
Reposted by Daniel Hoces
Our paper is finally out in @immunolcellbiol.bsky.social, think that transcription factor expression is all that? Well not if the genome is not prepared in a way to allow binding: here is a short 🧵1/
March 1, 2025 at 2:34 AM
Our paper is finally out in @immunolcellbiol.bsky.social, think that transcription factor expression is all that? Well not if the genome is not prepared in a way to allow binding: here is a short 🧵1/
Reposted by Daniel Hoces
1/ Ever wonder how a clearly brilliant person – someone great a math and engineering and company building – can display shockingly unintelligent thinking when it comes to politics? Neuroscience has the answer!
February 17, 2025 at 11:54 PM
1/ Ever wonder how a clearly brilliant person – someone great a math and engineering and company building – can display shockingly unintelligent thinking when it comes to politics? Neuroscience has the answer!
Reposted by Daniel Hoces
Two weeks left to apply for a postdoc position with the Slack group! Please spread the word!
Interested in microbial #metabolism, #mucosalbiology and #UTI? Then check out the open postdoctoral position in the Mucosal Immunology Group at ETH Zurich! NB: All applications must go via the ETH job portal:
www.jobs.ethz.ch/job/view/JOP...
Closing date: 24th Feburary
🧪🧫🔬
www.jobs.ethz.ch/job/view/JOP...
Closing date: 24th Feburary
🧪🧫🔬
Postdoctoral researcher –Understanding bacterial metabolism in the urinary tract
www.jobs.ethz.ch
February 10, 2025 at 8:13 PM
Two weeks left to apply for a postdoc position with the Slack group! Please spread the word!
Reposted by Daniel Hoces
Our new work!
The 3D affinities of the OT-I TCR to foreign and self-antigens predict their 2D affinities and reveal imperfect antigen discrimination
www.biorxiv.org/content/10.1...
The 3D affinities of the OT-I TCR to foreign and self-antigens predict their 2D affinities and reveal imperfect antigen discrimination
www.biorxiv.org/content/10.1...
January 16, 2025 at 8:10 AM
Our new work!
The 3D affinities of the OT-I TCR to foreign and self-antigens predict their 2D affinities and reveal imperfect antigen discrimination
www.biorxiv.org/content/10.1...
The 3D affinities of the OT-I TCR to foreign and self-antigens predict their 2D affinities and reveal imperfect antigen discrimination
www.biorxiv.org/content/10.1...
Reposted by Daniel Hoces
Two studies published in @nature.com today showing that Tpex-like cells develop independent from acute or chronic infection
#Tpex
www.nature.com/articles/s41...
#Tpex
www.nature.com/articles/s41...
January 9, 2025 at 8:33 AM
Two studies published in @nature.com today showing that Tpex-like cells develop independent from acute or chronic infection
#Tpex
www.nature.com/articles/s41...
#Tpex
www.nature.com/articles/s41...
Reposted by Daniel Hoces
Our work led by Anna Huhn is now published!
The molecular reach of antibodies crucially underpins their viral neutralisation capacity
lnkd.in/epe8YZPm
Thank you to the reviewers for constructive feedback!
The molecular reach of antibodies crucially underpins their viral neutralisation capacity
lnkd.in/epe8YZPm
Thank you to the reviewers for constructive feedback!
January 4, 2025 at 4:28 PM
Our work led by Anna Huhn is now published!
The molecular reach of antibodies crucially underpins their viral neutralisation capacity
lnkd.in/epe8YZPm
Thank you to the reviewers for constructive feedback!
The molecular reach of antibodies crucially underpins their viral neutralisation capacity
lnkd.in/epe8YZPm
Thank you to the reviewers for constructive feedback!
Reposted by Daniel Hoces
Happy New Year! Excited about our new study on a timed epigenetic switch controlling T cell and ILC lineage decisions in the thymus! In a nutshell: timing is everything.
The study was led by the fantastic @nickpease.bsky.social. A thread: (1/n)
doi.org/10.1242/dev....
The study was led by the fantastic @nickpease.bsky.social. A thread: (1/n)
doi.org/10.1242/dev....
A timed epigenetic switch balances T and ILC lineage proportions in the thymus
Highlighted Article: Delayed activation of the T-cell lineage commitment regulator Bcl11b in mouse thymic progenitors due to distal enhancer deletion reduces T-cell output and increases Zbtb16-driven ...
doi.org
January 3, 2025 at 7:21 PM
Happy New Year! Excited about our new study on a timed epigenetic switch controlling T cell and ILC lineage decisions in the thymus! In a nutshell: timing is everything.
The study was led by the fantastic @nickpease.bsky.social. A thread: (1/n)
doi.org/10.1242/dev....
The study was led by the fantastic @nickpease.bsky.social. A thread: (1/n)
doi.org/10.1242/dev....
Reposted by Daniel Hoces
Thrilled to share our @sciimmunology.bsky.social paper! We report that rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. science.org/doi/10.1126/...
January 4, 2025 at 12:34 AM
Thrilled to share our @sciimmunology.bsky.social paper! We report that rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. science.org/doi/10.1126/...
Reposted by Daniel Hoces
Prior antigen experience of CAR T cells determines functional attributes and amenability to transcription factor-mediated functional enhancement
www.nature.com/articles/s41...
@koledegolier.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@koledegolier.bsky.social
www.nature.com/articles/s41...
January 2, 2025 at 8:12 PM
Prior antigen experience of CAR T cells determines functional attributes and amenability to transcription factor-mediated functional enhancement
www.nature.com/articles/s41...
@koledegolier.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@koledegolier.bsky.social
www.nature.com/articles/s41...
Reposted by Daniel Hoces
Reposted by Daniel Hoces
'The TME of Long Term Survival cases was distinguished by coinfiltration of T cells, B cells & plasma cells, along with upregulation of the PD-1/PD-L1 pathway. Remarkably, these prognostic associations were almost entirely restricted to tumors with high-epithelial content & the C4/DIF mol. subtype'
JCI -
Immunological and molecular features of the tumor microenvironment of long-term survivors of ovarian cancer
www.jci.org
December 22, 2024 at 10:33 AM
'The TME of Long Term Survival cases was distinguished by coinfiltration of T cells, B cells & plasma cells, along with upregulation of the PD-1/PD-L1 pathway. Remarkably, these prognostic associations were almost entirely restricted to tumors with high-epithelial content & the C4/DIF mol. subtype'
Reposted by Daniel Hoces
"(...) reinforcing 41BB costimulation on the day of vaccination did not result in a substantial improvement in vaccine responses. However, reinforcing 41BB costimulation on day 4 after vaccination, when 41BB expression levels were highest, resulted in a profound improvement in CD8+ T cell responses"
JCI -
Delayed reinforcement of costimulation improves the efficacy of mRNA vaccines in mice
www.jci.org
December 21, 2024 at 12:28 PM
"(...) reinforcing 41BB costimulation on the day of vaccination did not result in a substantial improvement in vaccine responses. However, reinforcing 41BB costimulation on day 4 after vaccination, when 41BB expression levels were highest, resulted in a profound improvement in CD8+ T cell responses"
Reposted by Daniel Hoces
🖐️ Hi Mam! - A superantigen (MAM) goes to the head of the class (II) to find alternatives to TCRs for specific peptide:MHC binders doi.org/10.1038/s415...
December 21, 2024 at 1:00 PM
🖐️ Hi Mam! - A superantigen (MAM) goes to the head of the class (II) to find alternatives to TCRs for specific peptide:MHC binders doi.org/10.1038/s415...
This is a clever way to use synthetic biology: taking a toxin that overactivate the immune system (superantigen), rationally modify its core components and transform it into a platform of immunotherapy agents.
Congratulations to @haotiandu.bsky.social and @possuhuanglab.bsky.social on the 2 papers!
Congratulations to @haotiandu.bsky.social and @possuhuanglab.bsky.social on the 2 papers!
1/ In two back-to-back papers, we present our de novo TRACeR platform for targeting MHC-I and MHC-II antigens
TRACeR for MHC-I: go.nature.com/4gcLzn5
TRACeR for MHC-II: go.nature.com/4gj5OQk
TRACeR for MHC-I: go.nature.com/4gcLzn5
TRACeR for MHC-II: go.nature.com/4gj5OQk
December 17, 2024 at 2:07 PM
This is a clever way to use synthetic biology: taking a toxin that overactivate the immune system (superantigen), rationally modify its core components and transform it into a platform of immunotherapy agents.
Congratulations to @haotiandu.bsky.social and @possuhuanglab.bsky.social on the 2 papers!
Congratulations to @haotiandu.bsky.social and @possuhuanglab.bsky.social on the 2 papers!