Prof Danny Altmann
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daltmann.bsky.social
Prof Danny Altmann
@daltmann.bsky.social
13K followers 540 following 330 posts
Professor of Immunology, Imperial College London. Editor of OUP Oxford Open Immunology. Co-author - Penguin Long Covid Handbook. Discusses: Covid-19, Long Covid, T cells, immunogenetics and HLA, respiratory infection, science policy, arboviruses, C19th lit
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daltmann.bsky.social
Prof Danny Altmann @daltmann.bsky.social · Nov 7
Dipping toe in the water after many years at the other place, trying the transition. Mainly aiming to discuss exciting stuff happening in immunology research, including but not only responses in Covid-19 and Long Covid. Please follow if this could be of interest
Reposted by Prof Danny Altmann
natrevcancer.nature.com
🥳 Our 9th most downloaded #REVIEW in 2025:

The immune microenvironment of colorectal cancer

#TME #colorectalcancer @NatResCancer
#NRCtop10of2025
The immune microenvironment of colorectal cancer - Nature Reviews Cancer
In this Review, Kennel and Greten highlight the role of immune cells in colorectal cancer (CRC) development, progression and metastasis as well as the impact of therapies on the immune microenvironment. They emphasize the need for novel strategies to enhance immunogenicity and CRC patient stratification to improve outcomes.
dlvr.it
February 3, 2026 at 4:48 PM
daltmann.bsky.social
“I’m really excited [about the shingles research in particular] because it’s big data. These studies are not small or speculative or hypothetical, but solid and credible,” Altmann says…
February 3, 2026 at 11:13 AM
daltmann.bsky.social
Should you pay £500 for a shingles jab?

www.thetimes.com/article/9573...
Should you pay £500 for a shingles jab?
As new studies suggest some vaccinations could lower the risk of dementia and heart disease, the experts weigh in on whether it’s worth a shot
www.thetimes.com
February 3, 2026 at 11:09 AM
daltmann.bsky.social
Segmented filamentous bacteria reprogramming of alveolar macrophages limits postinfluenza bacterial pneumonia | Science Immunology www.science.org/doi/10.1126/...
Segmented filamentous bacteria reprogramming of alveolar macrophages limits postinfluenza bacterial pneumonia
SFB colonization phenotypically alters alveolar macrophages, maintaining their antibacterial functions in inflamed interferon-rich lungs.
www.science.org
February 3, 2026 at 6:56 AM
daltmann.bsky.social
www.nature.com/articles/s41...
Environmentally driven immune imprinting protects against allergy - Nature
In a mouse model, environmental immunostimulation in early life led to cross-reactive adaptive immune memory and reduced type II immune responses to allergens, indicating a mechanistic relationship be...
www.nature.com
January 29, 2026 at 2:48 PM
Reposted by Prof Danny Altmann
brownecfm.bsky.social
Outstanding article from my friend Lucyl Harrison in @theconversation.com today.

'Human character changed in December 2019, when SARS-CoV-2 was discovered and the COVID pandemic began in earnest'.

theconversation.com/on-being-ill...
On Being Ill at 100: Virginia Woolf’s ‘best essay’ still shapes how we read sickness
Woolf argues that illness is ‘the great confessional’ which is never talked about in literature.
theconversation.com
January 27, 2026 at 12:02 PM
Reposted by Prof Danny Altmann
auschwitzmemorial.bsky.social
Auschwitz was at the end of a process. We must remember that it did not start from gas chambers.

This hatred gradually developed: from ideas, words, stereotypes & prejudice through legal exclusion, dehumanization & escalating violence... to systematic and industrial murder.

Auschwitz took time.
A bird's-eye view of a former Auschwitz II-Birkenau camp showing a wide dirt pathway flanked by parallel rows of barbed-wire fences. Groups of visitors walk along the path, surrounded by the remnants of brick structures and barracks, now reduced to foundations. Green grass contrasts with the somber history of the site, as the path leads toward a guard tower in the distance.
January 27, 2026 at 11:00 AM
daltmann.bsky.social
On this #HMD2026 I think of my survivor Mum, Marlene, liberated on this day, 1945 - offered horsemeat and vodka by the incoming liberators - and words of Ettie Hillesum's Holocaust Diary: 'I find life beautiful and I feel free. The sky within me is as wide as the one stretching above my head.'
estherrockett.bsky.social Esther Rockett 🚀 @estherrockett.bsky.social · 8d
Hell of a double feature for Holocaust Remembrance Day - we should always be aware that this capacity for evil never sleeps, never wanes and exists across cultures to this day. We must always fight it | Simon Schama: The Road To Auschwitz in iview iview.abc.net.au/show/simon-s...
January 27, 2026 at 9:29 AM
Reposted by Prof Danny Altmann
lucympowell.bsky.social
Today marks 81 years since the liberation of Auschwitz.

We must never forget the horrors of the Holocaust.

#HolocaustMemorialDay
January 27, 2026 at 9:22 AM
Reposted by Prof Danny Altmann
chrischirp.bsky.social
Please please vaccinate your child against measles.

This is from our @independentsage.bsky.social report from last year, led by @trishgreenhalgh.bsky.social & @helensalisbury.bsky.social

independentsage.org/wp-content/u...
January 26, 2026 at 5:55 PM
Reposted by Prof Danny Altmann
drjoepajak.bsky.social
Long COVID👉 neurological, cardiovascular and immune dysfunction, needs recognition and care pathways.
@virusesimmunity.bsky.social @michaelpelusomd.bsky.social @daltmann.bsky.social @weselymd.bsky.social @nisreenalwan.bsky.social et al
@nature.com
Vol 11, 92, 2025
www.nature.com/articles/s41...
January 24, 2026 at 12:51 PM
Reposted by Prof Danny Altmann
drjoepajak.bsky.social
Long COVID 👉 neurological, cardiovascular and immune dysfunction, needs recognition and care pathways.
@virusesimmunity.bsky.social @michaelpelusomd.bsky.social @daltmann.bsky.social @weselymd.bsky.social @nisreenalwan.bsky.social et al
@natrevdiseaseprimers.nature.com
www.nature.com/articles/s41...
COVID-19 associated neurological and psychological manifestations - Nature Reviews Disease Primers
This PrimeView highlights the mechanisms of COVID-19-associated neurological and psychological manifestations, and accompanies the Primer on this topic by Wilson et al.
www.nature.com
January 24, 2026 at 12:53 PM
daltmann.bsky.social
Discoveries beyond molecular mimicry describe how EBV drives multiple sclerosis: Cell www.cell.com/cell/fulltex...
Discoveries beyond molecular mimicry describe how EBV drives multiple sclerosis
In the current issue of Cell, three papers describe new mechanistic information about how EBV transforms B cells to become antigen-presenting cells in the brain that drive demyelinating disease.
www.cell.com
January 22, 2026 at 4:24 PM
daltmann.bsky.social
A variety of early hominin species shared the Afar region of Ethiopia www.nature.com/articles/d41...
A variety of early hominin species shared the Afar region of Ethiopia
Fossils reveal that at least four types of hominin, including Paranthropus, were present in northern Ethiopia between 3 million and 2.4 million years ago.
www.nature.com
January 22, 2026 at 11:53 AM
daltmann.bsky.social
Bacterial metabolites induce cell wall remodeling, antifungal resistance, and immune recognition of commensal fungi: Current Biology www.cell.com/current-biol...
Bacterial metabolites induce cell wall remodeling, antifungal resistance, and immune recognition of commensal fungi
Davis et al. demonstrate that common gastrointestinal bacteria secrete metabolites that induce global cell remodeling in Candida albicans. C. albicans uses the HOG cascade, a central stress pathway, t...
www.cell.com
January 19, 2026 at 7:35 PM
Reposted by Prof Danny Altmann
jhumimmunity.org
Increased prevalence of #autoantibodies neutralizing IFNλ2/3 in young individuals with #CysticFibrosis. New report from Kevin Groen, Emanuela Bruscia, Marc Emmenegger, Benjamin Hale @benhale.bsky.social and colleagues: rupress.org/jhi/article/...

#Autoimmunity #Infections
January 19, 2026 at 2:45 PM
Reposted by Prof Danny Altmann
erictopol.bsky.social
A vaccine to prevent colon cancer.
Proof-of-concept for strong immune response and safety via neoantigens given to people carrying mutations for Lynch syndrome
nature.com/articles/s41...
Nous-209 neoantigen vaccine for cancer prevention in Lynch syndrome carriers: a phase 1b/2 trial - Nature Medicine
In a phase 1b/2 trial, an off-the-shelf vaccine using gorilla adenoviral and modified vaccinia Ankara vectors with over 200 mutated peptides known to be present in persons with mismatch-repair-deficie...
nature.com
January 16, 2026 at 4:27 PM
daltmann.bsky.social
Challenging Claims of an Autism Epidemic — Misconceptions and a Path Forward | New England Journal of Medicine www.nejm.org/doi/full/10....
Challenging Claims of an Autism Epidemic — Misconceptions and a Path Forward | NEJM
Autism research programs should focus on both causes and effective services and supports. Alarmist claims, chasing of debunked theories of causation, and further stigmatizing autism are counterprod...
www.nejm.org
January 17, 2026 at 2:49 PM
Reposted by Prof Danny Altmann
trishgreenhalgh.bsky.social
Whoever got this unethical trial cancelled, you just saved some lives. Kennedy, you should be ashamed of yourself for backing it in the first place.
www.theguardian.com/us-news/2026...
Controversial US study on hepatitis B vaccines in Africa is cancelled
$1.6m project drew outrage over ethical questions about withholding vaccines proven to prevent disease
www.theguardian.com
January 15, 2026 at 7:10 PM
daltmann.bsky.social
Immune signature-based uncoupling of checkpoint inhibitor efficacy and toxicity: Immunity www.cell.com/immunity/ful...
Immune signature-based uncoupling of checkpoint inhibitor efficacy and toxicity
Lucas et al. evaluate the interferon-gamma (IFN-γ) signature against toxicity and efficacy in four neoadjuvant melanoma immunotherapy regimens. IFN-γ-high scores associated with overall favorable effi...
www.cell.com
January 14, 2026 at 9:12 AM
Reposted by Prof Danny Altmann
cfgtedinburgh.bsky.social
"CAR-T therapy has been available on the NHS for several years for certain types of leukaemia and lymphoma but has only now been extended to adults with B-cell ALL."

#genetherapy #celltherapy

www.bbc.co.uk/news/article...
First leukaemia patient to get pioneering drug on NHS says it is 'very sci-fi'
Oscar Murphy has an aggressive form of the blood cancer and is the first to get CAR-T therapy in the UK.
www.bbc.co.uk
January 14, 2026 at 7:38 AM
Reposted by Prof Danny Altmann
sheencr.bsky.social
Great to see two papers out that show the benefits of RSV vaccination (monoclonal treatment) to prevent severe RSV infection. A quick thread to unpick what these vaccines are as there are 2 quite different products in clinical use and it can be confusing what the terminology means. #HealthPolicy 🧵
Universal nirsevimab slashes RSV infant hospitalizations, study suggests
www.cidrap.umn.edu
January 14, 2026 at 8:20 AM
Reposted by Prof Danny Altmann
ahandvanish.bsky.social
Monoclonal antibody Lu AG09222 decreased monthly migraine days:

www.nejm.org/doi/full/10.... #LongCovid
A Monoclonal Antibody to PACAP for Migraine Prevention | NEJM
Targeting pituitary adenylate cyclase–activating polypeptide (PACAP) is a new avenue for treating migraine. The efficacy and safety of intravenous Lu AG09222, a humanized monoclonal antibody direct...
www.nejm.org
January 8, 2026 at 9:28 PM
daltmann.bsky.social
Chinese Immune Multi-Omics Atlas | Science www.science.org/doi/10.1126/...
Chinese Immune Multi-Omics Atlas
Human peripheral blood exhibits molecular and cellular heterogeneity across populations, yet the underlying mechanisms remain unclear. We present the Chinese Immune Multi-Omics Atlas (CIMA), character...
www.science.org
January 8, 2026 at 10:46 PM
daltmann.bsky.social
HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion: Cell www.cell.com/cell/fulltex...
HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion
Melanoma cells escape immune surveillance by releasing MHC-antigen-loaded large EVs, known as melanosomes, that directly engage and impair CD8+ T cell receptors.
www.cell.com
January 8, 2026 at 4:54 PM