Programming stimulus responsiveness into living systems enables advanced biocomputation. Here, the authors autonomously compile proteins with defined topology that can be site-specifically tethered to and conditionally released from biomaterials and cells following user-specified Boolean logic.

Non-peripheral myonuclei are characteristic of skeletal muscle pathology and severe injury but also appear after exercise and with aging. Displaced myonuclei are typically attributed to the activity o...

TRAF6 bridges innate immune signaling to mitophagy to promote glucose control during metabolic stress.

Magrinelli et al. delineated the pheno-genotypic spectrum of NDUFA9-related mitochondrial disease based on eight new and four previously reported cases. Bi

Glycolytic enzymes sense metabolite levels to adapt rapidly to changing energy demands, but measuring the levels of these effectors with spatiotemp...

In this study, using a combination of quantitative biochemical assays and fluorescence microscopy, the authors demonstrate that a fraction of free extracellular mitochondria can enter recipient cells through macropinocytosis. Once internalized, mitochondria are able to escape from endosomal compartments into the cytosol, where they may integrate into the endogenous mitochondrial network.

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...

Dias et al. discover that the orphan solute carrier protein, SLC25A45, enables mitochondrial import of methylated amino acids. SLC25A45-dependent mitochondrial uptake of trimethyllysine drives carniti...

Methylated amino acids accumulate upon the degradation of methylated proteins and are implicated in diverse metabolic and signaling pathways. Disturbe…

Park, Nicaise, Tsitsipatis, and colleagues discover transcriptional and epigenetic markers in human PMS iNSCs and fibroblasts that may underlie their senescent and inflammatory state. Novel DARGs with...

Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that na...