Lightnews — Scholar-powered news

Reposted by Korolchuk Lab

Eric Chevet @ericchevet.bsky.social · 1d

This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

Highlight: A genome-to-proteome map reveals how natural variants drive proteome diversity and shape fitnes www.science.org/doi/10.1126/...

bims-proteo 2025-10-12 papers

biomed.news

5 7

Reposted by Korolchuk Lab

Catalina Vasilescu, PhD @cvasilescu.bsky.social · 1d

Fresh selection of papers on #MitochondrialDisease from #week41! 📚 💚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
www.science.org/doi/10.1126/...

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations

Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...

www.science.org

1 10 14

Reposted by Korolchuk Lab

Christian Frezza @frezzalab.bsky.social · 2d

Good Sunday, all. Your weekly curated summary of papers in #cancermetabolism and #mitochondrialbiology is ready, don't miss it as it is full of exceptional discoveries: biomed.news/bims-camemi/... Biomed News #keepreading

"To see takes time, like to have a friend takes time." -Georgia O'Keeffe

10 21

Korolchuk Lab @korolchuklab.bsky.social · 1d

#Autophagy and #mTOR paper published last week, lots of cool stuff, enjoy!

biomed.news/bims-auttor/...

5 7

Korolchuk Lab @korolchuklab.bsky.social · 3d

Great to see it worked at the end, well done, Michele! You definitely confirm the rule that activity on science social media accounts correlates with the number and impact of first author publications, a lesson to many others aspiring for an academic career. Many congratulations again!

1

Korolchuk Lab @korolchuklab.bsky.social · 3d

Congrats, super cool! 👏🏼👏🏼👏🏼

1 1

Reposted by Korolchuk Lab

Michele Frison @frisophagy.bsky.social · 3d

How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease?

This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.

www.science.org/doi/10.1126/...

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations

Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...

www.science.org

4 19 39

Korolchuk Lab @korolchuklab.bsky.social · 4d

A new set of guidelines on the use of in vitro models in #PD and #Ageing research #Justpublished, don’t miss it! 👇🏼👇🏼👇🏼

rdcu.be/eKanG

Investigating the ageing-Parkinson’s disease nexus: standardisation of in vitro models and techniques by the PD-AGE network

npj Parkinson's Disease - Investigating the ageing-Parkinson’s disease nexus: standardisation of in vitro models and techniques by the PD-AGE network

rdcu.be

Reposted by Korolchuk Lab

Wiseman Lab @wisemanlab.bsky.social · 11d

Scripps is conducting a tenure track assistant professor search. This is a broad search across multiple departments for outstanding individuals that could integrate into the multi-disciplinary environment at Scripps Research. All interested should apply! Please share. apply.interfolio.com/174756

Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio

apply.interfolio.com

4 5

Reposted by Korolchuk Lab

Eric Chevet @ericchevet.bsky.social · 9d

This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

Highlight: Translation landscape of stress granules www.science.org/doi/10.1126/...

bims-proteo 2025-10-05 papers

biomed.news

4 6

Reposted by Korolchuk Lab

Catalina Vasilescu, PhD @cvasilescu.bsky.social · 8d

#MitochondrialDisease papers from #week40! 📚 💚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

A few highlights below! 👇

DDHD2 provides a flux of saturated fatty acids for neuronal energy and function
www.nature.com/articles/s42...

DDHD2 provides a flux of saturated fatty acids for neuronal energy and function - Nature Metabolism

Saber et al. show that the lipase DDHD2 provides endogenous saturated fatty acids to support fatty acid oxidation and energy production, proteostasis and membrane trafficking balance.

www.nature.com

1 6 12

Korolchuk Lab @korolchuklab.bsky.social · 8d

#Autophagy and #mTOR papers from last week, enjoy thanks to @biomednews.bsky.social pre-selection engine. DM them if you want your own personalised feed.

biomed.news/bims-auttor/...

a woman in a red and white striped shirt is throwing papers into the air

ALT: a woman in a red and white striped shirt is throwing papers into the air

media.tenor.com

5 10

Reposted by Korolchuk Lab

Catalina Vasilescu, PhD @cvasilescu.bsky.social · 15d

#MitochondrialDisease papers from #week39! 📚 👇
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social

A few highlights below!

Ribonucleotide incorporation into mitochondrial DNA drives inflammation - Nature

Imbalanced nucleotide metabolism leads to age- and mtDNA-dependent inflammatory responses and senescence-associated secretory phenotype in senescence.

nature.com

1 8 14

Reposted by Korolchuk Lab

Michele Frison @frisophagy.bsky.social · 29d

In this week's issue of mitophagy news 🪫🗑️:

-Urolithin A increases healthspan via MERCS and Ca2+-mitophagy
-Parkin Induces Ubiquitination and Large Extracellular Vesicle Release of HMGB1 to Activate Antitumor Immunity
-a Parkin and hTau mouse cross

biomed.news/bims-tofagi/...

Urolithin A ameliorates the age-dependent decline of ER-mitochondria contacts and alters intracellular Ca2+ balance.

5 4

Korolchuk Lab @korolchuklab.bsky.social · 15d

#Autophagy and #mTOR papers from last 4 weeks, buildup due to laziness but lots of cool stuff here, have a look!

biomed.news/bims-auttor/...

biomed.news/bims-auttor/...

biomed.news/bims-auttor/...

biomed.news/bims-auttor/...

Ive Been Doing A Bunch Of Research Mitchell Moffit GIF

ALT: Ive Been Doing A Bunch Of Research Mitchell Moffit GIF

media.tenor.com

1 8

Korolchuk Lab @korolchuklab.bsky.social · Sep 4

And another amazing #mTOR paper👇🏼Where do people get strength from to put so much work into this?

www.life-science-alliance.org/content/8/11...

Amino acid–dependent TSC2 dephosphorylation by lysosome–PP2A regulates mTORC1 signaling transduction

The mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, composed of amino acid (AA)–sensing (Ragulator/LAMTOR-Rag) and growth factor (GF)–sensing (AKT-TSC1/2-Rheb) axes, pivotally regu...

www.life-science-alliance.org

3 7

Korolchuk Lab @korolchuklab.bsky.social · Sep 2

#mTOR research field never ceases to amaze, what a tour de force! 👇🏼

mTORC1 senses glutamine and other amino acids through GCN2 | The EMBO Journal www.embopress.org/doi/full/10....

mTORC1 senses glutamine and other amino acids through GCN2 | The EMBO Journal

imageimageDuring starvation, individual amino acid levels are thought to be relayed via distinct metabolic sensors, but how mTORC1 senses glutamine remains unclear. This study finds that GCN2 kinase acts as a unifying module in suppression of ...

www.embopress.org

9 18

Korolchuk Lab @korolchuklab.bsky.social · Aug 24

www.nature.com/articles/s41...

Structural basis for the dynamic regulation of mTORC1 by amino acids - Nature

Using cryo-electron microscopy, the interactions of Sestrin2 and CASTOR1 with GATOR2 were resolved, revealing how mTORC1 activation is regulated and how nutrient availability triggers signalling for c...

www.nature.com

6 17

Korolchuk Lab @korolchuklab.bsky.social · Aug 19

Proteomic aging signatures across mouse organs and life stages | The EMBO Journal www.embopress.org/doi/full/10....

Proteomic aging signatures across mouse organs and life stages | The EMBO Journal

imageimageGenomic and transcriptomic studies have advanced our system-level understanding of aging, but large-scale proteomic analyses of the underlying processes remain limited. This resource provide...

www.embopress.org

1 3

Korolchuk Lab @korolchuklab.bsky.social · Aug 17

#mTOR and #autophagy papers from last week. Lots of interesting new stuff, enjoy thanks to @biomednews.bsky.social pre-selection!

biomed.news/bims-auttor/...

a man wearing a top hat is reading a book about nintendo

ALT: a man wearing a top hat is reading a book about nintendo

media.tenor.com

3 6

Reposted by Korolchuk Lab

Christian Frezza @frezzalab.bsky.social · Aug 17

Good Sunday all! There is another beutifully exciting selection of papers in #cancermetabolism and #mitochondrialbiology waiting for you here: biomed.news/bims-camemi/... Biomed News #keepreading

"Things take the time they take. Don't worry."

Mary Oliver

a cartoon chef holding a piece of paper that says me when reading an article and its very good

ALT: a cartoon chef holding a piece of paper that says me when reading an article and its very good

media.tenor.com

6 20

Reposted by Korolchuk Lab

Nature Cell Biology @natcellbio.nature.com · Aug 14

🍹@martenslab.bsky.social @elias-adriaenssens.bsky.social & co show that, unlike soluble, transmembrane cargo receptors initiate autophagosome biogenesis by recruiting the FIP200/ULK1 or WIPI–ATG13 complex, revealing unexpected flexibility in the selective #autophagy machinery.
bit.ly/4lpGh9P

Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery - Nature Cell Biology

Adriaenssens et al. show that unlike soluble cargo receptors, transmembrane cargo receptors initiate autophagosome biogenesis by recruiting the FIP200/ULK1 or WIPI–ATG13 complex, revealing unexpected ...

bit.ly

9 14

Reposted by Korolchuk Lab

asofiahcosta.bsky.social @asofiahcosta.bsky.social · Aug 10

Just finished selecting the top novel computational and analytical methods for small molecule analysis.

biomed.news/bims-metlip/...

A collaboration with @Bims_BiomedNews

a person is pushing a stack of books on a table and one of the books has the letter t on it

ALT: a person is pushing a stack of books on a table and one of the books has the letter t on it

media.tenor.com

4 6

Reposted by Korolchuk Lab

Eric Chevet @ericchevet.bsky.social · Aug 10

This week's selection of articles and many #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

bims-proteo 2025-08-10 papers

biomed.news

4 10

Reposted by Korolchuk Lab

Christian Frezza @frezzalab.bsky.social · Aug 10

Good Sunday all. A wonderful selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you. Check it here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"Our plans never turn out as tasty as reality."-Ram Dass

a man sitting on a bench reading a book with the words this is what i 'm doing at the moment

ALT: a man sitting on a bench reading a book with the words this is what i 'm doing at the moment

media.tenor.com

8 18