Korolchuk Lab
@korolchuklab.bsky.social
Cell biology lab at Newcastle University, UK, molecular mechanisms of nutrient sensing and autophagy, ageing and age-related disease 🇺🇦
Reposted by Korolchuk Lab
Ho ho ho, happy Sunday egg-ficionados! Here is another great issue of #cebooc: biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/41241715/
Runner-up: pubmed.ncbi.nlm.nih.gov/41271398/
Thanks @biomednews.bsky.social for preselecting!
Highlight: pubmed.ncbi.nlm.nih.gov/41241715/
Runner-up: pubmed.ncbi.nlm.nih.gov/41271398/
Thanks @biomednews.bsky.social for preselecting!
November 23, 2025 at 8:01 AM
Ho ho ho, happy Sunday egg-ficionados! Here is another great issue of #cebooc: biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/41241715/
Runner-up: pubmed.ncbi.nlm.nih.gov/41271398/
Thanks @biomednews.bsky.social for preselecting!
Highlight: pubmed.ncbi.nlm.nih.gov/41241715/
Runner-up: pubmed.ncbi.nlm.nih.gov/41271398/
Thanks @biomednews.bsky.social for preselecting!
Reposted by Korolchuk Lab
Good Sunday, all. What a great week for #cancermetabolism and #mitochondrialbiology. Find here a selection of groundbreaking discoveries: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"Trying to define yourself is like trying to bite your own teeth."-Alan Watts
"Trying to define yourself is like trying to bite your own teeth."-Alan Watts
November 23, 2025 at 6:51 AM
Good Sunday, all. What a great week for #cancermetabolism and #mitochondrialbiology. Find here a selection of groundbreaking discoveries: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"Trying to define yourself is like trying to bite your own teeth."-Alan Watts
"Trying to define yourself is like trying to bite your own teeth."-Alan Watts
Reposted by Korolchuk Lab
🧠🔬 Postdoc positions open!
The MAP team at the IINS in beautiful Bordeaux is looking for curious and independent researchers to study how neuronal synapses work, adapt, and change at the molecular and cellular levels.
More about the offers 👉 shorturl.at/4KoxR
More about the team 👉 shorturl.at/lzFmN
The MAP team at the IINS in beautiful Bordeaux is looking for curious and independent researchers to study how neuronal synapses work, adapt, and change at the molecular and cellular levels.
More about the offers 👉 shorturl.at/4KoxR
More about the team 👉 shorturl.at/lzFmN
Mechanisms of Adaptive Processes in brain circuits (MAP) × IINS
Interdisciplinary Institute for Neuroscience
shorturl.at
November 16, 2025 at 6:30 PM
🧠🔬 Postdoc positions open!
The MAP team at the IINS in beautiful Bordeaux is looking for curious and independent researchers to study how neuronal synapses work, adapt, and change at the molecular and cellular levels.
More about the offers 👉 shorturl.at/4KoxR
More about the team 👉 shorturl.at/lzFmN
The MAP team at the IINS in beautiful Bordeaux is looking for curious and independent researchers to study how neuronal synapses work, adapt, and change at the molecular and cellular levels.
More about the offers 👉 shorturl.at/4KoxR
More about the team 👉 shorturl.at/lzFmN
#Autophagy and #mTOR papers from last week, enjoy thanks to @biomednews.bsky.social pre-selection!
biomed.news/bims-auttor/...
biomed.news/bims-auttor/...
a woman is laying on her stomach in the leaves reading a book .
ALT: a woman is laying on her stomach in the leaves reading a book .
media.tenor.com
November 16, 2025 at 10:39 AM
#Autophagy and #mTOR papers from last week, enjoy thanks to @biomednews.bsky.social pre-selection!
biomed.news/bims-auttor/...
biomed.news/bims-auttor/...
Reposted by Korolchuk Lab
🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
November 15, 2025 at 9:53 AM
🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
#Autophagy and #mTOR papers from last three weeks, enjoy!
biomed.news/bims-auttor/...
biomed.news/bims-auttor/...
biomed.news/bims-auttor/...
biomed.news/bims-auttor/...
biomed.news/bims-auttor/...
biomed.news/bims-auttor/...
bims-auttor 2025-10-26 papers
biomed.news
November 9, 2025 at 12:59 PM
#Autophagy and #mTOR papers from last three weeks, enjoy!
biomed.news/bims-auttor/...
biomed.news/bims-auttor/...
biomed.news/bims-auttor/...
biomed.news/bims-auttor/...
biomed.news/bims-auttor/...
biomed.news/bims-auttor/...
Looking forward to presenting and discussing our data, and making new friends of course!
Looking forward to tomorrow’s
@crc1430.bsky.social seminar
@unidue.bsky.social! We are excited to welcome Viktor Korolchuk
@korolchuklab.bsky.social, who will present on:
"Selective autophagy in ageing: mechanisms and functions"
#Autophagy #CellBiology #Collaboration
@crc1430.bsky.social seminar
@unidue.bsky.social! We are excited to welcome Viktor Korolchuk
@korolchuklab.bsky.social, who will present on:
"Selective autophagy in ageing: mechanisms and functions"
#Autophagy #CellBiology #Collaboration
October 27, 2025 at 10:23 PM
Looking forward to presenting and discussing our data, and making new friends of course!
Reposted by Korolchuk Lab
This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
highlight: Role of AAA-ATPase Cdc48p in peroxisomal quality control www.cell.com/cell-reports...
highlight: Role of AAA-ATPase Cdc48p in peroxisomal quality control www.cell.com/cell-reports...
bims-proteo 2025-10-19 papers
biomed.news
October 19, 2025 at 5:28 AM
This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
highlight: Role of AAA-ATPase Cdc48p in peroxisomal quality control www.cell.com/cell-reports...
highlight: Role of AAA-ATPase Cdc48p in peroxisomal quality control www.cell.com/cell-reports...
Reposted by Korolchuk Lab
Good Sunday, mitolovers! 🌟 Exciting news in the world of #cancermetabolism and #mitochondrialbiology! 🧬 Check out the papers from last week here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading📚
"Knowledge is an unending adventure at the edge of uncertainty."-Jacob Bronowski
"Knowledge is an unending adventure at the edge of uncertainty."-Jacob Bronowski
October 19, 2025 at 5:35 AM
Good Sunday, mitolovers! 🌟 Exciting news in the world of #cancermetabolism and #mitochondrialbiology! 🧬 Check out the papers from last week here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading📚
"Knowledge is an unending adventure at the edge of uncertainty."-Jacob Bronowski
"Knowledge is an unending adventure at the edge of uncertainty."-Jacob Bronowski
A strong effort by the #autophagy and #mTOR field last week, lots of interesting published papers in the link below 👇🏼
biomed.news/bims-auttor/...
biomed.news/bims-auttor/...
a young man wearing a hoodie that says you don t wanna miss it
ALT: a young man wearing a hoodie that says you don t wanna miss it
media.tenor.com
October 19, 2025 at 11:06 AM
A strong effort by the #autophagy and #mTOR field last week, lots of interesting published papers in the link below 👇🏼
biomed.news/bims-auttor/...
biomed.news/bims-auttor/...
Reposted by Korolchuk Lab
q.e.d Science
Critical Thinking AI for constructive criticism and science evaluation
qedscience.com
October 15, 2025 at 12:22 PM
Proud to be involved in this great paper describing a novel mechanism of #synuclein aggregation with implications for potential #PD treatment, don’t miss it! 👇🏼👇🏼👇🏼
Congratulations to the team!
www.embopress.org/doi/full/10....
Congratulations to the team!
www.embopress.org/doi/full/10....
Ubiquilin-2 liquid droplets catalyze α-synuclein fibril formation | The EMBO Journal
imageimageFibril formation of α-synuclein is central to Parkinson’s disease (PD) pathology. This study shows that UBQLN2 droplets catalyze α-synuclein fibrillization via their liquid-gel/solid transition, while a small molecule targeting UBQLN2 ...
www.embopress.org
October 15, 2025 at 9:14 AM
Proud to be involved in this great paper describing a novel mechanism of #synuclein aggregation with implications for potential #PD treatment, don’t miss it! 👇🏼👇🏼👇🏼
Congratulations to the team!
www.embopress.org/doi/full/10....
Congratulations to the team!
www.embopress.org/doi/full/10....
Reposted by Korolchuk Lab
This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: A genome-to-proteome map reveals how natural variants drive proteome diversity and shape fitnes www.science.org/doi/10.1126/...
Highlight: A genome-to-proteome map reveals how natural variants drive proteome diversity and shape fitnes www.science.org/doi/10.1126/...
bims-proteo 2025-10-12 papers
biomed.news
October 12, 2025 at 8:11 AM
This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: A genome-to-proteome map reveals how natural variants drive proteome diversity and shape fitnes www.science.org/doi/10.1126/...
Highlight: A genome-to-proteome map reveals how natural variants drive proteome diversity and shape fitnes www.science.org/doi/10.1126/...
Reposted by Korolchuk Lab
Fresh selection of papers on #MitochondrialDisease from #week41! 📚 💚
biomed.news/bims-mitdis/...
@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
www.science.org/doi/10.1126/...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
www.science.org/doi/10.1126/...
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...
www.science.org
October 12, 2025 at 11:06 AM
Fresh selection of papers on #MitochondrialDisease from #week41! 📚 💚
biomed.news/bims-mitdis/...
@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
www.science.org/doi/10.1126/...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
www.science.org/doi/10.1126/...
Reposted by Korolchuk Lab
Good Sunday, all. Your weekly curated summary of papers in #cancermetabolism and #mitochondrialbiology is ready, don't miss it as it is full of exceptional discoveries: biomed.news/bims-camemi/... Biomed News #keepreading
"To see takes time, like to have a friend takes time." -Georgia O'Keeffe
"To see takes time, like to have a friend takes time." -Georgia O'Keeffe
October 12, 2025 at 5:41 AM
Good Sunday, all. Your weekly curated summary of papers in #cancermetabolism and #mitochondrialbiology is ready, don't miss it as it is full of exceptional discoveries: biomed.news/bims-camemi/... Biomed News #keepreading
"To see takes time, like to have a friend takes time." -Georgia O'Keeffe
"To see takes time, like to have a friend takes time." -Georgia O'Keeffe
#Autophagy and #mTOR paper published last week, lots of cool stuff, enjoy!
biomed.news/bims-auttor/...
biomed.news/bims-auttor/...
October 12, 2025 at 9:13 AM
#Autophagy and #mTOR paper published last week, lots of cool stuff, enjoy!
biomed.news/bims-auttor/...
biomed.news/bims-auttor/...
Reposted by Korolchuk Lab
How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease?
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...
www.science.org
October 10, 2025 at 8:45 AM
How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease?
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
A new set of guidelines on the use of in vitro models in #PD and #Ageing research #Justpublished, don’t miss it! 👇🏼👇🏼👇🏼
rdcu.be/eKanG
rdcu.be/eKanG
Investigating the ageing-Parkinson’s disease nexus: standardisation of in vitro models and techniques by the PD-AGE network
npj Parkinson's Disease - Investigating the ageing-Parkinson’s disease nexus: standardisation of in vitro models and techniques by the PD-AGE network
rdcu.be
October 9, 2025 at 11:18 AM
A new set of guidelines on the use of in vitro models in #PD and #Ageing research #Justpublished, don’t miss it! 👇🏼👇🏼👇🏼
rdcu.be/eKanG
rdcu.be/eKanG
Reposted by Korolchuk Lab
Scripps is conducting a tenure track assistant professor search. This is a broad search across multiple departments for outstanding individuals that could integrate into the multi-disciplinary environment at Scripps Research. All interested should apply! Please share. apply.interfolio.com/174756
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
October 2, 2025 at 4:33 PM
Scripps is conducting a tenure track assistant professor search. This is a broad search across multiple departments for outstanding individuals that could integrate into the multi-disciplinary environment at Scripps Research. All interested should apply! Please share. apply.interfolio.com/174756
Reposted by Korolchuk Lab
This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: Translation landscape of stress granules www.science.org/doi/10.1126/...
Highlight: Translation landscape of stress granules www.science.org/doi/10.1126/...
bims-proteo 2025-10-05 papers
biomed.news
October 5, 2025 at 6:28 AM
This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: Translation landscape of stress granules www.science.org/doi/10.1126/...
Highlight: Translation landscape of stress granules www.science.org/doi/10.1126/...
Reposted by Korolchuk Lab
#MitochondrialDisease papers from #week40! 📚 💚
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
A few highlights below! 👇
DDHD2 provides a flux of saturated fatty acids for neuronal energy and function
www.nature.com/articles/s42...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
A few highlights below! 👇
DDHD2 provides a flux of saturated fatty acids for neuronal energy and function
www.nature.com/articles/s42...
DDHD2 provides a flux of saturated fatty acids for neuronal energy and function - Nature Metabolism
Saber et al. show that the lipase DDHD2 provides endogenous saturated fatty acids to support fatty acid oxidation and energy production, proteostasis and membrane trafficking balance.
www.nature.com
October 5, 2025 at 9:33 AM
#MitochondrialDisease papers from #week40! 📚 💚
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
A few highlights below! 👇
DDHD2 provides a flux of saturated fatty acids for neuronal energy and function
www.nature.com/articles/s42...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
A few highlights below! 👇
DDHD2 provides a flux of saturated fatty acids for neuronal energy and function
www.nature.com/articles/s42...
#Autophagy and #mTOR papers from last week, enjoy thanks to @biomednews.bsky.social pre-selection engine. DM them if you want your own personalised feed.
biomed.news/bims-auttor/...
biomed.news/bims-auttor/...
a woman in a red and white striped shirt is throwing papers into the air
ALT: a woman in a red and white striped shirt is throwing papers into the air
media.tenor.com
October 5, 2025 at 8:51 AM
#Autophagy and #mTOR papers from last week, enjoy thanks to @biomednews.bsky.social pre-selection engine. DM them if you want your own personalised feed.
biomed.news/bims-auttor/...
biomed.news/bims-auttor/...
Reposted by Korolchuk Lab
#MitochondrialDisease papers from #week39! 📚 👇
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social
A few highlights below!
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social
A few highlights below!
Ribonucleotide incorporation into mitochondrial DNA drives inflammation - Nature
Imbalanced nucleotide metabolism leads to age- and mtDNA-dependent inflammatory responses and senescence-associated secretory phenotype in senescence.
nature.com
September 28, 2025 at 10:06 AM
#MitochondrialDisease papers from #week39! 📚 👇
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social
A few highlights below!
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social
A few highlights below!
Reposted by Korolchuk Lab
In this week's issue of mitophagy news 🪫🗑️:
-Urolithin A increases healthspan via MERCS and Ca2+-mitophagy
-Parkin Induces Ubiquitination and Large Extracellular Vesicle Release of HMGB1 to Activate Antitumor Immunity
-a Parkin and hTau mouse cross
biomed.news/bims-tofagi/...
-Urolithin A increases healthspan via MERCS and Ca2+-mitophagy
-Parkin Induces Ubiquitination and Large Extracellular Vesicle Release of HMGB1 to Activate Antitumor Immunity
-a Parkin and hTau mouse cross
biomed.news/bims-tofagi/...
September 14, 2025 at 11:24 AM
In this week's issue of mitophagy news 🪫🗑️:
-Urolithin A increases healthspan via MERCS and Ca2+-mitophagy
-Parkin Induces Ubiquitination and Large Extracellular Vesicle Release of HMGB1 to Activate Antitumor Immunity
-a Parkin and hTau mouse cross
biomed.news/bims-tofagi/...
-Urolithin A increases healthspan via MERCS and Ca2+-mitophagy
-Parkin Induces Ubiquitination and Large Extracellular Vesicle Release of HMGB1 to Activate Antitumor Immunity
-a Parkin and hTau mouse cross
biomed.news/bims-tofagi/...