Lightnews — Scholar-powered news

Christian Endisch, MD

@christianendisch.bsky.social

28 followers 52 following 4 posts

Neurologist interested in neuroprognostication and disorders of consciousness https://scholar.google.de/citations?user=AGbhaIwAAAAJ&hl=de

scholar.google.de

Posts Media Videos Starter Packs

Pinned

Christian Endisch, MD @christianendisch.bsky.social · Dec 23

Tremendous honor to have @thelancet.bsky.social Neuroloy featuring me and our research in the rubric Lifeline ⭐️⭐️⭐️

🙏 Thanks to all my mentors in the field of @ercresus.bsky.social @neurocritical.bsky.social @jama.com @neurocritcarej.bsky.social @dgn-ev.bsky.social

www.thelancet.com/journals/lan...

Christian Endisch

Christian Endisch is a neurologist in the department of neurology at the Charité Universitätsmedizin Berlin in Germany. He obtained his medical degree from the Charité Universitätsmedizin Berlin, undertaking study visits in Denmark and Sweden, and successfully defended his doctoral thesis with summa cum laude. His main research focus is on neuroprognostication and neurophysiological techniques in patients with disorders of consciousness.

www.thelancet.com

Reposted by Christian Endisch, MD

SfN Journals @sfnjournals.bsky.social · 22d

#eNeuro | SpinalTRAQ: A Novel Pipeline for Volumetric Cervical Spinal Cord Analysis Identifies the Corticospinal Tract Synaptic Projectome in Healthy and Post-stroke Mice
https://doi.org/10.1523/ENEURO.0276-25.2025

1 1

Reposted by Christian Endisch, MD

European Journal of Neurology @europeanjournalofneurology.ean.org · 27d

Chen et al. report in “Efficacy and Safety of Twelve Anti-Dyskinetic Drugs in Parkinson's Disease” that amantadine ER is more effective than IR for dyskinesia, and both reduce OFF time better than other drugs.

📚 Read now: onlinelibrary.wiley.com/doi/10.1111/...
#Neurology
@ean.org #WileyNeuro

2 1

Reposted by Christian Endisch, MD

JAMA Network Open @jamanetworkopen.com · Sep 19

RCT: For patients with spinal cord injury, augmenting mean arterial pressure >85 vs 65 mmHg did not improve 6‐month neurological outcomes, and the MAP >85 group had more respiratory complications, longer mechanical ventilation, and worse organ dysfunction.

#NCS2025

ja.ma/4naOW1t

Stacked bar graph showing the percentage of patients with different AIS grades in ABP and CBP groups at baseline and 6 months. The AIS grades are 'Died', 'A', 'B', 'C', and 'D'. Transitions between states are visually represented.

2 1

Reposted by Christian Endisch, MD

Michael Okun @michaelokun.bsky.social · Sep 16

To shunt or not to shunt, that is the (NPH) question? The first large randomized trial of shunting for normal pressure hydrocephalus (NPH) just dropped in NEJM, and there was clear benefit for walking, and it favored the group receiving shunts. @parkinsondotorg.bsky.social

3 3

Reposted by Christian Endisch, MD

Michael Okun @michaelokun.bsky.social · Sep 1

What is the 2025 update on antibody therapies for Alzheimer’s? Spoiler alert: think EAC or effectiveness, access and cost. A critically important topic in a recent piece in JAMA. Early adopters enthusiastic, safety signals remain consistent w/ trials, questions remain. @alzassociation.bsky.social

Reposted by Christian Endisch, MD

Center for Molecular Integrative Neuroresilience @icahncmin.bsky.social · Aug 17

A new study by Puja Agarwal, Sonal Agrawal, Julie Schneider, et al. @rushalzheimers.bsky.social provides more evidence that #MIND & other diets like it can protect against #Dementia – as well as giving us some clues as to why. Learn More @jamanetworkopen.com 👉
jamanetwork.com/journals/jam...

3 2

Reposted by Christian Endisch, MD

JAMA @jama.com · Jul 28

Patent foramen ovale (PFO) is present in approximately 25% of all adults and is a common cause of stroke in young and middle-aged patients.

This review discusses PFO-associated stroke management.

ja.ma/4orDOyr

1 3 7

Reposted by Christian Endisch, MD

Maëlan Menétrey @maelanmenetrey.bsky.social · Jul 14

🚨 New 2-in-1 paper: a review on #EEG brain oscillations (www.sciencedirect.com/science/arti...) and a website with recorded talks from a symposium that featured 8 speakers discussing the present and future of the field (brain-waves-workshop.github.io/2024/).

🧠 #neuroimaging #neuroskyence

EEG brain waves and alpha rhythms: Past, current and future direction

Nearly a century after the first EEG recordings, we assess the progress made in EEG research, focusing on the challenges, novel theories and methods, …

www.sciencedirect.com

1 6 13

Reposted by Christian Endisch, MD

Resuscitation @resuscitation.bsky.social · Jul 25

Neurofilament light chain evaluated with a new automated commercially available method for outcome prediction in out-of-hospital cardiac arrest patients

www.resuscitationjournal.com/article/S03...

#Resuscitation

1 1

Reposted by Christian Endisch, MD

NEJM AI @ai.nejm.org · Jul 21

SpikeNet2, a deep-learning model shown to achieve expert-level performance in detecting epileptiform discharges from EEG recordings while significantly reducing false positives, demonstrates strong generalizability across diverse datasets. Learn more: nejm.ai/4lq1Qr4

#AI #MedSky #NeuroSky

Figure 2. The Pipeline of Hard-Negative Mining.

2 1

Reposted by Christian Endisch, MD

Stephane Legriel @stlegriel.bsky.social · Jul 20

#Cardiacarrest from neurological causes: for whom the brain tolls - Resuscitation www.resuscitationjournal.com/article/S030... @resuscitation.bsky.social @stlegriel.bsky.social #marinepaul

Cardiac arrest from neurological causes: for whom the brain tolls

Cardiac arrest of neurological cause (CA-NC) is an entity whose incidence is unknown. The main reason for this is that the medical literature is mainly concerned with cardiac arrest due to cardiac cau...

www.resuscitationjournal.com

2 4 6

Reposted by Christian Endisch, MD

Resuscitation @resuscitation.bsky.social · Jul 19

Serum neurofilament light chain and multimodal neuroprognostication after cardiac arrest – a retrospective cohort study

www.resuscitationjournal.com/article/S03...

#Resuscitation

1 1

Reposted by Christian Endisch, MD

Resuscitation @resuscitation.bsky.social · Jul 20

Neurologic etiologies of cardiac arrest are associated with early withdrawal of life-sustaining therapy

www.resuscitationjournal.com/article/S03...

#Resuscitation

Reposted by Christian Endisch, MD

The Lancet Neurology @thelancetneuro.bsky.social · Jul 7

A pooled analysis of of the four INTERACT trials suggests intensive blood pressure-lowering initiated within several hours of intracerebral haemorrhage onset was safe and improved functional recovery, without a clear effect on haematoma growth. Check it out in our latest issue: tinyurl.com/mrnmv5f6

1 1 1

Reposted by Christian Endisch, MD

Neurocritical Care @neurocritcarej.bsky.social · Jun 20

Al-Salahat et al: Outcomes of Spinal Cord Infarction with Thrombolysis: A Nationwide Analysis

Link: link.springer.com/ar...

@neurocritical #neurocritcare

Christian Endisch, MD @christianendisch.bsky.social · May 20

Brain injury after cardiac arrest is not as homogeneous and global as previously thought ❗️

We identified different histopathological phenotypes in 319 (!) patients with postmortem brain autopsies 🧠 🔬

@resuscitation.bsky.social
@neurocritical.bsky.social

www.sciencedirect.com/science/arti...

Histopathological patterns of hypoxic-ischemic encephalopathy after cardiac arrest: A retrospective brain autopsy study of 319 patients

Understanding the pathophysiology of hypoxic-ischemic encephalopathy (HIE) provides important knowledge for the interpretation of neuroprognostic inve…

www.sciencedirect.com

2 4

Reposted by Christian Endisch, MD

Michael Okun @michaelokun.bsky.social · May 18

Do we need to rethink near-death experiences? What’s really happening in the brain? NDEs might be a hardwired coping strategy: the dissociation, calmness, and detachment when facing death may actually be an evolutionarily protective response.

1 5

Reposted by Christian Endisch, MD

Michael Okun @michaelokun.bsky.social · May 9

Is the "New Brunswick Neurological Syndrome of Unknown Cause" actually a new disease? The data out strongly suggest NO. We must carefully study and share data on clusters of 'unknown' cases, and especially those cases that draw intense attention from the media. Examine and use pathology.

1 3 4

Christian Endisch, MD @christianendisch.bsky.social · Apr 12

‼️Largest cohort of postmortem 🧠 autopsies after cardiac arrest ‼️
@resusplus.bsky.social @ercresus.bsky.social

Correlation between

🧠 🔬 Microscopic brain injury

✳️ Duration of resuscitation
✳️ Regain of consciousness

📖Read more:

www.sciencedirect.com/science/arti...

Duration of resuscitation, regain of consciousness and histopathological severity of hypoxic-ischemic encephalopathy after cardiac arrest

To study the histopathologically quantified severity of hypoxic-ischemic encephalopathy (HIE) in deceased cardiac arrest unbiased by death causes and …

www.sciencedirect.com

2 6

Reposted by Christian Endisch, MD

Neurocritical Care @neurocritcarej.bsky.social · Apr 10

Zhang et al: Contralateral Neurovascular Coupling in Patients with Ischemic Stroke After Endovascular Thrombectomy

Link:link.springer.com/ar...

@neurocritical #neurocritcare

3 6

Reposted by Christian Endisch, MD

The Lancet @thelancet.com · Apr 2

Neurological problems are a significant concern for patients receiving CAR T-cell therapy, yet there are no best practice guidelines.

In @thelancetoncol.bsky.social, a Review provides guidance on managing neurological issues associated with CAR T-cell therapy: tinyurl.com/3fxd5vtt

Figure showing CAR T-cell therapy-associated neurotoxicities. Copyright: Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

10 31

Reposted by Christian Endisch, MD

The Lancet Respiratory Medicine @lancetrespirmed.bsky.social · Mar 28

3/ Decisions to withdraw or withhold life-sustaining therapies in patients with and without acute brain injury: a secondary analysis of cohort studies🔗 tinyurl.com/4z6w3vv5

Decisions to withdraw or withhold life-sustaining therapies in patients with and without acute brain injury: a secondary analysis of two prospective cohort studies

Our findings suggest that WLST decisions are significantly more common in patients with ABI versus patients without ABI and occur earlier in this group. The rationale for early WLST following ABI warr...

tinyurl.com

2 2

Reposted by Christian Endisch, MD

Allen Institute @alleninstitute.org · Mar 13

OP-ED: "Consciousness or pseudo-consciousness? A clash of two paradigms" by Meritorious Investigator Christof Koch and collaborators

🧠📈 www.nature.com/articles/s41...

Consciousness or pseudo-consciousness? A clash of two paradigms - Nature Neuroscience

Integrated information theory (IIT) starts from consciousness, which is subjective, and accounts for its presence and quality in objective, testable terms. Attempts to label as ‘pseudoscientific’ a th...

www.nature.com

1 4 22

Reposted by Christian Endisch, MD

Nature Neuroscience @natneuro.nature.com · Mar 11

Then, Consciousness or pseudo-consciousness? A clash of two paradigms

www.nature.com/articles/s41...

Consciousness or pseudo-consciousness? A clash of two paradigms - Nature Neuroscience

www.nature.com

1 2 6

Christian Endisch, MD @christianendisch.bsky.social · Feb 24

Pleasure of contributing to Handbook of Clinical Neurology, Vol. 207: „Coma, Stupor, and Related Disorders of Consciousness“ 🌟

@neurocritical.bsky.social
Check out our chapter ✅

Title: „Evoked potentials in patients with disorders of consciousness“

www.sciencedirect.com/science/arti...

Evoked potentials in patients with disorders of consciousness

Acute coma in the intensive care unit and persistent disorders of consciousness (DoC) in neuro-rehabilitation are frequent in patients with hypoxic–is…