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Mart Krupovic

Mart Krupovic

@mkrupovic.bsky.social

2.5K followers 430 following 84 posts

Virus origins/diversity/evolution; mobilome; Archaea.
Head of the Cell Biology and Virology of Archaea Unit at Institut Pasteur:
https://research.pasteur.fr/en/team/archaeal-virology/

Biology 41%

Environmental science 29%

more

Posts Replies Media Videos

Mart Krupovic @mkrupovic.bsky.social · 7h

Congrats to all coauthors, @sonaida.bsky.social, Ulysse Guyet, @tomdelmont.bsky.social, Eugene Koonin, et al. @pasteur.fr @cnrs.fr

Mart Krupovic @mkrupovic.bsky.social · 7h

Check out our latest paper on mirusviruses, one of the most remarkable new groups of protist viruses - extremely diverse, carry lots of spliceosomal introns (including new homing introns) and are at the evolutionary crossroads between tailed phages and herpesviruses! www.nature.com/articles/s41...

Widespread and intron-rich mirusviruses are predicted to reproduce in nuclei of unicellular eukaryotes - Nature Microbiology

Environmental metagenomic explorations show that Mirusviricota lineages lack essential replication and transcription genes and contain spliceosomal introns, suggesting nuclear reproduction.

Reposted by Mart Krupovìč

Sofia Medvedeva @sonaida.bsky.social · 10h

www.nature.com/articles/s41...

Thrilled to share our new study! We show that mirusviruses include lineages packed with spliceosomal introns and likely replicating in the nucleus of unicellular eukaryotes—a sharp contrast to most large and giant eukaryotic viruses that replicate in the cytoplasm.

Widespread and intron-rich mirusviruses are predicted to reproduce in nuclei of unicellular eukaryotes - Nature Microbiology

Environmental metagenomic explorations show that Mirusviricota lineages lack essential replication and transcription genes and contain spliceosomal introns, suggesting nuclear reproduction.

Reposted by Mart Krupovìč

Osterman Ilya @ostermanilya.bsky.social · 10h

Intron-rich viruses - WOW!
rdcu.be/eSfG2

Widespread and intron-rich mirusviruses are predicted to reproduce in nuclei of unicellular eukaryotes - Nature Microbiology

Environmental metagenomic explorations show that Mirusviricota lineages lack essential replication and transcription genes and contain spliceosomal introns, suggesting nuclear reproduction.

Reposted by Mart Krupovìč

BejaLab @bejalab.bsky.social · 3d

Arbitrium systems control lysis/lysogeny through the regulation of small antirepressor proteins www.biorxiv.org/content/10.1...

Reposted by Mart Krupovìč

Satoshi Kawato 川戸智 @kawatosatoshi.bsky.social · 4d

New update for the gbdraw web app!🚀
You can now display gene labels ONLY on the first genome in the linear diagram. Just select "First" in the "Label layout" option.
Try it out here👉: gbdraw.streamlit.app
#gbdraw #bioinformatics #genomics #visualization #virology #microbiology #streamlit

Reposted by Mart Krupovìč, Jean-Yves Tinévez

Christophe Zimmer @chzimmer.bsky.social · 5d

Recently out: “Uniform dynamics of cohesin-mediated loop extrusion in living human cells”. In this study led by brilliant former PhD student Thomas Sabaté we use live cell microscopy and polymer simulations to characterize how DNA loops and TADs form in human cells by cohesin-driven extrusion. (1/4)

Reposted by Simon Roux, Mart Krupovìč, Mya Breitbart , and 2 more Simon Roux, Mart Krupovìč, Mya Breitbart, José R. Penadés, Alan McNally

Alexander Harms @aharms485.bsky.social · 8d

🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages.

Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.

A thread 1/8

Reposted by Mart Krupovìč

Daniela Barillà @danielabarilla.bsky.social · 8d

Let’s wrap things up: my commentary on the Asgard hypernucleosomes.

Congratulations to all the authors of the paper 🍾!

kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

Cryo-EM reveals open and closed Asgard chromatin assemblies: Molecular Cell www.cell.com/molecular-ce...

Cryo-EM reveals open and closed Asgard chromatin assemblies

Ranawat et al. show the cryo-EM structures of Asgard archaeal chromatin assemblies, revealing that the histone HHoB assembles into both compact closed and extended open hypernucleosomes. The closed co...

Reposted by Mart Krupovìč

roop-dhillon.bsky.social @roop-dhillon.bsky.social · 11d

New video on Nested Symbiosis in extreme environments out on my YouTube Channel. Give it a watch if you can, a great paper by @mkrupovic.bsky.social

Original Paper: doi.org/10.1038/s415...

youtu.be/OQR5obtf7-4

Nested Symbiosis in Extreme Environments

YouTube video by Archaeal Adventures

Reposted by Mart Krupovìč

Rubén González @rubengonzalez.bsky.social · 12d

Version 2 is out! More comprehensive text plus new tissue- and pathway-specific analysis revealing how different viruses trigger systemic aging through diverse mechanisms.
www.biorxiv.org/content/10.1...

Reposted by Mart Krupovìč

Vivek Mutalik @vivekmutalik.bsky.social · 13d

Amazing piece of work from @rtoshiro.bsky.social
& Kim Seed at UC Berkeley. 🙌
Played a tiny role in this work.

Surviving phage attack dynamically regulates bacterial immunity to defeat counterdefenses

www.biorxiv.org/content/10.1...

Mart Krupovic @mkrupovic.bsky.social · 13d

Welcome to @pasteur.fr , Spyros! It will be great to have you!

Reposted by Mart Krupovìč

Karim Majzoub @karimaj.bsky.social · 14d

My lab is recruiting a post-doc ! please share ! emploi.cnrs.fr/Offres/CDD/U...

Mart Krupovic @mkrupovic.bsky.social · 15d

Thanks Karim.

Reposted by Mart Krupovìč

Yann Moalic @drym.bsky.social · 16d

www.nature.com/articles/s41...

Viruses and virus satellites of haloarchaea and their nanosized DPANN symbionts reveal intricate nested interactions - Nature Microbiology

An exploration of the viromes of haloarchaea and their ultra-small DPANN symbionts reveals plasmid-derived satellites of viruses from both archaeal groups, highlighting the complexity of nested symbio...

Reposted by Mart Krupovìč, Mya Breitbart

BejaLab @bejalab.bsky.social · 16d

Viral NblA proteins negatively affect oceanic cyanobacterial photosynthesis www.nature.com/articles/s41...
this project was led by @omernadel.bsky.social and is a joint work between the labs of @bejalab.bsky.social, Debbie Lindell and Oded Kleifeld from @biologytechnion.bsky.social

the sun is shining through the clouds in the sky above the ocean

ALT: the sun is shining through the clouds in the sky above the ocean

media.tenor.com

Reposted by Simon Roux, Mart Krupovìč, José R. Penadés

Sorek Lab @soreklab.bsky.social · 22d

Preprint: Bacteria sense virus-induced genome degradation via methylated mononucleotides

tinyurl.com/ch3damp

We show how molecular byproducts released during virus-induced cell exploitation are used as signals to trigger host immunity

Revealed by the amazing Ilya Osterman. See his thread below👇

Reposted by Mart Krupovìč

Fengbin (Jerry) Wang @jerryknowsnothing.bsky.social · 25d

Check out the fancy anti-parallel cytochrome nanowire bundles structure we've solved. This structure originates from a bacterium, strain name WTL (well-to-live), isolated by the Bond group from the Soudan Underground Iron Mine, located 713 m below the surface. www.biorxiv.org/content/10.1...

A Bundled Antiparallel Cytochrome Nanowire Structure Suggests Roles in Cell-Cell Electron Transfer and Biofilm Formation

Long-range extracellular electron transfer enables respiring microbes to use minerals, other organisms, or electrodes as electron acceptors by transporting electrons microns away from the cell surface...

www.biorxiv.org

Reposted by Mart Krupovìč

Romain Villa @romain-villa.bsky.social · 25d

Curious about the top methane-maker in your gut? Meet this month's featured microbe and find out! 🦠💨🔥 in @cp-trendsmicrobiol.bsky.social #archaeasky
@sgribaldo.bsky.social @pasteur.fr
🔗 Full article linked in reply👇
www.sciencedirect.com/science/arti...

Methanobrevibacter smithii

www.sciencedirect.com

Reposted by Mart Krupovìč, Maria Faticov

DEEMteam_Orsay @deemteam.bsky.social · 26d

This paper has been a must! Great collaboration with @mkrupovic.bsky.social and @yifanzhou.bsky.social, a N&V by a legend of halophilic archaea tinyurl.com/yc3dcv72, and one picture of one of our expeditions to Dallol making the cover of the November issue of @natmicrobiol.nature.com

rdcu.be/eLtCH

Reposted by Mart Krupovìč, Jason Williams

Svetlana Dodonova @dodonova-sveta.bsky.social · Oct 28

Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...

Reposted by Mart Krupovìč

Fengbin (Jerry) Wang @jerryknowsnothing.bsky.social · Oct 24

First time posting on Bluesky! 🥳 We discovered a new pilus family in cyanobacteria. The pilin has a novel protein fold that forms a super-tight double-layer tube. Similar gene clusters exist in a few cyanobacterial orders. A great collaboration with John and others! www.nature.com/articles/s41...

A family of tubular pili from harmful algal bloom forming cyanobacterium Microcystis aeruginosa - Nature Communications

Ricca et al discover a new family of tubular pili in Microcystis aeruginosa, a harmful algal bloom-forming cyanobacterium. These pili are crucial for buoyancy by forming cell micro-colonies, which inc...

Reposted by Mart Krupovìč

Soil Microbial Ecology Group @soilmicrobes.bsky.social · Oct 21

📣 PhD Scholarship Opportunity for International Students!
Are you looking to do a PhD in soil microbial and viral ecology?
✍️ Get in touch now!!
✅ Requirements: Masters degree, Distinguished CV, Highly motivated
⏳ Application deadline: November 24
www.univ-lyon1.fr/recherche/fo...

www.univ-lyon1.fr

Reposted by Mart Krupovìč

Fabai Wu @fabaiwu.bsky.social · Oct 21

Glad to share our paper out today @NatureEcoEvo: “Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor”. www.nature.com/articles/s41... #microsky #archaeasky

Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor - Nature Ecology & Evolution

Phylogenetic and biochemical analyses show a diversity of components of the DNA replication machinery in different Asgard archaea that contributed to the eukaryotic DNA replication machinery.

Reposted by Mart Krupovìč, David Moreira

Nature Microbiology @natmicrobiol.nature.com · Oct 20

Viruses and virus satellites of haloarchaea and their nanosized DPANN symbionts reveal intricate nested interactions

Out now in Nature Microbiology, by Yifan Zhou, Mart Krupovic & colleagues.
@mkrupovic.bsky.social
@yifanzhou.bsky.social
@deemteam.bsky.social

www.nature.com/articles/s41...

Viruses and virus satellites of haloarchaea and their nanosized DPANN symbionts reveal intricate nested interactions - Nature Microbiology

An exploration of the viromes of haloarchaea and their ultra-small DPANN symbionts reveals plasmid-derived satellites of viruses from both archaeal groups, highlighting the complexity of nested symbio...

Reposted by David Moreira

Mart Krupovic @mkrupovic.bsky.social · Oct 20

A nice N&V article by Mike Dyall-Smith on our recent paper
( www.nature.com/articles/s41... ):

www.nature.com/articles/s41...

Archaeal symbioses all the way down - Nature Microbiology

Ethiopian salt lakes feature unique microbial communities with nesting layers of symbioses, where haloarchaea and their ultra-small archaeal symbionts are prey to viruses, which are in turn hijacked b...

Reposted by Mart Krupovìč

Simon Roux @simrouxvirus.bsky.social · Oct 18

Now published: EnVhogDB, a large database of viral protein family HMM profiles to help functional annotation of new phage genomes - peercommunityjournal.org/articles/10....

EnVhogDB: an extended view of the viral protein families on Earth through a vast collection of HMM profiles

peercommunityjournal.org

Reposted by Simon Roux, David Moreira

Mart Krupovic @mkrupovic.bsky.social · Oct 17

Check out our paper on intricate nested interactions between viruses and virus satellites of haloarchaea and their nanosized DPANN symbionts. Excellent collaboration with @deemteam.bsky.social, @anagtz.bsky.social and Michail Yakimov
Free access link: rdcu.be/eLtCH
🧵 by @yifanzhou.bsky.social 👇

Yifan ZHOU @yifanzhou.bsky.social · Oct 17

Our work on viruses and virus satellites of haloarchaea and their DPANN symbionts is out today in Nature Microbiology!
@mkrupovic.bsky.social @deemteam.bsky.social @anagtz.bsky.social
www.nature.com/articles/s41...

Viruses and virus satellites of haloarchaea and their nanosized DPANN symbionts reveal intricate nested interactions - Nature Microbiology

An exploration of the viromes of haloarchaea and their ultra-small DPANN symbionts reveals plasmid-derived satellites of viruses from both archaeal groups, highlighting the complexity of nested symbio...