Thelonevirologist
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Thelonevirologist
@thelonevirologist.bsky.social
Virologist. Likes history, hiking, tea, coffee & a good movie.Favourite viruses? Coronavirus, Emerging & Oncogenic Viruses. Favourite country? UK. Dad. Bibliophile.
Experts fear for US childhood vaccine schedule after hepatitis B guideline change

www.theguardian.com/us-news/2025...
Experts fear for US childhood vaccine schedule after hepatitis B guideline change
Pediatricians say panel’s decision will create confusion and access issues, and condemn ‘parody of public health’
www.theguardian.com
December 6, 2025 at 1:36 PM
Fewer people are being vaccinated against respiratory diseases www.cidrap.umn.edu/adult-non-fl...
Fewer people are being vaccinated against respiratory diseases
www.cidrap.umn.edu
December 6, 2025 at 12:59 AM
8yo:”I did this while the other kids did their math. It was a lot but not difficult at all.”
December 5, 2025 at 9:59 PM
An End to Hepatitis B Shots for All Newborns www.nytimes.com/2025/12/05/h...
An End to Hepatitis B Shots for All Newborns
www.nytimes.com
December 5, 2025 at 4:00 PM
Exploring influenza A virus receptor distribution in the lactating mammary gland of domesticated livestock and in human breast tissue www.journalofdairyscience.org/article/S002...
Exploring influenza A virus receptor distribution in the lactating mammary gland of domesticated livestock and in human breast tissue
The spread of the highly pathogenic avian influenza (HPAI) H5N1 virus in dairy cattle, particularly affecting the mammary glands, highlights the adaptability of influenza A viruses (IAV) to infect non...
www.journalofdairyscience.org
December 5, 2025 at 2:51 AM
France reports MERS in 2 travelers who had been to Middle East

www.cidrap.umn.edu/france-repor...
France reports MERS in 2 travelers who had been to Middle East
No secondary transmission chains have been identified in France.
www.cidrap.umn.edu
December 5, 2025 at 12:49 AM
Kennedy’s Methodical 2-Decade Quest to Dismantle Vaccine Policy

www.nytimes.com/2025/12/04/u...
Kennedy’s Methodical 2-Decade Quest to Dismantle Vaccine Policy
www.nytimes.com
December 4, 2025 at 10:05 PM
CDC advisers delay vote on restricting infant hepatitis B vaccinations in tense meeting

www.theguardian.com/us-news/2025...
CDC advisers delay vote on restricting infant hepatitis B vaccinations in tense meeting
From 1990 to 2019, reported cases of acute hepatitis B among kids declined by 99% due to infant immunization
www.theguardian.com
December 4, 2025 at 8:02 PM
Aluminium is crucial to vaccines — and safe. Why are US advisers debating it? www.nature.com/articles/d41...
Aluminium is crucial to vaccines — and safe. Why are US advisers debating it?
RFK Jr’s vaccine advisory panel will be discussing the inclusion of adjuvants in childhood vaccinations this week. Here’s what’s at stake.
www.nature.com
December 4, 2025 at 4:13 PM
Paramyxovirus matrix protein redirects METTL3 for dual regulation of viral replication and immune evasion

journals.plos.org/plospathogen...
Paramyxovirus matrix protein redirects METTL3 for dual regulation of viral replication and immune evasion
Author summary In this study, we have identified a sophisticated strategy employed by paramyxoviruses to manipulate host epitranscriptomic RNA modification machinery during infection. Our research sho...
journals.plos.org
December 4, 2025 at 4:07 PM
Targeting envelope lipids with 2,6‑di‑O‑methyl‑3‑acetyl‑β‑cyclodextrin impairs infectivity of SARS‑CoV‑2 and Japanese encephalitis virus journals.asm.org/doi/10.1128/...
Targeting envelope lipids with 2,6‑di‑O‑methyl‑3‑acetyl‑β‑cyclodextrin impairs infectivity of SARS‑CoV‑2 and Japanese encephalitis virus | Journal of Virology
The SARS-CoV-2 pandemic has highlighted the urgent need for effective antiviral strategies that can interrupt viral transmission before pathogen-specific vaccines or therapeutic interventions become available. In this study, we demonstrate that DMA-β-CyD is the first compound shown to reduce the infectivity of SARS-CoV-2 and Japanese encephalitis virus (JEV) particles by interacting with aminophospholipids, such as phosphatidylserine (PS). By exploiting differences in lipid composition between viral envelopes and host cell membranes, DMA-β-CyD provides a novel, lipid-targeting antiviral mechanism and may serve as a valuable platform for addressing infections caused by emerging and drug-resistant viral pathogens. This study underscores the therapeutic potential of disrupting envelope lipids as a broad-spectrum antiviral strategy.
journals.asm.org
December 4, 2025 at 4:05 PM
The proteomics of the giant cedratvirus particles reveals unique and shared features with pitho-like viruses journals.asm.org/doi/10.1128/...
The proteomics of the giant cedratvirus particles reveals unique and shared features with pitho-like viruses | Journal of Virology
There are still only a few studies on the proteomics of giant viruses. Research published to date has revealed the presence of several proteins involved in processes such as transcription (including R...
journals.asm.org
December 4, 2025 at 4:05 PM
A Threat to Evidence-Based Vaccine Policy and Public Health Security at the FDA | New England Journal of Medicine www.nejm.org/doi/full/10....
A Threat to Evidence-Based Vaccine Policy and Public Health Security at the FDA | NEJM
Twelve former commissioners of the FDA express concern that the agency’s recent moves will undermine a regulatory model designed to ensure vaccine safety, effectiveness, and availability.
www.nejm.org
December 3, 2025 at 11:48 PM
Quick takes: Marburg cases reach 13, avian flu detections in Alaska www.cidrap.umn.edu/marburg/quic...
Quick takes: Marburg cases reach 13, avian flu detections in Alaska
Officials also confirmed a new avian flu detection in dairy cattle in California.
www.cidrap.umn.edu
December 3, 2025 at 11:47 PM
US measles outbreak tops 1,800 cases as respiratory illness surveillance returns www.cidrap.umn.edu/measles/us-m...
US measles outbreak tops 1,800 cases as respiratory illness surveillance returns
www.cidrap.umn.edu
December 3, 2025 at 11:47 PM
Vaccinating newborns against hepatitis B saves lives. Why might a CDC panel stop recommending it? www.cidrap.umn.edu/childhood-va...
Vaccinating newborns against hepatitis B saves lives. Why might a CDC panel stop recommending it?
www.cidrap.umn.edu
December 3, 2025 at 11:47 PM
Avian coronavirus IBV-induced activation of the NLRP3–Caspase-1–IL-1β axis in renal collecting ducts contributes to nephropathogenesis journals.asm.org/doi/10.1128/...
Avian coronavirus IBV-induced activation of the NLRP3–Caspase-1–IL-1β axis in renal collecting ducts contributes to nephropathogenesis | Journal of Virology
In vivo studies in chickens demonstrate that the activation of the NLRP3 inflammasome is a key driver of renal injury during infectious bronchitis virus (IBV) infection. Pharmacological inhibition of NLRP3 significantly alleviates renal inflammation and tissue damage without affecting viral replication, highlighting the central role of host inflammatory responses in disease progression. Importantly, we report for the first time that NLRP3 activation is predominantly localized to AQP2-positive collecting ducts, a nephron segment essential for uric acid excretion and electrolyte balance. IBV infection reprograms these epithelial cells into a pro-inflammatory, metabolically dysregulated state, promoting urate crystal formation and amplifying tissue injury. These findings reveal a spatially confined epithelial-immune axis of coronavirus-induced renal pathology and suggest new avenues for targeted intervention.
journals.asm.org
December 3, 2025 at 7:35 PM
The oncolytic avian reovirus p17 protein triggers chaperone-mediated autophagy by modulating Hsp90 and the T-complex protein-1 ring complex chaperones and co-chaperones to activate the IKK/NF-κB signaling journals.asm.org/doi/10.1128/...
The oncolytic avian reovirus p17 protein triggers chaperone-mediated autophagy by modulating Hsp90 and the T-complex protein-1 ring complex chaperones and co-chaperones to activate the IKK/NF-κB signa...
This study reveals that the oncolytic avian reovirus (ARV) p17 activates chaperone-mediated autophagy in Vero and A549 cells by modulating the Hsp90/Cdc37, T-complex protein-1 ring complex (TRiC)/Hsc7...
journals.asm.org
December 3, 2025 at 7:35 PM