Pediatricians say panel’s decision will create confusion and access issues, and condemn ‘parody of public health’

Between July and October 2025, among the total 117 influenza A(H1N1)pdm09 strains characterised in Catalonia, 20% to 100% per week were carrying the NA:S247N substitution. The mutation, conferring reduced susceptibility to oseltamivir, was phenotypically confirmed (IC50 between 0.82 and 1.63 nM, compared to median IC50 of 0.3 nM for susceptible strains). An increased proportion of S247N variants was also observed in sequence data (10,944 sequences) from other parts of Spain and five of 35 submitting countries across Europe.

Author summary Flaviviridae viruses—including JEV, CSFV, and HCV—deploy intricate molecular strategies to subvert host innate immune surveillance and establish chronic infections, representing signifi...

EMBO Reports - The “Make America Healthy Again” (MAHA) movement are ascendent in the USA, led by Secretary for Health Robert F Kennedy Jr. But despite a superficially laudable intent,...

The spread of the highly pathogenic avian influenza (HPAI) H5N1 virus in dairy cattle, particularly affecting the mammary glands, highlights the adaptability of influenza A viruses (IAV) to infect non...

No secondary transmission chains have been identified in France.

From 1990 to 2019, reported cases of acute hepatitis B among kids declined by 99% due to infant immunization

RFK Jr’s vaccine advisory panel will be discussing the inclusion of adjuvants in childhood vaccinations this week. Here’s what’s at stake.

This study reveals how the bat coronavirus HKU5 recognizes ACE2 receptors across mammals and birds, uncovering a cross-class receptor usage in coronaviruses and highlighting its potential for interspe...

Author summary In this study, we have identified a sophisticated strategy employed by paramyxoviruses to manipulate host epitranscriptomic RNA modification machinery during infection. Our research sho...

The SARS-CoV-2 pandemic has highlighted the urgent need for effective antiviral strategies that can interrupt viral transmission before pathogen-specific vaccines or therapeutic interventions become available. In this study, we demonstrate that DMA-β-CyD is the first compound shown to reduce the infectivity of SARS-CoV-2 and Japanese encephalitis virus (JEV) particles by interacting with aminophospholipids, such as phosphatidylserine (PS). By exploiting differences in lipid composition between viral envelopes and host cell membranes, DMA-β-CyD provides a novel, lipid-targeting antiviral mechanism and may serve as a valuable platform for addressing infections caused by emerging and drug-resistant viral pathogens. This study underscores the therapeutic potential of disrupting envelope lipids as a broad-spectrum antiviral strategy.

There are still only a few studies on the proteomics of giant viruses. Research published to date has revealed the presence of several proteins involved in processes such as transcription (including R...

This study highlights the importance of monitoring Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels, which are the main animal source of this virus that can occasionally inf...

Twelve former commissioners of the FDA express concern that the agency’s recent moves will undermine a regulatory model designed to ensure vaccine safety, effectiveness, and availability.

Officials also confirmed a new avian flu detection in dairy cattle in California.

Dhori virus (DHOV) is a pathogenic tick-borne virus in the genus Thogotovirus, in the family Orthomyxoviridae. Despite evidence of DHOV exposure in various mammals, including humans, its basic biology...

In vivo studies in chickens demonstrate that the activation of the NLRP3 inflammasome is a key driver of renal injury during infectious bronchitis virus (IBV) infection. Pharmacological inhibition of NLRP3 significantly alleviates renal inflammation and tissue damage without affecting viral replication, highlighting the central role of host inflammatory responses in disease progression. Importantly, we report for the first time that NLRP3 activation is predominantly localized to AQP2-positive collecting ducts, a nephron segment essential for uric acid excretion and electrolyte balance. IBV infection reprograms these epithelial cells into a pro-inflammatory, metabolically dysregulated state, promoting urate crystal formation and amplifying tissue injury. These findings reveal a spatially confined epithelial-immune axis of coronavirus-induced renal pathology and suggest new avenues for targeted intervention.

This study reveals that the oncolytic avian reovirus (ARV) p17 activates chaperone-mediated autophagy in Vero and A549 cells by modulating the Hsp90/Cdc37, T-complex protein-1 ring complex (TRiC)/Hsc7...

Equine arteritis virus (EAV) is the causative agent of equine viral arteritis, a notifiable respiratory and reproductive disease of equids that causes significant losses to the equine industry. This s...