Mart Krupovic
@mkrupovic.bsky.social
Virus origins/diversity/evolution; mobilome; Archaea.
Head of the Cell Biology and Virology of Archaea Unit at Institut Pasteur:
https://research.pasteur.fr/en/team/archaeal-virology/
Head of the Cell Biology and Virology of Archaea Unit at Institut Pasteur:
https://research.pasteur.fr/en/team/archaeal-virology/
Check out our paper in PLoS Genetics with @umbertorosani.bsky.social and Marco Gerdol on the highly dynamic pangenome of basal chordates. It is enriched in defence and immunity genes (like in prokaryotes) and follows Mendelian inheritanceis rules. @plos.org journals.plos.org/plosgenetics...
August 18, 2025 at 10:30 PM
Check out our paper in PLoS Genetics with @umbertorosani.bsky.social and Marco Gerdol on the highly dynamic pangenome of basal chordates. It is enriched in defence and immunity genes (like in prokaryotes) and follows Mendelian inheritanceis rules. @plos.org journals.plos.org/plosgenetics...
Previously characterized OLD family ATPases-nucleases participate in anti-virus defense (abortive infection, Gabija, retrons, PARIS). A new class of #archaeal OLD family enzymes is instead implicated in cell cycle control. New work from the group of Yulong Shen. www.biorxiv.org/content/10.1...
March 30, 2025 at 6:48 PM
Previously characterized OLD family ATPases-nucleases participate in anti-virus defense (abortive infection, Gabija, retrons, PARIS). A new class of #archaeal OLD family enzymes is instead implicated in cell cycle control. New work from the group of Yulong Shen. www.biorxiv.org/content/10.1...
When infected with a virus, Saccharolobus islandicus can become up to 20 µm in diameter (20x increase in diameter and 8000x increase in volume compared to noninfected cells)! www.pnas.org/doi/full/10....
March 9, 2025 at 1:32 PM
When infected with a virus, Saccharolobus islandicus can become up to 20 µm in diameter (20x increase in diameter and 8000x increase in volume compared to noninfected cells)! www.pnas.org/doi/full/10....
Archaeal Virology Unit @pasteur.fr stands up for science!
@vsevillia.bsky.social, Titouan, @miguelgrv.bsky.social, Eduardo, @anton1nouriss.bsky.social, ..., Virginija, @sonaida.bsky.social, Jovan
@vsevillia.bsky.social, Titouan, @miguelgrv.bsky.social, Eduardo, @anton1nouriss.bsky.social, ..., Virginija, @sonaida.bsky.social, Jovan
March 7, 2025 at 3:48 PM
Archaeal Virology Unit @pasteur.fr stands up for science!
@vsevillia.bsky.social, Titouan, @miguelgrv.bsky.social, Eduardo, @anton1nouriss.bsky.social, ..., Virginija, @sonaida.bsky.social, Jovan
@vsevillia.bsky.social, Titouan, @miguelgrv.bsky.social, Eduardo, @anton1nouriss.bsky.social, ..., Virginija, @sonaida.bsky.social, Jovan
Check out the magnificent #baculovirus structure! The unique virion architecture and structural atlas of hallmark proteins place baculo-like viruses into a separate new realm. Many insights into baculo biology and evolution. Collab with the group of Fasséli Coulibaly. www.science.org/doi/10.1126/...
December 23, 2024 at 7:23 PM
Check out the magnificent #baculovirus structure! The unique virion architecture and structural atlas of hallmark proteins place baculo-like viruses into a separate new realm. Many insights into baculo biology and evolution. Collab with the group of Fasséli Coulibaly. www.science.org/doi/10.1126/...
Very glad to see our story on the choreography of #ESCRT proteins in #archaeal cell division finally published in mBio - Junfeng Liu et al "A relay race of ESCRT-III paralogs drives cell division in a hyperthermophilic archaeon" journals.asm.org/doi/10.1128/...
December 21, 2024 at 6:46 PM
Very glad to see our story on the choreography of #ESCRT proteins in #archaeal cell division finally published in mBio - Junfeng Liu et al "A relay race of ESCRT-III paralogs drives cell division in a hyperthermophilic archaeon" journals.asm.org/doi/10.1128/...
An interesting paper for the EV (extracellular vesicle) fans by Patel et al. @ahnaskop.bsky.social lab: "Extracellular vesicles, including large translating vesicles called midbody remnants, are released during the cell cycle"
www.molbiolcell.org/doi/10.1091/...
www.molbiolcell.org/doi/10.1091/...
December 17, 2024 at 5:34 PM
An interesting paper for the EV (extracellular vesicle) fans by Patel et al. @ahnaskop.bsky.social lab: "Extracellular vesicles, including large translating vesicles called midbody remnants, are released during the cell cycle"
www.molbiolcell.org/doi/10.1091/...
www.molbiolcell.org/doi/10.1091/...
Who would have thought that #dolphins (short-finned pilot whale, killer whale, false killer whale and pantropical spotted dolphin) host #anelloviruses with the most complex, extravagantly large capsid proteins? Collab. with the Varsani (@viralnomad.bsky.social) team journals.asm.org/doi/10.1128/...
December 13, 2024 at 6:20 PM
Who would have thought that #dolphins (short-finned pilot whale, killer whale, false killer whale and pantropical spotted dolphin) host #anelloviruses with the most complex, extravagantly large capsid proteins? Collab. with the Varsani (@viralnomad.bsky.social) team journals.asm.org/doi/10.1128/...
Before this hysteria spreads any further, a graphical explanation of what ICTV does and doesn't do. None of the virus names have been changed or will ever be changed by ICTV (it's outside the remit). Only species names have changed. This has been explained so many times... doi.org/10.1007/s007...
December 12, 2024 at 3:27 PM
Before this hysteria spreads any further, a graphical explanation of what ICTV does and doesn't do. None of the virus names have been changed or will ever be changed by ICTV (it's outside the remit). Only species names have changed. This has been explained so many times... doi.org/10.1007/s007...
Cryo-ET suggests that the small EVs are formed by budding from the cell membrane and are trapped under the cell wall prior to liberation through local disruptions in the cell wall, revealing parallels with EV biogenesis in monoderm bacteria.
June 23, 2024 at 1:02 PM
Cryo-ET suggests that the small EVs are formed by budding from the cell membrane and are trapped under the cell wall prior to liberation through local disruptions in the cell wall, revealing parallels with EV biogenesis in monoderm bacteria.
We characterize EVs produced by the dominant human gut methanogen, Methanobrevibacter smithii, which, unlike most archaea, contains a peptidoglycan cell wall. M. smithii are variable in diameter (~20-100 nm), with the majority being of ~30 nm.
June 23, 2024 at 1:01 PM
We characterize EVs produced by the dominant human gut methanogen, Methanobrevibacter smithii, which, unlike most archaea, contains a peptidoglycan cell wall. M. smithii are variable in diameter (~20-100 nm), with the majority being of ~30 nm.
Extracellular vesicles (#EVs) of human gut methanogenic #archaea! Two preprints posted on bioRxiv today - one by us, together with @sgribaldo.bsky.social lab (doi.org/10.1101/2024...), and the other by
@chmoei.bsky.social lab (doi.org/10.1101/2024...).
@chmoei.bsky.social lab (doi.org/10.1101/2024...).
June 23, 2024 at 1:00 PM
Extracellular vesicles (#EVs) of human gut methanogenic #archaea! Two preprints posted on bioRxiv today - one by us, together with @sgribaldo.bsky.social lab (doi.org/10.1101/2024...), and the other by
@chmoei.bsky.social lab (doi.org/10.1101/2024...).
@chmoei.bsky.social lab (doi.org/10.1101/2024...).
The new virus group, provisionally named "Thalassapleoviridae", is distantly related to hyperhalophilic archaeal viruses of the family Pleolipoviridae. They share the (thus far) archaea-specific membrane fusion protein, but come from deep-sea hydrothermal vents 🔥
January 25, 2024 at 5:19 PM
The new virus group, provisionally named "Thalassapleoviridae", is distantly related to hyperhalophilic archaeal viruses of the family Pleolipoviridae. They share the (thus far) archaea-specific membrane fusion protein, but come from deep-sea hydrothermal vents 🔥
Have a look at our paper on a new group of pleomorphic viruses infecting marine hyperthermophilic #archaea of the class Archaeoglobi. The virus coexists in a stable relationship with its host. Congrats to Diana Baquero and Eduardo Bignon. @ISMEJ doi.org/10.1093/isme...
January 25, 2024 at 5:14 PM
Have a look at our paper on a new group of pleomorphic viruses infecting marine hyperthermophilic #archaea of the class Archaeoglobi. The virus coexists in a stable relationship with its host. Congrats to Diana Baquero and Eduardo Bignon. @ISMEJ doi.org/10.1093/isme...
The other group of RNA viruses in the hot springs is distantly related to partitiviruses. Presence of the RBS motifs and the fact that the analyzed hot springs are overwhelmingly dominated by bacteria, suggest that these viruses infect bacteria rather than eukaryotes.
January 17, 2024 at 11:52 PM
The other group of RNA viruses in the hot springs is distantly related to partitiviruses. Presence of the RBS motifs and the fact that the analyzed hot springs are overwhelmingly dominated by bacteria, suggest that these viruses infect bacteria rather than eukaryotes.
Relatives of the 'hot' viruses are also found in marine waters. This group could represent a separate phylum, which we propose to name ‘Artimaviricota’ after the potential link to viral RTs (arti) and ‘artima’ which means ‘close’ in Lithuanian, or even a third kingdom within the realm Riboviria.
January 17, 2024 at 11:50 PM
Relatives of the 'hot' viruses are also found in marine waters. This group could represent a separate phylum, which we propose to name ‘Artimaviricota’ after the potential link to viral RTs (arti) and ‘artima’ which means ‘close’ in Lithuanian, or even a third kingdom within the realm Riboviria.
Viruses from one of the groups encode an RdRP which is structurally more closely similar to retroviral reverse-transcriptases (RTs) than to RdRPs of other known RNA viruses. The ‘hot’ RdRPs and RTs share a specific structural feature in the palm domain.
January 17, 2024 at 11:47 PM
Viruses from one of the groups encode an RdRP which is structurally more closely similar to retroviral reverse-transcriptases (RTs) than to RdRPs of other known RNA viruses. The ‘hot’ RdRPs and RTs share a specific structural feature in the palm domain.
Glad to present our new paper on RNA viruses in acidic hot springs. @NatureMicrobiol Together with S. Urayama, A. Fukudome, E. Koonin, T. Nunoura et al, we were hoping to find archaeal RNA viruses, instead we discovered a bunch of highly unusual bacterial viruses: www.nature.com/articles/s41...
January 17, 2024 at 11:46 PM
Glad to present our new paper on RNA viruses in acidic hot springs. @NatureMicrobiol Together with S. Urayama, A. Fukudome, E. Koonin, T. Nunoura et al, we were hoping to find archaeal RNA viruses, instead we discovered a bunch of highly unusual bacterial viruses: www.nature.com/articles/s41...
"Gene duplication as a major force driving the genome expansion in some giant viruses"-Machado et al describe a new giant virus, Cedratvirus pambiensis, and show that its 623,564 kb genome has evolved through gene duplication, a common theme among giant viruses. #giantViruses doi.org/10.1128/jvi....
December 15, 2023 at 7:32 PM
"Gene duplication as a major force driving the genome expansion in some giant viruses"-Machado et al describe a new giant virus, Cedratvirus pambiensis, and show that its 623,564 kb genome has evolved through gene duplication, a common theme among giant viruses. #giantViruses doi.org/10.1128/jvi....
Does not get old! doi.org/10.1016/S016...
November 19, 2023 at 6:03 PM
Does not get old! doi.org/10.1016/S016...
ATV has always been in a separate family from SSV1: www.microbiologyresearch.org/content/jour...
November 1, 2023 at 9:39 AM
ATV has always been in a separate family from SSV1: www.microbiologyresearch.org/content/jour...
Check out our paper on mechanical tomography of an #archaeal lemon-shaped virus which reveals membrane-like fluidity of the capsid and liquid nucleoprotein cargo. Great collaboration with Miguel Cantero, Virginija Cvirkaite-Krupovic & Pedro de Pablo @PNAS www.pnas.org/doi/10.1073/...
October 13, 2023 at 7:53 AM
Check out our paper on mechanical tomography of an #archaeal lemon-shaped virus which reveals membrane-like fluidity of the capsid and liquid nucleoprotein cargo. Great collaboration with Miguel Cantero, Virginija Cvirkaite-Krupovic & Pedro de Pablo @PNAS www.pnas.org/doi/10.1073/...
A compendium of viruses from methanogenic #archaea reveals their diversity and adaptations to the gut environment - a fruitful collaboration with colleagues from Institut Pasteur, Sofia Medvedeva, Simonetta Gribaldo and Guillaume Borrel. www.nature.com/articles/s41...
September 25, 2023 at 6:47 PM
A compendium of viruses from methanogenic #archaea reveals their diversity and adaptations to the gut environment - a fruitful collaboration with colleagues from Institut Pasteur, Sofia Medvedeva, Simonetta Gribaldo and Guillaume Borrel. www.nature.com/articles/s41...