How various tumoral metabolites impact antitumor T cell immunity is an area of active research. Ma et al. demonstrate that succinate enhances mitochondrial fitness and induces epigenetic reprogramming to promote CD8+ T cell stemness, thereby augmenting antitumor immunity. Succinate treatment has the potential to synergize with checkpoint therapy and optimize CAR efficacy.

The primary input to deciding on the merit of proposals submitted to the NIH for potential funding, as most of my remaining blog audience well knows, is the outcome of the initial peer-review proce…

Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...

Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...

Malignant tumors are characterized by diverse metabolic stresses, including nutrient shortages, hypoxia, and buildup of metabolic by-products. To understand how cancer cells adapt to such challenges, ...

Leveraging modern scientific tools and techniques, Jain intends to transform our understanding of the critical roles that vitamins play in health and disease.

TRAF6 bridges innate immune signaling to mitophagy to promote glucose control during metabolic stress.

Although the anti-inflammatory benefits of exercise are well-documented, the specific mechanisms responsible for these advantages remain uncertain. N-lactoyl-phenylalanine (Lac-Phe), a major metabolit...

Nicotinamide adenine dinucleotide plays a central role in energy metabolism, and its decline is linked to various degenerative diseases. While NAD+ restoration holds therapeutic promise, its long term...

Using a zebrafish-based screen, Civiletto and colleagues identify the herb-derived metabolites thymol and carvacrol as activators of autophagy and mitophagy, demonstrating their therapeutic potential in C. elegans and mouse models.

Engineered prime editor systems with reduced occurrences of unwanted insertions or deletions during genome editing are developed.

Monitoring T cell metabolism during chimeric antigen receptor T manufacturing using optical metabolic imaging enables fine-tuning of manufacturing conditions to increase T cell yield and fitness.

The prevailing notion that mitochondrial diseases arise from ATP deficiency is challenged by recent evidence that oxidative phosphorylation defects trigger maladaptive stress responses consuming exces...

Loss-of-function variants of ABCA7, associated with Alzheimer’s disease, result in disrupted lipid metabolism, mitochondrial function, DNA repair and synaptic signalling pathways in the human brain.