Anupam Patgiri
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apatgiri.bsky.social
Anupam Patgiri
@apatgiri.bsky.social
1.8K followers 1.7K following 240 posts
Assistant Professor @EmoryMedicine passionate about #mitochondria #metabolism and #chemicalbiology | PhD @aroralabnyu, Postdoc @VamsiMootha | Amateur Photographer | Lab website: patgirilab.org | 🇮🇳🇺🇸
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Reposted by Anupam Patgiri
cvasilescu.bsky.social
#week50 of #mitochondrialdisease literature! 📚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social

Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency
Meisel et al
https://www.nature.com/articles/s41586-025-09821-2 Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency Meisel et al
December 14, 2025 at 1:32 PM
Reposted by Anupam Patgiri
olzmannlab.bsky.social
Happy to see our News & Views is out! We highlight two landmark papers demonstrating the potential for therapeutic targeting of FSP1 and #ferroptosis in in vivo cancer models. Beautiful work from @ubellackerlab.bsky.social, Thales Papagiannakopoulos, and colleagues. 🥳
www.nature.com/articles/s41...
In vivo models bring FSP1 inhibitors to life - Nature Cell Biology
FSP1 is a key suppressor of lipid peroxidation and ferroptosis, yet it is largely dispensable in standard cell culture models. Two new studies now show that FSP1 becomes essential for tumour growth in...
www.nature.com
December 12, 2025 at 4:15 PM
Reposted by Anupam Patgiri
nature.com
Nature research paper: Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency

go.nature.com/4pqQwNK
Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency - Nature
A forward genetic screen in Caenorhabditis elegans reveals that decreased levels of the ferredoxin FDX2 suppress the loss of frataxin in worms and in mice by relief of FDX2 inhibition of frataxin-stimulated NFS1 activity.
go.nature.com
December 11, 2025 at 3:36 PM
Reposted by Anupam Patgiri
michaelringel.bsky.social
Why do we age? A detailed look at the data shows only one theory that matches observation: onlinelibrary.wiley.com/doi/epdf/10....
Why we age
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onlinelibrary.wiley.com
December 11, 2025 at 3:42 AM
apatgiri.bsky.social
Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency www.nature.com/articles/s41...
Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency - Nature
A forward genetic screen in Caenorhabditis elegans reveals that decreased levels of the ferredoxin FDX2 suppress the loss of frataxin in worms and in mice by relief of FDX2 inhibition of fra...
www.nature.com
December 10, 2025 at 5:58 PM
apatgiri.bsky.social
Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender

www.sciencedirect.com/science/arti...
Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender
Excessive exercise impairs cognitive function, but the underlying mechanism remains unclear. Here, we show that excessive vigorous exercise-induced la…
www.sciencedirect.com
December 10, 2025 at 4:12 PM
apatgiri.bsky.social
Nanomaterial-induced mitochondrial biogenesis enhances intercellular mitochondrial transfer efficiency

www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
December 9, 2025 at 3:40 AM
apatgiri.bsky.social
Longitudinal Metabolomic Profiling of Biogenic Amines in Plasma and CSF, and Their Correlation, Reveals Sex-Specific and Age Changes in TgF344 Alzheimer's Disease Transgenic and Wildtype Rats

www.biorxiv.org/content/10.6...
Longitudinal Metabolomic Profiling of Biogenic Amines in Plasma and CSF, and Their Correlation, Reveals Sex-Specific and Age Changes in TgF344 Alzheimer's Disease Transgenic and Wildtype Rats
Background: Alterations in amine metabolism have been implicated Alzheimer's disease (AD). Cerebrospinal fluid (CSF) and plasma are key biofluids in AD research. CSF is considered to better reflect br...
www.biorxiv.org
December 8, 2025 at 4:15 PM
Reposted by Anupam Patgiri
barteltlab.bsky.social
🚨 New #MyoBlue preprint: Today, we report a cellular cross-species RNA-seq atlas of myogenesis - using mouse & human cell culture models combined with in vivo snRNA-seq from muscle we provide a comprehensive resource for investigating #SkeletalMuscle differentiation.

www.biorxiv.org/content/10.6...
A cellular cross-species RNA-seq atlas captures the transcriptional dynamics of myogenesis
Skeletal muscle formation and regeneration is a tightly regulated process involving extensive transcriptional reprogramming as proliferating myoblasts fuse into mature myotubes. However, a comparative...
www.biorxiv.org
December 8, 2025 at 9:26 AM
Reposted by Anupam Patgiri
korolchuklab.bsky.social
#Autophagy and #mTOR papers published this week. Some really important stuff here, both in terms of new mechanisms as well as tools, don’t miss it 👇🏼👇🏼👇🏼

biomed.news/bims-auttor/...
a cartoon of squidward from spongebob squarepants says you 're not doing the technique
ALT: a cartoon of squidward from spongebob squarepants says you 're not doing the technique
media.tenor.com
December 7, 2025 at 12:55 PM
Reposted by Anupam Patgiri
ryanlab.bsky.social
📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

Cytochrome c oxidase dependent respiration is essential for T cell activation, proliferation and memory formation
December 7, 2025 at 2:07 PM
apatgiri.bsky.social
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis

www.cell.com/molecular-ce...
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis
Zheng et al. demonstrate that mitochondria remodel the structure and composition of mitochondrial ribosomes in response to metabolic state. This structural “gear-switching” mechanism fine-tunes mitoch...
www.cell.com
December 7, 2025 at 5:04 PM
Reposted by Anupam Patgiri
cvasilescu.bsky.social
Such a great collection of papers on #mitochondrialdisease from #week49! 📚 Congratulations to all authors! biomed.news/bims-mitdis/...
@biomednews.bsky.social @mitoscientist.bsky.social

Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis
Wang et al
https://www.cell.com/cms/10.1016/j.cell.2025.11.002/asset/6a29b9bb-e6a4-4eb7-a86a-b1f1f5fd697f/main.assets/fx1_lrg.jpg
December 7, 2025 at 2:54 PM
Reposted by Anupam Patgiri
andreamorandi.bsky.social
Here is my weekly selection of #anticancer #therapy and #metabolic #reprogramming. Enjoy!

biomed.news/bims-meract/...

🙏 @biomednews.bsky.social
Family Guy Brian GIF
ALT: Family Guy Brian GIF
media.tenor.com
December 7, 2025 at 9:47 AM
Reposted by Anupam Patgiri
frezzalab.bsky.social
Good Sunday, all. Don't miss this week's selection of papers in #cancermetabolism and #mitochondrialbiology as there are some true gems: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"The everyday human gesture is always a heartbeat away from the miraculous."-Nick Cave
a pointilllist mito
December 7, 2025 at 6:47 AM
apatgiri.bsky.social
Oxidative pentose phosphate pathway is required for T cell activation and antitumor immunity
www.pnas.org/doi/10.1073/...
Oxidative pentose phosphate pathway is required for T cell activation and antitumor immunity | PNAS
Glucose is catabolized by two major metabolic pathways, glycolysis and the oxidative pentose phosphate pathway (oxPPP). The oxPPP generates nicotin...
www.pnas.org
December 6, 2025 at 4:17 PM
Reposted by Anupam Patgiri
frezzalab.bsky.social
Good morning, all. A great selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"Calm down. Both your sins and your good deeds will be lost in oblivion." - Czesław Miłosz
November 30, 2025 at 6:22 AM
Reposted by Anupam Patgiri
cvasilescu.bsky.social
#mitochondrialdisease collection of papers from #week48! 📚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social

Inhibition of oligomeric BAX by an anti-apoptotic dimer
Newman et al
https://www.cell.com/cell/abstract/S0092-8674(25)01242-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867425012425%3Fshowall%3Dtrue
November 30, 2025 at 12:38 PM
apatgiri.bsky.social
Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis

www.cell.com/cell/abstrac...
Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis
Wang et al. identify a new lytic cell death pathway, mitoxyperilysis, triggered by the synergy of innate immune activation and metabolic stress. This process is regulated by mTORC2 and involves persis...
www.cell.com
November 28, 2025 at 4:18 PM
Reposted by Anupam Patgiri
manu-lera.bsky.social
#OpenCloning is a an Open Source alternative to SnapGene/Benchling that supports automation and integration with other software

✅ Free
🔓 Open Source
🧬 More cloning methods than SnapGene
🤖 Can be automated with python
👨‍🔬 Built by a researcher — for researchers!

👉 Check it out at opencloning.org
A cloning strategy as depicted in the OpenCloning website
November 24, 2025 at 4:57 PM
apatgiri.bsky.social
Grateful for the wonderful people and amazing opportunities in my life - and the simple joy of homemade food and slowing down. Wishing everyone a warm and joyful Thanksgiving! 🍂🦃

#ThanksgivingEve #Thanksgiving #Gratitude #Thankful #HomemadeFood #TurkeyTime #HolidayCooking #FoodLove #MadeWithLove
November 26, 2025 at 2:37 PM
Reposted by Anupam Patgiri
elife.bsky.social
Evidence from 14 research funding programmes confirms that early winners tend to keep winning (Matthew effect). But the idea that an early setback makes you stronger later doesn’t replicate widely.
buff.ly/UEtcRd4
eLife Assessment This important study reports the results of efforts to replicate two phenomena of significant interest to early-career scientists and scientific policymakers: the Matthew effect and the early-career setback effect. Several previous studies of these effects have focused on early-career researchers with grant proposals that fell just below or just above a funding threshold. Those just above the threshold were more likely to be successful when they applied for funding later in the career (an example of the well-known Matthew effect), while those just below were more likely to go on to have stronger publication records (the early-career setback effect). In this study the Matthew effect was found to be robust across funders, and to generalize from those close to the funding threshold to the whole population. The early-career setback effect was not robust across funders and did not generalize to the whole population. The evidence reported is convincing.
November 25, 2025 at 11:02 AM
Reposted by Anupam Patgiri
pride-ebi.bsky.social
PXD062734 🚨

Proteomic analysis of binding partners of the OMM anchored ubiquitin-fusion degradation substrate

🚨 New dataset alert! 🚨
November 24, 2025 at 11:00 AM
Reposted by Anupam Patgiri
shoshana.bsky.social
Boston's Mayor Wu playing with Yo-Yo Ma at Symphony Hall
November 23, 2025 at 5:11 AM
Reposted by Anupam Patgiri
ryanlab.bsky.social
📢Last 2 weeks of #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️

biomed.news/bims-imicid/...
biomed.news/bims-imicid/...

Exciting to have a paper in the collection!

An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice
November 23, 2025 at 1:05 PM