Gao, Chan1; Budzinski, Hélène1 ; Pardon, Patrick1 ; Le Menach, Karyn1; Labadie, Pierre1 1 Univ. Bordeaux, CNRS, Bordeaux INP, EPOC, UMR 5805, F-33600 Pessac, France

A novel drug-loaded D/P-g-PSB nanogel-incorporated hydrogel by the electrostatic attraction-driven self-assembling process. Sequential drug releasing property (melatonin is released first by physical diffusion, and then ibuprofen is released as the charge shielding effect and hydrogel degradation). This ion-sensitive hydrogel platform with sequentially releasing drug effects, combining anti-inflammatory effects and blocking the ROCK pathway, shows excellent repair of SCI. Abstract Spinal cord injury (SCI), a highly disabling injury to the central nervous system, has a complex and sequential pathogenesis. Traditional multiple-delivery systems rely on a physical mix of nanoparticles or drugs in hydrogels, which lacks the controllability of the drug. To solve these problems, an integrative hydrogel system cross-linked with a Per-g-PSB nanogel is designed. Dendritic macromolecular nanogels (Per-g-PSB) could not only act as cross-linkers to adjust the hydrogel mechanical properties but also form a dynamic network (Dex/Per-g-PSB hydrogel). Most importantly, a large amount of charge could lead to a significant sustained release via electrostatic interactions. The hydrogel platform (Mel/Ibu@D/P-g-PSB) realizes the sequential release of melatonin and ibuprofen by different mechanisms. Melatonin is first released by diffusion and exhibits significant neuroprotective effects during the acute phase by downregulating the expression of inflammatory cytokines. Ibuprofen is released in the second stage due to strong electrostatic interactions, and it reduces RhoA signaling activation by blocking the ROCK pathway in the subacute phase, which reduces the deleterious cascade reaction after spinal cord injury. These results show that the ion-sensitive hydrogel platform with sequentially releasing drug effects, combining anti-inflammatory effects and blocking the ROCK pathway, shows excellent repair of SCI.

A zwitterionic pyrrole (ZiPy) additive is designed to simultaneously suppress polyiodide shuttling and stabilize the zinc anode in Zn–I 2 batteries. ZiPy regulates interfacial pH, optimizes Zn 2+ solvation, and promotes (002)-oriented Zn deposition, enabling outstanding cycling stability over 45 000 cycles and excellent low-temperature endurance, offering new insights for advanced Zn–I 2 energy storage systems. Abstract The shuttling of polyiodides in zinc-iodine (Zn–I 2 ) batteries causes severe active-material loss and zinc-anode corrosion, leading to poor cycling stability. In this work, zwitterionic pyrrole (ZiPy) is designed as a bifunctional additive to adsorb polyiodides and simultaneously stabilize the Zn anode. Experimental and theoretical results demonstrate that the incorporation of ZiPy regulates the interfacial pH, alters the solvation structure of Zn 2+ ions, and promotes the preferential growth of zinc along the (002) crystal plane. Furthermore, the Zn–I 2 battery incorporating ZiPy demonstrated superior cycling performance (completing 45 000 cycles at a high current density of 8 A g −1 ) and low-temperature endurance, achieving a capacity retention of nearly 90.1% after 45 000 cycles at −40 °C. This work sheds light on the development of future high-performance Zn–I 2 batteries through zwitterionic electrolyte engineering.

Investigation of the Bioactivities of N, N, N-Trimethyl Chitosan Derivatives Constructed with Sulfonic Zwitterionic Moieties

In this work, we benchmark quadrupolar NMR crystallography guided crystal structure prediction (QNMRX-CSP) for determining the crystal structures of two zwitterionic organic HCl salts, L-ornithine HCl...

UCL Discovery is UCL's open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.

Gradient zwitterionic polymer interphases drive reversibility of metal anodes.

In this study the separation performance of nine surface grafted zwitterionic chromatography columns for HILIC mode glycan profiling of IgG derived gl…

UCL Discovery is UCL's open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.