Distinct tumor immune microenvironmental (TIME) landscapes drive divergent immunotherapy responses in glioblastoma academic.oup.com/neuro-oncolo...
Distinct tumor immune microenvironmental (TIME) landscapes drive divergent immunotherapy responses in glioblastoma
AbstractBackground. Immunotherapies have improved outcomes in many cancers but remain largely ineffective in glioblastoma (GBM). We investigated whether im
academic.oup.com
February 3, 2026 at 12:56 PM
Distinct tumor immune microenvironmental (TIME) landscapes drive divergent immunotherapy responses in glioblastoma academic.oup.com/neuro-oncolo...
Organoid technology is one of the most significant advancements deriving from developmental biology. Yet, many aspects of the biology of organoid itself remain elusive, one of which is the role of mesenchymal stem cells.
This review:
doi.org/10.1016/j.cd...
by Wang et al discusses this in detail.
This review:
doi.org/10.1016/j.cd...
by Wang et al discusses this in detail.
January 10, 2026 at 5:33 PM
Organoid technology is one of the most significant advancements deriving from developmental biology. Yet, many aspects of the biology of organoid itself remain elusive, one of which is the role of mesenchymal stem cells.
This review:
doi.org/10.1016/j.cd...
by Wang et al discusses this in detail.
This review:
doi.org/10.1016/j.cd...
by Wang et al discusses this in detail.
🐝 New research finds the mechanism by which tree species richness influences bee diversity—taxonomic, phylogenetic, and functional—through alterations in the microenvironmental conditions in the understory.
📖 Read the full paper here ➡️ buff.ly/cHvVYER
📖 Read the full paper here ➡️ buff.ly/cHvVYER
January 7, 2026 at 1:01 PM
🐝 New research finds the mechanism by which tree species richness influences bee diversity—taxonomic, phylogenetic, and functional—through alterations in the microenvironmental conditions in the understory.
📖 Read the full paper here ➡️ buff.ly/cHvVYER
📖 Read the full paper here ➡️ buff.ly/cHvVYER
📣Next @immunopasteur.bsky.social seminar today
Mikäel Pittet (Université de Genève)
Myeloid cells: Microenvironmental coordination in cancers
Invited by Philippe Bousso
Mikäel Pittet (Université de Genève)
Myeloid cells: Microenvironmental coordination in cancers
Invited by Philippe Bousso
January 12, 2024 at 9:28 AM
📣Next @immunopasteur.bsky.social seminar today
Mikäel Pittet (Université de Genève)
Myeloid cells: Microenvironmental coordination in cancers
Invited by Philippe Bousso
Mikäel Pittet (Université de Genève)
Myeloid cells: Microenvironmental coordination in cancers
Invited by Philippe Bousso
Through geographic regression, we discovered spatially-structured multicellular hubs and signaling circuits, where cell-vs-tissue rebalancing and stress responses depended on the composition of neighboring cells and nearby microenvironmental signals (10/n)
December 22, 2025 at 4:35 PM
Through geographic regression, we discovered spatially-structured multicellular hubs and signaling circuits, where cell-vs-tissue rebalancing and stress responses depended on the composition of neighboring cells and nearby microenvironmental signals (10/n)
The Establishment of Prostate-specific, SKP2 Humanized Mice by CRISPR Knock-in Method Reveals Neoplastic Initiation and Microenvironmental Reprogramming #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-8384571/latest
https://www.researchsquare.com/article/rs-8384571/latest
January 9, 2026 at 8:01 AM
The Establishment of Prostate-specific, SKP2 Humanized Mice by CRISPR Knock-in Method Reveals Neoplastic Initiation and Microenvironmental Reprogramming #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-8384571/latest
https://www.researchsquare.com/article/rs-8384571/latest
In this Review, Sarkar et al. highlight the potential of using spatial transcriptomics to expand our understanding of normal and cancer stem cells within their microenvironmental niches.
Learn more here:
➡️ tinyurl.com/gd351956
Learn more here:
➡️ tinyurl.com/gd351956
January 17, 2025 at 5:45 PM
In this Review, Sarkar et al. highlight the potential of using spatial transcriptomics to expand our understanding of normal and cancer stem cells within their microenvironmental niches.
Learn more here:
➡️ tinyurl.com/gd351956
Learn more here:
➡️ tinyurl.com/gd351956
🧫 Emerging concepts like SWAT cells (structural WNT-regulated adipose tissue cells) show that even multipotent APCs can diverge toward fibrotic or adipogenic fates depending on microenvironmental cues.
5/8
5/8
April 15, 2025 at 1:01 PM
🧫 Emerging concepts like SWAT cells (structural WNT-regulated adipose tissue cells) show that even multipotent APCs can diverge toward fibrotic or adipogenic fates depending on microenvironmental cues.
5/8
5/8
Microenvironmental information significantly improves the recognition of cell types in human lung cancer patients
https://www.biorxiv.org/content/10.1101/2025.07.09.663829v1
July 14, 2025 at 12:13 PM
Microenvironmental information significantly improves the recognition of cell types in human lung cancer patients
https://www.biorxiv.org/content/10.1101/2025.07.09.663829v1
Cancers with high rates of chromosomal instability (CIN) do badly – aggressive, typically therapy-resistant and prone to metastasis. We asked if these cancers have a distinct microenvironmental landscape that could help us understand what drives them, and how they might be therapeutically vulnerable
Chromosomal instability shapes the tumor microenvironment of esophageal adenocarcinoma via a cGAS–chemokine–myeloid axis
Chromosomal instability (CIN), a characteristic feature of esophageal adenocarcinoma (EAC), drives tumor aggressiveness and therapy resistance, presenting an intractable problem in cancer treatment. C...
www.biorxiv.org
May 12, 2025 at 12:08 PM
Cancers with high rates of chromosomal instability (CIN) do badly – aggressive, typically therapy-resistant and prone to metastasis. We asked if these cancers have a distinct microenvironmental landscape that could help us understand what drives them, and how they might be therapeutically vulnerable
📃Scientific paper: Quantifying Tumor Heterogeneity via MRI Habitats to Characterize Microenvironmental Alterations in H...
➡️ Continued on ES/IODE
➡️ Continued on ES/IODE
February 18, 2024 at 2:41 AM
📃Scientific paper: Quantifying Tumor Heterogeneity via MRI Habitats to Characterize Microenvironmental Alterations in H...
➡️ Continued on ES/IODE
➡️ Continued on ES/IODE
Osteochondrogenic Transdifferentiation of Vascular Smooth Muscle Cells and Microenvironmental Dynamics in Medial Arterial Calcification https://www.biorxiv.org/content/10.1101/2025.10.28.684711v1
October 29, 2025 at 2:30 AM
Osteochondrogenic Transdifferentiation of Vascular Smooth Muscle Cells and Microenvironmental Dynamics in Medial Arterial Calcification https://www.biorxiv.org/content/10.1101/2025.10.28.684711v1
Extracellular vesicles from a novel chordoma cell line, ARF-8, promote tumorigenic microenvironmental changes when incubated with the parental cells and with human osteoblasts. https://www.biorxiv.org/content/10.1101/2024.10.06.616873v1
Extracellular vesicles from a novel chordoma cell line, ARF-8, promote tumorigenic microenvironmental changes when incubated with the parental cells and with human osteoblasts. https://www.biorxiv.org/content/10.1101/2024.10.06.616873v1
Chordomas are rare, generally slow-growing spinal tumors that nonetheless exhibit progressive charac
www.biorxiv.org
October 7, 2024 at 5:48 AM
Extracellular vesicles from a novel chordoma cell line, ARF-8, promote tumorigenic microenvironmental changes when incubated with the parental cells and with human osteoblasts. https://www.biorxiv.org/content/10.1101/2024.10.06.616873v1
Combinations of genomic alterations and immune microenvironmental features associate with patient survival in multiple cancer types https://www.biorxiv.org/content/10.1101/2024.12.27.630504v1
December 27, 2024 at 11:51 PM
Combinations of genomic alterations and immune microenvironmental features associate with patient survival in multiple cancer types https://www.biorxiv.org/content/10.1101/2024.12.27.630504v1
One of my PhD project aims was to scale up the production of retinal stem cells/progenitors using bioreactor through adjusting microenvironmental measures like oxygen, pH and shear stress level #science #research #visionresearch #stemcells #biotechnology
October 11, 2023 at 11:35 AM
One of my PhD project aims was to scale up the production of retinal stem cells/progenitors using bioreactor through adjusting microenvironmental measures like oxygen, pH and shear stress level #science #research #visionresearch #stemcells #biotechnology
This single-center, phase 2 #clinicaltrial demonstrates the efficacy and safety of R-ICE-X, a mechanism-based #TailoredTherapy, which precisely targets both genetic and microenvironmental alterations in R/R DLBCL. #medsky #STTT
#OpenAccess: www.nature.com/articles/s41...
#OpenAccess: www.nature.com/articles/s41...
August 5, 2025 at 1:02 PM
This single-center, phase 2 #clinicaltrial demonstrates the efficacy and safety of R-ICE-X, a mechanism-based #TailoredTherapy, which precisely targets both genetic and microenvironmental alterations in R/R DLBCL. #medsky #STTT
#OpenAccess: www.nature.com/articles/s41...
#OpenAccess: www.nature.com/articles/s41...
9/ Conclusion: Tumors follow reproducible self-organization programs that are sufficient to pattern cell states in time and space.
We propose that such tissue-intrinsic programs cooperate with microenvironmental cues to collectively drive phenotypic heterogeneity and plasticity.
We propose that such tissue-intrinsic programs cooperate with microenvironmental cues to collectively drive phenotypic heterogeneity and plasticity.
October 16, 2025 at 9:55 PM
9/ Conclusion: Tumors follow reproducible self-organization programs that are sufficient to pattern cell states in time and space.
We propose that such tissue-intrinsic programs cooperate with microenvironmental cues to collectively drive phenotypic heterogeneity and plasticity.
We propose that such tissue-intrinsic programs cooperate with microenvironmental cues to collectively drive phenotypic heterogeneity and plasticity.
Subcellular assessment of algal carbon storage and chloroplasts across the microenvironmental landscape of a photosymbiotic coral https://www.biorxiv.org/content/10.1101/2025.08.19.671130v1
August 20, 2025 at 4:30 PM
Subcellular assessment of algal carbon storage and chloroplasts across the microenvironmental landscape of a photosymbiotic coral https://www.biorxiv.org/content/10.1101/2025.08.19.671130v1
Our January issue is live!
www.nature.com/nchembio/vol...
The cover depicts a method for real-time monitoring of microenvironmental changes in protein substructures using site-specific integration of a noncanonical amino acid with a rotor-based fluorophore
www.nature.com/nchembio/vol...
The cover depicts a method for real-time monitoring of microenvironmental changes in protein substructures using site-specific integration of a noncanonical amino acid with a rotor-based fluorophore
January 8, 2026 at 4:38 PM
Our January issue is live!
www.nature.com/nchembio/vol...
The cover depicts a method for real-time monitoring of microenvironmental changes in protein substructures using site-specific integration of a noncanonical amino acid with a rotor-based fluorophore
www.nature.com/nchembio/vol...
The cover depicts a method for real-time monitoring of microenvironmental changes in protein substructures using site-specific integration of a noncanonical amino acid with a rotor-based fluorophore
Tumor microenvironmental determinants of high-risk DCIS progression https://www.biorxiv.org/content/10.1101/2023.12.01.569676v1
Tumor microenvironmental determinants of high-risk DCIS progression https://www.biorxiv.org/content/10.1101/2023.12.01.569676v1
Ductal carcinoma in situ (DCIS) constitutes an array of morphologically recognized intraductal neopl
www.biorxiv.org
December 4, 2023 at 9:58 PM
Tumor microenvironmental determinants of high-risk DCIS progression https://www.biorxiv.org/content/10.1101/2023.12.01.569676v1
Depletion of microenvironmental syndecan-2 impairs hematopoietic stem cell self-renewal and cytokine responses #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.1101/2025.11.07.687077v1
https://www.biorxiv.org/content/10.1101/2025.11.07.687077v1
November 10, 2025 at 8:00 AM
Depletion of microenvironmental syndecan-2 impairs hematopoietic stem cell self-renewal and cytokine responses #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.1101/2025.11.07.687077v1
https://www.biorxiv.org/content/10.1101/2025.11.07.687077v1
Organ specific microenvironmental MR1 expression in cutaneous melanoma https://www.biorxiv.org/content/10.1101/2023.12.28.573554v1
Organ specific microenvironmental MR1 expression in cutaneous melanoma https://www.biorxiv.org/content/10.1101/2023.12.28.573554v1
The microenvironment is an important regulator of intertumoral trafficking and activity of immune ce
www.biorxiv.org
December 29, 2023 at 2:51 AM
Organ specific microenvironmental MR1 expression in cutaneous melanoma https://www.biorxiv.org/content/10.1101/2023.12.28.573554v1
In 2021, Farahani et al. identified the relation between ERK activity and the mechanical microenvironment. Microenvironmental signals jointly activate the ERK pathway via receptor-ligand interactions, resulting in increased ERK activity on stiffer substrates.
bsky.app/profile/epim...
bsky.app/profile/epim...
March 30, 2025 at 7:57 AM
In 2021, Farahani et al. identified the relation between ERK activity and the mechanical microenvironment. Microenvironmental signals jointly activate the ERK pathway via receptor-ligand interactions, resulting in increased ERK activity on stiffer substrates.
bsky.app/profile/epim...
bsky.app/profile/epim...
APOE Tumor-Associated Macrophages and CD4-DOCK4 T Cells Reveal Distinct Microenvironmental Features in HER2-Low and HER2-0 Hormone Receptor-Positive Breast Cancer https://www.biorxiv.org/content/10.1101/2025.09.04.674072v1
September 9, 2025 at 1:53 PM
APOE Tumor-Associated Macrophages and CD4-DOCK4 T Cells Reveal Distinct Microenvironmental Features in HER2-Low and HER2-0 Hormone Receptor-Positive Breast Cancer https://www.biorxiv.org/content/10.1101/2025.09.04.674072v1
Tour de force from @melissabarroux.bsky.social on evolutionary and microenvironmental dynamics of oesophageal adenocarcinoma through neoadjuvant therapy
Published @natcancer.nature.com
Melissa is an outstanding new clinician scientist.. one to watch.
www.nature.com/articles/s43...
@icr.ac.uk
Published @natcancer.nature.com
Melissa is an outstanding new clinician scientist.. one to watch.
www.nature.com/articles/s43...
@icr.ac.uk
Evolutionary and immune microenvironment dynamics during neoadjuvant treatment of esophageal adenocarcinoma - Nature Cancer
Graham and colleagues analyzed locally advanced esophageal adenocarcinoma clinical trial patient samples and identified major changes in gene expression profiles and immune microenvironment compositio...
www.nature.com
May 15, 2025 at 5:20 PM
Tour de force from @melissabarroux.bsky.social on evolutionary and microenvironmental dynamics of oesophageal adenocarcinoma through neoadjuvant therapy
Published @natcancer.nature.com
Melissa is an outstanding new clinician scientist.. one to watch.
www.nature.com/articles/s43...
@icr.ac.uk
Published @natcancer.nature.com
Melissa is an outstanding new clinician scientist.. one to watch.
www.nature.com/articles/s43...
@icr.ac.uk