Nature Chemical Biology
@natchembio.nature.com
A scientific journal devoted to publishing the most compelling research, opinion and analysis at the intersection of chemistry and biology.
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Our December issue is live!
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The cover depicts a diffusion-based generative deep learning pipeline for de novo design of a macrocyclic peptide targeting the protein, myeloid cell leukemia 1
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The cover depicts a diffusion-based generative deep learning pipeline for de novo design of a macrocyclic peptide targeting the protein, myeloid cell leukemia 1
Come join our team! The deadline is December 7, but the application is quick. Only a cover letter, CV, and a short Research Highlight are needed #chemsky #chemjob #chembio
Job vacancy: Nature Chemical Biology is hiring
Nature Chemical Biology is seeking an Associate or Senior Editor. This is a permanent full-time position within the editorial team. The vacancy is for one of the offices based in USA or China.
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Nature Chemical Biology is seeking an Associate or Senior Editor. This is a permanent full-time position within the editorial team. The vacancy is for one of the offices based in USA or China.
springernature.wd3.myworkdayjobs.com/en-US/Spring...
Associate or Senior Editor, Nature Chemical Biology
Job Title: Associate or Senior Editor, Nature Chemical Biology Organization: Nature Portfolio Location: New York, Washington DC, Jersey City, Beijing or Shanghai – Hybrid working Model Closing date: D...
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December 3, 2025 at 9:22 PM
Selinexor is a covalent inhibitor of the nuclear export receptor exportin 1 (XPO1). A new paper reveals that selinexor mediates XPO1 degradation through an allosteric molecular glue mechanism
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SINE compounds activate exportin 1 degradation through an allosteric mechanism - Nature Chemical Biology
Selinexor is a covalent inhibitor of the nuclear export receptor exportin 1 (XPO1). Wing, Fung and Kwanten et al. found that selinexor mediates XPO1 degradation through an allosteric molecule glue mec...
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December 3, 2025 at 9:15 PM
Selinexor is a covalent inhibitor of the nuclear export receptor exportin 1 (XPO1). A new paper reveals that selinexor mediates XPO1 degradation through an allosteric molecular glue mechanism
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Radical Fe(II)/α-ketoglutarate-dependent halogenases are powerful biocatalysts for C-H functionalization. A new paper reveals the mechanistic basis for chemoselectivity in a lysine halogenase
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Dynamic metal coordination controls chemoselectivity in a radical halogenase - Nature Chemical Biology
Radical FeII/α-ketoglutarate-dependent halogenases are powerful biocatalysts for C–H functionalization. Here, the authors reveal the mechanistic basis for chemoselectivity in a lysine halogenase.
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December 3, 2025 at 9:09 PM
Radical Fe(II)/α-ketoglutarate-dependent halogenases are powerful biocatalysts for C-H functionalization. A new paper reveals the mechanistic basis for chemoselectivity in a lysine halogenase
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www.nature.com/articles/s41...
Molecular basis of SAM-AMP synthesis and degradation in the type III-B CRISPR-Cas system
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Molecular basis of SAM-AMP synthesis and degradation in the type III-B CRISPR–Cas system - Nature Chemical Biology
The CorA-associated type III-B CRISPR–Cas system synthesizes S-adenosyl methionine (SAM)-AMP, triggering immune responses. Through structural characterization and biochemical validation, Duan and Jin ...
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December 3, 2025 at 9:04 PM
Molecular basis of SAM-AMP synthesis and degradation in the type III-B CRISPR-Cas system
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Our December issue is live!
www.nature.com/nchembio/vol...
The cover depicts a diffusion-based generative deep learning pipeline for de novo design of a macrocyclic peptide targeting the protein, myeloid cell leukemia 1
www.nature.com/nchembio/vol...
The cover depicts a diffusion-based generative deep learning pipeline for de novo design of a macrocyclic peptide targeting the protein, myeloid cell leukemia 1
December 3, 2025 at 8:58 PM
Our December issue is live!
www.nature.com/nchembio/vol...
The cover depicts a diffusion-based generative deep learning pipeline for de novo design of a macrocyclic peptide targeting the protein, myeloid cell leukemia 1
www.nature.com/nchembio/vol...
The cover depicts a diffusion-based generative deep learning pipeline for de novo design of a macrocyclic peptide targeting the protein, myeloid cell leukemia 1
Job vacancy: Nature Chemical Biology is hiring
Nature Chemical Biology is seeking an Associate or Senior Editor. This is a permanent full-time position within the editorial team. The vacancy is for one of the offices based in USA or China.
springernature.wd3.myworkdayjobs.com/en-US/Spring...
Nature Chemical Biology is seeking an Associate or Senior Editor. This is a permanent full-time position within the editorial team. The vacancy is for one of the offices based in USA or China.
springernature.wd3.myworkdayjobs.com/en-US/Spring...
Associate or Senior Editor, Nature Chemical Biology
Job Title: Associate or Senior Editor, Nature Chemical Biology Organization: Nature Portfolio Location: New York, Washington DC, Jersey City, Beijing or Shanghai – Hybrid working Model Closing date: D...
springernature.wd3.myworkdayjobs.com
November 20, 2025 at 5:41 PM
Job vacancy: Nature Chemical Biology is hiring
Nature Chemical Biology is seeking an Associate or Senior Editor. This is a permanent full-time position within the editorial team. The vacancy is for one of the offices based in USA or China.
springernature.wd3.myworkdayjobs.com/en-US/Spring...
Nature Chemical Biology is seeking an Associate or Senior Editor. This is a permanent full-time position within the editorial team. The vacancy is for one of the offices based in USA or China.
springernature.wd3.myworkdayjobs.com/en-US/Spring...
Reposted by Nature Chemical Biology
A new paper from @zhilindseylin.bsky.social @jimwellsucsf.bsky.social and colleagues presents temporal mapping of extracellular and intracellular neighborhoods of a protein of interest with MultiMap photoproximity labeling proteomics, here applied to EGFR
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www.nature.com/articles/s41...
Temporal photoproximity labeling of ligand-activated EGFR neighborhoods using MultiMap - Nature Chemical Biology
A multiscale photoproximity labeling proteomics workflow captures dynamic neighborhoods of extracellular and intracellular epidermal growth factor (EGF) receptor interactomes during early, middle and ...
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November 19, 2025 at 8:23 PM
A new paper from @zhilindseylin.bsky.social @jimwellsucsf.bsky.social and colleagues presents temporal mapping of extracellular and intracellular neighborhoods of a protein of interest with MultiMap photoproximity labeling proteomics, here applied to EGFR
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nitrogen fixation by nitrogenase requires a metallocofactor built by dedicated multiprotein machinery. Structural snapshots of a precursor entering a key maturase reveal the dynamic process of FeMo-cofactor assembly
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Dynamics driving the precursor in NifEN scaffold during nitrogenase FeMo-cofactor assembly - Nature Chemical Biology
Nitrogen fixation by nitrogenase requires a metallocofactor built by a dedicated multiprotein machinery. Here, the authors captured structural snapshots of a precursor entering a key maturase, reveali...
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November 19, 2025 at 8:21 PM
Nitrogen fixation by nitrogenase requires a metallocofactor built by dedicated multiprotein machinery. Structural snapshots of a precursor entering a key maturase reveal the dynamic process of FeMo-cofactor assembly
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A new Review discusses how degrons of different types, with an emphasis on high-order structural ones, regulate substrate-E3 interactions and how their dysregulation is linked to human diseases
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www.nature.com/articles/s41...
Degrons and degradation signals beyond short linear motifs - Nature Chemical Biology
Degrons are degradation signals in target proteins to direct recognition and degradation by the ubiquitin–proteasome system. Wang et al. introduce degrons of different types, with an emphasis on high-...
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November 14, 2025 at 8:51 PM
A new Review discusses how degrons of different types, with an emphasis on high-order structural ones, regulate substrate-E3 interactions and how their dysregulation is linked to human diseases
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A large-scale metagenomic, single-bacterial sequencing and biochemical study reveal the untapped biosynthetic potential of ‘Entotheonella’ symbionts in marine sponges
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Chemical richness and diversity of uncultivated ‘Entotheonella’ symbionts in marine sponges - Nature Chemical Biology
Marine sponges host bacteria that produce diverse bioactive compounds. Here, the authors conduct a large-scale metagenomic, single-bacterial and biochemical study to reveal the untapped biosynthetic p...
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November 14, 2025 at 8:46 PM
A large-scale metagenomic, single-bacterial sequencing and biochemical study reveal the untapped biosynthetic potential of ‘Entotheonella’ symbionts in marine sponges
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A new Perspective discusses how elevated-temperature crystallography uncovers hidden dynamic states of protein, ligand, and water molecules, expanding insights into the protein conformational landscape for drug design
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Unfreezing structural biology for drug discovery - Nature Chemical Biology
This Perspective discusses how elevated-temperature crystallography uncovers hidden dynamic states of protein, ligand and water molecules, expanding insights into the protein conformational landscape ...
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November 10, 2025 at 2:38 PM
A new Perspective discusses how elevated-temperature crystallography uncovers hidden dynamic states of protein, ligand, and water molecules, expanding insights into the protein conformational landscape for drug design
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A new Review by Agnese Nicoli and Michelle Frei examines the progress in developing synthetic small-molecule fluorophores and how these in combination with innovative labeling strategies can advance chemical biology
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Synthetic fluorophores for live-cell fluorescence microscopy and biosensing - Nature Chemical Biology
Performing live-cell microscopy experiments with high spatial and temporal resolution requires fluorophores with highly optimized properties. This Review examines the progress in developing synthetic ...
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November 4, 2025 at 5:26 PM
A new Review by Agnese Nicoli and Michelle Frei examines the progress in developing synthetic small-molecule fluorophores and how these in combination with innovative labeling strategies can advance chemical biology
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A new paper developed a small molecule that exploits the high abundance of mutant p53 and binds p53 Y220C delivering a mitosis blocker, killing TP53 mutant cancer cells while sparing healthy ones
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Mutant p53 protein accumulation is selectively targetable by proximity-inducing drugs - Nature Chemical Biology
Exploiting the high abundance of mutant p53 protein, a small molecule was developed that specifically binds to p53-Y220C mutants and delivers a mitosis blocker, killing TP53-mutant cancer cells while ...
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November 4, 2025 at 5:24 PM
A new paper developed a small molecule that exploits the high abundance of mutant p53 and binds p53 Y220C delivering a mitosis blocker, killing TP53 mutant cancer cells while sparing healthy ones
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mapping oxidatively damaged bases and abasic sites at single-nucleotide resolutions reveals transcription-related strand biases, patterns mirroring cancer mutational signatures, and the action of anticancer drug irofulven
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www.nature.com/articles/s41...
Click-code-seq reveals strand biases of DNA oxidation and depurination in human genome - Nature Chemical Biology
By mapping oxidatively damaged bases and abasic sites at single-nucleotide resolution in human cells, Takhaveev et al. observed transcription-related strand biases, patterns mirroring cancer mutationa...
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October 31, 2025 at 2:01 PM
Mapping oxidatively damaged bases and abasic sites at single-nucleotide resolutions reveals transcription-related strand biases, patterns mirroring cancer mutational signatures, and the action of anticancer drug irofulven
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A new paper reports a tungsten-dependent aldehyde:ferredoxin oxidoreductase as the enzyme responsible for acetate reduction to acetaldehyde for ethanol biosynthesis in the gas-converting bacteria C. autoethanogenum
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www.nature.com/articles/s41...
Carbon-monoxide-driven bioethanol production operates through a tungsten-dependent catalyst - Nature Chemical Biology
Microbial alcohol production from waste gases could enable sustainable carbon cycling. Now, the tungsten-dependent aldehyde:ferredoxin oxidoreductase from the gas-converting bacterium Clostridium auto...
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October 31, 2025 at 2:01 PM
A new paper reports a tungsten-dependent aldehyde:ferredoxin oxidoreductase as the enzyme responsible for acetate reduction to acetaldehyde for ethanol biosynthesis in the gas-converting bacteria C. autoethanogenum
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www.nature.com/articles/s41...
Our November issue is live!
www.nature.com/nchembio/vol...
The cover depicts a SEM image of a dorsal surface of liverwort M. polymorpha female thallus. Liverwort were found to have a noncanonical pathway for the regulation of master growth repressor DELLA.
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The cover depicts a SEM image of a dorsal surface of liverwort M. polymorpha female thallus. Liverwort were found to have a noncanonical pathway for the regulation of master growth repressor DELLA.
October 31, 2025 at 2:00 PM
Our November issue is live!
www.nature.com/nchembio/vol...
The cover depicts a SEM image of a dorsal surface of liverwort M. polymorpha female thallus. Liverwort were found to have a noncanonical pathway for the regulation of master growth repressor DELLA.
www.nature.com/nchembio/vol...
The cover depicts a SEM image of a dorsal surface of liverwort M. polymorpha female thallus. Liverwort were found to have a noncanonical pathway for the regulation of master growth repressor DELLA.
A new paper shows that SIRT1-driven deacetylation of MED1 under stress modifies gene expression by enhancing RNA Pol II action, promoting survival and growth of ER+ breast cancer cells----highlighting a potential therapeutic target
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www.nature.com/articles/s41...
MED1 IDR deacetylation controls stress responsive genes through RNA Pol II recruitment - Nature Chemical Biology
SIRT1-driven deacetylation of the MED1 subunit of the Mediator complex under stress modifies gene expression by enhancing RNA polymerase II action, promoting survival and growth of estrogen-receptor-p...
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October 27, 2025 at 3:42 PM
A new paper shows that SIRT1-driven deacetylation of MED1 under stress modifies gene expression by enhancing RNA Pol II action, promoting survival and growth of ER+ breast cancer cells----highlighting a potential therapeutic target
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A method called PIGEON-FEATHER can unambiguously determine residue-level energies of local unfolding from conventional HX-MS datasets
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Site-resolved energetic information from HX–MS experiments - Nature Chemical Biology
Hydrogen exchange–mass spectrometry (HX–MS) is used to qualitatively assess how perturbations such as mutations and ligand binding impact protein ensembles. However, in theory, HX–MS data contain the ...
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October 17, 2025 at 4:53 PM
A method called PIGEON-FEATHER can unambiguously determine residue-level energies of local unfolding from conventional HX-MS datasets
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Phenotypic screening of an endophyte-derived compound library identifies a potent anti-NSCLC lead DAA and uncovers LIC1 as a key regulator of autophagy in NSCLC
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www.nature.com/articles/s41...
A small molecule targets LIC1 to suppress lung tumor growth by inducing autophagy - Nature Chemical Biology
Phenotypic screening of an endophyte-derived compound library led to identification of a potent anti-non-small cell lung cancer (NSCLC) lead compound, the 3,4-diisobutyryl derivative of auxarthrol A, ...
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October 17, 2025 at 4:49 PM
Phenotypic screening of an endophyte-derived compound library identifies a potent anti-NSCLC lead DAA and uncovers LIC1 as a key regulator of autophagy in NSCLC
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A new Review discusses strategies for integrating microbial metabolism with catalytic systems to enable sustainable chemical production
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Advances in integrating microbial metabolism with catalytic systems - Nature Chemical Biology
This Review discusses recent strategies for integrating microbial metabolism with chemocatalysis, electrocatalysis, photocatalysis and biocatalysis to enable sustainable chemical production. By highli...
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October 17, 2025 at 4:45 PM
A new Review discusses strategies for integrating microbial metabolism with catalytic systems to enable sustainable chemical production
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Reposted by Nature Chemical Biology
Scientists at VIB, Daria Ezeriņa and Joris Messens, with global partners, developed HyPerFLEX🌈 HyPerFLEX tracks cellular stress in real time, glows in multiple colours, works in low-oxygen environments, and could revolutionise research on aging, inflammation & disease!
October 16, 2025 at 1:28 PM
Scientists at VIB, Daria Ezeriņa and Joris Messens, with global partners, developed HyPerFLEX🌈 HyPerFLEX tracks cellular stress in real time, glows in multiple colours, works in low-oxygen environments, and could revolutionise research on aging, inflammation & disease!
A new paper reveals the structural basis of how E. coli and T. thermophilus RNA polymerases initiate transcription from Np4 alarmones producing Np4-capped transcripts
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www.nature.com/articles/s41...
Molecular basis for noncanonical transcription initiation from Np4A alarmones - Nature Chemical Biology
Duan and Kaushik et al. reveal the structural basis of how Escherichia coli and Thermus thermophilus RNA polymerases initiate transcription from Np4A alarmones producing Np4-capped transcripts. The ca...
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October 17, 2025 at 4:38 PM
A new paper reveals the structural basis of how E. coli and T. thermophilus RNA polymerases initiate transcription from Np4 alarmones producing Np4-capped transcripts
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Nature Chemical Biology
Our new paper entitled “Boolean Logic-gated Protein Presentation through Autonomously Compiled Molecular Topology” is now live at Nature Chemical Biology (@natchembio.nature.com)! Check it out!
📜: www.nature.com/articles/s41...
@uwnews.uw.edu feature write-up: www.washington.edu/news/2025/10...
📜: www.nature.com/articles/s41...
@uwnews.uw.edu feature write-up: www.washington.edu/news/2025/10...
October 13, 2025 at 4:22 PM
Our new paper entitled “Boolean Logic-gated Protein Presentation through Autonomously Compiled Molecular Topology” is now live at Nature Chemical Biology (@natchembio.nature.com)! Check it out!
📜: www.nature.com/articles/s41...
@uwnews.uw.edu feature write-up: www.washington.edu/news/2025/10...
📜: www.nature.com/articles/s41...
@uwnews.uw.edu feature write-up: www.washington.edu/news/2025/10...
Key DNA repair enzyme PARP1 promotes transcriptional restart after DNA damage through PARylating and stabilizing AFF1 by preventing its ubiquitylation by the E3 ligase Siah1
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Stabilization of AFF1 by PARylation ensures transcriptional restart after DNA damage - Nature Chemical Biology
Zhu, Fu, Zhu, Li and colleagues found that the key DNA repair enzyme poly(ADP-ribose) polymerase 1 promotes transcriptional restart after DNA damage through PARylating and stabilizing AFF1 by preventing its ubiquitylation by the E3 ligase Siah1.
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October 8, 2025 at 8:02 PM
Key DNA repair enzyme PARP1 promotes transcriptional restart after DNA damage through PARylating and stabilizing AFF1 by preventing its ubiquitylation by the E3 ligase Siah1
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A new study presents prime-editing-based inversion with enhanced performance that enables efficient and precise genomic inversions from kilobase to chromosome scale for chromosomal engineering, disease modeling, and studying 3D genome architecture
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www.nature.com/articles/s41...
Efficient and precise inversion of genomic DNA from large to chromosomal scale - Nature Chemical Biology
This study presents prime-editing-based inversion with enhanced performance, a prime editing-based system that enables efficient and precise genomic inversions from kilobase to chromosome scale, offering a powerful tool for chromosomal engineering, disease modeling and studying three-dimensional genome architecture.
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October 8, 2025 at 8:00 PM
A new study presents prime-editing-based inversion with enhanced performance that enables efficient and precise genomic inversions from kilobase to chromosome scale for chromosomal engineering, disease modeling, and studying 3D genome architecture
www.nature.com/articles/s41...
www.nature.com/articles/s41...