Huge congratulations to the entire team and to @mcaouaille.bsky.social for this outstanding PhD thesis work; an ambitious, beautifully executed study that pushes both TB immunology and intravital imaging into entirely new territory.
#Tuberculosis #ImmunoSky #MicroSky #Microscopy
#Tuberculosis #ImmunoSky #MicroSky #Microscopy
December 11, 2025 at 6:07 AM
Huge congratulations to the entire team and to @mcaouaille.bsky.social for this outstanding PhD thesis work; an ambitious, beautifully executed study that pushes both TB immunology and intravital imaging into entirely new territory.
#Tuberculosis #ImmunoSky #MicroSky #Microscopy
#Tuberculosis #ImmunoSky #MicroSky #Microscopy
A dysregulated hepcidin-iron axis impairs antiviral immunity & induces lethal #liver pathology in neonates.
Hepcidin‑iron dysregulation drives neonatal #rotavirus damage. Folic acid shows therapeutic benefit in biliary atresia.
www.sciencedirect.com/science/arti... #OpenAccess #MicroSky #ImmunoSky
Hepcidin‑iron dysregulation drives neonatal #rotavirus damage. Folic acid shows therapeutic benefit in biliary atresia.
www.sciencedirect.com/science/arti... #OpenAccess #MicroSky #ImmunoSky
December 9, 2025 at 10:26 AM
A dysregulated hepcidin-iron axis impairs antiviral immunity & induces lethal #liver pathology in neonates.
Hepcidin‑iron dysregulation drives neonatal #rotavirus damage. Folic acid shows therapeutic benefit in biliary atresia.
www.sciencedirect.com/science/arti... #OpenAccess #MicroSky #ImmunoSky
Hepcidin‑iron dysregulation drives neonatal #rotavirus damage. Folic acid shows therapeutic benefit in biliary atresia.
www.sciencedirect.com/science/arti... #OpenAccess #MicroSky #ImmunoSky
Pathogenesis of Various Pulmonary Diseases by Tuning Immune Response:
Insight from Host-Microbial Crosstalk
www.sciencedirect.com/science/arti... #OpenAccess #microbiota #immunology #MicroSky #MedSky #ImmunoSky
Insight from Host-Microbial Crosstalk
www.sciencedirect.com/science/arti... #OpenAccess #microbiota #immunology #MicroSky #MedSky #ImmunoSky
December 8, 2025 at 1:37 PM
Pathogenesis of Various Pulmonary Diseases by Tuning Immune Response:
Insight from Host-Microbial Crosstalk
www.sciencedirect.com/science/arti... #OpenAccess #microbiota #immunology #MicroSky #MedSky #ImmunoSky
Insight from Host-Microbial Crosstalk
www.sciencedirect.com/science/arti... #OpenAccess #microbiota #immunology #MicroSky #MedSky #ImmunoSky
#NewResearch
Eosinophils enhance granuloma-mediated control of persistent Salmonella infection in mice through CCL11-driven recruitment and MBP-dependent modulation of macrophage polarization and bacterial clearance.
#MicroSky 🦠 #ImmunoSky
www.nature.com/articles/s41...
Eosinophils enhance granuloma-mediated control of persistent Salmonella infection in mice through CCL11-driven recruitment and MBP-dependent modulation of macrophage polarization and bacterial clearance.
#MicroSky 🦠 #ImmunoSky
www.nature.com/articles/s41...
Eosinophils enhance granuloma-mediated control of persistent Salmonella infection in mice - Nature Microbiology
Eosinophils enhance granuloma-mediated control of persistent Salmonella infection in mice through CCL11-driven recruitment and MBP-dependent modulation of macrophage polarization and bacterial clearan...
www.nature.com
November 26, 2025 at 3:58 PM
#NewResearch
Eosinophils enhance granuloma-mediated control of persistent Salmonella infection in mice through CCL11-driven recruitment and MBP-dependent modulation of macrophage polarization and bacterial clearance.
#MicroSky 🦠 #ImmunoSky
www.nature.com/articles/s41...
Eosinophils enhance granuloma-mediated control of persistent Salmonella infection in mice through CCL11-driven recruitment and MBP-dependent modulation of macrophage polarization and bacterial clearance.
#MicroSky 🦠 #ImmunoSky
www.nature.com/articles/s41...
#Medsky🧪 #IDsky #microsky #pharmsky #immunosky #publichealth
@natrevdrugdiscov.nature.com
Novartis’s #ganaplacide plus #lumefantrine ( #GanLum) is as effective as standard-of-care artemether plus lumefantrine (Coartem) for acute, uncomplicated malaria due to P. falciparum
@natrevdrugdiscov.nature.com
Novartis’s #ganaplacide plus #lumefantrine ( #GanLum) is as effective as standard-of-care artemether plus lumefantrine (Coartem) for acute, uncomplicated malaria due to P. falciparum
November 26, 2025 at 3:56 PM
#Medsky🧪 #IDsky #microsky #pharmsky #immunosky #publichealth
@natrevdrugdiscov.nature.com
Novartis’s #ganaplacide plus #lumefantrine ( #GanLum) is as effective as standard-of-care artemether plus lumefantrine (Coartem) for acute, uncomplicated malaria due to P. falciparum
@natrevdrugdiscov.nature.com
Novartis’s #ganaplacide plus #lumefantrine ( #GanLum) is as effective as standard-of-care artemether plus lumefantrine (Coartem) for acute, uncomplicated malaria due to P. falciparum
Divergent viral phosphodiesterases for immune signaling evasion
www.sciencedirect.com/science/arti... #OpenAccess #virology #immunology #MicroSky #ImmunoSky @ucberkeleyofficial.bsky.social
www.sciencedirect.com/science/arti... #OpenAccess #virology #immunology #MicroSky #ImmunoSky @ucberkeleyofficial.bsky.social
November 26, 2025 at 8:41 AM
Divergent viral phosphodiesterases for immune signaling evasion
www.sciencedirect.com/science/arti... #OpenAccess #virology #immunology #MicroSky #ImmunoSky @ucberkeleyofficial.bsky.social
www.sciencedirect.com/science/arti... #OpenAccess #virology #immunology #MicroSky #ImmunoSky @ucberkeleyofficial.bsky.social
#Medsky🧪 #IDSky #Immunosky #microsky #neurosky #publichealth The interplay between the gut-immune-brain axis & #COVID is increasingly recognized as a significant factor in the manifestation & progression of #idiopathicParkinson’s disease.
November 19, 2025 at 5:13 AM
#Medsky🧪 #IDSky #Immunosky #microsky #neurosky #publichealth The interplay between the gut-immune-brain axis & #COVID is increasingly recognized as a significant factor in the manifestation & progression of #idiopathicParkinson’s disease.
#Medsky🧪 #immunosky #oncosky #microsky #drugdevelopment @science.org
#Separase, a large #protease (140–250 kDa in size), is characterised by its primary structure, which includes a substantial N-terminal regulatory region alongside its C-terminal catalytic domain.
#Separase, a large #protease (140–250 kDa in size), is characterised by its primary structure, which includes a substantial N-terminal regulatory region alongside its C-terminal catalytic domain.
November 15, 2025 at 5:03 AM
#Medsky🧪 #immunosky #oncosky #microsky #drugdevelopment @science.org
#Separase, a large #protease (140–250 kDa in size), is characterised by its primary structure, which includes a substantial N-terminal regulatory region alongside its C-terminal catalytic domain.
#Separase, a large #protease (140–250 kDa in size), is characterised by its primary structure, which includes a substantial N-terminal regulatory region alongside its C-terminal catalytic domain.
Phage SSB detection by retron Eco8 msDNA unleashes nuclease-mediated immunity
www.sciencedirect.com/science/arti... #bacteriophage #phage #immunity #immunology #MicroSky #ImmunoSky
www.sciencedirect.com/science/arti... #bacteriophage #phage #immunity #immunology #MicroSky #ImmunoSky
November 1, 2025 at 6:53 PM
Phage SSB detection by retron Eco8 msDNA unleashes nuclease-mediated immunity
www.sciencedirect.com/science/arti... #bacteriophage #phage #immunity #immunology #MicroSky #ImmunoSky
www.sciencedirect.com/science/arti... #bacteriophage #phage #immunity #immunology #MicroSky #ImmunoSky
Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation
www.sciencedirect.com/science/arti... #virology #immunity #immunology #MicroSky #ImmunoSky
www.sciencedirect.com/science/arti... #virology #immunity #immunology #MicroSky #ImmunoSky
November 1, 2025 at 6:45 PM
Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation
www.sciencedirect.com/science/arti... #virology #immunity #immunology #MicroSky #ImmunoSky
www.sciencedirect.com/science/arti... #virology #immunity #immunology #MicroSky #ImmunoSky
#Medsky🧪 #microsky #immunosky #publichealth #Pathophysiology, #etiology, Progression & Complications of #Diverticulitis & Acute Diverticulitis . A Review & Risk factors
Diverticulitis results in approximately 200 000 hospitalizations annually in the US, with an estimated health care expenditure of more than $6.3 billion annually. This Review summarizes the pathogenesis, diagnosis, and treatment of diverticulitis.
ja.ma/4q0P9pC
ja.ma/4q0P9pC
October 8, 2025 at 1:09 PM
#Medsky🧪 #microsky #immunosky #publichealth #Pathophysiology, #etiology, Progression & Complications of #Diverticulitis & Acute Diverticulitis . A Review & Risk factors
Immunometabolic reprogramming of macrophages by gut #microbiota-derived cadaverine controls colon #inflammation.
Cadaverine rewires macrophage metabolism via Nrf2 activation. Concentration dictates anti- or pro-inflammatory outcomes.
www.cell.com/cell-host-mi... #MicroSky #ImmunoSky
Cadaverine rewires macrophage metabolism via Nrf2 activation. Concentration dictates anti- or pro-inflammatory outcomes.
www.cell.com/cell-host-mi... #MicroSky #ImmunoSky
October 5, 2025 at 2:07 PM
Immunometabolic reprogramming of macrophages by gut #microbiota-derived cadaverine controls colon #inflammation.
Cadaverine rewires macrophage metabolism via Nrf2 activation. Concentration dictates anti- or pro-inflammatory outcomes.
www.cell.com/cell-host-mi... #MicroSky #ImmunoSky
Cadaverine rewires macrophage metabolism via Nrf2 activation. Concentration dictates anti- or pro-inflammatory outcomes.
www.cell.com/cell-host-mi... #MicroSky #ImmunoSky
#Medsky🧪 #microsky #immunosky #publichealth Nutrient starvation profoundly impacts the gut microbiome by altering its composition, diversity & function. When preferred dietary nutrients, particularly fibre, become scarce, bacteria shift their metabolic strategies to survive.
#Perspective
Estrela and Huang discuss nutrient starvation in the context of the gut microbiome, outlining what is known and highlighting key questions for future research to address knowledge gaps.
#MicroSky #MicrobiomeSky 🦠
www.nature.com/articles/s41...
Estrela and Huang discuss nutrient starvation in the context of the gut microbiome, outlining what is known and highlighting key questions for future research to address knowledge gaps.
#MicroSky #MicrobiomeSky 🦠
www.nature.com/articles/s41...
How nutrient starvation impacts the gut microbiome - Nature Microbiology
In this Perspective, Estrela and Huang discuss nutrient starvation in the context of the gut microbiome, outlining what is known and highlighting key questions for future research to address knowledge gaps.
www.nature.com
October 2, 2025 at 5:11 AM
#Medsky🧪 #microsky #immunosky #publichealth Nutrient starvation profoundly impacts the gut microbiome by altering its composition, diversity & function. When preferred dietary nutrients, particularly fibre, become scarce, bacteria shift their metabolic strategies to survive.
A #Bacteroides fragilis protease activates host PAR2 to induce intestinal #pain and #inflammation
www.cell.com/cell-host-mi... #microbiology #immunology #MicroSky #ImmunoSky #IDSky
www.cell.com/cell-host-mi... #microbiology #immunology #MicroSky #ImmunoSky #IDSky
September 30, 2025 at 8:17 AM
A #Bacteroides fragilis protease activates host PAR2 to induce intestinal #pain and #inflammation
www.cell.com/cell-host-mi... #microbiology #immunology #MicroSky #ImmunoSky #IDSky
www.cell.com/cell-host-mi... #microbiology #immunology #MicroSky #ImmunoSky #IDSky
#Medsky #IDsky #microsky #immunosky #publichealth The #Cryptococcusyeast, known for its polysaccharide (sugar) capsule (This "sugar coating" is a 🔑 virulence factor that allows it to survive in the human body and cause disease ) has become increasingly common as a CNS pathogen.
September 29, 2025 at 9:36 AM
#Medsky #IDsky #microsky #immunosky #publichealth The #Cryptococcusyeast, known for its polysaccharide (sugar) capsule (This "sugar coating" is a 🔑 virulence factor that allows it to survive in the human body and cause disease ) has become increasingly common as a CNS pathogen.
Thrilled to share my work from the @jkagan1.bsky.social lab!
TLDR: O-acetylation and wall teichoic acid compete for space on S. aureus peptidoglycan. This competition regulates DNA release, and thus immune receptor activation, during infection!
www.biorxiv.org/content/10.1...
#microsky #immunosky
TLDR: O-acetylation and wall teichoic acid compete for space on S. aureus peptidoglycan. This competition regulates DNA release, and thus immune receptor activation, during infection!
www.biorxiv.org/content/10.1...
#microsky #immunosky
Wall teichoic acid is required for DNA-triggered innate immune receptor activation by Staphylococcus aureus
Receptors that stimulate inflammation are commonly activated by ligands that are buried within microbial cells. The mechanisms that facilitate immunostimulatory ligand release from microbes during inf...
www.biorxiv.org
September 26, 2025 at 11:31 AM
Thrilled to share my work from the @jkagan1.bsky.social lab!
TLDR: O-acetylation and wall teichoic acid compete for space on S. aureus peptidoglycan. This competition regulates DNA release, and thus immune receptor activation, during infection!
www.biorxiv.org/content/10.1...
#microsky #immunosky
TLDR: O-acetylation and wall teichoic acid compete for space on S. aureus peptidoglycan. This competition regulates DNA release, and thus immune receptor activation, during infection!
www.biorxiv.org/content/10.1...
#microsky #immunosky
A #Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity
www.cell.com/molecular-ce... #OpenAccess #MicroSky #IDSky #ImmunoSky
www.cell.com/molecular-ce... #OpenAccess #MicroSky #IDSky #ImmunoSky
September 25, 2025 at 7:34 AM
A #Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity
www.cell.com/molecular-ce... #OpenAccess #MicroSky #IDSky #ImmunoSky
www.cell.com/molecular-ce... #OpenAccess #MicroSky #IDSky #ImmunoSky
Di-(2-ethylhexyl) Phthalate Induces #Endometriosis by Modulating IGF-1 m6A Methylation via the Intestinal Odoribacter–Butyric Acid Axis in Female Rats
www.sciencedirect.com/science/arti... #OpenAccess #microbiota #epigenetics #MicroSky #ImmunoSky #MedSky
www.sciencedirect.com/science/arti... #OpenAccess #microbiota #epigenetics #MicroSky #ImmunoSky #MedSky
September 24, 2025 at 6:56 PM
Di-(2-ethylhexyl) Phthalate Induces #Endometriosis by Modulating IGF-1 m6A Methylation via the Intestinal Odoribacter–Butyric Acid Axis in Female Rats
www.sciencedirect.com/science/arti... #OpenAccess #microbiota #epigenetics #MicroSky #ImmunoSky #MedSky
www.sciencedirect.com/science/arti... #OpenAccess #microbiota #epigenetics #MicroSky #ImmunoSky #MedSky
Fungal resistance in rice is restored by interfamily transfer of an evolutionarily lost co-receptor.
STOM is a previously unreported fungal MAMP conserved across pathogenic fungi. STOMR/STOMRh is a receptor/co-receptor pair critical for STOM sensing
www.cell.com/cell-host-mi... #MicroSky #ImmunoSky
STOM is a previously unreported fungal MAMP conserved across pathogenic fungi. STOMR/STOMRh is a receptor/co-receptor pair critical for STOM sensing
www.cell.com/cell-host-mi... #MicroSky #ImmunoSky
September 18, 2025 at 7:30 AM
Fungal resistance in rice is restored by interfamily transfer of an evolutionarily lost co-receptor.
STOM is a previously unreported fungal MAMP conserved across pathogenic fungi. STOMR/STOMRh is a receptor/co-receptor pair critical for STOM sensing
www.cell.com/cell-host-mi... #MicroSky #ImmunoSky
STOM is a previously unreported fungal MAMP conserved across pathogenic fungi. STOMR/STOMRh is a receptor/co-receptor pair critical for STOM sensing
www.cell.com/cell-host-mi... #MicroSky #ImmunoSky
#Medsky #iDsky #microsky #immunosky #publichealth
In the comparative study from Anhui, 🇨🇳 , analyzed the return of the H1N1pdm09 #influenzavirus in the 2022/2023 season & compared it with previous epidemic years. The study found
journals.asm.org/doi/10.1128/...
In the comparative study from Anhui, 🇨🇳 , analyzed the return of the H1N1pdm09 #influenzavirus in the 2022/2023 season & compared it with previous epidemic years. The study found
journals.asm.org/doi/10.1128/...
H1N1pdm09 returns: a comparative study in Anhui, China | Microbiology Spectrum
The H1N1pdm09-associated morbidity and mortality impact negatively on the socio-economic
status of the affected population. Potential modification of the genetic and antigenic
traits of the virus, as ...
journals.asm.org
September 9, 2025 at 1:51 PM
#Medsky #iDsky #microsky #immunosky #publichealth
In the comparative study from Anhui, 🇨🇳 , analyzed the return of the H1N1pdm09 #influenzavirus in the 2022/2023 season & compared it with previous epidemic years. The study found
journals.asm.org/doi/10.1128/...
In the comparative study from Anhui, 🇨🇳 , analyzed the return of the H1N1pdm09 #influenzavirus in the 2022/2023 season & compared it with previous epidemic years. The study found
journals.asm.org/doi/10.1128/...
#Medsky🧪 #IDsky #microsky #immunosky #publichealth @cidjournal.bsky.social
Body Mass Index and Incident #Tuberculosis in Close Tuberculosis Contacts ~ 95% of people infected with M. tuberculosis do not progress TB .
academic.oup.com/cid/advance-...
Body Mass Index and Incident #Tuberculosis in Close Tuberculosis Contacts ~ 95% of people infected with M. tuberculosis do not progress TB .
academic.oup.com/cid/advance-...
September 8, 2025 at 2:00 PM
#Medsky🧪 #IDsky #microsky #immunosky #publichealth @cidjournal.bsky.social
Body Mass Index and Incident #Tuberculosis in Close Tuberculosis Contacts ~ 95% of people infected with M. tuberculosis do not progress TB .
academic.oup.com/cid/advance-...
Body Mass Index and Incident #Tuberculosis in Close Tuberculosis Contacts ~ 95% of people infected with M. tuberculosis do not progress TB .
academic.oup.com/cid/advance-...
Interferons in health and disease.
Excellent review article.
www.cell.com/cell/fulltex... #immunology #ImmunoSky #MicroSky
Excellent review article.
www.cell.com/cell/fulltex... #immunology #ImmunoSky #MicroSky
August 22, 2025 at 9:36 AM
Interferons in health and disease.
Excellent review article.
www.cell.com/cell/fulltex... #immunology #ImmunoSky #MicroSky
Excellent review article.
www.cell.com/cell/fulltex... #immunology #ImmunoSky #MicroSky
Immunopathogenesis of lethal #H5N1 avian #influenza virus clade 2.3.4.4b infection in macaques
www.cell.com/immunity/ful... #flu #MicroSky #IDSky #ImmunoSky
www.cell.com/immunity/ful... #flu #MicroSky #IDSky #ImmunoSky
August 20, 2025 at 4:52 PM
Immunopathogenesis of lethal #H5N1 avian #influenza virus clade 2.3.4.4b infection in macaques
www.cell.com/immunity/ful... #flu #MicroSky #IDSky #ImmunoSky
www.cell.com/immunity/ful... #flu #MicroSky #IDSky #ImmunoSky
#Medsky🧪 #IDsky #immunosky #Microsky #publichealth The #clinicalReview @natrevgastrohep.nature.com delves into the profound impact of diet on shaping the #gutmicrobiome & host immunity .
The gut microbiome connects nutrition and human health
Nature Reviews Gastroenterology & Hepatology - In this Review, Sanz and colleagues discuss how diet shapes the gut microbiome, the role of diet–microbiome interactions on the immune,...
www.nature.com
August 16, 2025 at 6:27 AM
#Medsky🧪 #IDsky #immunosky #Microsky #publichealth The #clinicalReview @natrevgastrohep.nature.com delves into the profound impact of diet on shaping the #gutmicrobiome & host immunity .