Huang et al. report that in SCA3, increased perivascular space (PVS) burden in key brain regions correlates with motor impairment. PVS could be a new biomarker for monitoring the disease. Please read at: buff.ly/y4awn6C
April 16, 2025 at 11:04 AM
Huang et al. report that in SCA3, increased perivascular space (PVS) burden in key brain regions correlates with motor impairment. PVS could be a new biomarker for monitoring the disease. Please read at: buff.ly/y4awn6C
Polish Prime Minister Donald Tusk on Friday blamed "Russian hackers" for a cyberattack that knocked his ruling party's website offline ahead of a presidential vote this weekend.
u.afp.com/ScA3
u.afp.com/ScA3
May 16, 2025 at 3:45 PM
Polish Prime Minister Donald Tusk on Friday blamed "Russian hackers" for a cyberattack that knocked his ruling party's website offline ahead of a presidential vote this weekend.
u.afp.com/ScA3
u.afp.com/ScA3
Re: [PATCH v2] iio: accel: sca3000: remove duplicated code in sca3 ... Jonathan Cameron writes: (...
http://lkml.org/lkml/2025/4/26/192
Result Details
http://lkml.org/lkml/2025/4/26/192
Result Details
Awakari App
awakari.com
April 26, 2025 at 10:56 AM
Re: [PATCH v2] iio: accel: sca3000: remove duplicated code in sca3 ... Jonathan Cameron writes: (...
http://lkml.org/lkml/2025/4/26/192
Result Details
http://lkml.org/lkml/2025/4/26/192
Result Details
DBS not effective long term for #SCA3 #MachadoJoseph disease dystonia. @DBSThinkTank this has been consistent with other case reports and underscores that when using for SCA's make sure the palliative effect matches the situation. @DBSThinkTank @leaddbs...
November 30, 2024 at 12:50 PM
DBS not effective long term for #SCA3 #MachadoJoseph disease dystonia. @DBSThinkTank this has been consistent with other case reports and underscores that when using for SCA's make sure the palliative effect matches the situation. @DBSThinkTank @leaddbs...
Allosteric modulation of ataxin-3 aggregation and potential therapeutic strategies for Machado-Joseph disease. The power of teamwork to tackle complex biological questions!
👉https://www.biorxiv.org/content/10.1101/2025.01.22.633970v1
#Neurodegeneration #SCA3 #Allostery #Aggregation #Preprint
👉https://www.biorxiv.org/content/10.1101/2025.01.22.633970v1
#Neurodegeneration #SCA3 #Allostery #Aggregation #Preprint
February 6, 2025 at 4:20 PM
Allosteric modulation of ataxin-3 aggregation and potential therapeutic strategies for Machado-Joseph disease. The power of teamwork to tackle complex biological questions!
👉https://www.biorxiv.org/content/10.1101/2025.01.22.633970v1
#Neurodegeneration #SCA3 #Allostery #Aggregation #Preprint
👉https://www.biorxiv.org/content/10.1101/2025.01.22.633970v1
#Neurodegeneration #SCA3 #Allostery #Aggregation #Preprint
During #CTGCTDays2025, the GENE H Conference – Gene Therapy covered genome editing, biosafety, and neuro-focused applications. UC/GeneT presented SCA3 strategies (allele-specific silencing & gene inactivation). Program& abstracts: ctgct.si/en/ctgct-day...
@kemijski.bsky.social
@ctgct.bsky.social
@kemijski.bsky.social
@ctgct.bsky.social
September 18, 2025 at 10:23 AM
During #CTGCTDays2025, the GENE H Conference – Gene Therapy covered genome editing, biosafety, and neuro-focused applications. UC/GeneT presented SCA3 strategies (allele-specific silencing & gene inactivation). Program& abstracts: ctgct.si/en/ctgct-day...
@kemijski.bsky.social
@ctgct.bsky.social
@kemijski.bsky.social
@ctgct.bsky.social
This is part of a larger project that also includes trying to treat SCA3, the rare genetic disease my family suffers from, so this is super exciting
In my life I've seen treatments for AIDs developed, vaccines for Ebola and malaria, and now this. Medical science is one is the areas that still consistently seems to make these miraculous advances and I'm genuinely grateful to everyone involved.
www.bbc.co.uk/news/article...
www.bbc.co.uk/news/article...
Huntington's disease successfully treated for first time
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
www.bbc.co.uk
September 24, 2025 at 2:28 PM
This is part of a larger project that also includes trying to treat SCA3, the rare genetic disease my family suffers from, so this is super exciting
VICO Scientist Bas Rottgering presented our SCA3 program VO659 at the Dutch Antisense Therapeutics Symposium! Our poster on exon-skipping ASO therapy represents collaboration with @unileiden.bsky.social. This approach could offer new treatment options for neurodegenerative disease patients.
June 12, 2025 at 1:34 PM
VICO Scientist Bas Rottgering presented our SCA3 program VO659 at the Dutch Antisense Therapeutics Symposium! Our poster on exon-skipping ASO therapy represents collaboration with @unileiden.bsky.social. This approach could offer new treatment options for neurodegenerative disease patients.
OPPORTUNITIES
⏰Oct 24➡️PhD holder researcher➡️Project "Ataxin-3 protein interactions changes in Machado-Joseph Disease (MJD)/spinocerebellar ataxia type 3 (SCA3) as novel ther. targets" at #i3S
Profile: PhD in Life & Health Sci, Biochem, Mol Biol or related...
👉https://tinyurl.com/4uw9pmjs
#i3Sjobs
⏰Oct 24➡️PhD holder researcher➡️Project "Ataxin-3 protein interactions changes in Machado-Joseph Disease (MJD)/spinocerebellar ataxia type 3 (SCA3) as novel ther. targets" at #i3S
Profile: PhD in Life & Health Sci, Biochem, Mol Biol or related...
👉https://tinyurl.com/4uw9pmjs
#i3Sjobs
tinyurl.com
October 3, 2025 at 1:56 PM
Orent seriously asked me why should would bother reading something I recently wrote up on Machado Joseph Disease/SCA3 (because it’s also regarded as being caused by a CAG expansion mutation) after she had just recently responded to me asking whether she was interested in reading it with “Sure!”.
May 28, 2025 at 1:40 PM
Orent seriously asked me why should would bother reading something I recently wrote up on Machado Joseph Disease/SCA3 (because it’s also regarded as being caused by a CAG expansion mutation) after she had just recently responded to me asking whether she was interested in reading it with “Sure!”.
As for why this is relevant/something you can’t ignore, the genetic consensus take on “Groote Eylandt Syndrome” is that it’s Machado Joseph Disease/SCA3, and thus allegedly the same kind of genetic disease as Huntington’s. And yet, nobody denies that they have elevated levels of Mn on Groote.
May 25, 2025 at 4:55 PM
As for why this is relevant/something you can’t ignore, the genetic consensus take on “Groote Eylandt Syndrome” is that it’s Machado Joseph Disease/SCA3, and thus allegedly the same kind of genetic disease as Huntington’s. And yet, nobody denies that they have elevated levels of Mn on Groote.
Epilepsy is also such a fascinating border defying disease, as is schizophrenia (as you say), as well as parkinsons and Huntington's (or our own family disease, the neurodegenerative genetic condition ADCA SCA3)
August 22, 2024 at 7:06 PM
Epilepsy is also such a fascinating border defying disease, as is schizophrenia (as you say), as well as parkinsons and Huntington's (or our own family disease, the neurodegenerative genetic condition ADCA SCA3)
Here’s what I put together for you on Groote Eylandt Syndrome/MJD/SCA3 @maaikeverbruggen.bsky.social. Not my best work, but I think it covers enough of what it needs to. Along with the timeline I’m reposting (which contains my sources), here’s pages 1-4 (of 12) of what I wrote:
May 24, 2025 at 6:50 AM
Here’s what I put together for you on Groote Eylandt Syndrome/MJD/SCA3 @maaikeverbruggen.bsky.social. Not my best work, but I think it covers enough of what it needs to. Along with the timeline I’m reposting (which contains my sources), here’s pages 1-4 (of 12) of what I wrote:
Note the date. Still, if I’m not mistaken, it’s Mark Purdey who should get credit for being the first person to suggest that environmental exposures can account for CAG expansion mutations based on his Groote Eylandt Machado Joseph Disease/SCA3 research.
May 25, 2025 at 7:49 AM
Note the date. Still, if I’m not mistaken, it’s Mark Purdey who should get credit for being the first person to suggest that environmental exposures can account for CAG expansion mutations based on his Groote Eylandt Machado Joseph Disease/SCA3 research.
NOW ONLINE: biomarkers of progression of spinocerebellar ataxia type 3 - data from SCA3 mutation carriers before and after onset of ataxia, as part of the European Spinocerebellar ataxia type 3/Machado-Joseph disease Initiative (ESMI)
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Progression of biological markers in spinocerebellar ataxia type 3: longitudinal analysis of prospective data from the ESMI cohort
Our study provides quantitative information on the progression of biological markers
in SCA3 mutation carriers before and after onset of ataxia, and allowed the identification
of predictors for clinic...
www.thelancet.com
July 3, 2025 at 2:04 PM
NOW ONLINE: biomarkers of progression of spinocerebellar ataxia type 3 - data from SCA3 mutation carriers before and after onset of ataxia, as part of the European Spinocerebellar ataxia type 3/Machado-Joseph disease Initiative (ESMI)
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Small non-coding RNA content in plasma-derived extracellular vesicles distinguish ataxic SCA3 mutation carriers from pre-ataxic and control subjects https://www.biorxiv.org/content/10.1101/2024.01.04.574044v1
Small non-coding RNA content in plasma-derived extracellular vesicles distinguish ataxic SCA3 mutation carriers from pre-ataxic and control subjects https://www.biorxiv.org/content/10.1101/2024.01.04.574044v1
Spinocerebellar ataxia type 3 (SCA3), a neurodegenerative disorder caused by a CAG expansion in the
www.biorxiv.org
January 5, 2024 at 4:17 PM
Small non-coding RNA content in plasma-derived extracellular vesicles distinguish ataxic SCA3 mutation carriers from pre-ataxic and control subjects https://www.biorxiv.org/content/10.1101/2024.01.04.574044v1
It's almost time for me to go to the doctor to confirm that I still have SCA3 (it's genetic) and it's getting worse (and progressive).
Always a fun time, but then I am going to go to trader joe's and buy all the junk food.
First though, I really should put on some pants.
Always a fun time, but then I am going to go to trader joe's and buy all the junk food.
First though, I really should put on some pants.
July 18, 2025 at 7:56 PM
It's almost time for me to go to the doctor to confirm that I still have SCA3 (it's genetic) and it's getting worse (and progressive).
Always a fun time, but then I am going to go to trader joe's and buy all the junk food.
First though, I really should put on some pants.
Always a fun time, but then I am going to go to trader joe's and buy all the junk food.
First though, I really should put on some pants.
Diese Studie liefert quantitative Informationen zur Progression biologischer Marker bei SCA3-Mutationsträgern, vor und nach Beginn der Ataxie, und ermöglicht so die Identifizierung von Prädiktoren für die klinische Progression.
Kenntnisse über den Verlauf biologischer Marker bei >>
3/5
Kenntnisse über den Verlauf biologischer Marker bei >>
3/5
July 16, 2025 at 4:47 PM
Diese Studie liefert quantitative Informationen zur Progression biologischer Marker bei SCA3-Mutationsträgern, vor und nach Beginn der Ataxie, und ermöglicht so die Identifizierung von Prädiktoren für die klinische Progression.
Kenntnisse über den Verlauf biologischer Marker bei >>
3/5
Kenntnisse über den Verlauf biologischer Marker bei >>
3/5
Notably, SCA2 was the most common type (30%), followed by SCA3 (15%), SCA7 (15%), and SCA10 (1 case). This contrasts with other Brazilian populations, where SCA3 dominates.
October 29, 2025 at 12:45 AM
Notably, SCA2 was the most common type (30%), followed by SCA3 (15%), SCA7 (15%), and SCA10 (1 case). This contrasts with other Brazilian populations, where SCA3 dominates.
She has ADCA, subtype SCA3 (spinocerebellar ataxia). Her cerebellum is mostly destroyed and she has very little control of her body left. She struggles to eat and talk and hold anything.
My sister has it too, but not yet as advanced, but my mom got way older than her family members ever did.
My sister has it too, but not yet as advanced, but my mom got way older than her family members ever did.
September 16, 2024 at 10:30 AM
She has ADCA, subtype SCA3 (spinocerebellar ataxia). Her cerebellum is mostly destroyed and she has very little control of her body left. She struggles to eat and talk and hold anything.
My sister has it too, but not yet as advanced, but my mom got way older than her family members ever did.
My sister has it too, but not yet as advanced, but my mom got way older than her family members ever did.
Here’s what I’ve put together for a timeline of research into “Groote Eylandt Syndrome” (aka Machado Joseph Disease/SCA3). If it looks like I’ve missed anything important, please let me know. Thanks.
May 22, 2025 at 8:38 PM
Here’s what I’ve put together for a timeline of research into “Groote Eylandt Syndrome” (aka Machado Joseph Disease/SCA3). If it looks like I’ve missed anything important, please let me know. Thanks.
A Core Pattern of Cerebellar and Brainstem Degeneration and Reduced Cerebrocerebellar Structural Covariance in Spinocerebellar Ataxia Type 3 (SCA3): MRI Volumetrics from ENIGMA-Ataxia https://www.biorxiv.org/content/10.1101/2025.08.08.669370v1
August 9, 2025 at 7:15 AM
A Core Pattern of Cerebellar and Brainstem Degeneration and Reduced Cerebrocerebellar Structural Covariance in Spinocerebellar Ataxia Type 3 (SCA3): MRI Volumetrics from ENIGMA-Ataxia https://www.biorxiv.org/content/10.1101/2025.08.08.669370v1
In this work, we explore molecular and structural insights into CLR01 binding to ataxin-3 and follow its impact from cells all the way to SCA3/MJD animal models.
This truly collaborative effort was only possible through strong interdisciplinary teamwork.
@ataxiafoundation.bsky.social @ec.europa.eu
This truly collaborative effort was only possible through strong interdisciplinary teamwork.
@ataxiafoundation.bsky.social @ec.europa.eu
November 27, 2025 at 12:05 PM
In this work, we explore molecular and structural insights into CLR01 binding to ataxin-3 and follow its impact from cells all the way to SCA3/MJD animal models.
This truly collaborative effort was only possible through strong interdisciplinary teamwork.
@ataxiafoundation.bsky.social @ec.europa.eu
This truly collaborative effort was only possible through strong interdisciplinary teamwork.
@ataxiafoundation.bsky.social @ec.europa.eu
Small non-coding RNA content in plasma-derived extracellular vesicles distinguish ataxic SCA3 mutation carriers from pre-ataxic and control subjects https://www.biorxiv.org/content/10.1101/2024.01.04.574044v1
Small non-coding RNA content in plasma-derived extracellular vesicles distinguish ataxic SCA3 mutation carriers from pre-ataxic and control subjects https://www.biorxiv.org/content/10.1101/2024.01.04.574044v1
Spinocerebellar ataxia type 3 (SCA3), a neurodegenerative disorder caused by a CAG expansion in the
www.biorxiv.org
January 5, 2024 at 4:17 PM
Small non-coding RNA content in plasma-derived extracellular vesicles distinguish ataxic SCA3 mutation carriers from pre-ataxic and control subjects https://www.biorxiv.org/content/10.1101/2024.01.04.574044v1
My right shoulder/arm has been mildly hurting for a while now, over and above the SCA3 symptoms. Turns out I have mild bursitis, impingement, and rotator cuff strain, and I guess this summer is going to be the summer of physical therapy.
Man, I am so over getting old, & also so, so over this year.
Man, I am so over getting old, & also so, so over this year.
June 6, 2025 at 2:02 AM
My right shoulder/arm has been mildly hurting for a while now, over and above the SCA3 symptoms. Turns out I have mild bursitis, impingement, and rotator cuff strain, and I guess this summer is going to be the summer of physical therapy.
Man, I am so over getting old, & also so, so over this year.
Man, I am so over getting old, & also so, so over this year.