An acclaimed researcher is an expert at explaining complicated problems. Now she has to confront the most vexing question: What is happening to her?

Natural history data show that respiratory function is impaired in SMA patients. Observational studies have shown stabilization of respiratory function in adult SMA patients treated with nusinersen. H...

IntroductionThe management of educational stressors and predictors of cognitive performance outcomes, such as test anxiety and learning strategies (LS), pose...

Susumu Kitagawa, Richard Robson and Omar Yaghi pioneered the creation of metal-organic frameworks, which can capture and store molecules such as carbon dioxide.

Nature Reviews Materials - The development of structural design methodologies in reticular chemistry promotes the discovery of periodic solids, such as metal–organic frameworks. In this...

Wie lassen sich die Behandlungserwartungen der Patient:innen nutzen, um den Therapieerfolg zu optimieren? Diese Frage diskutiert Laura Weisenburger.

Klinische Studien sind ein zentraler Baustein bei der Entwicklung von neuen Therapien sowie bei der Optimierung bestehender Behandlungsmethoden. Durch die Teilnahme an klinischen Studien können unsere...

Finden Sie eine Stelle am Universitätsklinikum Essen

Cell Death & Disease - In vitro model of retinoblastoma derived tumor and stromal cells for tumor microenvironment (TME) studies

Neutrophils are readily activated immune cells after ischemic stroke in mice and patients. Still, the impact of gut microbiota on neutrophil activation and its influence on inflammatory brain injury remain undefined. We report that natural microbiota colonization of germ-free (GF) mice induces substantial neutrophil activation and deteriorates stroke pathology. The colonized Ex-GF stroke mice had considerably larger infarct sizes and higher sensorimotor deficits than GF littermates. Furthermore, employing an antibiotic-based mouse model of microbiota deficiency, we demonstrate that gut microbiota depletion induces a juvenile neutrophil phenotype characterized by the upregulation of resting state surface receptors, reduced inflammatory proteins, and levels of circulating NETs. This disarming of neutrophil responses was associated with decreased expression of brain inflammatory genes, vascular thrombus formation, reduced infarct size, and alleviated behavioral deficits. We conclude that gut microbes strongly influence neutrophil activation after stroke and thus directly contribute to stroke severity.