INNISFREE's new sunscreen, designed to address photoaging, is set to hit shelves on September 1, 2025. Learn about its innovative approach and survey results.

The photoprotective efficacy of natural skin-active complexes is well recognized, yet their application is often hindered by the challenge of deciphering their complex, multi-component, and multi-target mechanisms. To bridge the gap between established phenotypes and molecular mechanisms, we developed an AI-driven integrated platform that combines phytochemical profiling, network pharmacology, and deep learning-based target prediction with rigorous biophysical validation. We applied this platform to investigate RRBE, a bioactive complex refined from red rice bran extract. In vivo clinical studies confirmed that RRBE significantly accelerates the resolution of UV-induced erythema, while cellular and 3D tissue models demonstrated robust suppression of oxidative stress and DNA damage responses. To decode its material basis, the platform deconstructed RRBE into 10 distinct chemical modules. Leveraging our SCOPE-DTI deep learning model for global target prediction, we identified flavonoids (Module 1) and phenolic acids (Module 10) as the primary bioactive drivers relevant to photoprotection. These computational predictions were structurally supported by molecular docking and definitively validated in a physiological environment via Cellular Thermal Shift Assay-Mass Spectrometry (CETSA-MS). Mechanistically, RRBE functions through a synergistic polypharmacology: (1) Module 1 components, represented by procyanidin B2, target NDUFA7 to stabilize mitochondrial function and mitigate ROS; (2) Module 10 components, exemplified by caffeic acid, ferulic acid, and p-coumaric acid, engage FKBP11 and HSP90AA1 to regulate protein homeostasis and stress responses. This work not only deciphers the polypharmacological basis of RRBE's photoprotective action but also validates a scalable "AI-guided, cell-validated" discovery pipeline, offering a rational paradigm for uncovering the protective benefits of complex natural extracts.

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Cosmesi naturale, cosmetologia, tecniche di massaggio, consigli, estetica, trucco, alimentazione

Photoaging is a process of accelerated skin aging induced by ultraviolet radiation (UVR) and other exogenous factors, characterized by deepened wrinkl…

【Sun Protection Against UV rays】 The grass fed tallow sunscreen organic providing all day protection for the skin, reducing the risk of sunburn, tanning, and photoaging. Package Dimensions ‏ : ‎ 4.49 x 1.5 x 1.5 inches; 2.93 ounces Manufacturer ‏ : ‎ Evolvique ASIN ‏ : ‎ B0F5W26XH5 Country of Origin ‏ : ‎ China 【Sun Protection Against UV rays】 The grass fed tallow sunscreen organic providing all day protection for the skin, reducing the risk of sunburn, tanning, and photoaging.

Abstract. Microplastic-derived dissolved organic matter (MP-DOM) has attracted widespread attention due to their adverse effects on ecological health. Howe