Aging Science News
@agingbiology.bsky.social
Latest news in the biology and genetics of aging, covering longevity science, rejuvenation technologies and life-extension research.
Aging as the wound that fails to heal: a bioenergetic continuum of resolution failure
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Aging as the wound that fails to heal: a bioenergetic continuum of resolution failure - Biogerontology
Aging may be conceptualized as a wound that fails to heal, characterized by persistent, unresolved inflammation. Building on Ogrodnik’s “unhealed wound” model, this Perspective extends the Exposure-Re...
link.springer.com
November 28, 2025 at 12:58 AM
Aging as the wound that fails to heal: a bioenergetic continuum of resolution failure
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Topological turning points across the human lifespan
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Topological turning points across the human lifespan - Nature Communications
Researchers discovered five phases of brain rewiring across the lifespan. The eras of childhood, adolescence, adulthood, early aging, and late aging each have characteristic rewiring of structural con...
www.nature.com
November 27, 2025 at 11:46 PM
Topological turning points across the human lifespan
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Defying death: The origins of ageing
www.ft.com/content/a33d...
www.ft.com/content/a33d...
Defying death: The origins of ageing
Why do we age? Can it be stopped?
www.ft.com
November 27, 2025 at 10:15 PM
Defying death: The origins of ageing
www.ft.com/content/a33d...
www.ft.com/content/a33d...
Why we age is still longevity’s biggest question
longevity.technology/news/why-we-...
longevity.technology/news/why-we-...
Why we age is still longevity’s biggest question
Aging researcher expands on how addressing 100 key problems can provide the field with a roadmap for future investigation.
longevity.technology
November 27, 2025 at 6:49 PM
Why we age is still longevity’s biggest question
longevity.technology/news/why-we-...
longevity.technology/news/why-we-...
Potential dietary geroprotectors and their impact on key mechanisms of aging
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Potential dietary geroprotectors and their impact on key mechanisms of aging - Biogerontology
Aging involves progressive accumulation of molecular and cellular damage, leading to functional decline and increased susceptibility to age-related diseases. Natural low-molecular-weight geroprotector...
link.springer.com
November 27, 2025 at 4:41 PM
Potential dietary geroprotectors and their impact on key mechanisms of aging
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Solitary eating is linked to reduced brain volume in cognitively unimpaired individuals and possible future cognitive decline
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Solitary eating is linked to reduced brain volume in cognitively unimpaired individuals and possible future cognitive decline - npj Aging
npj Aging - Solitary eating is linked to reduced brain volume in cognitively unimpaired individuals and possible future cognitive decline
www.nature.com
November 27, 2025 at 12:39 PM
Solitary eating is linked to reduced brain volume in cognitively unimpaired individuals and possible future cognitive decline
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A collagen amino acid composition supplementation reduces biological age in humans and increases health and lifespan in vivo
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A collagen amino acid composition supplementation reduces biological age in humans and increases health and lifespan in vivo - npj Aging
npj Aging - A collagen amino acid composition supplementation reduces biological age in humans and increases health and lifespan in vivo
www.nature.com
November 27, 2025 at 1:16 AM
A collagen amino acid composition supplementation reduces biological age in humans and increases health and lifespan in vivo
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Organ-specific proteomic aging clocks predict disease and longevity across diverse populations
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Organ-specific proteomic aging clocks predict disease and longevity across diverse populations - Nature Aging
Wang, Xiao and colleagues develop and validate organ-specific proteomic aging clocks across large population cohorts in the UK, the USA and China, which show strong performance in tracking organ aging...
www.nature.com
November 26, 2025 at 11:58 PM
Organ-specific proteomic aging clocks predict disease and longevity across diverse populations
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Cellular senescence related gene signature predicts prognosis and immune features in skin cutaneous melanoma
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Cellular senescence related gene signature predicts prognosis and immune features in skin cutaneous melanoma - Discover Oncology
Background Skin cutaneous melanoma (SKCM) is the deadliest skin cancer, with rising global incidence. Cellular senescence plays an essential role in tumorigenesis, progression, and immune modulation i...
link.springer.com
November 26, 2025 at 2:48 PM
Cellular senescence related gene signature predicts prognosis and immune features in skin cutaneous melanoma
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Boy with rare condition amazes doctors after world-first gene therapy
www.bbc.com/news/article...
www.bbc.com/news/article...
Hunter syndrome: Boy with rare condition amazes doctors after world-first gene therapy
Oliver has an inherited condition called Hunter syndrome, which causes progressive damage to the body and brain.
www.bbc.com
November 26, 2025 at 1:26 AM
Boy with rare condition amazes doctors after world-first gene therapy
www.bbc.com/news/article...
www.bbc.com/news/article...
Oxytocin enhances neurogenesis and synaptic plasticity to attenuate age-related cognitive decline in aged mice
www.ibroneuroreports.org/article/S266...
www.ibroneuroreports.org/article/S266...
Oxytocin enhances neurogenesis and synaptic plasticity to attenuate age-related cognitive decline in aged mice
Brain aging is characterized by progressive structural and functional deterioration,
leading to cognitive decline and impaired social functioning. A key factor in this
process is the age-related decli...
www.ibroneuroreports.org
November 25, 2025 at 10:48 PM
Oxytocin enhances neurogenesis and synaptic plasticity to attenuate age-related cognitive decline in aged mice
www.ibroneuroreports.org/article/S266...
www.ibroneuroreports.org/article/S266...
Obesity jab drug fails to slow Alzheimer's
www.bbc.com/news/article...
www.bbc.com/news/article...
Obesity drug semaglutide fails to slow Alzheimer's
There were initial hopes that the drug in weight loss jab Wegovy could slow progression of dementia.
www.bbc.com
November 25, 2025 at 4:55 PM
Obesity jab drug fails to slow Alzheimer's
www.bbc.com/news/article...
www.bbc.com/news/article...
Calorie Restriction Attenuates Transcriptional Aging Signatures in White Matter Oligodendrocytes and Immune Cells of the Monkey Brain
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Calorie Restriction Attenuates Transcriptional Aging Signatures in White Matter Oligodendrocytes and Immune Cells of the Monkey Brain
Our single nuclei RNA sequencing data reveal that long-term calorie restriction in aged rhesus monkeys reduces neuroinflammation and preserves glial metabolism. In oligodendrocytes, calorie restricti....
onlinelibrary.wiley.com
November 25, 2025 at 3:42 PM
Calorie Restriction Attenuates Transcriptional Aging Signatures in White Matter Oligodendrocytes and Immune Cells of the Monkey Brain
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Statistical Methods in Aging Research: Improving Current Practices and Embracing Emerging Approaches
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
Statistical Methods in Aging Research: Improving Current Practices and Embracing Emerging Approaches
Aging research relies on varied statistical methods, and applying these methods appropriately is important for scientific rigor. However, proper use of these statistical techniques is a challenge. We ...
www.annualreviews.org
November 24, 2025 at 10:46 PM
Statistical Methods in Aging Research: Improving Current Practices and Embracing Emerging Approaches
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
Autonomous AI Agents Discover Aging Interventions from Millions of Molecular Profiles
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Autonomous AI Agents Discover Aging Interventions from Millions of Molecular Profiles
Decades of publicly available molecular studies have generated millions of samples testing diverse interventions, yet these datasets were rarely analyzed for their effects on aging. Aging clocks now e...
www.biorxiv.org
November 24, 2025 at 3:46 PM
Autonomous AI Agents Discover Aging Interventions from Millions of Molecular Profiles
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
β-galactosidase-targeted senolytic prodrug ameliorates preclinical models of post-traumatic osteoarthritis
www.thelancet.com/journals/ebi...
www.thelancet.com/journals/ebi...
β-galactosidase-targeted senolytic prodrug ameliorates preclinical models of post-traumatic osteoarthritis
SSK1 is an effective candidate for senolytics in alleviating OA. The anti-ageing therapeutic
effect of SSK1 lies in restoring a regenerative phenotype by improving the proliferation
microenvironment, ...
www.thelancet.com
November 23, 2025 at 11:49 PM
β-galactosidase-targeted senolytic prodrug ameliorates preclinical models of post-traumatic osteoarthritis
www.thelancet.com/journals/ebi...
www.thelancet.com/journals/ebi...
Drug-mediated disruption of the aging gut microbiota and mucosal immune system
www.frontiersin.org/journals/agi...
www.frontiersin.org/journals/agi...
Frontiers | Drug-mediated disruption of the aging gut microbiota and mucosal immune system
The human gut microbiota is comprised predominantly of bacteria, and also includes archaea, fungi, and viruses. The gastrointestinal epithelium, mucosal barr...
www.frontiersin.org
November 23, 2025 at 5:58 PM
Drug-mediated disruption of the aging gut microbiota and mucosal immune system
www.frontiersin.org/journals/agi...
www.frontiersin.org/journals/agi...
DNA Methylation Signatures of Systemic Inflammation Are Associated With Brain Volume, Cognitive Trajectories, and Long-Term Dementia Risk
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com
November 23, 2025 at 3:19 PM
DNA Methylation Signatures of Systemic Inflammation Are Associated With Brain Volume, Cognitive Trajectories, and Long-Term Dementia Risk
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Biological age measured by DNA methylation clocks and frailty: a systematic review and meta-analysis
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Biological age measured by DNA methylation clocks and frailty: a systematic review and meta-analysis
Higher GrimAge EAA is consistently associated with higher frailty. Future research
should focus on developing and validating DNA methylation clocks that integrate molecular
surrogates of health risk a...
www.thelancet.com
November 23, 2025 at 12:43 AM
Biological age measured by DNA methylation clocks and frailty: a systematic review and meta-analysis
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Nanomaterial-induced mitochondrial biogenesis enhances intercellular mitochondrial transfer efficiency
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Nanomaterial-induced mitochondrial biogenesis enhances intercellular mitochondrial transfer efficiency | PNAS
Intercellular mitochondrial transfer, the spontaneous exchange of mitochondria between
cells, is a recently described phenomenon crucial for cellul...
www.pnas.org
November 22, 2025 at 10:27 PM
Nanomaterial-induced mitochondrial biogenesis enhances intercellular mitochondrial transfer efficiency
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
A multi-omics molecular landscape of 30 tissues in aging female rhesus macaques
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A multi-omics molecular landscape of 30 tissues in aging female rhesus macaques - Nature Methods
This Resource provides a multi-omic tissue atlas of aging in nonhuman primates.
www.nature.com
November 22, 2025 at 3:08 PM
A multi-omics molecular landscape of 30 tissues in aging female rhesus macaques
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Increased genetic protection against Alzheimer’s disease in centenarians
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Increased genetic protection against Alzheimer’s disease in centenarians - GeroScience
We constructed a polygenic protective score specific to Alzheimer’s disease (AD PPS) based on the current literature among the participants enrolled in five studies of healthy aging and extreme longev...
link.springer.com
November 22, 2025 at 1:28 PM
Increased genetic protection against Alzheimer’s disease in centenarians
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Targeting PURPL RNA enabled rejuvenation of senescence cells via epigenetic reprogramming
translational-medicine.biomedcentral.com/articles/10....
translational-medicine.biomedcentral.com/articles/10....
Targeting PURPL RNA enabled rejuvenation of senescence cells via epigenetic reprogramming - Journal of Translational Medicine
Cellular senescence is a fundamental driver of ageing and age-related diseases, characterized by irreversible growth arrest and profound epigenetic alterations. While long non-coding RNAs (lncRNAs) ha...
translational-medicine.biomedcentral.com
November 21, 2025 at 11:19 PM
Targeting PURPL RNA enabled rejuvenation of senescence cells via epigenetic reprogramming
translational-medicine.biomedcentral.com/articles/10....
translational-medicine.biomedcentral.com/articles/10....
An atlas of mitochondrial ATP synthase activity across the lifespan
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
An atlas of mitochondrial ATP synthase activity across the lifespan
Mitochondrial dysfunction and declining energy production are hallmarks of aging, yet we lack a comprehensive systems-level view of ATP synthase (Comp…
www.sciencedirect.com
November 21, 2025 at 3:14 PM
An atlas of mitochondrial ATP synthase activity across the lifespan
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
miRNA changes with ageing and caloric restriction in male rat skeletal muscle: potential roles in muscle cell function
link.springer.com/article/10.1...
link.springer.com/article/10.1...
miRNA changes with ageing and caloric restriction in male rat skeletal muscle: potential roles in muscle cell function - Biogerontology
The mechanisms underlying skeletal muscle ageing, whilst poorly understood, are thought to involve dysregulated micro (mi)RNA expression. Using young and aged rat skeletal muscle tissue, we applied hi...
link.springer.com
November 20, 2025 at 11:43 PM
miRNA changes with ageing and caloric restriction in male rat skeletal muscle: potential roles in muscle cell function
link.springer.com/article/10.1...
link.springer.com/article/10.1...