Raphaël Pantier
@r-pantier.bsky.social
Group leader @igbmc.bsky.social interested in chromatin and cell fate decisions | Former postdoc in Adrian Bird's lab (University of Edinburgh)
https://www.igbmc.fr/en/recherche/teams/genomic-and-epigenomic-regulation-of-cell-fate
https://www.igbmc.fr/en/recherche/teams/genomic-and-epigenomic-regulation-of-cell-fate
Pinned
TET knockout cells transit between pluripotent states and exhibit precocious germline entry | The EMBO Journal
imageimageThe roles of TET DNA demethylases during early development remain poorly defined.
This work uncovers independence of early mouse embryonic stem cell (ESC) transitions
from TET proteins but a...
www.embopress.org
1/5 Glad to share our latest work with Ian Chambers’ lab published @embojournal.org in which we investigated the role of TET DNA de-methylases during cell fate transitions.
Great team effort, many thanks to Sara Gonzalez Brito @ebarbieri.bsky.social @edinuni-irr.bsky.social
doi.org/10.1038/s443...
Great team effort, many thanks to Sara Gonzalez Brito @ebarbieri.bsky.social @edinuni-irr.bsky.social
doi.org/10.1038/s443...
Reposted by Raphaël Pantier
The IGBMC is recruiting a new Computational Biology Group Leader through the ENACT AI Chair for Scientific Discoveries, covering cancer, developmental, and structural biology. Join one of Europe’s leading life science centers!
cluster-ia-enact.ai/appels-a-pro...
Deadline: Jan 7, 2026
cluster-ia-enact.ai/appels-a-pro...
Deadline: Jan 7, 2026
November 13, 2025 at 9:33 AM
The IGBMC is recruiting a new Computational Biology Group Leader through the ENACT AI Chair for Scientific Discoveries, covering cancer, developmental, and structural biology. Join one of Europe’s leading life science centers!
cluster-ia-enact.ai/appels-a-pro...
Deadline: Jan 7, 2026
cluster-ia-enact.ai/appels-a-pro...
Deadline: Jan 7, 2026
Reposted by Raphaël Pantier
🚀 Excited to share my latest paper on using SHAP, to predict direct target genes of chromatin-associated factors! Check it out for insights into gene regulation and the power of explainable AI in genomics! #XAI #SHAP #Genomics
doi.org/10.1371/jour...
Let's break down what we found! 👇
doi.org/10.1371/jour...
Let's break down what we found! 👇
Modelling transcription with explainable AI uncovers context-specific epigenetic gene regulation at promoters and gene bodies
Author summary Genes are turned on or off through complex processes involving many proteins that interact with DNA wrapped histones and modify their structure. These changes, known as epigenetic modif...
doi.org
October 24, 2025 at 11:37 AM
🚀 Excited to share my latest paper on using SHAP, to predict direct target genes of chromatin-associated factors! Check it out for insights into gene regulation and the power of explainable AI in genomics! #XAI #SHAP #Genomics
doi.org/10.1371/jour...
Let's break down what we found! 👇
doi.org/10.1371/jour...
Let's break down what we found! 👇
1/5 Glad to share our latest work with Ian Chambers’ lab published @embojournal.org in which we investigated the role of TET DNA de-methylases during cell fate transitions.
Great team effort, many thanks to Sara Gonzalez Brito @ebarbieri.bsky.social @edinuni-irr.bsky.social
doi.org/10.1038/s443...
Great team effort, many thanks to Sara Gonzalez Brito @ebarbieri.bsky.social @edinuni-irr.bsky.social
doi.org/10.1038/s443...
TET knockout cells transit between pluripotent states and exhibit precocious germline entry | The EMBO Journal
imageimageThe roles of TET DNA demethylases during early development remain poorly defined.
This work uncovers independence of early mouse embryonic stem cell (ESC) transitions
from TET proteins but a...
www.embopress.org
October 30, 2025 at 4:40 PM
1/5 Glad to share our latest work with Ian Chambers’ lab published @embojournal.org in which we investigated the role of TET DNA de-methylases during cell fate transitions.
Great team effort, many thanks to Sara Gonzalez Brito @ebarbieri.bsky.social @edinuni-irr.bsky.social
doi.org/10.1038/s443...
Great team effort, many thanks to Sara Gonzalez Brito @ebarbieri.bsky.social @edinuni-irr.bsky.social
doi.org/10.1038/s443...
Reposted by Raphaël Pantier
TET knockout cells transit between pluripotent states and exhibit precocious germline entry
Ian Chambers and collaborators
www.embopress.org/doi/full/10....
Ian Chambers and collaborators
www.embopress.org/doi/full/10....
October 27, 2025 at 12:25 PM
TET knockout cells transit between pluripotent states and exhibit precocious germline entry
Ian Chambers and collaborators
www.embopress.org/doi/full/10....
Ian Chambers and collaborators
www.embopress.org/doi/full/10....
Reposted by Raphaël Pantier
👉 The next TriRhena Gene Regulation Club takes place at the Friedrich Miescher Institute @fmiscience.bsky.social in Basel.
📅 Nov. 5th, 2025 (14:00-20:00)
📌 FMI, Basel
✍️ Registration deadline: Oct. 20th, 2025
Attendance is free 💸 , but registration mandatory:
www.ie-freiburg.mpg.de/gene-regulat...
📅 Nov. 5th, 2025 (14:00-20:00)
📌 FMI, Basel
✍️ Registration deadline: Oct. 20th, 2025
Attendance is free 💸 , but registration mandatory:
www.ie-freiburg.mpg.de/gene-regulat...
TriRhena Gene Regulation Club
The TriRhena Gene Regulation Club is a one-day symposium that brings together researchers from France (IGBMC), Germany (MPI-IE) and Switzerland (FMI) who share a common interest in gene regulation.
www.ie-freiburg.mpg.de
September 26, 2025 at 8:02 AM
👉 The next TriRhena Gene Regulation Club takes place at the Friedrich Miescher Institute @fmiscience.bsky.social in Basel.
📅 Nov. 5th, 2025 (14:00-20:00)
📌 FMI, Basel
✍️ Registration deadline: Oct. 20th, 2025
Attendance is free 💸 , but registration mandatory:
www.ie-freiburg.mpg.de/gene-regulat...
📅 Nov. 5th, 2025 (14:00-20:00)
📌 FMI, Basel
✍️ Registration deadline: Oct. 20th, 2025
Attendance is free 💸 , but registration mandatory:
www.ie-freiburg.mpg.de/gene-regulat...
Reposted by Raphaël Pantier
Check out our new collaborative preprint about Affinity-ligand purification of native human low-abundance multi-protein complexes doi.org/10.1101/2025...
Affinity-ligand purification of native human low-abundance multi-protein complexes for structure determination
In human cells, large multi-protein transcription co-activators, such as chromatin remodelers or histone acetyltransferases, play critical roles in gene-expression regulation and are often implicated ...
doi.org
August 12, 2025 at 7:30 AM
Check out our new collaborative preprint about Affinity-ligand purification of native human low-abundance multi-protein complexes doi.org/10.1101/2025...
Reposted by Raphaël Pantier
Genetic gatekeepers of gametogenesis? TET proteins jointly jam germline specification, synergistically steering cells towards somatic fates.
@justingutbio.bsky.social's new #preLight talks about the work of @r-pantier.bsky.social and the team. Have a look!
@justingutbio.bsky.social's new #preLight talks about the work of @r-pantier.bsky.social and the team. Have a look!
TET knockout cells transit between pluripotent states and exhibit precocious germline entry - preLights
Genetic gatekeepers of gametogenesis? TET proteins jointly jam germline specification, synergistically steering cells towards somatic fates.
prelights.biologists.com
August 6, 2025 at 8:58 AM
Genetic gatekeepers of gametogenesis? TET proteins jointly jam germline specification, synergistically steering cells towards somatic fates.
@justingutbio.bsky.social's new #preLight talks about the work of @r-pantier.bsky.social and the team. Have a look!
@justingutbio.bsky.social's new #preLight talks about the work of @r-pantier.bsky.social and the team. Have a look!
Reposted by Raphaël Pantier
Excited to announce I recently highlighted another preprint for @prelights.bsky.social. In this preprint, @r-pantier.bsky.social and co-authors from the Chambers Lab at the University of Edinburgh find that the TET proteins act together to help mammalian cells specify into somatic lineages.
TET knockout cells transit between pluripotent states and exhibit precocious germline entry - preLights
Genetic gatekeepers of gametogenesis? TET proteins jointly jam germline specification, synergistically steering cells towards somatic fates.
prelights.biologists.com
August 5, 2025 at 4:20 PM
Excited to announce I recently highlighted another preprint for @prelights.bsky.social. In this preprint, @r-pantier.bsky.social and co-authors from the Chambers Lab at the University of Edinburgh find that the TET proteins act together to help mammalian cells specify into somatic lineages.
Reposted by Raphaël Pantier
Excited our paper is out in Cell @cp-cell.bsky.social!
🧬⚡ DNA photo-crosslinking proteomics in living cells
🎯 Pinpoints protein-DNA interactions to single amino acids
🌎 Globally quantifies DNA binding for >1800 proteins at a timescale of minutes
🔗 www.cell.com/cell/fulltex...
🧵
🧬⚡ DNA photo-crosslinking proteomics in living cells
🎯 Pinpoints protein-DNA interactions to single amino acids
🌎 Globally quantifies DNA binding for >1800 proteins at a timescale of minutes
🔗 www.cell.com/cell/fulltex...
🧵
The human proteome with direct physical access to DNA
Zero-distance photo-crosslinking reveals direct protein-DNA interactions in living
cells, enabling quantitative analysis of the DNA-interacting proteome on a timescale
of minutes with single-amino-aci...
www.cell.com
May 23, 2025 at 7:06 AM
Excited our paper is out in Cell @cp-cell.bsky.social!
🧬⚡ DNA photo-crosslinking proteomics in living cells
🎯 Pinpoints protein-DNA interactions to single amino acids
🌎 Globally quantifies DNA binding for >1800 proteins at a timescale of minutes
🔗 www.cell.com/cell/fulltex...
🧵
🧬⚡ DNA photo-crosslinking proteomics in living cells
🎯 Pinpoints protein-DNA interactions to single amino acids
🌎 Globally quantifies DNA binding for >1800 proteins at a timescale of minutes
🔗 www.cell.com/cell/fulltex...
🧵
Reposted by Raphaël Pantier
🚨 New preprint out! Do you think Single Molecule Footprinting and Fiber-seq are super cool but aren't sure how to unlock their full potential? HiddenFoot can help you: www.biorxiv.org/content/10.1...
May 17, 2025 at 5:00 PM
🚨 New preprint out! Do you think Single Molecule Footprinting and Fiber-seq are super cool but aren't sure how to unlock their full potential? HiddenFoot can help you: www.biorxiv.org/content/10.1...
Reposted by Raphaël Pantier
Nature research paper: Low overlap of transcription factor DNA binding and regulatory targets
https://go.nature.com/4jedGUz
https://go.nature.com/4jedGUz
Low overlap of transcription factor DNA binding and regulatory targets - Nature
A near-complete survey of transcription factor activities in Saccharomyces cerevisiae reveals that most transcription factors have both activator and repressor activities and limited overlap between their binding sites on DNA and regulation of nearby genes.
go.nature.com
April 17, 2025 at 12:47 PM
Nature research paper: Low overlap of transcription factor DNA binding and regulatory targets
https://go.nature.com/4jedGUz
https://go.nature.com/4jedGUz
Reposted by Raphaël Pantier
🚨3 weeks left to apply!🚨
We’re hiring 2 new Group Leaders at IGBMC – early career researchers welcome
🌟 We offer salary support for up to 3 years while you secure a permanent position in the French system.
Come join an international research environment in Strasbourg!
www.nature.com/naturecareer...
We’re hiring 2 new Group Leaders at IGBMC – early career researchers welcome
🌟 We offer salary support for up to 3 years while you secure a permanent position in the French system.
Come join an international research environment in Strasbourg!
www.nature.com/naturecareer...
Call For Two Group Leader Positions - Strasbourg-Ville, Bas-Rhin (FR) job with IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) | 12837602
The Institute of Genetics, Molecular and Cellular Biology (IGBMC) is seeking two outstanding group leaders to establish independent research teams.
www.nature.com
April 9, 2025 at 11:42 AM
🚨3 weeks left to apply!🚨
We’re hiring 2 new Group Leaders at IGBMC – early career researchers welcome
🌟 We offer salary support for up to 3 years while you secure a permanent position in the French system.
Come join an international research environment in Strasbourg!
www.nature.com/naturecareer...
We’re hiring 2 new Group Leaders at IGBMC – early career researchers welcome
🌟 We offer salary support for up to 3 years while you secure a permanent position in the French system.
Come join an international research environment in Strasbourg!
www.nature.com/naturecareer...
Reposted by Raphaël Pantier
Hey! Check out our latest publication. A great collaboration with @longchrom.bsky.social and a nice example of how a negative result, the absence of a response to a transcriptional perturbation, can actually reveal an intriguing gene-specific buffering mechanism.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
March 31, 2025 at 7:30 AM
Hey! Check out our latest publication. A great collaboration with @longchrom.bsky.social and a nice example of how a negative result, the absence of a response to a transcriptional perturbation, can actually reveal an intriguing gene-specific buffering mechanism.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Raphaël Pantier
Fully funded (at UK home rate) #PhD studentships to start 2025/2026 at University of Exeter, UK. #Chromatin #StemCells #Signalling #ProteinStructure #LineageCommitment #Transcription
Please spread the word, and anyone interested please contact me.
lsi.exeter.ac.uk/groups/hendr...
Please spread the word, and anyone interested please contact me.
lsi.exeter.ac.uk/groups/hendr...
Hendrich Group - Starting Sept 2025 - Living Systems Institute - University of Exeter
LSI PHD studentship – start September 2025 or January 2026 Project 1: Title of Project: Control of chromatin remodeller activity...
lsi.exeter.ac.uk
March 29, 2025 at 8:11 AM
Fully funded (at UK home rate) #PhD studentships to start 2025/2026 at University of Exeter, UK. #Chromatin #StemCells #Signalling #ProteinStructure #LineageCommitment #Transcription
Please spread the word, and anyone interested please contact me.
lsi.exeter.ac.uk/groups/hendr...
Please spread the word, and anyone interested please contact me.
lsi.exeter.ac.uk/groups/hendr...
Reposted by Raphaël Pantier
Come start your lab in beautiful Strasbourg 🇫🇷 www.nature.com/naturecareer...
Call For Two Group Leader Positions - Strasbourg-Ville, Bas-Rhin (FR) job with IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) | 12837602
The Institute of Genetics, Molecular and Cellular Biology (IGBMC) is seeking two outstanding group leaders to establish independent research teams.
www.nature.com
March 22, 2025 at 1:50 PM
Come start your lab in beautiful Strasbourg 🇫🇷 www.nature.com/naturecareer...
Reposted by Raphaël Pantier
Hey! This was the result of a fantastic collaboration with the @longchrom.bsky.social lab, where we found evidence for a gene-specific buffering mechanism to compensate for transcriptional perturbations.
Almost 17 years after opening our yeast cell division lab, our first transcription paper in mouse embryonic stem cells! www.science.org/doi/10.1126/...
March 20, 2025 at 10:32 AM
Hey! This was the result of a fantastic collaboration with the @longchrom.bsky.social lab, where we found evidence for a gene-specific buffering mechanism to compensate for transcriptional perturbations.
Reposted by Raphaël Pantier
Almost 17 years after opening our yeast cell division lab, our first transcription paper in mouse embryonic stem cells! www.science.org/doi/10.1126/...
March 19, 2025 at 6:59 PM
Almost 17 years after opening our yeast cell division lab, our first transcription paper in mouse embryonic stem cells! www.science.org/doi/10.1126/...
Reposted by Raphaël Pantier
We're hiring! The Development & Stem Cells department at @igbmc.bsky.social, Strasbourg 🇫🇷 is recruiting a group leader working in cell & developmental biology. Our Integrated Structural Biology department also has an open call. More details below! + contact me for informal enquiries #sciencejobs
February 28, 2025 at 9:01 AM
We're hiring! The Development & Stem Cells department at @igbmc.bsky.social, Strasbourg 🇫🇷 is recruiting a group leader working in cell & developmental biology. Our Integrated Structural Biology department also has an open call. More details below! + contact me for informal enquiries #sciencejobs
Reposted by Raphaël Pantier
This is not my normal field but it was written by my husband- he is meant to be promoting it but doesn't do social media so you have to make do with me instead 😄
Cohesin as an essential disruptor of chromosome organization: Molecular Cell www.cell.com/molecular-ce...
Cohesin as an essential disruptor of chromosome organization: Molecular Cell www.cell.com/molecular-ce...
Cohesin as an essential disruptor of chromosome organization
Chromosomes are long strings of DNA carrying multiple genes. A chromosomal factor
called cohesin creates loops of DNA proposed to be functional units of the genome.
By contrast, it is proposed here th...
www.cell.com
February 5, 2025 at 12:33 PM
This is not my normal field but it was written by my husband- he is meant to be promoting it but doesn't do social media so you have to make do with me instead 😄
Cohesin as an essential disruptor of chromosome organization: Molecular Cell www.cell.com/molecular-ce...
Cohesin as an essential disruptor of chromosome organization: Molecular Cell www.cell.com/molecular-ce...
Reposted by Raphaël Pantier
The next TriRhena Gene Regulation Club takes place at
IGBMC #Strasbourg. Save your seat & submit a talk. Strengthen your local #epigenetics network & collaborate with peers.
📅 5 Feb. 2025 | 14:00
🎟️ Free entry, registration required
✍️ Register by: 24. Jan.
www.ie-freiburg.mpg.de/gene-regulat...
IGBMC #Strasbourg. Save your seat & submit a talk. Strengthen your local #epigenetics network & collaborate with peers.
📅 5 Feb. 2025 | 14:00
🎟️ Free entry, registration required
✍️ Register by: 24. Jan.
www.ie-freiburg.mpg.de/gene-regulat...
January 14, 2025 at 9:32 AM
The next TriRhena Gene Regulation Club takes place at
IGBMC #Strasbourg. Save your seat & submit a talk. Strengthen your local #epigenetics network & collaborate with peers.
📅 5 Feb. 2025 | 14:00
🎟️ Free entry, registration required
✍️ Register by: 24. Jan.
www.ie-freiburg.mpg.de/gene-regulat...
IGBMC #Strasbourg. Save your seat & submit a talk. Strengthen your local #epigenetics network & collaborate with peers.
📅 5 Feb. 2025 | 14:00
🎟️ Free entry, registration required
✍️ Register by: 24. Jan.
www.ie-freiburg.mpg.de/gene-regulat...
Reposted by Raphaël Pantier
Loved being back in Edinburgh. Such a beautiful city, such great science. Great to catch up with Adrian, @cathyabbott.bsky.social @cellysally.bsky.social @hannahlong.bsky.social @kashyapchhatbar.bsky.social @r-pantier.bsky.social et al. Thanks Cath+Adrian for the hospitality and Congrats Sara!
November 23, 2024 at 8:42 AM
Loved being back in Edinburgh. Such a beautiful city, such great science. Great to catch up with Adrian, @cathyabbott.bsky.social @cellysally.bsky.social @hannahlong.bsky.social @kashyapchhatbar.bsky.social @r-pantier.bsky.social et al. Thanks Cath+Adrian for the hospitality and Congrats Sara!