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prelights.bsky.social
preLights
@prelights.bsky.social
3.2K followers 920 following 190 posts
A preprint highlights service run by the biological community and supported by The Company of Biologists (@biologists.bsky.social).
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prelights.bsky.social
preLights @prelights.bsky.social · Sep 1
🚨 New call for preLighters!🚨

Help us highlight the most exciting biological #preprints. Share your insights, build your profile, and be part of a supportive community! 🌍

Interested? Apply today & help shape the future of science publishing! 📢

More info: prelights.biologists.com/news/join-th...
prelights.bsky.social
GV101 will, GV101 will ROCK you!

Collaborative #preprint from David Herrmann & team
@garvaninstitute.bsky.social describes the impact of a ROCK2-specific inhibitor on both stromal & epithelial cells in the context of triple-negative breast cancer.
#preLight by Sharvari Pitke ⬇️
ROCK2 inhibition has a dual role in reducing ECM remodelling and cell growth, while impairing migration and invasion - preLights
GV101 will, GV101 will ROCK you!
prelights.biologists.com
November 28, 2025 at 2:43 PM
Reposted by preLights
the-node.bsky.social
After his wonderful webinar on ‘Creativity and Science Communication’ for the Node, Anatolii Kozlov @anatoliikozlov.bsky.social shares his thoughts on the process of sharing your science in a way that is unique to you.

Check it out ⤵️: thenode.biologists.com/creativity-a...

#scicomm #creativity
Creativity and Science Communication - the Node
Science communication isn’t just about podcasts or fairs—it’s about making research relatable. Jargon and narrow topics can create barriers, so the challenge is to blend scientific language with every...
thenode.biologists.com
November 27, 2025 at 1:22 PM
prelights.bsky.social
Not aspartate production or redox control, but a secret third thing: Aspartate transaminases may be important for epigenetic regulation during erythropoiesis🩸

Hannah Pletcher covers work from Narges Pourmandi &colleagues @lyssiotislab.bsky.social
#preLight⬇️
prelights.biologists.com/highlights/a...
Aspartate transaminases are required for blood development - preLights
Not aspartate production or redox control, but a secret third thing: Aspartate transaminases may be important for epigenetic regulation during erythropoiesis.
prelights.biologists.com
November 27, 2025 at 3:04 PM
prelights.bsky.social
When geometry isn’t enough, actin helps plant cells decide where to divide, ensuring robust tissue patterning. 🌱 #PlantBiology

Goldy & team uncover a central role for F-actin as a cortical landmark.

#preLight by Jeny Jose @umeaplantsciencecentre.se ⬇️ 👀
prelights.biologists.com/highlights/a...
Actin Counters Geometry to Guide Plant Cell Division - preLights
When geometry isn’t enough, actin helps plant cells decide where to divide, ensuring robust tissue patterning
prelights.biologists.com
November 27, 2025 at 10:42 AM
prelights.bsky.social
The challenge of diagnosing Schistosoma haematobium infections in school-aged children in SW Nigeria

@halataha.bsky.social highlights important work underscoring the urgent need for improved diagnostics & interventions in endemic regions #preprint
#preLight⬇️
prelights.biologists.com/highlights/s...
Schistosoma haematobium DNA and Eggs in the Urine Sample of School-Age Children (SAC) in South-West Nigeria - preLights
Schistosoma haematobium DNA & eggs detected in urine of school-aged children in SW Nigeria. Findings underscore the urgent need for improved diagnostics & interventions in endemic regions.
prelights.biologists.com
November 26, 2025 at 2:14 PM
prelights.bsky.social
Battling the TB blues...😷

A pharmacokinetic-pharmacodynamic approach by Aguilar-Ayala & colleagues #IMI_ERA4TB to characterise the activity of TBAJ-587 and its metabolites. #preprint #pharmacology

Latest #preLight from @goh-zhanghe.bsky.social ⬇️👀
prelights.biologists.com/highlights/i...
In vitro pharmacokinetics and pharmacodynamics of the diarylquinoline TBAJ-587 and its metabolites against Mycobacterium tuberculosis - preLights
Battling the TB blues: a pharmacokinetic-pharmacodynamic approach by Aguilar-Ayala and colleagues to characterise the activity of TBAJ-587 and its metabolites
prelights.biologists.com
November 25, 2025 at 4:44 PM
prelights.bsky.social
Exposing hydrophilic residues pushes misfolded ER proteins towards degradation. 🗑️

Ana Sanchez-Molina: “…this study reshapes our understanding of protein quality control…” #preprint from Rudolf Pisa & Tom A. Rapoport #HarvardMed

#preLight ⬇️ 👀
prelights.biologists.com/highlights/l...
Lipid bilayer thinning near a ubiquitin ligase selects ER membrane proteins for degradation - preLights
Exposing hydrophilic residues pushes misfolded ER proteins towards degradation.
prelights.biologists.com
November 25, 2025 at 10:20 AM
prelights.bsky.social
How an immature glymphatic system fails to suppress #Zika virus infection in the brain 🧠

Jimeng Li highlights work from Jhulimar Guilherme Doerl & colleagues #ufrnbr #preprint

Check out the #preLight! ⬇️ 👀
prelights.biologists.com/highlights/m...
Maturation of the glymphatic system confers innate resistance of the brain to Zika virus infection - preLights
The necessary wait – How an immature glymphatic system fails to suppress Zika virus infection in the brain
prelights.biologists.com
November 24, 2025 at 3:04 PM
Reposted by preLights
clytia-vlfr.bsky.social
Drawing together findings from several projects over many years, we make a case that neural cell types in the Clytia larva have two embryological origins: i-cells and ectodermal.
bioRxiv 2025.11.17.688882; doi: doi.org/10.1101/2025...
Separation of the Early gastrula into oral and aboral halves shows that some neural cell tupes derive from aboral ectoderm, and others from i-cells
November 19, 2025 at 7:43 AM
prelights.bsky.social
On how Vangl2 shapes the heart❤️

Planar cell polarity protein, Vangl2, goes out of its way to shape the heart through a planar polarity-independent mechanism. #preprint from the team of @meilhacsigolene.bsky.social

#preLight by @prakash-patterns.bsky.social⬇️
prelights.biologists.com/highlights/v...
VANGL2 shapes the mouse heart tube from adjacent epithelia and without planar polarity - preLights
Planar cell polarity protein, Vangl2, goes out of its way to shape the heart through a planar polarity-independent mechanism.
prelights.biologists.com
November 20, 2025 at 12:04 PM
prelights.bsky.social
Reliable actin labelling in expansion #microscopy 🔬

Beautiful #preprint from Olivier Mercey, @lreymond.bsky.social & team @dudinlab.bsky.social @centriolelab.bsky.social

Read the latest #preLight from @kanishka03.bsky.social ⬇️👀
prelights.biologists.com/highlights/h...
HAK-actin, U-ExM-compatible probe to image the actin cytoskeleton - preLights
HAK-actin is a new probe that may help researchers see the actin cytoskeleton in sharper detail using expansion microscopy.
prelights.biologists.com
November 19, 2025 at 11:58 AM
prelights.bsky.social
A deep dive into how transcription factors shape radial glia fate and clonal dynamics.

Manuel Lessi: this work “combines the strengths of primary cultures and pooled CRISPRi perturbation”. #preprint Jingwen Ding & team @brainevodevo.bsky.social

#preLight ⬇️
prelights.biologists.com/highlights/d...
Dissecting Gene Regulatory Networks Governing Human Cortical Cell Fate - preLights
A deep dive into how transcription factors shape radial glia fate and clonal dynamics
prelights.biologists.com
November 18, 2025 at 11:59 AM
prelights.bsky.social
Those who migrate together, develop together.

Marsupial cranial neural crest cells migrate as epithelial-like sheets to form craniofacial structures. #preprint from Axel Newton & team #PaskLab #DevBio

#prelight by Heather Pollington ⬇️👀
prelights.biologists.com/highlights/g...
Getting a head start: Craniofacial heterochrony in marsupials involves dynamic changes to molecular and cellular mechanisms underlying neural crest development - preLights
Those who migrate together, develop together: Marsupial cranial neural crest cells migrate as epithelial-like sheets to form craniofacial structures, providing a potential mechanism that promotes acce...
prelights.biologists.com
November 17, 2025 at 1:36 PM
prelights.bsky.social
How do endothelial cells differ across tissues?

🗺️ A new single-cell atlas of over 3 million cells shows how microenvironmental signals shape endothelial diversity. #preprint from Kaifu Chen & team

#preLight by Charis Qi ⬇️👀
prelights.biologists.com/highlights/h...
Human single-cell atlas analysis reveals heterogeneous endothelial signaling - preLights
How do endothelial cells differ across tissues? A new single-cell atlas of over 3 million cells shows how microenvironmental signals shape endothelial diversity.
prelights.biologists.com
November 13, 2025 at 4:08 PM
prelights.bsky.social
Another two preLights resulting from the preprint review initiative led by Marcus Oliveira #UFRJ #Brazil

1️⃣ How tinkering with a basic energy pathway in cells can unexpectedly switch off key immune signals.

#preLight by Yan Aveiro dos Reis ⬇️👀
prelights.biologists.com/highlights/i...
Inhibition of NF-κB Signaling by the Reactive Glycolytic Metabolite Methylglyoxal - preLights
This research uncovers how tinkering with a basic energy pathway in cells can unexpectedly switch off key immune signals—pointing to new ways of controlling inflammation and even cancer.
prelights.biologists.com
November 13, 2025 at 2:21 PM
prelights.bsky.social
Do you love the monthly #preprint lists on @the-node.bsky.social?

Good news, our #preLighters have teamed up with the Node to nominate standout articles and share one-paragraph insights on why they’re excited.

Check out their October highlights ⬇️ 👀
thenode.biologists.com/prelighters-...
November 13, 2025 at 12:35 PM
Reposted by preLights
the-node.bsky.social
You must have been looking forward to... October in preprints!

Check out the latest #preprints on #DevBio, #StemCell biology and related topics with, starting this month, @prelights.bsky.social picks 👇👀

thenode.biologists.com/october-in-p...
October in preprints - the Node
Welcome to our monthly trawl for developmental and stem cell biology (and related) preprints. The preprints this month are hosted on bioRxiv.
thenode.biologists.com
November 13, 2025 at 12:30 PM
Reposted by preLights
the-node.bsky.social
Our next #DevPres webinar focusses on regeneration with talks from Stephanie Tsai and Ben Cox @beeeencox.bsky.social.

📆Wed 19 November
🕓16:00 GMT/UTC

For more info and to register: thenode.biologists.com/development-...
November 12, 2025 at 10:15 AM
prelights.bsky.social
Introducing an “identifiability-guided assessment” framework & applying it to longitudinal Alzheimer’s datasets. 🧠

My Nguyen highlights important work from Juliet Jiang & team #ADNI3study

#neuroscience #preLight ⬇️

prelights.biologists.com/highlights/i...
Identifiability-Guided Assessment of Digital Twins in Alzheimer’s Disease Clinical Research and Care - preLights
The authors present an “identifiability-guided assessment” framework—a new approach to pinpoint which parameters in a personalized digital twin model can be confidently trusted.
prelights.biologists.com
November 11, 2025 at 12:39 PM
prelights.bsky.social
Do you love fashion shows?

Well, chicken’s MHC class II is an immune fashion icon that presents the same viral peptide to T cells in both a 9- and 10-amino acid outfit. 📸✨ #preprint #immunology

First solo #preLight from Mitchell Sarmie ⬇️ 👀
prelights.biologists.com/highlights/a...
A major histocompatibility complex (MHC) class II molecule that binds the same viral pathogen peptide with both nonamer and decamer core sequences for presentation to T cells - preLights
Do you love fashion shows? Well, chicken’s MHC class II is an immune fashion icon that presents the same viral peptide to T cells in both a 9- and 10-amino acid outfit.
prelights.biologists.com
November 10, 2025 at 4:11 PM
Reposted by preLights
biologists.bsky.social
This year we are celebrating our 100-year anniversary. Discover some of the most important milestones on our 100-year timeline: www.biologists.com/100-years/ti...
100 years timeline
Back to 100 years anniversary page
www.biologists.com
November 10, 2025 at 8:56 AM
prelights.bsky.social
Mass extinction can be detected in phylogenetic trees that have been estimated using flawed methodologies.

@tomacarruthers.bsky.social discusses a #preprint from Minghao Du & team @ibensens.bsky.social

#evolution #paleontology

#preLight ⬇️
prelights.biologists.com/highlights/e...
Evaluating the impact and detectability of mass extinctions on total-evidence dating - preLights
Mass extinction can be detected in phylogenetic trees that have been estimated using flawed methodologies.
prelights.biologists.com
November 10, 2025 at 3:56 PM
prelights.bsky.social
Not one, but two new posts from Mohammed Jalloh 🙌

1️⃣ Designing protein binders computationally requires more than just filling in histidines—you need smarter placement of histidine & other charged amino acids #preprint @uwproteindesign.bsky.social

#preLight⬇️
prelights.biologists.com/highlights/c...
Computational design of pH-sensitive binders - preLights
Designing protein binders computationally requires more than just filling in histidines—you need smarter placement of histidine and other charged amino acids to get truly pH-sensitive protein interact...
prelights.biologists.com
November 6, 2025 at 12:14 PM
Reposted by preLights
leopoldparts.bsky.social
New 🧬✂️ pre-print! We show that paired prime editing can efficiently generate large deletions — even >1 Mb — with high precision and at scale. We use this to perform the first pooled prime deletion screen across the human genome.

🔗 biorxiv.org/content/10.1...

A short thread (by Juliane Weller)👇
Generating long deletions across the genome with pooled paired prime editing screens
Engineered deletions are a powerful probe for studying genome architecture, function, and regulation. Yet, the lack of effective methods to create them in large numbers and at multi-kilobase scale has...
biorxiv.org
November 5, 2025 at 2:17 PM
prelights.bsky.social
The physics behind the immune response: focus on viscoelasticity

@ramadio.bsky.social covers a #mooneylab #preprint

"In this work, the authors devise a system capable of tuning viscoelasticity of collagen I independently of stiffness..."

#preLight ⬇️
prelights.biologists.com/highlights/m...
Matrix viscoelasticity regulates dendritic cell migration and immune priming - preLights
The physics behind the immune response: focus on viscoelasticity
prelights.biologists.com
November 5, 2025 at 2:52 PM