Ethan (Chee Kiang) Ewe
@ethanewe.bsky.social
Postdoc, firstgen, scientist, worm breeder, cats dad 🏳️🌈
Pinned
🔥my latest paper from @odedrechavi.bsky.social lab🔥
we found small RNAs act across tissues to regulate fertlity in C. elegans 🪱. Surprisingly, we also found that O2-sensing neurons inhibit germline maintenance. Follow along our journey👇https://www.biorxiv.org/content/10.1101/2025.08.07.669182v1
we found small RNAs act across tissues to regulate fertlity in C. elegans 🪱. Surprisingly, we also found that O2-sensing neurons inhibit germline maintenance. Follow along our journey👇https://www.biorxiv.org/content/10.1101/2025.08.07.669182v1
Reposted by Ethan (Chee Kiang) Ewe
such a fantastic gang <3
Great day with these certified knuckleheads that are absolutely the best (and future) of their fields 🧪 @ethanewe.bsky.social @marliesoomen.bsky.social @giuliapaci.bsky.social @amjeve.bsky.social @maxfarnworth.bsky.social @anzymiller.bsky.social Martina and Toshi
December 8, 2025 at 8:50 PM
such a fantastic gang <3
Reposted by Ethan (Chee Kiang) Ewe
Great day with these certified knuckleheads that are absolutely the best (and future) of their fields 🧪 @ethanewe.bsky.social @marliesoomen.bsky.social @giuliapaci.bsky.social @amjeve.bsky.social @maxfarnworth.bsky.social @anzymiller.bsky.social Martina and Toshi
December 8, 2025 at 8:41 PM
Great day with these certified knuckleheads that are absolutely the best (and future) of their fields 🧪 @ethanewe.bsky.social @marliesoomen.bsky.social @giuliapaci.bsky.social @amjeve.bsky.social @maxfarnworth.bsky.social @anzymiller.bsky.social Martina and Toshi
Reposted by Ethan (Chee Kiang) Ewe
Reposted by Ethan (Chee Kiang) Ewe
Our Lab @ NCBS, Bangalore is hiring PhD students!
If you’re excited about cell & developmental biology, tissue mechanics, and imaging — come join us! We use C. elegans to uncover how forces shape organs 🧫🔬
CSIR/DBT/ICMR fellowship holders encouraged to apply!Apply 👉 lnkd.in/gr9EUHnp
If you’re excited about cell & developmental biology, tissue mechanics, and imaging — come join us! We use C. elegans to uncover how forces shape organs 🧫🔬
CSIR/DBT/ICMR fellowship holders encouraged to apply!Apply 👉 lnkd.in/gr9EUHnp
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
December 8, 2025 at 10:55 AM
Our Lab @ NCBS, Bangalore is hiring PhD students!
If you’re excited about cell & developmental biology, tissue mechanics, and imaging — come join us! We use C. elegans to uncover how forces shape organs 🧫🔬
CSIR/DBT/ICMR fellowship holders encouraged to apply!Apply 👉 lnkd.in/gr9EUHnp
If you’re excited about cell & developmental biology, tissue mechanics, and imaging — come join us! We use C. elegans to uncover how forces shape organs 🧫🔬
CSIR/DBT/ICMR fellowship holders encouraged to apply!Apply 👉 lnkd.in/gr9EUHnp
Reposted by Ethan (Chee Kiang) Ewe
PHA-4/FoxA controls the function of pharyngeal and extrapharyngeal enteric neurons in C. elegans
genesdev.cshlp.org/content/earl...
genesdev.cshlp.org/content/earl...
PHA-4/FoxA controls the function of pharyngeal and extrapharyngeal enteric neurons in C. elegans
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
genesdev.cshlp.org
December 7, 2025 at 6:18 AM
PHA-4/FoxA controls the function of pharyngeal and extrapharyngeal enteric neurons in C. elegans
genesdev.cshlp.org/content/earl...
genesdev.cshlp.org/content/earl...
Reposted by Ethan (Chee Kiang) Ewe
We’re tackling inequalities in research & publishing.
See what we’ve achieved in the last 6 months & what’s next for 2025 👇
buff.ly/2GIgGPH
See what we’ve achieved in the last 6 months & what’s next for 2025 👇
buff.ly/2GIgGPH
December 6, 2025 at 7:15 PM
We’re tackling inequalities in research & publishing.
See what we’ve achieved in the last 6 months & what’s next for 2025 👇
buff.ly/2GIgGPH
See what we’ve achieved in the last 6 months & what’s next for 2025 👇
buff.ly/2GIgGPH
Reposted by Ethan (Chee Kiang) Ewe
WormTagDB: A Systematic Survey of Endogenously Tagged Proteins in C. elegans and Roadmap Towards the Tagged Proteome https://www.biorxiv.org/content/10.64898/2025.12.02.691955v1
December 5, 2025 at 9:32 PM
WormTagDB: A Systematic Survey of Endogenously Tagged Proteins in C. elegans and Roadmap Towards the Tagged Proteome https://www.biorxiv.org/content/10.64898/2025.12.02.691955v1
Reposted by Ethan (Chee Kiang) Ewe
Nature research paper: Dated gene duplications elucidate the evolutionary assembly of eukaryotes
go.nature.com/4azJDF8
go.nature.com/4azJDF8
Dated gene duplications elucidate the evolutionary assembly of eukaryotes - Nature
Analysis of eukaryotic gene sequences using a relaxed molecular clock methodology indicate that eukaryotes emerged 3.0–2.25 billion years ago as a result of mitochondrial endosymbiosis with complex archaea that already possessed an elaborated cytoskeleton, membrane trafficking, endomembrane, phagocytotic machinery and a nucleus.
go.nature.com
December 5, 2025 at 9:18 AM
Nature research paper: Dated gene duplications elucidate the evolutionary assembly of eukaryotes
go.nature.com/4azJDF8
go.nature.com/4azJDF8
I met the most wonderful peer group through this program!
A path to success: Development's Pathway to Independence programme
In this Perspective, @ingridtsang.bsky.social discusses how our Pathway to Independence (PI) programme helps postdocs establish their own labs and showcases the progress of our inaugural 2023 fellows.
doi.org/10.1242/dev....
In this Perspective, @ingridtsang.bsky.social discusses how our Pathway to Independence (PI) programme helps postdocs establish their own labs and showcases the progress of our inaugural 2023 fellows.
doi.org/10.1242/dev....
December 3, 2025 at 5:04 PM
I met the most wonderful peer group through this program!
Reposted by Ethan (Chee Kiang) Ewe
December 3, 2025 at 5:00 PM
Reposted by Ethan (Chee Kiang) Ewe
A path to success: Development's Pathway to Independence programme
In this Perspective, @ingridtsang.bsky.social discusses how our Pathway to Independence (PI) programme helps postdocs establish their own labs and showcases the progress of our inaugural 2023 fellows.
doi.org/10.1242/dev....
In this Perspective, @ingridtsang.bsky.social discusses how our Pathway to Independence (PI) programme helps postdocs establish their own labs and showcases the progress of our inaugural 2023 fellows.
doi.org/10.1242/dev....
December 3, 2025 at 5:00 PM
A path to success: Development's Pathway to Independence programme
In this Perspective, @ingridtsang.bsky.social discusses how our Pathway to Independence (PI) programme helps postdocs establish their own labs and showcases the progress of our inaugural 2023 fellows.
doi.org/10.1242/dev....
In this Perspective, @ingridtsang.bsky.social discusses how our Pathway to Independence (PI) programme helps postdocs establish their own labs and showcases the progress of our inaugural 2023 fellows.
doi.org/10.1242/dev....
Reposted by Ethan (Chee Kiang) Ewe
#Celegans adapts to starvation & other stressors by transiting through the quiescent #dauer stage, but how? This study shows that TOR activity is inhibited by AMPK & a novel RNA-binding helicase in the #GermLine during dauer, preserving developmental quiescence @plosbiology.org 🧪 plos.io/48NEHvc
December 3, 2025 at 1:51 PM
#Celegans adapts to starvation & other stressors by transiting through the quiescent #dauer stage, but how? This study shows that TOR activity is inhibited by AMPK & a novel RNA-binding helicase in the #GermLine during dauer, preserving developmental quiescence @plosbiology.org 🧪 plos.io/48NEHvc
Reposted by Ethan (Chee Kiang) Ewe
We built this site to allow you to probe our single-nucleus RNA-seq data for adult #Celegans neurons (wt & daf-2 herms, and wt males v herms): cestaan.princeton.edu
and a microPub about how to use it: www.micropublication.org/journals/bio...
We hope the #Celegans community finds it useful! 🧪
and a microPub about how to use it: www.micropublication.org/journals/bio...
We hope the #Celegans community finds it useful! 🧪
CeSTAAN: An atlas of C. elegans adult neurons for fast queries of single-nucleus RNA sequencing data | microPublication
www.micropublication.org
December 1, 2025 at 3:44 PM
We built this site to allow you to probe our single-nucleus RNA-seq data for adult #Celegans neurons (wt & daf-2 herms, and wt males v herms): cestaan.princeton.edu
and a microPub about how to use it: www.micropublication.org/journals/bio...
We hope the #Celegans community finds it useful! 🧪
and a microPub about how to use it: www.micropublication.org/journals/bio...
We hope the #Celegans community finds it useful! 🧪
Reposted by Ethan (Chee Kiang) Ewe
Pleased to share our latest work by Annesha Ghosh. Using genetic screens, we identify that the deubiquitinase USP-14 regulates innate immunity in C. elegans.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Deubiquitinase USP-14 controls intestinal distension-induced immune activation in Caenorhabditis elegans via Wnt/β-catenin signaling
Pathogen infections disrupt multiple host cellular processes, and hosts have consequently evolved mechanisms to detect these perturbations and initiate appropriate immune responses. In Caenorhabditis ...
www.biorxiv.org
November 29, 2025 at 1:31 AM
Pleased to share our latest work by Annesha Ghosh. Using genetic screens, we identify that the deubiquitinase USP-14 regulates innate immunity in C. elegans.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Ethan (Chee Kiang) Ewe
sept-1/zina-1 is an Ancient Toxin-Antidote System in Caenorhabditis elegans https://www.biorxiv.org/content/10.1101/2025.11.28.691152v1
December 1, 2025 at 3:20 AM
sept-1/zina-1 is an Ancient Toxin-Antidote System in Caenorhabditis elegans https://www.biorxiv.org/content/10.1101/2025.11.28.691152v1
Reposted by Ethan (Chee Kiang) Ewe
What happens to the germline under heat stress?
New study in #G3journal shows how wild-type #Celegans increase their germline apoptosis levels from the physiological baseline in response to moderate temperature stress to maintain fertility. buff.ly/SXdoQFA
New study in #G3journal shows how wild-type #Celegans increase their germline apoptosis levels from the physiological baseline in response to moderate temperature stress to maintain fertility. buff.ly/SXdoQFA
November 27, 2025 at 2:02 PM
What happens to the germline under heat stress?
New study in #G3journal shows how wild-type #Celegans increase their germline apoptosis levels from the physiological baseline in response to moderate temperature stress to maintain fertility. buff.ly/SXdoQFA
New study in #G3journal shows how wild-type #Celegans increase their germline apoptosis levels from the physiological baseline in response to moderate temperature stress to maintain fertility. buff.ly/SXdoQFA
Reposted by Ethan (Chee Kiang) Ewe
All hail Caenorhabditis elegans, one of the most researched organisms on Earth. Collaborative data sharing in the nematode research community led to four Nobel Prize-winning discoveries about human development and disease. In PNAS: https://ow.ly/uNqU50Xyj4e
November 26, 2025 at 7:01 PM
All hail Caenorhabditis elegans, one of the most researched organisms on Earth. Collaborative data sharing in the nematode research community led to four Nobel Prize-winning discoveries about human development and disease. In PNAS: https://ow.ly/uNqU50Xyj4e
Reposted by Ethan (Chee Kiang) Ewe
Genetic and environmental interactions outweigh mitonuclear coevolution for complex traits in Drosophila https://www.biorxiv.org/content/10.1101/2025.11.24.689096v1
November 26, 2025 at 5:32 AM
Genetic and environmental interactions outweigh mitonuclear coevolution for complex traits in Drosophila https://www.biorxiv.org/content/10.1101/2025.11.24.689096v1
Reposted by Ethan (Chee Kiang) Ewe
One of the most-viewed PNAS articles in the last week is “Neurodevelopmental disorder–linked Argonaute mutations permit delayed RISC formation and unusual shortening of miRNAs by 3′→5′ trimming.” Explore now: https://ow.ly/hwP450XxHM6
For more trending articles, visit https://ow.ly/q6Cl50XxHGN.
For more trending articles, visit https://ow.ly/q6Cl50XxHGN.
November 25, 2025 at 10:00 PM
One of the most-viewed PNAS articles in the last week is “Neurodevelopmental disorder–linked Argonaute mutations permit delayed RISC formation and unusual shortening of miRNAs by 3′→5′ trimming.” Explore now: https://ow.ly/hwP450XxHM6
For more trending articles, visit https://ow.ly/q6Cl50XxHGN.
For more trending articles, visit https://ow.ly/q6Cl50XxHGN.
Reposted by Ethan (Chee Kiang) Ewe
Interventions that promote healthy #aging differ in their effectiveness between individuals. This #Celegans study shows that the effect of a pro- #longevity intervention can be strongly influenced by early-life #splicing factor activity & metabolic landscape @plosbiology.org 🧪 plos.io/49AxSOv
November 25, 2025 at 5:33 PM
Interventions that promote healthy #aging differ in their effectiveness between individuals. This #Celegans study shows that the effect of a pro- #longevity intervention can be strongly influenced by early-life #splicing factor activity & metabolic landscape @plosbiology.org 🧪 plos.io/49AxSOv
Reposted by Ethan (Chee Kiang) Ewe
Our results also uncover an even deeper principle. Nematode and plant F-box proteins are thought to engage in arms races with parasitic elements. In this conflict, accidental targeting of self-proteins is inevitable—making the birth of selfish genes a by-product of innate immunity.
November 24, 2025 at 1:03 PM
Our results also uncover an even deeper principle. Nematode and plant F-box proteins are thought to engage in arms races with parasitic elements. In this conflict, accidental targeting of self-proteins is inevitable—making the birth of selfish genes a by-product of innate immunity.
Reposted by Ethan (Chee Kiang) Ewe
🪱 Selfish genes are everywhere and drive some of biology’s biggest innovations (CRISPR, antibody recombination, epigenetics). Yet almost no one asks the obvious question: how does a selfish gene begin? Our new manuscript uncovers how selfishness can emerge directly from the host genome.
November 24, 2025 at 1:03 PM
🪱 Selfish genes are everywhere and drive some of biology’s biggest innovations (CRISPR, antibody recombination, epigenetics). Yet almost no one asks the obvious question: how does a selfish gene begin? Our new manuscript uncovers how selfishness can emerge directly from the host genome.
Reposted by Ethan (Chee Kiang) Ewe
From nematode to Nobel: How community-shared resources fueled the rise of Caenorhabditis elegans as a research organism - a perspective written by 11 scientists, six of whom are Nobel laureates
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
November 24, 2025 at 11:08 PM
From nematode to Nobel: How community-shared resources fueled the rise of Caenorhabditis elegans as a research organism - a perspective written by 11 scientists, six of whom are Nobel laureates
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Love this!
Recurrent evolution of selfishness from an essential tRNA synthetase in Caenorhabditis tropicalis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Recurrent evolution of selfishness from an essential tRNA synthetase in Caenorhabditis tropicalis - Nature Ecology & Evolution
In Caenorhabditis tropicalis, three toxin–antidote elements arose via gene duplication from the essential tRNA-synthetase subunit FARS-3. The ancestral antidote probably acquired affinity for FARS-3, ...
www.nature.com
November 23, 2025 at 4:57 PM
Love this!
Reposted by Ethan (Chee Kiang) Ewe
The students in my "Working with the Worm" course had an in-lab session where they went from picking their first worm to DAPI staining all in the span of 2 hours! Here's a poster on C. elegans life stages created from their awesome DAPI-stained worms :)
November 21, 2025 at 9:14 PM
The students in my "Working with the Worm" course had an in-lab session where they went from picking their first worm to DAPI staining all in the span of 2 hours! Here's a poster on C. elegans life stages created from their awesome DAPI-stained worms :)