Prateek GV
@prateekgv.bsky.social
data scientist @calico life sciences. fan of @arsenal football club. powered by research and coffee.
Reposted by Prateek GV
Three years ago, we showed ~70% of lifespan variation in yeast traces to rDNA copy number. Ribosomal DNA, encoded as 5S and 45S subunits in hundreds of copies, vary substantially across humans. Does this copy number variation, and sequence variation within these paralogs, matter for humans?
January 22, 2026 at 5:39 PM
Three years ago, we showed ~70% of lifespan variation in yeast traces to rDNA copy number. Ribosomal DNA, encoded as 5S and 45S subunits in hundreds of copies, vary substantially across humans. Does this copy number variation, and sequence variation within these paralogs, matter for humans?
Reposted by Prateek GV
🌍 Birds have the highest blood glucose levels of any vertebrate group.
So, how do birds resist the harmful effects of high blood sugar and glycation?
So, how do birds resist the harmful effects of high blood sugar and glycation?
A bird’s sweet deal
Analysis of 88 bird species reveals that those with higher blood glucose levels appear to be able to resist one of the harmful effects of glucose.
buff.ly
June 14, 2025 at 10:44 PM
🌍 Birds have the highest blood glucose levels of any vertebrate group.
So, how do birds resist the harmful effects of high blood sugar and glycation?
So, how do birds resist the harmful effects of high blood sugar and glycation?
Reposted by Prateek GV
OUT NOW: Gut metagenomes reveal interactions between dietary restriction, ageing and the microbiome in genetically diverse mice
#microsky #microbiomesky 🧪
www.nature.com/articles/s41...
#microsky #microbiomesky 🧪
www.nature.com/articles/s41...
Gut metagenomes reveal interactions between dietary restriction, ageing and the microbiome in genetically diverse mice - Nature Microbiology
Using a cohort of nearly 1,000 genetically diverse mice undergoing dietary restriction over the lifespan, the authors reveal numerous insights into the interactions between the gut microbiome, host ge...
www.nature.com
March 31, 2025 at 5:09 PM
OUT NOW: Gut metagenomes reveal interactions between dietary restriction, ageing and the microbiome in genetically diverse mice
#microsky #microbiomesky 🧪
www.nature.com/articles/s41...
#microsky #microbiomesky 🧪
www.nature.com/articles/s41...
Reposted by Prateek GV
New brain aging study is out today in Nature
The largest single-cell RNA seq dataset of mouse brain aging reveals incredible insights and could pave the way for future therapies to slow or manage the impacts of the aging process. 🧵 #studyBRAIN
The largest single-cell RNA seq dataset of mouse brain aging reveals incredible insights and could pave the way for future therapies to slow or manage the impacts of the aging process. 🧵 #studyBRAIN
January 1, 2025 at 5:07 PM
New brain aging study is out today in Nature
The largest single-cell RNA seq dataset of mouse brain aging reveals incredible insights and could pave the way for future therapies to slow or manage the impacts of the aging process. 🧵 #studyBRAIN
The largest single-cell RNA seq dataset of mouse brain aging reveals incredible insights and could pave the way for future therapies to slow or manage the impacts of the aging process. 🧵 #studyBRAIN
Reposted by Prateek GV
My book is (at last) out, just in time for Christmas!
A blog post to celebrate and present it: francisbach.com/my-book-is-o...
A blog post to celebrate and present it: francisbach.com/my-book-is-o...
December 21, 2024 at 3:23 PM
My book is (at last) out, just in time for Christmas!
A blog post to celebrate and present it: francisbach.com/my-book-is-o...
A blog post to celebrate and present it: francisbach.com/my-book-is-o...
Reposted by Prateek GV
Thrilled to see this paper out!! 🧪
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Spatial transcriptomic clocks reveal cell proximity effects in brain ageing
Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...
rdcu.be
December 18, 2024 at 10:40 PM
Thrilled to see this paper out!! 🧪
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Reposted by Prateek GV
If you do GWAS or rare variant association studies, check out this short thread on the concept of SPECIFICITY, and why it is a major determinant of what we find:
Why do association studies prioritize trait-specific variants???
A quick thread about the importance of thinking about all traits at once 👇 1/6 (🧪🧬)
A quick thread about the importance of thinking about all traits at once 👇 1/6 (🧪🧬)
December 17, 2024 at 3:41 PM
If you do GWAS or rare variant association studies, check out this short thread on the concept of SPECIFICITY, and why it is a major determinant of what we find:
Reposted by Prateek GV
A collection published across Nature Portfolio journals presents early draft maps of cells in the human body from the Human Cell Atlas initiative. The research leverages new data and analytical tools to aid our understanding of human health and disease at a cellular level. 🧪
The Human Cell Atlas: towards a first draft atlas
In a collection of research articles and related content, the Human Cell Atlas consortium presents tools, data and ideas towards the generation of their first draft atlas of cells in the human body.
go.nature.com
November 20, 2024 at 4:50 PM
A collection published across Nature Portfolio journals presents early draft maps of cells in the human body from the Human Cell Atlas initiative. The research leverages new data and analytical tools to aid our understanding of human health and disease at a cellular level. 🧪