Here, the authors show how HSV-1 rewires the host cell’s chromatin architecture during lytic infection by hijacking transcription machinery and forming contacts between viral and host genomes.

Nature Reviews Molecular Cell Biology - Pia Cosma recounts the development of STORM, which was the first microscopy method to break the diffraction limit of light.

Nature Reviews Molecular Cell Biology, Published online: 06 May 2025; doi:10.1038/s41580-025-00856-xPia Cosma recounts the development of STORM, which was the first microscopy method to break the diffraction limit of light.

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Background The regulation of chromatin accessibility is essential in eukaryotic cells as one of several mechanisms that ensure gene activation occurs at appropriate times and in appropriate cell types...

The complex life cycle of the malaria parasite Plasmodium falciparum involves several major differentiation stages, each requiring strict control of gene expression. Fundamental changes in chromatin structure and epigenetic modifications during life cycle progression suggest a central role for these mechanisms in regulating the transcriptional program of malaria parasite development1–6. P. falciparum chromatin is distinct from other eukaryotes, with an extraordinarily high AT content (>80%)7 and highly divergent histones resulting in atypical DNA packaging properties8. Moreover, the chromatin remodellers that are critical for shaping chromatin structure are not conserved and are unexplored in P. falciparum. Here we identify P. falciparum Snf2L (PfSnf2L, encoded by PF3D7_1104200) as an ISWI-related ATPase that actively repositions P. falciparum nucleosomes in vitro. Our results demonstrate that PfSnf2L is essential, regulating both asexual development and sexual differentiation. PfSn

Structural maintenance of chromosomes (SMC) complexes are thought to shape genomes by extruding DNA loops, but recent genetic tests have challenged the “loop extrusion hypothesis.” Here, Uhlmann explores whether SMC complexes might form chromatin loops by sequential DNA-DNA capture, akin to how cohesin establishes sister chromatid cohesion.

Higher-order chromatin structure and DNA methylation are critical for gene regulation, but how these vary across the human body remains unclear. We performed multi-omic profiling of 3D genome structur...

Fibroblastic reticular cells are the source of Notch ligands promoting the differentiation of short-lived effector CD8+ T cells. Induction of early Notch s