Patrycja Kozik
@patrycja-kozik.bsky.social
Cell biologist and immunologist. Group Leader at MRC LMB.
🧪 Dendritic cells, antigen presentation, endocytic escape
🧪 Dendritic cells, antigen presentation, endocytic escape
Reposted by Patrycja Kozik
Happy to share our newest preprint on antigen presentation of Mtb-derived peptides on MHC-I: www.biorxiv.org/cgi/content/...
This is a follow up to our previous paper where we applied immunopeptidomics to understand MHC-I presentation by Mtb-infected cells: elifesciences.org/articles/84070
This is a follow up to our previous paper where we applied immunopeptidomics to understand MHC-I presentation by Mtb-infected cells: elifesciences.org/articles/84070
www.biorxiv.org
November 20, 2025 at 4:27 PM
Happy to share our newest preprint on antigen presentation of Mtb-derived peptides on MHC-I: www.biorxiv.org/cgi/content/...
This is a follow up to our previous paper where we applied immunopeptidomics to understand MHC-I presentation by Mtb-infected cells: elifesciences.org/articles/84070
This is a follow up to our previous paper where we applied immunopeptidomics to understand MHC-I presentation by Mtb-infected cells: elifesciences.org/articles/84070
Reposted by Patrycja Kozik
GPR34 is a splenic cDC1 receptor that is required for efferocytosis and for the cross-presentation of apoptotic cell–associated antigen to CD8 T cells @jem.org
rupress.org/jem/article/...
rupress.org/jem/article/...
November 10, 2025 at 5:59 PM
GPR34 is a splenic cDC1 receptor that is required for efferocytosis and for the cross-presentation of apoptotic cell–associated antigen to CD8 T cells @jem.org
rupress.org/jem/article/...
rupress.org/jem/article/...
Reposted by Patrycja Kozik
An authoritative review on phagosome immunobiology by David Underhill and Kai Li. Highly recommend for anyone interested in innate immunity, antigen presentation, infection and host defense.
@cedarssinai.bsky.social
rdcu.be/eNIFY
@cedarssinai.bsky.social
rdcu.be/eNIFY
Phagocytosis: a process that shapes immune responses to engulfed meals
Nature Reviews Immunology - In this Review, Li and Underhill discuss recent advances in understanding the process of phagocytosis. The authors highlight how phagocytosis is integral for innate...
rdcu.be
October 31, 2025 at 7:22 PM
An authoritative review on phagosome immunobiology by David Underhill and Kai Li. Highly recommend for anyone interested in innate immunity, antigen presentation, infection and host defense.
@cedarssinai.bsky.social
rdcu.be/eNIFY
@cedarssinai.bsky.social
rdcu.be/eNIFY
Reposted by Patrycja Kozik
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
October 28, 2025 at 8:06 AM
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Reposted by Patrycja Kozik
Delighted that our latest paper is out @jem.org. An intriguing study led by Ana Cardoso exploring the role of DNGR-1 in mouse dendritic cell precursors.
Cardoso et al. @reisesousalab.bsky.social show that DNGR-1–deficient pre-cDCs display cell-intrinsic alterations in their ability to colonize peripheral organs. Their findings highlight an unexpected role for innate immune receptors in regulating cDCpoiesis. rupress.org/jem/article/...
May 13, 2025 at 5:41 PM
Delighted that our latest paper is out @jem.org. An intriguing study led by Ana Cardoso exploring the role of DNGR-1 in mouse dendritic cell precursors.
Looking forward to meeting PFP enthusiasts at the Prato conference on Pore Forming Proteins in June!
⏰ Early Bird Registration deadline - May 16th ⏰
www.pratopores.org/speakers
#PFPsky
⏰ Early Bird Registration deadline - May 16th ⏰
www.pratopores.org/speakers
#PFPsky
Speakers — Prato Pores
www.pratopores.org
May 12, 2025 at 8:17 AM
Looking forward to meeting PFP enthusiasts at the Prato conference on Pore Forming Proteins in June!
⏰ Early Bird Registration deadline - May 16th ⏰
www.pratopores.org/speakers
#PFPsky
⏰ Early Bird Registration deadline - May 16th ⏰
www.pratopores.org/speakers
#PFPsky
Reposted by Patrycja Kozik
At last, direct demonstration that tapasin dependent MHC-I molecules experience greater tapasin filtering, resulting in less diverse MHC-I immunopeptidomes that are enriched in high affinity peptide-MHC-I complexes. Well done Andy and Rachel! links.email.frontiersin.org/ls/click?upn...
Frontiers | Evidence of focusing the MHC class I immunopeptidome by tapasin
Major Histocompatibility Complex class I (MHC-I) molecules bind and present peptides to cytotoxic T cells, protecting against pathogens and cancer. MHC-I is ...
links.email.frontiersin.org
May 8, 2025 at 6:34 AM
At last, direct demonstration that tapasin dependent MHC-I molecules experience greater tapasin filtering, resulting in less diverse MHC-I immunopeptidomes that are enriched in high affinity peptide-MHC-I complexes. Well done Andy and Rachel! links.email.frontiersin.org/ls/click?upn...
Reposted by Patrycja Kozik
Wow! Amazing response in the first few days of registration opening for www.emds2025.com
Be sure to register early to avoid disappointment.
🚨 Abstract deadline is FRIDAY 30th MAY
(Sneak peak of @profandrewmac.bsky.social rehearsing for the 'Scotland Experience' social.)
Be sure to register early to avoid disappointment.
🚨 Abstract deadline is FRIDAY 30th MAY
(Sneak peak of @profandrewmac.bsky.social rehearsing for the 'Scotland Experience' social.)
May 2, 2025 at 12:34 PM
Wow! Amazing response in the first few days of registration opening for www.emds2025.com
Be sure to register early to avoid disappointment.
🚨 Abstract deadline is FRIDAY 30th MAY
(Sneak peak of @profandrewmac.bsky.social rehearsing for the 'Scotland Experience' social.)
Be sure to register early to avoid disappointment.
🚨 Abstract deadline is FRIDAY 30th MAY
(Sneak peak of @profandrewmac.bsky.social rehearsing for the 'Scotland Experience' social.)
Reposted by Patrycja Kozik
👉 When splenic metallophilic marginal zone macrophages do antigen cross-presentation equally well as conventional DC1. Congrats to the team of Peter van Endert from @inem-necker.bsky.social for this work published in @cp-immunity.bsky.social
www.cell.com/immunity/abs...
www.cell.com/immunity/abs...
Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors
Metallophilic marginal zone macrophages are positioned strategically within the spleen
to process internalized blood-borne materials. Mauvais et al. find that these CD169+
macrophages cross-prime CD8+...
www.cell.com
April 9, 2025 at 9:10 AM
👉 When splenic metallophilic marginal zone macrophages do antigen cross-presentation equally well as conventional DC1. Congrats to the team of Peter van Endert from @inem-necker.bsky.social for this work published in @cp-immunity.bsky.social
www.cell.com/immunity/abs...
www.cell.com/immunity/abs...
Reposted by Patrycja Kozik
Thank you to organisers Philippe Bousso,
Gillian Griffiths @griffithslab.bsky.social , Milka Sarris &
Michael Sixt, and everyone who joined us for our 'Immune Cell Interactions in Development, Homeostasis and Immunity' Workshop.
biologists.com/workshops
Gillian Griffiths @griffithslab.bsky.social , Milka Sarris &
Michael Sixt, and everyone who joined us for our 'Immune Cell Interactions in Development, Homeostasis and Immunity' Workshop.
biologists.com/workshops
March 3, 2025 at 4:21 PM
Thank you to organisers Philippe Bousso,
Gillian Griffiths @griffithslab.bsky.social , Milka Sarris &
Michael Sixt, and everyone who joined us for our 'Immune Cell Interactions in Development, Homeostasis and Immunity' Workshop.
biologists.com/workshops
Gillian Griffiths @griffithslab.bsky.social , Milka Sarris &
Michael Sixt, and everyone who joined us for our 'Immune Cell Interactions in Development, Homeostasis and Immunity' Workshop.
biologists.com/workshops
Reposted by Patrycja Kozik
Our work on K63-polyubiquitin in membrane trafficking is out! Check out how we use a high affinity and specific sensor for K63-polyUb to identify K63-polyubiquitylated plasma membrane proteins in clusters of vesicles containing ATG9A.
Link: www.molbiolcell.org/doi/10.1091/...
Link: www.molbiolcell.org/doi/10.1091/...
Trafficking of K63-polyubiquitin modified membrane proteins in a macroautophagy-independent pathway is linked to ATG9A | Molecular Biology of the Cell
Cytoplasmic K63-linked polyubiquitin signals have well-established roles in endocytosis and selective autophagy. However, how these signals help to direct different cargos to different intracellular t...
www.molbiolcell.org
February 24, 2025 at 6:48 AM
Our work on K63-polyubiquitin in membrane trafficking is out! Check out how we use a high affinity and specific sensor for K63-polyUb to identify K63-polyubiquitylated plasma membrane proteins in clusters of vesicles containing ATG9A.
Link: www.molbiolcell.org/doi/10.1091/...
Link: www.molbiolcell.org/doi/10.1091/...
February 22, 2025 at 11:52 PM
Reposted by Patrycja Kozik
The LMB Rising Talent Fellowship for Black heritage scientists is open for applicants!
With this 3 year postdoc position we want to enable scientists of Black heritage to learn & grow their experience.
To apply and for full details check here: www2.mrc-lmb.cam.ac.uk/recruitment/...
Please share!
With this 3 year postdoc position we want to enable scientists of Black heritage to learn & grow their experience.
To apply and for full details check here: www2.mrc-lmb.cam.ac.uk/recruitment/...
Please share!
January 23, 2025 at 12:19 PM
The LMB Rising Talent Fellowship for Black heritage scientists is open for applicants!
With this 3 year postdoc position we want to enable scientists of Black heritage to learn & grow their experience.
To apply and for full details check here: www2.mrc-lmb.cam.ac.uk/recruitment/...
Please share!
With this 3 year postdoc position we want to enable scientists of Black heritage to learn & grow their experience.
To apply and for full details check here: www2.mrc-lmb.cam.ac.uk/recruitment/...
Please share!
Reposted by Patrycja Kozik
Our latest ‘Cell Scientist to Watch’ interview is with Kelly Nguyen @kellythd-nguyen.bsky.social @mrclmb.bsky.social. We learn about Kelly’s career, her advice on collaborative research and her passion for martial arts.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
February 10, 2025 at 12:25 PM
Our latest ‘Cell Scientist to Watch’ interview is with Kelly Nguyen @kellythd-nguyen.bsky.social @mrclmb.bsky.social. We learn about Kelly’s career, her advice on collaborative research and her passion for martial arts.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
Reposted by Patrycja Kozik
It's finally out – actually out and in print! Many thanks to @jcornlab.bsky.social @matthiasmuhar.bsky.social @jakobfarnung.bsky.social and all the fantastic collaborators. What started as pure curiosity lead to an amazing find!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
C-terminal amides mark proteins for degradation via SCF–FBXO31 - Nature
SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.
www.nature.com
February 12, 2025 at 8:23 PM
It's finally out – actually out and in print! Many thanks to @jcornlab.bsky.social @matthiasmuhar.bsky.social @jakobfarnung.bsky.social and all the fantastic collaborators. What started as pure curiosity lead to an amazing find!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Patrycja Kozik
Interested in cellular cross-talks between dendritic cells and T lymphocytes in lung cancer? Our team is recruiting a postdoctoral associate in immunology at Institut Pasteur Paris!
research.pasteur.fr/fr/job/post-...
research.pasteur.fr/fr/job/post-...
Post-Doctoral position in cancer immunology and immunotherapy, Institut Pasteur, Paris, France - Research
Deciphering the role of intra-tumoral dendritic cells in the dynamic controlof CD4+ and CD8+ lymphocytes in lung cancer. A 3-year, post-doctoral position is available in the Guermonprez lab at Institu...
research.pasteur.fr
February 12, 2025 at 4:46 PM
Interested in cellular cross-talks between dendritic cells and T lymphocytes in lung cancer? Our team is recruiting a postdoctoral associate in immunology at Institut Pasteur Paris!
research.pasteur.fr/fr/job/post-...
research.pasteur.fr/fr/job/post-...
Reposted by Patrycja Kozik
Melero&Co discuss the crucial role of conventional type 1 dendritic cells in cross-presenting antigens to prime CD8+ T cells to mount anti-tumour immunity and highlight how this can be exploited for #CancerImmunotherapy
@unav.edu
📖 ⬇️
@unav.edu
📖 ⬇️
Cross-priming in cancer immunology and immunotherapy - Nature Reviews Cancer
www.nature.com
February 11, 2025 at 4:04 PM
Melero&Co discuss the crucial role of conventional type 1 dendritic cells in cross-presenting antigens to prime CD8+ T cells to mount anti-tumour immunity and highlight how this can be exploited for #CancerImmunotherapy
@unav.edu
📖 ⬇️
@unav.edu
📖 ⬇️
Reposted by Patrycja Kozik
There is a Postdoc job available in my lab to study fundamental mechanisms of antiviral immunity, specifically in the context of viral nucleic acid sensing. Please take a look here and contact me if interested:
#immunosky #virology 🧪
www.jobs.cam.ac.uk/job/50254/
#immunosky #virology 🧪
www.jobs.cam.ac.uk/job/50254/
Research Assistant / Research Associate (Fixed Term) - Job Opportunities - University of Cambridge
Research Assistant / Research Associate (Fixed Term) in the Department of Pathology at the University of Cambridge.
www.jobs.cam.ac.uk
February 11, 2025 at 12:23 PM
There is a Postdoc job available in my lab to study fundamental mechanisms of antiviral immunity, specifically in the context of viral nucleic acid sensing. Please take a look here and contact me if interested:
#immunosky #virology 🧪
www.jobs.cam.ac.uk/job/50254/
#immunosky #virology 🧪
www.jobs.cam.ac.uk/job/50254/
Reposted by Patrycja Kozik
WDFY4-dependent cross-presentation of immune complexes by cDC1 and cDC2 @jem.org
doi.org/10.1084/jem....
doi.org/10.1084/jem....
February 8, 2025 at 4:30 AM
WDFY4-dependent cross-presentation of immune complexes by cDC1 and cDC2 @jem.org
doi.org/10.1084/jem....
doi.org/10.1084/jem....
Reposted by Patrycja Kozik
Join our Structural Studies Division, leading a research group developing computational methods to address questions in molecular & cellular biology!
You will be supported by core funding, excellent facilities & enthusiastic colleagues.
Apply by 18 MAR
www.nature.com/naturecareer...
You will be supported by core funding, excellent facilities & enthusiastic colleagues.
Apply by 18 MAR
www.nature.com/naturecareer...
January 30, 2025 at 12:21 PM
Join our Structural Studies Division, leading a research group developing computational methods to address questions in molecular & cellular biology!
You will be supported by core funding, excellent facilities & enthusiastic colleagues.
Apply by 18 MAR
www.nature.com/naturecareer...
You will be supported by core funding, excellent facilities & enthusiastic colleagues.
Apply by 18 MAR
www.nature.com/naturecareer...
Reposted by Patrycja Kozik
We are excited to announce the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors, Oct 1-2 2025, Lausanne, Switzerland.
Registrations open March 1 - Attendance limited to 150 participants.
More info: wp.unil.ch/immunobiolog...
#ImmunoSky
Registrations open March 1 - Attendance limited to 150 participants.
More info: wp.unil.ch/immunobiolog...
#ImmunoSky
Symposium immunobiology
wp.unil.ch
January 28, 2025 at 2:33 PM
We are excited to announce the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors, Oct 1-2 2025, Lausanne, Switzerland.
Registrations open March 1 - Attendance limited to 150 participants.
More info: wp.unil.ch/immunobiolog...
#ImmunoSky
Registrations open March 1 - Attendance limited to 150 participants.
More info: wp.unil.ch/immunobiolog...
#ImmunoSky
Reposted by Patrycja Kozik
📆ny resolution #immunosky:
REGISTER NOW #phagocytes25
phagocytes2025.com
20 🔝speakers
28 short talks + posters
📌Madrid @CNIC_CARDIO
📆26-28 March '25
Organized by www.inmunologia.org
Support by #TRR332 #TRR359 #inmunotek #EMBOevents
Bursaries by @efis-immunology.bsky.social @eurjimmunol.bsky.social
REGISTER NOW #phagocytes25
phagocytes2025.com
20 🔝speakers
28 short talks + posters
📌Madrid @CNIC_CARDIO
📆26-28 March '25
Organized by www.inmunologia.org
Support by #TRR332 #TRR359 #inmunotek #EMBOevents
Bursaries by @efis-immunology.bsky.social @eurjimmunol.bsky.social
January 8, 2025 at 2:01 PM
📆ny resolution #immunosky:
REGISTER NOW #phagocytes25
phagocytes2025.com
20 🔝speakers
28 short talks + posters
📌Madrid @CNIC_CARDIO
📆26-28 March '25
Organized by www.inmunologia.org
Support by #TRR332 #TRR359 #inmunotek #EMBOevents
Bursaries by @efis-immunology.bsky.social @eurjimmunol.bsky.social
REGISTER NOW #phagocytes25
phagocytes2025.com
20 🔝speakers
28 short talks + posters
📌Madrid @CNIC_CARDIO
📆26-28 March '25
Organized by www.inmunologia.org
Support by #TRR332 #TRR359 #inmunotek #EMBOevents
Bursaries by @efis-immunology.bsky.social @eurjimmunol.bsky.social
Reposted by Patrycja Kozik
A cellular Christmas tree made from molten copper drops. Splats of copper sometimes happen when welding and they often take the shape of different cell types. I collect these off my shop floor because they look cool…….and yes, they make my sciency senses tingle!
Merry Christmas!
#SciArt
Merry Christmas!
#SciArt
December 24, 2024 at 1:45 PM
A cellular Christmas tree made from molten copper drops. Splats of copper sometimes happen when welding and they often take the shape of different cell types. I collect these off my shop floor because they look cool…….and yes, they make my sciency senses tingle!
Merry Christmas!
#SciArt
Merry Christmas!
#SciArt
Reposted by Patrycja Kozik
MERRY CHRISTMAS!!! I'm not sure if this is how the gold, frankincense and myrrh were delivered, but perforin-2 is excellent at transporting gifts...
Made in #Modo for @patrycja-kozik.bsky.social Lab
#ArtAdventCalendar #SciArt
More projects: e-nox.net/portfolio/
Made in #Modo for @patrycja-kozik.bsky.social Lab
#ArtAdventCalendar #SciArt
More projects: e-nox.net/portfolio/
December 24, 2024 at 1:46 PM
MERRY CHRISTMAS!!! I'm not sure if this is how the gold, frankincense and myrrh were delivered, but perforin-2 is excellent at transporting gifts...
Made in #Modo for @patrycja-kozik.bsky.social Lab
#ArtAdventCalendar #SciArt
More projects: e-nox.net/portfolio/
Made in #Modo for @patrycja-kozik.bsky.social Lab
#ArtAdventCalendar #SciArt
More projects: e-nox.net/portfolio/
Just a little reminder on the important role of perforin-2 in transport... 🎁🎁🎁
🎄 Happy Christmas everyone! 🎄
Image credits:
@e-nox.net
#KozikLabScience #PFPsky
🎄 Happy Christmas everyone! 🎄
Image credits:
@e-nox.net
#KozikLabScience #PFPsky
December 18, 2024 at 10:59 AM
Just a little reminder on the important role of perforin-2 in transport... 🎁🎁🎁
🎄 Happy Christmas everyone! 🎄
Image credits:
@e-nox.net
#KozikLabScience #PFPsky
🎄 Happy Christmas everyone! 🎄
Image credits:
@e-nox.net
#KozikLabScience #PFPsky