Vikram Paralkar
@paralkarlab.bsky.social
Physician-Scientist | University of Pennsylvania | Pol I, rRNA, Ribosomes, Chromatin, Transcription | Hematopoiesis and Leukemia | 🩸🔬🧪🧬
https://paralkarlab.med.upenn.edu
https://paralkarlab.med.upenn.edu
Pinned
Dynamics of Ribosomal RNA Transcription and Abundance in Normal and Leukemic Hematopoiesis
Transcription of ribosomal RNAs (rRNAs) from rDNA repeats is the first step of ribosome biogenesis, accounting for a major portion of all cellular transcription. Often regarded as a housekeeping proce...
www.biorxiv.org
📣 New preprint 📣
We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation.
Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)
We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation.
Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)
I now know how antigens feel... 😅
November 22, 2025 at 1:24 PM
I now know how antigens feel... 😅
Most of us wouldn't be able to tell that this blot is fake! We're headed towards a topsy-turvy future. 😵💫
Finally the scary example. The image of a western blot with a time course experiment, staining a protein of interest, showing the increase of protein over time and a second staining with a control antibody that does not change over time
November 21, 2025 at 3:16 PM
Most of us wouldn't be able to tell that this blot is fake! We're headed towards a topsy-turvy future. 😵💫
Reposted by Vikram Paralkar
For 40+ years, the ASH Scholar Award has helped jumpstart careers in hematology—funding 678 awards, $82M in research, and $3B in follow-on funding. Learn more: https://bit.ly/4idJLvV
#ASHAwards
#ASHAwards
November 20, 2025 at 8:00 PM
For 40+ years, the ASH Scholar Award has helped jumpstart careers in hematology—funding 678 awards, $82M in research, and $3B in follow-on funding. Learn more: https://bit.ly/4idJLvV
#ASHAwards
#ASHAwards
Why did I never before realize that the Michelin that gives ⭐stars⭐ to restaurants for exquisite dining is the same puffy Michelin dude who sells tyres?!?
a man is hugging a michelin mascot in front of a sign for spark plugs
ALT: a man is hugging a michelin mascot in front of a sign for spark plugs
media.tenor.com
November 19, 2025 at 10:21 PM
Why did I never before realize that the Michelin that gives ⭐stars⭐ to restaurants for exquisite dining is the same puffy Michelin dude who sells tyres?!?
Step 1: Don't own any bitcoin.
November 17, 2025 at 10:32 PM
Step 1: Don't own any bitcoin.
It's so difficult to "score" applicants for our PhD and MD/PhD program this year - they are all so accomplished, eloquent, intelligent, and driven! My recommendation: Recruit them all! 😁
November 14, 2025 at 3:31 PM
It's so difficult to "score" applicants for our PhD and MD/PhD program this year - they are all so accomplished, eloquent, intelligent, and driven! My recommendation: Recruit them all! 😁
Hope this terrible law isn't passed by Congress...
“The prohibited activities would include joint research, co-authorship on papers, and advising a foreign graduate student or postdoctoral fellow. The language is retroactive, meaning any interactions during the previous 5 years could make a scientist ineligible for future federal funding.”
U.S. Congress considers sweeping ban on Chinese collaborations
Researchers speak out against proposal that would bar funding for U.S. scientists working with Chinese partners or training Chinese students
www.science.org
November 14, 2025 at 12:43 PM
Hope this terrible law isn't passed by Congress...
No. No. Absolutely not. The ethics of primate research are complicated enough already. Please DO NOT bring back Homo erectus or some other extinct human ancestor!
It's surprising that this is even a question, but was anyone asked about "de-extincting" the dire wolf? - Should scientists be allowed to bring distant human ancestors back to life? journals.plos.org/plosbiology/...
Should scientists be allowed to bring distant human ancestors back to life?
Recently, several attempts have been made to modify modern species with ancient DNA in the name of ‘de-extinction’. This Perspective argues that independent ethical oversight needs to be put in place…
journals.plos.org
November 7, 2025 at 2:57 PM
No. No. Absolutely not. The ethics of primate research are complicated enough already. Please DO NOT bring back Homo erectus or some other extinct human ancestor!
Mutations in mitochondrial rRNA are recurrently observed in cancers! 😳🤯
Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask?
rdcu.be/eN1jm
rdcu.be/eN1jm
Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer
Nature Genetics - Analysis of 14,106 tumor genomes highlights recurrent mutations in mitochondrial ribosomal RNA encoded within the mitochondrial genome. Mutations occur at hotspot positions and...
rdcu.be
November 6, 2025 at 11:53 AM
Mutations in mitochondrial rRNA are recurrently observed in cancers! 😳🤯
Reposted by Vikram Paralkar
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 5, 2025 at 5:20 PM
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
Reposted by Vikram Paralkar
👇👇 Mark your calendars! Fri, Dec 5, 3-7pm @ ASH. 🐔🐔
Important PSA! ASH Scientific Workshop website is experiencing a technical problem; YES, the Myeloid Workshop should be on the website and has an excellent speaker lineup already, stay tuned! @steidluli.bsky.social
November 5, 2025 at 1:22 AM
👇👇 Mark your calendars! Fri, Dec 5, 3-7pm @ ASH. 🐔🐔
Reposted by Vikram Paralkar
Important PSA! ASH Scientific Workshop website is experiencing a technical problem; YES, the Myeloid Workshop should be on the website and has an excellent speaker lineup already, stay tuned! @steidluli.bsky.social
November 2, 2025 at 6:10 PM
Important PSA! ASH Scientific Workshop website is experiencing a technical problem; YES, the Myeloid Workshop should be on the website and has an excellent speaker lineup already, stay tuned! @steidluli.bsky.social
Reposted by Vikram Paralkar
I am a boring old lady and I already dropped off my mail in ballot weeks ago, but YOU CAN STILL VOTE TOMORROW (well, some of you). These elections REALLY MATTER, so please don't sit them out. Apathy is our enemy.
a cup of coffee that says wake up go and vote
ALT: a cup of coffee that says wake up go and vote
media.tenor.com
November 4, 2025 at 1:13 AM
I am a boring old lady and I already dropped off my mail in ballot weeks ago, but YOU CAN STILL VOTE TOMORROW (well, some of you). These elections REALLY MATTER, so please don't sit them out. Apathy is our enemy.
Reposted by Vikram Paralkar
(1/10) How do diverse leukemia mutations converge on the same molecular program? In #RibackLab first manuscript @cp-cell.bsky.social, collaboration with @goodell-lab.bsky.social shows that disparate mutations rewire shared protein networks to form nuclear condensates called C-bodies.
November 4, 2025 at 5:58 PM
(1/10) How do diverse leukemia mutations converge on the same molecular program? In #RibackLab first manuscript @cp-cell.bsky.social, collaboration with @goodell-lab.bsky.social shows that disparate mutations rewire shared protein networks to form nuclear condensates called C-bodies.
What is the best fantasy film ever made?
I nominate Pan's Labyrinth! One of the most extraordinary and devastating movies I've ever watched.
I nominate Pan's Labyrinth! One of the most extraordinary and devastating movies I've ever watched.
Little Princess (Of The Underworld) GIF
ALT: Little Princess (Of The Underworld) GIF
media.tenor.com
November 3, 2025 at 12:48 AM
What is the best fantasy film ever made?
I nominate Pan's Labyrinth! One of the most extraordinary and devastating movies I've ever watched.
I nominate Pan's Labyrinth! One of the most extraordinary and devastating movies I've ever watched.
No spoilers, but was anyone else really frustrated with the ending of "A House of Dynamite"? The structure of the movie itself makes sense, but only if the ending is able to bring it together. The screenwriter and director entirely failed to achieve that goal.
October 31, 2025 at 4:39 PM
No spoilers, but was anyone else really frustrated with the ending of "A House of Dynamite"? The structure of the movie itself makes sense, but only if the ending is able to bring it together. The screenwriter and director entirely failed to achieve that goal.
Two PROTAC questions:
1) Does anyone know of a PROTAC for GFP (which could be used to degrade any GFP-tagged protein)?
2) Does anyone have experience with any of the available PROTACs for Halo (like HaloPROTAC3)?
1) Does anyone know of a PROTAC for GFP (which could be used to degrade any GFP-tagged protein)?
2) Does anyone have experience with any of the available PROTACs for Halo (like HaloPROTAC3)?
October 28, 2025 at 3:54 PM
Two PROTAC questions:
1) Does anyone know of a PROTAC for GFP (which could be used to degrade any GFP-tagged protein)?
2) Does anyone have experience with any of the available PROTACs for Halo (like HaloPROTAC3)?
1) Does anyone know of a PROTAC for GFP (which could be used to degrade any GFP-tagged protein)?
2) Does anyone have experience with any of the available PROTACs for Halo (like HaloPROTAC3)?
I don't know if it's just me, but it seems like the deluge of fall pumpkin references in everything - recipes, restaurants, social media, television shows, decorations - is just increasing exponentially year over year! 🎃
October 26, 2025 at 9:46 PM
I don't know if it's just me, but it seems like the deluge of fall pumpkin references in everything - recipes, restaurants, social media, television shows, decorations - is just increasing exponentially year over year! 🎃
Reposted by Vikram Paralkar
The actor's Michael J. Fox Foundation is now 25 years old, and has raised over $2.5 billion for Parkinson's research.
globalnews.ca/news/1149130...
globalnews.ca/news/1149130...
Michael J. Fox says representing the Parkinson’s community is a ‘privilege’ | Globalnews.ca
'People that had Parkinson's for years were stigmatized, so now to represent them, and to be a place marker in society ... I'm so humbled by it,' Fox said.
globalnews.ca
October 23, 2025 at 6:40 PM
The actor's Michael J. Fox Foundation is now 25 years old, and has raised over $2.5 billion for Parkinson's research.
globalnews.ca/news/1149130...
globalnews.ca/news/1149130...
Congratulations @oawlab.bsky.social! Richly deserved!
We're excited to share that Dr. Omar Abdel-Wahab, a leukemia specialist at MSK, has been elected to the @nam.edu.
With Dr. Abdel-Wahab’s appointment, a total of 28 MSK faculty members have been conferred with this recognition.
Congratulations, Dr. Abdel-Wahab!
bit.ly/49ezKw0
With Dr. Abdel-Wahab’s appointment, a total of 28 MSK faculty members have been conferred with this recognition.
Congratulations, Dr. Abdel-Wahab!
bit.ly/49ezKw0
Memorial Sloan Kettering Cancer Center Physician-Scientist Elected to the Prestigious National Academy of Medicine
Omar Abdel-Wahab, MD, Chair of the Molecular Pharmacology Program at Sloan Kettering Institute (SKI); Evnin Family Chair in Molecular Pharmacology and Attending Physician on the Leukemia Service at Me...
bit.ly
October 22, 2025 at 5:48 PM
Congratulations @oawlab.bsky.social! Richly deserved!
Congratulations @ksusztak.bsky.social and Gerd Blobel (not on Bluesky)!!!
Congratulations to the 3 @pennmedicine.bsky.social honorees elected to the National Academy of Medicine! Election to @nam.edu is considered one of the highest honors in the field of health & medicine. Check back this week as we profile each new member tinyurl.com/ysjzdrbk
October 22, 2025 at 2:59 PM
Congratulations @ksusztak.bsky.social and Gerd Blobel (not on Bluesky)!!!
Reposted by Vikram Paralkar
New “discrete state” model of hematopoiesis published in Nature Immunology. rdcu.be/eL8oO
We propose a hierarchical model of hematopoiesis where stable “discrete states” serve as key regulatory nodes.
We propose a hierarchical model of hematopoiesis where stable “discrete states” serve as key regulatory nodes.
A unified multimodal single-cell framework reveals a discrete state model of hematopoiesis in mice
Nature Immunology - Grimes and colleagues integrate multiomic features to create a framework that allows the isolation of discrete cell states across hematopoiesis and exploit the underlying gene...
rdcu.be
October 22, 2025 at 1:10 PM
New “discrete state” model of hematopoiesis published in Nature Immunology. rdcu.be/eL8oO
We propose a hierarchical model of hematopoiesis where stable “discrete states” serve as key regulatory nodes.
We propose a hierarchical model of hematopoiesis where stable “discrete states” serve as key regulatory nodes.
Reposted by Vikram Paralkar
This year the ASH Bridge Grant is funding 25 scientists with $3.75M, 5X more than last year, to keep hematology research moving forward. Congratulations to the recipients! https://bit.ly/3HJ51Ma
#HemeSky #MedSKy #ASHAwards
#HemeSky #MedSKy #ASHAwards
August 19, 2025 at 4:50 PM
This year the ASH Bridge Grant is funding 25 scientists with $3.75M, 5X more than last year, to keep hematology research moving forward. Congratulations to the recipients! https://bit.ly/3HJ51Ma
#HemeSky #MedSKy #ASHAwards
#HemeSky #MedSKy #ASHAwards
Why is it that the one time I don't ask, "Can you see my screen?" it takes three slides of me explaining complex graphs before someone chimes in with, "Uh, I'm not seeing any shared slides..."
October 18, 2025 at 2:03 PM
Why is it that the one time I don't ask, "Can you see my screen?" it takes three slides of me explaining complex graphs before someone chimes in with, "Uh, I'm not seeing any shared slides..."
Is there a particular kind of PPT "aesthetic" that's most effective for scientific presentations? There's a slide format with a minimalist aesthetic of Cell Press journals (which I like) that I'm increasingly seeing at conferences - is there a website where people are downloading such a template?
October 17, 2025 at 2:54 PM
Is there a particular kind of PPT "aesthetic" that's most effective for scientific presentations? There's a slide format with a minimalist aesthetic of Cell Press journals (which I like) that I'm increasingly seeing at conferences - is there a website where people are downloading such a template?