Vikram Paralkar
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paralkarlab.bsky.social
Vikram Paralkar
@paralkarlab.bsky.social
Physician-Scientist | University of Pennsylvania | Pol I, rRNA, Ribosomes, Chromatin, Transcription | Hematopoiesis and Leukemia | 🩸🔬🧪🧬
https://paralkarlab.med.upenn.edu
Ah I see. I'll read your paper in more detail to look into QC for Nanopore calls of 6mA. Thank you for these references!
November 18, 2025 at 5:09 PM
Thanks for this! Could you perhaps point me to references that could help me understand this in more detail? Specifically, the RNA salvage or RNA-DNA hybrid point that you mentioned - do they actually produce 6mA on DNA itself (or do they just cause erroneous calls by Nanopore)?
November 18, 2025 at 4:50 PM
Super interesting! Could I ask how confident we are that 6mA on DNA is not present in, say, mammals? Is it absolutely completely absent (because the methyltransferase doesn't even exist)? Or is it present at low and insignificant levels that are not physiologically relevant?
November 18, 2025 at 4:31 PM
Seriously, what are they thinking? If even this election result cannot give the Dems a spine, then we're lost...
November 10, 2025 at 12:34 AM
😂
November 9, 2025 at 6:57 PM
😭😭😭
November 8, 2025 at 11:08 PM
In the movie theater, when that scientist in Prometheus tried to pet a cobra-like hissing alien as through it were a kitten, I remember thinking, "Why do scriptwriters keep giving us these unbelievably moronic scientists who are just begging for horrific deaths...?"
November 8, 2025 at 6:13 PM
Congratulations! This is a genuinely beautiful story!
November 5, 2025 at 8:40 PM
Haha, hardly an influencer, but I'm retweeted your post! I'll quote-post it again tomorrow!
November 5, 2025 at 1:26 AM
Fantastic work! 👏
November 4, 2025 at 7:29 PM
This reflection comes on the heels of having just watched Guillermo Del Toro's Frankenstein, which is excellent as well, though Pan's Labyrinth is at a pinnacle that's unlikely to be touched.
a man with curly hair stands in front of a statue
ALT: a man with curly hair stands in front of a statue
media.tenor.com
November 3, 2025 at 1:07 AM