Olivia C. Ghirardelli Smith
@oliviacs.bsky.social
NIH/NIAID F30-funded MD-PhD student at the University of Minnesota. 4th year PhD student in the Masopust Lab studying how resident memory T cells communicate w/ the rest of the body.
https://scholar.google.com/citations?user=9462voUAAAAJ&hl=en
https://scholar.google.com/citations?user=9462voUAAAAJ&hl=en
Reposted by Olivia C. Ghirardelli Smith
We all know how powerful memories can feel, but new work published in @nature.com shows that the memory of being exposed to cold conditions in a specific environment can alter a mouse's whole-body metabolism 🧪 www.nature.com/articles/s41...
Cold memories control whole-body thermoregulatory responses - Nature
Cold-sensitive engrams contribute to learned thermoregulation in mice that are returned to an environment in which they previously experienced a cold challenge, through a network formed betw...
www.nature.com
April 25, 2025 at 3:04 AM
We all know how powerful memories can feel, but new work published in @nature.com shows that the memory of being exposed to cold conditions in a specific environment can alter a mouse's whole-body metabolism 🧪 www.nature.com/articles/s41...
Check out the case report we wrote on a fascinating case of teratoma in the testes. This case illustrates that pure mature teratomas occurring in postpubertal males cannot invariably be classified into the benign teratoma category.
www.frontiersin.org/journals/onc...
www.frontiersin.org/journals/onc...
Frontiers | Case Report: Prepubertal-type testicular teratoma with local metastasis in a postpubertal patient
www.frontiersin.org
March 23, 2025 at 11:03 PM
Check out the case report we wrote on a fascinating case of teratoma in the testes. This case illustrates that pure mature teratomas occurring in postpubertal males cannot invariably be classified into the benign teratoma category.
www.frontiersin.org/journals/onc...
www.frontiersin.org/journals/onc...
Reposted by Olivia C. Ghirardelli Smith
KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection
www.science.org/doi/10.1126/...
@science.org @nikjoshilabyale.bsky.social
www.science.org/doi/10.1126/...
@science.org @nikjoshilabyale.bsky.social
February 13, 2025 at 7:51 PM
KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection
www.science.org/doi/10.1126/...
@science.org @nikjoshilabyale.bsky.social
www.science.org/doi/10.1126/...
@science.org @nikjoshilabyale.bsky.social
Reposted by Olivia C. Ghirardelli Smith
YES. Need to say this loudly and often! This 2.46x is also the short-term ROI. Long-term ROI (more difficult to estimate) may ~10x. Highest for any gov't spending. And the source of discoveries necessary for all new drugs (industry important too but without NIH funded science there's no foundation)
February 8, 2025 at 3:54 PM
YES. Need to say this loudly and often! This 2.46x is also the short-term ROI. Long-term ROI (more difficult to estimate) may ~10x. Highest for any gov't spending. And the source of discoveries necessary for all new drugs (industry important too but without NIH funded science there's no foundation)
Reposted by Olivia C. Ghirardelli Smith
#WeekendRead! #LipidPower! Hugues, Sun &co show @natcomms.bsky.social that lymphatic endothelial cells #LECs modify cholesterol into oxysterols, blocking PPARg in intratumor macrophages & monocytes, making them more inflammatory thus potentiating anti-tumor T cell responses during immunotherapy!!
Lymphatic-derived oxysterols promote anti-tumor immunity and response to immunotherapy in melanoma - Nature Communications
VEGF-C induced lymphangiogenesis combined with immunotherapy approaches can promote anti-tumor immune responses. Here the authors report that lymphaticderived oxysterols promote anti-tumor immunity an...
www.nature.com
February 1, 2025 at 8:02 PM
#WeekendRead! #LipidPower! Hugues, Sun &co show @natcomms.bsky.social that lymphatic endothelial cells #LECs modify cholesterol into oxysterols, blocking PPARg in intratumor macrophages & monocytes, making them more inflammatory thus potentiating anti-tumor T cell responses during immunotherapy!!
Reposted by Olivia C. Ghirardelli Smith
A study in Nature Cancer provides genetic evidence that intrinsic developmental heterogeneity can prime individual, lifelong cancer susceptibility. https://go.nature.com/3PZla0G #Medsky 🧪
February 1, 2025 at 9:36 PM
A study in Nature Cancer provides genetic evidence that intrinsic developmental heterogeneity can prime individual, lifelong cancer susceptibility. https://go.nature.com/3PZla0G #Medsky 🧪
Reposted by Olivia C. Ghirardelli Smith
Why scratching makes a rash worse and a potential benefit to scratching--it reduced S. aureus on skin. Andrew Liu's paper from our lab is out now at #science #neuroimmune #immunology www.science.org/doi/10.1126/...
Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation
Itch is a dominant symptom in dermatitis, and scratching promotes cutaneous inflammation, thereby worsening disease. However, the mechanisms through which scratching exacerbates inflammation and wheth...
www.science.org
January 30, 2025 at 8:31 PM
Why scratching makes a rash worse and a potential benefit to scratching--it reduced S. aureus on skin. Andrew Liu's paper from our lab is out now at #science #neuroimmune #immunology www.science.org/doi/10.1126/...
Reposted by Olivia C. Ghirardelli Smith
Excited to share my PhD work from Rafi Ahmed’s lab, now published in @nature.com. We show how CD8 T cells overcome the inability to predict how long a viral infection will last by making adaptable precursor cells a priori—an elegant strategy for a non-prescient immune system! tinyurl.com/53nrpsa6
January 15, 2025 at 10:23 PM
Excited to share my PhD work from Rafi Ahmed’s lab, now published in @nature.com. We show how CD8 T cells overcome the inability to predict how long a viral infection will last by making adaptable precursor cells a priori—an elegant strategy for a non-prescient immune system! tinyurl.com/53nrpsa6
Reposted by Olivia C. Ghirardelli Smith
#Immunology out now @science.org
ILC2s contribute to glucose homeostasis. Neurons that innervate the gut from areas of the brain associated with glucose sensing can stimulate ILC2s in the gut to relocate to the pancreas upon fasting.
https://buff.ly/42iBst0
ILC2s contribute to glucose homeostasis. Neurons that innervate the gut from areas of the brain associated with glucose sensing can stimulate ILC2s in the gut to relocate to the pancreas upon fasting.
https://buff.ly/42iBst0
January 16, 2025 at 7:20 PM
#Immunology out now @science.org
ILC2s contribute to glucose homeostasis. Neurons that innervate the gut from areas of the brain associated with glucose sensing can stimulate ILC2s in the gut to relocate to the pancreas upon fasting.
https://buff.ly/42iBst0
ILC2s contribute to glucose homeostasis. Neurons that innervate the gut from areas of the brain associated with glucose sensing can stimulate ILC2s in the gut to relocate to the pancreas upon fasting.
https://buff.ly/42iBst0
Reposted by Olivia C. Ghirardelli Smith
How are durable antibody-responses to vaccines induced? News & Views paper discussing excellent new work by Cortese et al in Nature Immunology: www.nature.com/articles/s41...
Megakaryocytes promote long-lived plasmablasts via direct and indirect interactions. #ImmSky #HumanImmunology
Megakaryocytes promote long-lived plasmablasts via direct and indirect interactions. #ImmSky #HumanImmunology
January 2, 2025 at 5:27 PM
How are durable antibody-responses to vaccines induced? News & Views paper discussing excellent new work by Cortese et al in Nature Immunology: www.nature.com/articles/s41...
Megakaryocytes promote long-lived plasmablasts via direct and indirect interactions. #ImmSky #HumanImmunology
Megakaryocytes promote long-lived plasmablasts via direct and indirect interactions. #ImmSky #HumanImmunology
Reposted by Olivia C. Ghirardelli Smith
Looks like I’ll need to update my lymph node lectures. Very nice explanation for why there is preferential leukocyte recruitment to inflamed nodes. #immunosky
Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes
Lymph node swelling is a well-known symptom of infection. A shift in the chemoattractant code controls lymphocyte recruitment from blood into inflamed lymph nodes, allowing lymphocytes to accumulate so that even rare antigen-specific cells can encounter their activating antigen.
www.cell.com
January 5, 2025 at 9:21 PM
Looks like I’ll need to update my lymph node lectures. Very nice explanation for why there is preferential leukocyte recruitment to inflamed nodes. #immunosky
Reposted by Olivia C. Ghirardelli Smith
This paper is now online: www.nature.com/articles/s41... and it is fascinating!!
November 27, 2024 at 5:38 PM
This paper is now online: www.nature.com/articles/s41... and it is fascinating!!
Reposted by Olivia C. Ghirardelli Smith
Excited for the CellSymposia "Neuro-immune Axis: Charting the Periphery" in New York City Sept 7-9, 2025, in partnership with the Allen Discovery Center for Neuroimmune Interactions! Keynotes: David Julius & @tcellogic.bsky.social. Check out the speaker list! www.cell-symposia.com/neuroimmunol...
November 25, 2024 at 12:46 PM
Excited for the CellSymposia "Neuro-immune Axis: Charting the Periphery" in New York City Sept 7-9, 2025, in partnership with the Allen Discovery Center for Neuroimmune Interactions! Keynotes: David Julius & @tcellogic.bsky.social. Check out the speaker list! www.cell-symposia.com/neuroimmunol...
Reposted by Olivia C. Ghirardelli Smith
Ever wondered how fasting is benefiting the adaptive immune response? In @Nature we show that #ketogenesis promotes the function of #tcell in severe respiratory viral infections by providing #ketonebodies BHB as carbon source. Final edited version: www.nature.com/articles/s41...
Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19 - Nature
The ketone body β-hydroxybutyrate can be used as an alternative carbon source by T cells to maintain their function during severe respiratory viral infections, including infection with&...
www.nature.com
November 19, 2024 at 11:33 AM
Ever wondered how fasting is benefiting the adaptive immune response? In @Nature we show that #ketogenesis promotes the function of #tcell in severe respiratory viral infections by providing #ketonebodies BHB as carbon source. Final edited version: www.nature.com/articles/s41...
Reposted by Olivia C. Ghirardelli Smith
Another beautiful example of @victora.bsky.social 's LIPSTIC ("labeling immune partnerships by sorTagging intercellular contacts") technique in action!
Last month in #ScienceImmunology, Alex Chudnovskiy,
@victora.bsky.social, & al. used proximity-based labeling in combination with single-cell transcriptomics to characterize antigen-presenting dendritic cells in tumors and their draining lymph nodes.
@victora.bsky.social, & al. used proximity-based labeling in combination with single-cell transcriptomics to characterize antigen-presenting dendritic cells in tumors and their draining lymph nodes.
Proximity-dependent labeling identifies dendritic cells that drive the tumor-specific CD4+ T cell response
This study characterizes the dendritic cells that present antigen to tumor-specific CD4+ T cells in the tumor and tumor-draining lymph node.
www.science.org
November 19, 2024 at 7:20 PM
Another beautiful example of @victora.bsky.social 's LIPSTIC ("labeling immune partnerships by sorTagging intercellular contacts") technique in action!
Reposted by Olivia C. Ghirardelli Smith
Outstanding work from @KKellermanUCCOM @JankowskiLab @CincyImmunology @CincyMSTP @RothenbergLab @CincyResearch identifying a neuroimmune circuit involving IL-4 and NaV1.8+ sensory nerves that regulates allergic inflammation in the esophagus
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 18, 2024 at 4:00 PM
Outstanding work from @KKellermanUCCOM @JankowskiLab @CincyImmunology @CincyMSTP @RothenbergLab @CincyResearch identifying a neuroimmune circuit involving IL-4 and NaV1.8+ sensory nerves that regulates allergic inflammation in the esophagus
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Olivia C. Ghirardelli Smith
I made a starter pack for those of us interested in or working on T cells. Let me know if you would like to be added or know somebody that should be added.
Looking forward to scientific discussions and updates on our favorite immune cell type!
Looking forward to scientific discussions and updates on our favorite immune cell type!
November 18, 2024 at 5:19 PM
I made a starter pack for those of us interested in or working on T cells. Let me know if you would like to be added or know somebody that should be added.
Looking forward to scientific discussions and updates on our favorite immune cell type!
Looking forward to scientific discussions and updates on our favorite immune cell type!
Reposted by Olivia C. Ghirardelli Smith
How does route of mRNA vaccination impact localization and abundance of memory T cells? shorturl.at/foBMY.
Route of self-amplifying mRNA vaccination modulates the establishment of pulmonary resident memory CD8 and CD4 T cells
Intramuscular mRNA vaccination induces pulmonary resident memory T cells that can be further expanded with intranasal boosting.
shorturl.at
November 18, 2024 at 6:41 PM
How does route of mRNA vaccination impact localization and abundance of memory T cells? shorturl.at/foBMY.
Reposted by Olivia C. Ghirardelli Smith
Physician/scientists, let me know if you want to be added to this list: go.bsky.app/9PwKh1k
November 18, 2024 at 8:06 AM
Physician/scientists, let me know if you want to be added to this list: go.bsky.app/9PwKh1k
Ever wondered what T cell immunosurveillance of 🐭 mammary ducts looks like? Check out our image featured on the cover of Science Immunology, showing CD103+ (pink) antiviral memory T cells (cyan) w/ in the ductal epithelium 🤩
November 18, 2024 at 12:04 AM
Ever wondered what T cell immunosurveillance of 🐭 mammary ducts looks like? Check out our image featured on the cover of Science Immunology, showing CD103+ (pink) antiviral memory T cells (cyan) w/ in the ductal epithelium 🤩
Beyond grateful to receive an F30 from NIAID! This award will support my training in the Masopust lab studying how resident memory T cells communicate with the rest of the body 🗣️ Thank you to many in UMN MSTP, CFI, and beyond for the support.
November 18, 2024 at 12:03 AM
Beyond grateful to receive an F30 from NIAID! This award will support my training in the Masopust lab studying how resident memory T cells communicate with the rest of the body 🗣️ Thank you to many in UMN MSTP, CFI, and beyond for the support.