Olov Andersson
@o-andersson-lab.bsky.social
organogenesis, islet biology, regeneration, zebrafish, diabetes and associated diseases
https://www.uu.se/en/department/medical-cell-biology/research/research-groups/olov-andersson
https://www.uu.se/en/department/medical-cell-biology/research/research-groups/olov-andersson
Reposted by Olov Andersson
Bri2 BRICHOS domain inhibits cytotoxic IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress. #T1D #SC-islets #CellTherapy
link.springer.com/article/10.1... 🔓
link.springer.com/article/10.1... 🔓
Bri2 BRICHOS domain inhibits IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress - Diabetologia
Aims/hypothesis Accumulation of islet amyloid polypeptide (IAPP) and amyloid formation is associated with beta cell dysfunction and cell death in human islets and may also contribute to graft failure ...
link.springer.com
November 21, 2025 at 12:51 PM
Bri2 BRICHOS domain inhibits cytotoxic IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress. #T1D #SC-islets #CellTherapy
link.springer.com/article/10.1... 🔓
link.springer.com/article/10.1... 🔓
Reposted by Olov Andersson
Deadlines are approaching (some next week!) for @keystoneSymposia.bsky.social #IsletBiology & #Diabetes : #BetaCell Compensation, Failure & Recovery, this March in Breckenridge! See scholarship, abstract and discount reg dates: keysym.us/KSDiabetes26 #KSDiabetes26
Islet Biology and Diabetes: Beta Cell Compensation, Failure and Recovery | Keystone Symposia
Join us at the Keystone Symposia on Islet Biology and Diabetes: Beta Cell Compensation, Failure and Recovery, March 2026, in Breckenridge, with field leaders!
keysym.us
November 10, 2025 at 10:59 PM
Deadlines are approaching (some next week!) for @keystoneSymposia.bsky.social #IsletBiology & #Diabetes : #BetaCell Compensation, Failure & Recovery, this March in Breckenridge! See scholarship, abstract and discount reg dates: keysym.us/KSDiabetes26 #KSDiabetes26
Reposted by Olov Andersson
Nov 18 is the deadline for short talk abstracts + scholarship apps for the Keystone Symposium on Islet Biology & Diabetes. Hear more from @linnemannlab.bsky.social: 🎥 youtu.be/4olDczSNJMo.
Apply: keysym.us/KSDiabetes26
#KSDiabetes26 #diabetes #drugdiscovery @o-andersson-lab.bsky.social
Apply: keysym.us/KSDiabetes26
#KSDiabetes26 #diabetes #drugdiscovery @o-andersson-lab.bsky.social
KSQA: Dr. Amelia K. Linnemann (Islet Biology and Diabetes)
YouTube video by KeystoneSymposia
youtu.be
November 15, 2025 at 7:52 PM
Nov 18 is the deadline for short talk abstracts + scholarship apps for the Keystone Symposium on Islet Biology & Diabetes. Hear more from @linnemannlab.bsky.social: 🎥 youtu.be/4olDczSNJMo.
Apply: keysym.us/KSDiabetes26
#KSDiabetes26 #diabetes #drugdiscovery @o-andersson-lab.bsky.social
Apply: keysym.us/KSDiabetes26
#KSDiabetes26 #diabetes #drugdiscovery @o-andersson-lab.bsky.social
The deadline for short talks at the Keystone Islet Biology symposium is approaching (Nov 18th) - submit it here: www.keystonesymposia.org/conferences/...
For great science and skiing March 16-19th in Breckenridge, Colorado @linnemannlab.bsky.social @keystonesymposia.bsky.social
For great science and skiing March 16-19th in Breckenridge, Colorado @linnemannlab.bsky.social @keystonesymposia.bsky.social
November 9, 2025 at 10:50 PM
The deadline for short talks at the Keystone Islet Biology symposium is approaching (Nov 18th) - submit it here: www.keystonesymposia.org/conferences/...
For great science and skiing March 16-19th in Breckenridge, Colorado @linnemannlab.bsky.social @keystonesymposia.bsky.social
For great science and skiing March 16-19th in Breckenridge, Colorado @linnemannlab.bsky.social @keystonesymposia.bsky.social
Reposted by Olov Andersson
Happy to share that our preprint is now published at @embomolmed.org! We expanded on the benchmark of porcine ductal organoids by a pretty extensive proteomics dataset to compare organoids derived from different developmental stages of the pig #devbio #PancSky www.embopress.org/doi/full/10....
Benchmarking porcine pancreatic ductal organoids for drug screening applications | EMBO Molecular Medicine
imageimageState-of-the-art single-cell RNA sequencing and proteomics approaches were employed
to benchmark porcine and human pancreatic ductal organoid systems for use as a drug
screening and testing ...
www.embopress.org
November 5, 2025 at 7:50 PM
Happy to share that our preprint is now published at @embomolmed.org! We expanded on the benchmark of porcine ductal organoids by a pretty extensive proteomics dataset to compare organoids derived from different developmental stages of the pig #devbio #PancSky www.embopress.org/doi/full/10....
Any danish located postdoc who wants to apply to work with us and zebrafish, pls contact me (postdocs from other places can also get in touch, as we have other alternatives)
novonordiskfonden.dk/en/grant/pos...
novonordiskfonden.dk/en/grant/pos...
Postdoctoral Fellowships at Uppsala University - 2026 - Novo Nordisk Fonden
novonordiskfonden.dk
October 4, 2025 at 10:19 AM
Any danish located postdoc who wants to apply to work with us and zebrafish, pls contact me (postdocs from other places can also get in touch, as we have other alternatives)
novonordiskfonden.dk/en/grant/pos...
novonordiskfonden.dk/en/grant/pos...
Join us for the revival of the Islet Biology and Diabetes Keystone symposia in Breckenridge, Colorado on March 16-19, 2026, for great science and great skiing. You can register now for early bird rates: lnkd.in/dw59T7tc Joint with Gut-Brain Axis. @linnemannlab.bsky.social Erica Nishimura, Barak Blum
September 24, 2025 at 9:38 PM
Join us for the revival of the Islet Biology and Diabetes Keystone symposia in Breckenridge, Colorado on March 16-19, 2026, for great science and great skiing. You can register now for early bird rates: lnkd.in/dw59T7tc Joint with Gut-Brain Axis. @linnemannlab.bsky.social Erica Nishimura, Barak Blum
Reposted by Olov Andersson
Type 2 diabetes is often considered a protein misfolding disease. But where are these toxic proteins found? 🤔
🚨In new work out today in @natmetabolism.nature.com, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s42... 1/n
🚨In new work out today in @natmetabolism.nature.com, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s42... 1/n
LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes - Nature Metabolism
LONP1, whose expression is downregulated in islets from donors with type 2 diabetes, is vital to mediate efficient mitochondrial protein folding, thus preventing proteotoxicity and promoting islet β c...
nature.com
July 21, 2025 at 10:48 AM
Type 2 diabetes is often considered a protein misfolding disease. But where are these toxic proteins found? 🤔
🚨In new work out today in @natmetabolism.nature.com, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s42... 1/n
🚨In new work out today in @natmetabolism.nature.com, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s42... 1/n
Join us as a professor by taking this great opportunity in pharmacology (in any system/area) www.uu.se/en/about-uu/...
Professor of Pharmacology - Uppsala University
Professor of Pharmacology, Department of Medical Cell Biology, Uppsala University
www.uu.se
June 24, 2025 at 3:18 PM
Join us as a professor by taking this great opportunity in pharmacology (in any system/area) www.uu.se/en/about-uu/...
Reposted by Olov Andersson
🚨 Just out in Nature Communications:
Cholangiocytes contribute to hepatocyte regeneration after partial #liver #injury during growth in #zebrafish
We challenge old assumptions on liver regeneration!
🔗 nature.com/articles/s41...
🧵(1/8)
Cholangiocytes contribute to hepatocyte regeneration after partial #liver #injury during growth in #zebrafish
We challenge old assumptions on liver regeneration!
🔗 nature.com/articles/s41...
🧵(1/8)
Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish - Nature Communications
During partial liver injury in growing zebrafish, cholangiocytes regenerate hepatocytes through transdifferentiation, revealing a stage-specific regeneration mechanism regulated by mTORC1 signaling.
nature.com
June 6, 2025 at 11:39 AM
🚨 Just out in Nature Communications:
Cholangiocytes contribute to hepatocyte regeneration after partial #liver #injury during growth in #zebrafish
We challenge old assumptions on liver regeneration!
🔗 nature.com/articles/s41...
🧵(1/8)
Cholangiocytes contribute to hepatocyte regeneration after partial #liver #injury during growth in #zebrafish
We challenge old assumptions on liver regeneration!
🔗 nature.com/articles/s41...
🧵(1/8)
Our paper has been out for a while but was included in today's issue, featuring our cover suggestion made by the brilliant Mattias Karlen
www.nature.com/nchembio/vol...
@ckarampelias.bsky.social @uu.se
www.nature.com/nchembio/vol...
@ckarampelias.bsky.social @uu.se
June 1, 2025 at 7:25 PM
Our paper has been out for a while but was included in today's issue, featuring our cover suggestion made by the brilliant Mattias Karlen
www.nature.com/nchembio/vol...
@ckarampelias.bsky.social @uu.se
www.nature.com/nchembio/vol...
@ckarampelias.bsky.social @uu.se
Reposted by Olov Andersson
Bring your favourite model system and help advance our understanding of how living organisms interact with and adapt to their environment.
Apply here: uu.varbi.com/en/what:job/...
Apply here: uu.varbi.com/en/what:job/...
Assistant Professor in Environmental Physiology
Uppsala University’s tenure track system grants assistant professors the possibility to be assessed for promotion to the position as associate professor. The university provides support in various a
uu.varbi.com
April 8, 2025 at 12:34 AM
Bring your favourite model system and help advance our understanding of how living organisms interact with and adapt to their environment.
Apply here: uu.varbi.com/en/what:job/...
Apply here: uu.varbi.com/en/what:job/...
Reposted by Olov Andersson
We’re excited to share our recently published story
“A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as modulators of mucosal healing”
in @mucosalimmunol.bsky.social
Fantastic work led by @ramoralescastro.bsky.social !
www.mucosalimmunology.org/article/S193...
“A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as modulators of mucosal healing”
in @mucosalimmunol.bsky.social
Fantastic work led by @ramoralescastro.bsky.social !
www.mucosalimmunology.org/article/S193...
A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as major modulators of mucosal healing
The intestine is a semipermeable tissue responsible for the absorption of essential
nutrients while limiting exposure to harmful environmental factors. To maintain these
functions, the intestinal epit...
www.mucosalimmunology.org
May 14, 2025 at 8:17 PM
We’re excited to share our recently published story
“A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as modulators of mucosal healing”
in @mucosalimmunol.bsky.social
Fantastic work led by @ramoralescastro.bsky.social !
www.mucosalimmunology.org/article/S193...
“A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as modulators of mucosal healing”
in @mucosalimmunol.bsky.social
Fantastic work led by @ramoralescastro.bsky.social !
www.mucosalimmunology.org/article/S193...
Reposted by Olov Andersson
What an elegant study showing that the mode and shape of cell division is defined by interphase morphology! This work suggests how cell fate and morphological asymmetries can be propagated via cell division in tissues.
www.science.org/doi/10.1126/...
#academiasky
www.science.org/doi/10.1126/...
#academiasky
Interphase cell morphology defines the mode, symmetry, and outcome of mitosis
During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...
www.science.org
May 1, 2025 at 6:30 PM
What an elegant study showing that the mode and shape of cell division is defined by interphase morphology! This work suggests how cell fate and morphological asymmetries can be propagated via cell division in tissues.
www.science.org/doi/10.1126/...
#academiasky
www.science.org/doi/10.1126/...
#academiasky
At the Stainier lab’s 30th year celebration, funtastic colleagues
April 27, 2025 at 7:41 PM
At the Stainier lab’s 30th year celebration, funtastic colleagues
Great opportunity & startup for someone that wants to start their lab studying inflammation/immune system (perhaps in metabolism, diabetes or the islet...) external/international candidates are wanted:
uu.varbi.com/en/what:job/...
uu.varbi.com/en/what:job/...
Associate Senior Lecturer (SciLifeLab Fellow) in inflammation research
The Science for Life Laboratory (SciLifeLab) is a national center for leading edge technological infrastructures that supports large-scale data and hypothesis-driven research in the field of molecular
uu.varbi.com
April 4, 2025 at 9:17 PM
Great opportunity & startup for someone that wants to start their lab studying inflammation/immune system (perhaps in metabolism, diabetes or the islet...) external/international candidates are wanted:
uu.varbi.com/en/what:job/...
uu.varbi.com/en/what:job/...
Amazing work on a DRiP neoantigen in beta-cells, where a protective SNP creating an IRE1 digestion motif and reducing the level of ER stress, DRiP, and type 1 diabetes...
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Genetic protection from type 1 diabetes resulting from accelerated insulin mRNA decay
Insulin gene variation predisposes individuals to type 1 diabetes (T1D). We report
a new mechanism of genetic protection from T1D in which insulin mRNA with a protective
SNP is broken down by IRE1α, t...
www.cell.com
March 19, 2025 at 4:39 PM
Amazing work on a DRiP neoantigen in beta-cells, where a protective SNP creating an IRE1 digestion motif and reducing the level of ER stress, DRiP, and type 1 diabetes...
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Olov Andersson
Deadline extended to March 23!!👇
Don’t miss this unique meeting bringing together leading Swedish researchers and practitioners in diabetes to share the latest advancements in diabetes research
👉 lnkd.in/dbbh6vcd
Hope to see you in Umeå!
👉 lnkd.in/dbbh6vcd
Hope to see you in Umeå!
March 15, 2025 at 7:27 AM
Deadline extended to March 23!!👇
Reposted by Olov Andersson
Happy to share our work on pancreatic ductal organoids from the human-relevant pig model across developmental stages ranging from embryonic to adult animals and using them for drug screening applications from the @heikolickert.bsky.social lab. #PancSky #devbio 🧪🧬 www.biorxiv.org/content/10.1... /1
Benchmarking porcine pancreatic ductal organoids for drug screening applications
Primary human pancreatic ductal organoids (HPDO) have emerged as a model to study pancreas biology and disease. Yet, donor material availability, and a lack of extensive benchmarking limits the range ...
www.biorxiv.org
March 14, 2025 at 8:29 AM
Happy to share our work on pancreatic ductal organoids from the human-relevant pig model across developmental stages ranging from embryonic to adult animals and using them for drug screening applications from the @heikolickert.bsky.social lab. #PancSky #devbio 🧪🧬 www.biorxiv.org/content/10.1... /1
Thank you Bart Roep for visiting, explaining a "not unlikely" beta-cell-centric origin of type 1 diabetes, and giving us a sneak peak of next week's issue of Cell
March 11, 2025 at 9:23 PM
Thank you Bart Roep for visiting, explaining a "not unlikely" beta-cell-centric origin of type 1 diabetes, and giving us a sneak peak of next week's issue of Cell
Reposted by Olov Andersson
1/6 Proudly presenting Sharif’s @sharifiqbal.bsky.social paper on the role of Asporin in intestinal regeneration through TGF-B-dependent fetal-like reversion www.sciencedirect.com/science/arti... out in @cp-cellstemcell.bsky.social @pekka-katajisto.bsky.social @helsinki.fi @metastem.bsky.social 🧵
Fetal-like reversion in the regenerating intestine is regulated by mesenchymal asporin
Mesenchymal cells and the extracellular matrix (ECM) support epithelium during homeostasis and regeneration. However, the role of the mesenchyme in ep…
www.sciencedirect.com
March 7, 2025 at 12:30 PM
1/6 Proudly presenting Sharif’s @sharifiqbal.bsky.social paper on the role of Asporin in intestinal regeneration through TGF-B-dependent fetal-like reversion www.sciencedirect.com/science/arti... out in @cp-cellstemcell.bsky.social @pekka-katajisto.bsky.social @helsinki.fi @metastem.bsky.social 🧵
Reposted by Olov Andersson
A new #evolution #EvoDevo #devbio #amphioxus #invertebrate paper this week @ScienceAdvances | Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates
Single-cell profiling of the amphioxus digestive tract reveals scattered distribution of three endocrine-like cell clusters.
www.science.org
December 21, 2024 at 5:10 PM
A new #evolution #EvoDevo #devbio #amphioxus #invertebrate paper this week @ScienceAdvances | Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Reposted by Olov Andersson
Notable inclusions include latests works of the Martik Lab, @sgraingerphd.bsky.social, @singhlab.bsky.social, @ditalialab.bsky.social, @o-andersson-lab.bsky.social, @blmartin.bsky.social, @tillymommersteeg.bsky.social, Megason Lab, Yelon Lab, Maves Lab, @thelovelylab.bsky.social among others!
📃January in preprints
First preprint list of 2025 is out! Check out the #preprints in #DevBio, #StemCell biology (and related fields) that came out in January. Congrats to everyone involved 🎉 And as usual, let us know if we've missed anything 👀
thenode.biologists.com/january-in-p...
First preprint list of 2025 is out! Check out the #preprints in #DevBio, #StemCell biology (and related fields) that came out in January. Congrats to everyone involved 🎉 And as usual, let us know if we've missed anything 👀
thenode.biologists.com/january-in-p...
January in preprints - the Node
Welcome to our monthly trawl for developmental and stem cell biology (and related) preprints. The preprints this month are hosted on bioRxiv – use these
thenode.biologists.com
February 5, 2025 at 1:50 PM
Notable inclusions include latests works of the Martik Lab, @sgraingerphd.bsky.social, @singhlab.bsky.social, @ditalialab.bsky.social, @o-andersson-lab.bsky.social, @blmartin.bsky.social, @tillymommersteeg.bsky.social, Megason Lab, Yelon Lab, Maves Lab, @thelovelylab.bsky.social among others!
Check out our review on beta-cell regeneration - special thanks to the great coauthors @ckarampelias.bsky.social et al #UppsalaUniversity #HelmholtzMunich www.nature.com/articles/s41...
Mechanistic insights and approaches for beta cell regeneration - Nature Chemical Biology
This Review highlights recent advances in the identification of small-molecule mediators of beta cell regeneration, discussing the diverse pathways and cellular processes altered by these compounds.
www.nature.com
January 29, 2025 at 12:03 PM
Check out our review on beta-cell regeneration - special thanks to the great coauthors @ckarampelias.bsky.social et al #UppsalaUniversity #HelmholtzMunich www.nature.com/articles/s41...
Fancy joining our lab? apply here for a PhD student position, (DM me for potential postdoc opportunities)
www.uu.se/en/about-uu/...
www.uu.se/en/about-uu/...
PhD student in regeneration of insulin-producing beta-cells in diabetes models - Uppsala University
PhD student in regeneration of insulin-producing beta-cells in diabetes models, Institutionen för medicinsk cellbiologi, Uppsala University
www.uu.se
January 14, 2025 at 10:52 AM
Fancy joining our lab? apply here for a PhD student position, (DM me for potential postdoc opportunities)
www.uu.se/en/about-uu/...
www.uu.se/en/about-uu/...