Kate Ellacott
@neuroendo.bsky.social
Scientist & Educator @ UoExeter #Neuroendocrinology #glia #food intake #obesity #diabetes #metabolism.
Senior Editor at Journal of Neuroendocrinology
President of British Society for Neuroendocrinology.
Enthusiastic but average baker & equestrienne
Senior Editor at Journal of Neuroendocrinology
President of British Society for Neuroendocrinology.
Enthusiastic but average baker & equestrienne
Pinned
Kate Ellacott
@neuroendo.bsky.social
· Nov 20
Validation of a refined protocol for mouse oral glucose tolerance testing without gavage
A glucose tolerance test (GTT) is routinely used to assess glucose homeostasis in clinical settings and in preclinical research studies using rodent models. The procedure assesses the ability of the b...
www.biorxiv.org
We developed a simple mouse glucose tolerance test protocol for diabetes research with voluntary oral glucose dosing instead of gavage. More physiological/aligned to the human test & better for animal welfare 👇🏻
www.biorxiv.org/content/10.1...
Please DM for detailed info or to arrange a chat
www.biorxiv.org/content/10.1...
Please DM for detailed info or to arrange a chat
Reposted by Kate Ellacott
Calling on my #science network! TeamNDF is #hiring a postdoc to start in 2026!
Are you fascinated by metabolism and the brain? Do you want to dig into life long impacts and the molecular cause?
Learn more about the team and our research here: www.dife.de/en/research/...
Please share! 🧠 🍔 💉
Are you fascinated by metabolism and the brain? Do you want to dig into life long impacts and the molecular cause?
Learn more about the team and our research here: www.dife.de/en/research/...
Please share! 🧠 🍔 💉
November 22, 2025 at 12:15 PM
Calling on my #science network! TeamNDF is #hiring a postdoc to start in 2026!
Are you fascinated by metabolism and the brain? Do you want to dig into life long impacts and the molecular cause?
Learn more about the team and our research here: www.dife.de/en/research/...
Please share! 🧠 🍔 💉
Are you fascinated by metabolism and the brain? Do you want to dig into life long impacts and the molecular cause?
Learn more about the team and our research here: www.dife.de/en/research/...
Please share! 🧠 🍔 💉
Reposted by Kate Ellacott
An update on the Neural Regulation of Blood Glucose in Acute Stress from Professor Stanley @AmDiabetesAssn diabetesjournals.org/diabetes/art...
November 18, 2025 at 10:45 PM
An update on the Neural Regulation of Blood Glucose in Acute Stress from Professor Stanley @AmDiabetesAssn diabetesjournals.org/diabetes/art...
Reposted by Kate Ellacott
Learn about progressions at the Obesity Update, where leading voices in obesity endocrinology will be sharing new research and practical updates to improve clinical practice.
It's your last chance to secure your ticket to join us on 1 December in Nottingham: bit.ly/OBU25
It's your last chance to secure your ticket to join us on 1 December in Nottingham: bit.ly/OBU25
November 19, 2025 at 11:01 AM
Learn about progressions at the Obesity Update, where leading voices in obesity endocrinology will be sharing new research and practical updates to improve clinical practice.
It's your last chance to secure your ticket to join us on 1 December in Nottingham: bit.ly/OBU25
It's your last chance to secure your ticket to join us on 1 December in Nottingham: bit.ly/OBU25
Reposted by Kate Ellacott
The 100 yr pursuit for non-injectable #insulin ..Here based on mouse and mini pig data, “a skin-permeable polymer may enable non-invasive transdermal delivery of insulin, relieving patients with #diabetes from subcutaneous injections” www.nature.com/articles/s41...
A skin-permeable polymer for non-invasive transdermal insulin delivery - Nature
The fast skin-permeable polyzwitterion poly[2-(N-oxide-N,N-dimethylamino)ethyl methacrylate] may enable non-invasive transdermal delivery of insulin, and potentially facilitate the use of other protei...
www.nature.com
November 19, 2025 at 5:20 PM
The 100 yr pursuit for non-injectable #insulin ..Here based on mouse and mini pig data, “a skin-permeable polymer may enable non-invasive transdermal delivery of insulin, relieving patients with #diabetes from subcutaneous injections” www.nature.com/articles/s41...
Excited to be attending and speaking at #ICN2026 in Nagoya, Japan 🇯🇵.
@bsneuroendo.bsky.social has funding support available for members including covering early bird registration 🐥
Who else is going? 🧠
@bsneuroendo.bsky.social has funding support available for members including covering early bird registration 🐥
Who else is going? 🧠
We're delighted to supporting our members to attend #ICN2026 in Nagoya, Japan.
BSN will pay members’ early bird registration fees and provide grants to attend the meeting.
Further details to follow.
BSN will pay members’ early bird registration fees and provide grants to attend the meeting.
Further details to follow.
November 13, 2025 at 8:34 PM
Excited to be attending and speaking at #ICN2026 in Nagoya, Japan 🇯🇵.
@bsneuroendo.bsky.social has funding support available for members including covering early bird registration 🐥
Who else is going? 🧠
@bsneuroendo.bsky.social has funding support available for members including covering early bird registration 🐥
Who else is going? 🧠
Reposted by Kate Ellacott
Our new review is out today!
𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀
We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.
onlinelibrary.wiley.com/doi/10.1111/...
𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀
We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.
onlinelibrary.wiley.com/doi/10.1111/...
The Energetic Collapse of the Alzheimer's Brain: Metabolic Inflexibility Across Cells and Networks
Metabolic inflexibility in Alzheimer's disease. Schematic illustrating the biphasic trajectory of metabolic activity relative to canonical Alzheimer's disease (AD) biomarkers. In the presymptomatic p...
onlinelibrary.wiley.com
November 13, 2025 at 8:17 PM
Our new review is out today!
𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀
We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.
onlinelibrary.wiley.com/doi/10.1111/...
𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀
We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Kate Ellacott
Publishing in Journal of Neuroendocrinology directly benefits the community.
“The grant boosted research output, skills, and confidence, strengthened our local laboratory capacity & enhanced our professional ranking.”
- Prof Oluwole Akinola & Joseph Enya
www.neuroendo.org.uk...
“The grant boosted research output, skills, and confidence, strengthened our local laboratory capacity & enhanced our professional ranking.”
- Prof Oluwole Akinola & Joseph Enya
www.neuroendo.org.uk...
November 13, 2025 at 3:13 PM
Publishing in Journal of Neuroendocrinology directly benefits the community.
“The grant boosted research output, skills, and confidence, strengthened our local laboratory capacity & enhanced our professional ranking.”
- Prof Oluwole Akinola & Joseph Enya
www.neuroendo.org.uk...
“The grant boosted research output, skills, and confidence, strengthened our local laboratory capacity & enhanced our professional ranking.”
- Prof Oluwole Akinola & Joseph Enya
www.neuroendo.org.uk...
Reposted by Kate Ellacott
Oxytocin isn’t just the “love hormone”: it helps wire the brain’s metabolic circuits! 🧠
In our new @plosbiology.org study, we show that OT neurons guide the postnatal development of POMC and AgRP pathways that control energy balance
In our new @plosbiology.org study, we show that OT neurons guide the postnatal development of POMC and AgRP pathways that control energy balance
Oxytocin neurons drive melanocortin circuit maturation via vesicle release during a neonatal critical period
The melanocortin circuit of the hypothalamus is crucial for regulating energy balance, but the development of this circuit is incompletely understood. This study in mice shows that activity and vesicl...
journals.plos.org
November 13, 2025 at 4:22 PM
Oxytocin isn’t just the “love hormone”: it helps wire the brain’s metabolic circuits! 🧠
In our new @plosbiology.org study, we show that OT neurons guide the postnatal development of POMC and AgRP pathways that control energy balance
In our new @plosbiology.org study, we show that OT neurons guide the postnatal development of POMC and AgRP pathways that control energy balance
Reposted by Kate Ellacott
EASO ECN Best Thesis Award entry deadline: 11 Jan 2025!
Eligibility criteria
✅ You are completing or have completed your PhD thesis
✅ Have carried out the majority of work in Europe
✅ Be a member of an EASO-affiliated national #obesity association
Eligibility criteria
✅ You are completing or have completed your PhD thesis
✅ Have carried out the majority of work in Europe
✅ Be a member of an EASO-affiliated national #obesity association
EASO ECN Best Thesis Award 2026 – Applications Now Open! - EASO
Finalists will be invited to present their work at ECO2026, taking place in Istanbul, Türkiye (12-15 May 2026), where the winner will receive a €500 cash prize and complimentary registration and…
easo.org
November 13, 2025 at 5:30 PM
EASO ECN Best Thesis Award entry deadline: 11 Jan 2025!
Eligibility criteria
✅ You are completing or have completed your PhD thesis
✅ Have carried out the majority of work in Europe
✅ Be a member of an EASO-affiliated national #obesity association
Eligibility criteria
✅ You are completing or have completed your PhD thesis
✅ Have carried out the majority of work in Europe
✅ Be a member of an EASO-affiliated national #obesity association
Reposted by Kate Ellacott
Our new research article 🔬 suggests that the maturity of the pancreas at onset of type 1 diabetes may hold the key to understanding why the disease course differs in early vs later life 📈. Watch our video to learn more! Produced in collaboration with @amanigardner.bsky.social
youtu.be/O-Q0e5rEUy4
youtu.be/O-Q0e5rEUy4
Small things matter in Type 1 diabetes
YouTube video by University of Exeter
youtu.be
November 13, 2025 at 10:39 AM
Our new research article 🔬 suggests that the maturity of the pancreas at onset of type 1 diabetes may hold the key to understanding why the disease course differs in early vs later life 📈. Watch our video to learn more! Produced in collaboration with @amanigardner.bsky.social
youtu.be/O-Q0e5rEUy4
youtu.be/O-Q0e5rEUy4
Reposted by Kate Ellacott
We're pleased to share groundbreaking news from the Type 1 Diabetes Grand Challenge!
A research team led by Dr Sarah Richardson has uncovered why type 1 diabetes affects young children differently.
Read more here - bit.ly/4hXDUuJ
#ChangingLivesForGood #Type1DiabetesGrandChallenge
A research team led by Dr Sarah Richardson has uncovered why type 1 diabetes affects young children differently.
Read more here - bit.ly/4hXDUuJ
#ChangingLivesForGood #Type1DiabetesGrandChallenge
November 13, 2025 at 6:42 AM
We're pleased to share groundbreaking news from the Type 1 Diabetes Grand Challenge!
A research team led by Dr Sarah Richardson has uncovered why type 1 diabetes affects young children differently.
Read more here - bit.ly/4hXDUuJ
#ChangingLivesForGood #Type1DiabetesGrandChallenge
A research team led by Dr Sarah Richardson has uncovered why type 1 diabetes affects young children differently.
Read more here - bit.ly/4hXDUuJ
#ChangingLivesForGood #Type1DiabetesGrandChallenge
Reposted by Kate Ellacott
Ahead of #WorldDiabetesDay tomorrow, we're delighted to announce new landmark research that uncovers why type 1 #diabetes is more aggressive in young children.
1/3
1/3
November 13, 2025 at 11:48 AM
Ahead of #WorldDiabetesDay tomorrow, we're delighted to announce new landmark research that uncovers why type 1 #diabetes is more aggressive in young children.
1/3
1/3
Congratulations to @sarahibex.bsky.social and Team at the University of Exeter Medical school (@hls.exeter.ac.uk) on the breakthrough study on #diabetes pathology
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Small things matter: Lack of extraislet β cells in type 1 diabetes
Early loss of small extraislet β cells in children with type 1 diabetes could explain age-related differences in disease.
www.science.org
November 13, 2025 at 7:00 AM
Congratulations to @sarahibex.bsky.social and Team at the University of Exeter Medical school (@hls.exeter.ac.uk) on the breakthrough study on #diabetes pathology
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Wonderful to see this beautiful work from my colleagues @sarahibex.bsky.social and @pialeete.bsky.social from Exeter (@hls.exeter.ac.uk) featured on the BBC www.bbc.co.uk/news/article...
Scientists discover why type 1 diabetes is worse in children
They show cells that control blood sugar are more vulnerable in early childhood.
www.bbc.co.uk
November 13, 2025 at 6:49 AM
Wonderful to see this beautiful work from my colleagues @sarahibex.bsky.social and @pialeete.bsky.social from Exeter (@hls.exeter.ac.uk) featured on the BBC www.bbc.co.uk/news/article...
Reposted by Kate Ellacott
My SWBio PhD DTP project with Lukasz Chrobok (@chroboklab.bsky.social) and Kate Elliott (@neuroendo.bsky.social) is now advertised:
Run, sleep, repeat: Regular exercise for good health and longevity.
bpb-eu-w2.wpmucdn.com/blogs.bristo...
Run, sleep, repeat: Regular exercise for good health and longevity.
bpb-eu-w2.wpmucdn.com/blogs.bristo...
bpb-eu-w2.wpmucdn.com
November 11, 2025 at 9:07 PM
My SWBio PhD DTP project with Lukasz Chrobok (@chroboklab.bsky.social) and Kate Elliott (@neuroendo.bsky.social) is now advertised:
Run, sleep, repeat: Regular exercise for good health and longevity.
bpb-eu-w2.wpmucdn.com/blogs.bristo...
Run, sleep, repeat: Regular exercise for good health and longevity.
bpb-eu-w2.wpmucdn.com/blogs.bristo...
Reposted by Kate Ellacott
New review with @lab-williams.bsky.social out today! One of the most enjoyable things about being a new PI has been making new collaborations and seeing projects advance through the pipeline.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Mechanisms of Innate Immune Modulation by High-Fat Diet: Implications for Obesity and Asthma - Current Allergy and Asthma Reports
Purpose of the Review The innate immune system plays a critical role in mediating many of the physiological consequences of high-fat diet consumption. Dietary lipids, and specifically saturated fatty ...
link.springer.com
November 10, 2025 at 12:40 PM
New review with @lab-williams.bsky.social out today! One of the most enjoyable things about being a new PI has been making new collaborations and seeing projects advance through the pipeline.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Kate Ellacott
Planning your undergrad neuroendo lectures?
Use our undergrad education guide to help you plan your curricula. Includes:
🧠Definition of neuroendo
🧠Transferrable skills
🧠Related fields
🧠Free tools and resources
🧠Key concepts in neuroendo
Download: www.neuroendo.org.uk...
Use our undergrad education guide to help you plan your curricula. Includes:
🧠Definition of neuroendo
🧠Transferrable skills
🧠Related fields
🧠Free tools and resources
🧠Key concepts in neuroendo
Download: www.neuroendo.org.uk...
November 9, 2025 at 11:08 AM
Planning your undergrad neuroendo lectures?
Use our undergrad education guide to help you plan your curricula. Includes:
🧠Definition of neuroendo
🧠Transferrable skills
🧠Related fields
🧠Free tools and resources
🧠Key concepts in neuroendo
Download: www.neuroendo.org.uk...
Use our undergrad education guide to help you plan your curricula. Includes:
🧠Definition of neuroendo
🧠Transferrable skills
🧠Related fields
🧠Free tools and resources
🧠Key concepts in neuroendo
Download: www.neuroendo.org.uk...
Reposted by Kate Ellacott
Last few days to apply for these 2 fully funded PhD positions in my new group @manchester.ac.uk! Deadline this Saturday 15th Nov.
🚨 I’ve got some exciting news! I have two PhD positions available in my group to advance Digital Endocrinology at @manchester.ac.uk Please help disseminate widely (application deadline 15th Nov):
1. Modelling hormonal dynamics in the human HPA axis.
www.findaphd.com/phds/project...
(1/2)
1. Modelling hormonal dynamics in the human HPA axis.
www.findaphd.com/phds/project...
(1/2)
(EPSRC CASE) Modelling hormonal dynamics in the human HPA axis at The University of Manchester on FindAPhD.com
PhD Project - (EPSRC CASE) Modelling hormonal dynamics in the human HPA axis at The University of Manchester, listed on FindAPhD.com
www.findaphd.com
November 10, 2025 at 12:41 PM
Last few days to apply for these 2 fully funded PhD positions in my new group @manchester.ac.uk! Deadline this Saturday 15th Nov.
Reposted by Kate Ellacott
4yr MRC-funded postdoc position investigating circadian mechanisms in cardiometabolic disease, currently available @manchester.ac.uk
www.jobs.manchester.ac.uk/Job/JobDetai...
Come and join our brilliant Centre for Biological Timing team!
@bioclocksuk.bsky.social #chronobiology #circadian #postdoc
www.jobs.manchester.ac.uk/Job/JobDetai...
Come and join our brilliant Centre for Biological Timing team!
@bioclocksuk.bsky.social #chronobiology #circadian #postdoc
Research Associate in Circadian Mechanisms in Cardiometabolic Disease:Oxford Road
Due to the nature of the funding, KTP Associates who have already completed a KTP are not eligible to apply.
www.jobs.manchester.ac.uk
November 10, 2025 at 12:51 PM
4yr MRC-funded postdoc position investigating circadian mechanisms in cardiometabolic disease, currently available @manchester.ac.uk
www.jobs.manchester.ac.uk/Job/JobDetai...
Come and join our brilliant Centre for Biological Timing team!
@bioclocksuk.bsky.social #chronobiology #circadian #postdoc
www.jobs.manchester.ac.uk/Job/JobDetai...
Come and join our brilliant Centre for Biological Timing team!
@bioclocksuk.bsky.social #chronobiology #circadian #postdoc
Reposted by Kate Ellacott
Next PANS Symposium is on the way! Register now for the Bayer sponsored “Menopausal Hot Flushes” Symposium on November 21st.
November 10, 2025 at 7:38 PM
Next PANS Symposium is on the way! Register now for the Bayer sponsored “Menopausal Hot Flushes” Symposium on November 21st.
Reposted by Kate Ellacott
TOMORROW!
Join us at PANS next Nov 5th @ 1PM EST for Dr. Carol Elias lecture! You do not want to miss it! Register here: mgb-org.zoom.us/webinar/regi...
November 4, 2025 at 6:34 PM
TOMORROW!
Reposted by Kate Ellacott
Hungry to know about the incredible tanycytes? Check out our latest review article "Tanycytes: bloodhounds of the metabolic brain"👌
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Tanycytes: bloodhounds of the metabolic brain
Constant monitoring and fine-tuning of internal body status to maintain energy homeostasis despite changing physiological needs and environmental cond…
www.sciencedirect.com
November 1, 2025 at 12:56 PM
Hungry to know about the incredible tanycytes? Check out our latest review article "Tanycytes: bloodhounds of the metabolic brain"👌
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Kate Ellacott
We are currently accepting suggestions for symposium at the 2026 @ssibsociety.bsky.social annual meeting in Philadelphia next year. Check out the link below or DM/email if you have questions 👊
www.ssib.org/2026/symposi...
www.ssib.org/2026/symposi...
SSIB 2026 | Philadelphia, PA
www.ssib.org
October 31, 2025 at 3:13 PM
We are currently accepting suggestions for symposium at the 2026 @ssibsociety.bsky.social annual meeting in Philadelphia next year. Check out the link below or DM/email if you have questions 👊
www.ssib.org/2026/symposi...
www.ssib.org/2026/symposi...
Reposted by Kate Ellacott
Industry postdoc opening! My sister dept @ @boehringerglobal.bsky.social Germany (Obesity Research area) is seeking a post-PhD candidate with significant technical expertise in brain ephys & imaging. Feel free to DM me with any further questions.
Post Doc - Electrophysiology & Sensor imaging of brain-obesity circuits
Post Doc - Electrophysiology & Sensor imaging of brain-obesity circuits
jobs.boehringer-ingelheim.com
October 30, 2025 at 2:50 PM
Industry postdoc opening! My sister dept @ @boehringerglobal.bsky.social Germany (Obesity Research area) is seeking a post-PhD candidate with significant technical expertise in brain ephys & imaging. Feel free to DM me with any further questions.
Reposted by Kate Ellacott
Gut brain communication. A review of the distinct spinal and vagal afferent types alongside viscerofugal pathways revealed by advances in neurogenetic techniques and high-resolution anterograde tracing www.nature.com/articles/s41...
Gut–brain communication: types of sensory nerves and mechanisms of activation - Nature Reviews Gastroenterology & Hepatology
This Review explores the different types of sensory nerves involved in gut–brain communication, detailing the locations of these nerve endings in the gut and their mechanisms of activation. Insights a...
www.nature.com
October 29, 2025 at 10:22 AM
Gut brain communication. A review of the distinct spinal and vagal afferent types alongside viscerofugal pathways revealed by advances in neurogenetic techniques and high-resolution anterograde tracing www.nature.com/articles/s41...