Mattia Laffranchi
@mattia-laffranchi.bsky.social
Fixed-term researcher at University of Rome La Sapienza | Immunity, cancer, and the space in between.
Pinned
Check out one of our latest review on Chemerin (RARRES2) and it's roles in the regulation of immune responses on Journal of Leukocyte Biology.
doi.org/10.1093/jleu...
#science #immunology #review #chemerin #immunesystem
doi.org/10.1093/jleu...
#science #immunology #review #chemerin #immunesystem
Check out:
Increased co-expression of ICOS and PD-1 predicts poor overall survival in patients with acute myeloid leukemia
doi.org/10.1016/j.im...
High expression of ICOS was associated with poor outcomes in AML patients, with implications for novel AML therapies
#leukemia #ICB #immunobiology
Increased co-expression of ICOS and PD-1 predicts poor overall survival in patients with acute myeloid leukemia
doi.org/10.1016/j.im...
High expression of ICOS was associated with poor outcomes in AML patients, with implications for novel AML therapies
#leukemia #ICB #immunobiology
November 18, 2025 at 10:30 AM
Check out:
Increased co-expression of ICOS and PD-1 predicts poor overall survival in patients with acute myeloid leukemia
doi.org/10.1016/j.im...
High expression of ICOS was associated with poor outcomes in AML patients, with implications for novel AML therapies
#leukemia #ICB #immunobiology
Increased co-expression of ICOS and PD-1 predicts poor overall survival in patients with acute myeloid leukemia
doi.org/10.1016/j.im...
High expression of ICOS was associated with poor outcomes in AML patients, with implications for novel AML therapies
#leukemia #ICB #immunobiology
Reposted by Mattia Laffranchi
Reposted by Mattia Laffranchi
🚀 One week until the #EFIS on Tour Symposium lands in Bucharest, 🇷🇴
🤝 Chance to meet the EFIS Board and network w/ colleagues across Europe
✅ Finalize registration today via QR code
📅 November 14, 2025 at 13:00
#immunology
@yefis-immunology.bsky.social @hammarieke.bsky.social @bojanpolic.bsky.social
🤝 Chance to meet the EFIS Board and network w/ colleagues across Europe
✅ Finalize registration today via QR code
📅 November 14, 2025 at 13:00
#immunology
@yefis-immunology.bsky.social @hammarieke.bsky.social @bojanpolic.bsky.social
November 7, 2025 at 1:15 PM
🚀 One week until the #EFIS on Tour Symposium lands in Bucharest, 🇷🇴
🤝 Chance to meet the EFIS Board and network w/ colleagues across Europe
✅ Finalize registration today via QR code
📅 November 14, 2025 at 13:00
#immunology
@yefis-immunology.bsky.social @hammarieke.bsky.social @bojanpolic.bsky.social
🤝 Chance to meet the EFIS Board and network w/ colleagues across Europe
✅ Finalize registration today via QR code
📅 November 14, 2025 at 13:00
#immunology
@yefis-immunology.bsky.social @hammarieke.bsky.social @bojanpolic.bsky.social
Reposted by Mattia Laffranchi
November 12, 2025 at 12:32 AM
Reposted by Mattia Laffranchi
📢 We're SO EXCITED to host Prof. Jean-Laurent Casanova (@casanovalab.bsky.social) for our upcoming YI Seminar. If you're someone excited about the the human genetics of infectious diseases, this ain't a seminar you should miss! Do register at shorturl.at/J6gPh
November 9, 2025 at 10:39 PM
📢 We're SO EXCITED to host Prof. Jean-Laurent Casanova (@casanovalab.bsky.social) for our upcoming YI Seminar. If you're someone excited about the the human genetics of infectious diseases, this ain't a seminar you should miss! Do register at shorturl.at/J6gPh
Check out:
Altered serum concentrations of IL-8, IL-32 and IL-10 in patients with lung impairment 6 months after COVID-19
doi.org/10.1016/j.im...
Serum IL-32, IL-8, and IL-10 levels are associated to lung sequelae after COVID-19.
#COVID-19 #cytokine #immunology #immunobiology
Altered serum concentrations of IL-8, IL-32 and IL-10 in patients with lung impairment 6 months after COVID-19
doi.org/10.1016/j.im...
Serum IL-32, IL-8, and IL-10 levels are associated to lung sequelae after COVID-19.
#COVID-19 #cytokine #immunology #immunobiology
November 6, 2025 at 10:04 AM
Check out:
Altered serum concentrations of IL-8, IL-32 and IL-10 in patients with lung impairment 6 months after COVID-19
doi.org/10.1016/j.im...
Serum IL-32, IL-8, and IL-10 levels are associated to lung sequelae after COVID-19.
#COVID-19 #cytokine #immunology #immunobiology
Altered serum concentrations of IL-8, IL-32 and IL-10 in patients with lung impairment 6 months after COVID-19
doi.org/10.1016/j.im...
Serum IL-32, IL-8, and IL-10 levels are associated to lung sequelae after COVID-19.
#COVID-19 #cytokine #immunology #immunobiology
Reposted by Mattia Laffranchi
A computational method designs receptors called T-SenSERs, which have predictable signalling responses to tumour microenvironment soluble factors and can be co-expressed with conventional CARs in T cells to enhance their therapeutic activity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 4, 2025 at 1:04 AM
A computational method designs receptors called T-SenSERs, which have predictable signalling responses to tumour microenvironment soluble factors and can be co-expressed with conventional CARs in T cells to enhance their therapeutic activity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Mattia Laffranchi
Exciting #postdoc opportunity in KL Ung's group!
Understanding the molecular mechanisms of cell wall remodeling in pathogens
Learn more: shorturl.at/gPuFV
Deadline: January 15, 2026
Contact: [email protected]
#Protein #Biochemistry #StructuralBiology #Biophysics #CryoEM
Understanding the molecular mechanisms of cell wall remodeling in pathogens
Learn more: shorturl.at/gPuFV
Deadline: January 15, 2026
Contact: [email protected]
#Protein #Biochemistry #StructuralBiology #Biophysics #CryoEM
November 4, 2025 at 5:34 AM
Exciting #postdoc opportunity in KL Ung's group!
Understanding the molecular mechanisms of cell wall remodeling in pathogens
Learn more: shorturl.at/gPuFV
Deadline: January 15, 2026
Contact: [email protected]
#Protein #Biochemistry #StructuralBiology #Biophysics #CryoEM
Understanding the molecular mechanisms of cell wall remodeling in pathogens
Learn more: shorturl.at/gPuFV
Deadline: January 15, 2026
Contact: [email protected]
#Protein #Biochemistry #StructuralBiology #Biophysics #CryoEM
Reposted by Mattia Laffranchi
Exciting #postdoc opportunity in T. Gensollen's group!
How early-life interactions between the immune system and microbiota shape lifelong immune imprinting and disease risk
Learn more: shorturl.at/F8hqE
Deadline: January 15, 2026
Contact: [email protected]
#Immunology #Microbiology #Microbiota #Omics
How early-life interactions between the immune system and microbiota shape lifelong immune imprinting and disease risk
Learn more: shorturl.at/F8hqE
Deadline: January 15, 2026
Contact: [email protected]
#Immunology #Microbiology #Microbiota #Omics
Early-life Immune Imprinting and Inflammatory Diseases - IPBS-Toulouse
Our team studies neonatal immunity. We are particularly interested in mapping the mucosal cell subsets[…]
shorturl.at
November 4, 2025 at 5:32 AM
Exciting #postdoc opportunity in T. Gensollen's group!
How early-life interactions between the immune system and microbiota shape lifelong immune imprinting and disease risk
Learn more: shorturl.at/F8hqE
Deadline: January 15, 2026
Contact: [email protected]
#Immunology #Microbiology #Microbiota #Omics
How early-life interactions between the immune system and microbiota shape lifelong immune imprinting and disease risk
Learn more: shorturl.at/F8hqE
Deadline: January 15, 2026
Contact: [email protected]
#Immunology #Microbiology #Microbiota #Omics
Still relevant in Immunology:
Macrophages: Their role, activation and polarization in pulmonary diseases
www.sciencedirect.com/science/arti...
Key points:
The diverse functions of lung macrophages are attributable to their plasticity
#Macrophage #Immunology #Immunobiology #Elsevier
Macrophages: Their role, activation and polarization in pulmonary diseases
www.sciencedirect.com/science/arti...
Key points:
The diverse functions of lung macrophages are attributable to their plasticity
#Macrophage #Immunology #Immunobiology #Elsevier
October 25, 2025 at 1:37 PM
Still relevant in Immunology:
Macrophages: Their role, activation and polarization in pulmonary diseases
www.sciencedirect.com/science/arti...
Key points:
The diverse functions of lung macrophages are attributable to their plasticity
#Macrophage #Immunology #Immunobiology #Elsevier
Macrophages: Their role, activation and polarization in pulmonary diseases
www.sciencedirect.com/science/arti...
Key points:
The diverse functions of lung macrophages are attributable to their plasticity
#Macrophage #Immunology #Immunobiology #Elsevier
Check out our latest review on dendritic cells and their roles in cancer immune responses on Cellular & Molecular Immunology:
"Dendritic cell subsets in cancer immunity and tumor antigen sensing"
doi.org/10.1038/s414...
#science #immunology #review #dendriticcell #DC #immunesystem #cancer
"Dendritic cell subsets in cancer immunity and tumor antigen sensing"
doi.org/10.1038/s414...
#science #immunology #review #dendriticcell #DC #immunesystem #cancer
October 22, 2025 at 11:49 AM
Check out our latest review on dendritic cells and their roles in cancer immune responses on Cellular & Molecular Immunology:
"Dendritic cell subsets in cancer immunity and tumor antigen sensing"
doi.org/10.1038/s414...
#science #immunology #review #dendriticcell #DC #immunesystem #cancer
"Dendritic cell subsets in cancer immunity and tumor antigen sensing"
doi.org/10.1038/s414...
#science #immunology #review #dendriticcell #DC #immunesystem #cancer
Reposted by Mattia Laffranchi
The molecular basis for signalling between epithelial and mesenchymal cells in pancreatic cancer has now been revealed
go.nature.com/3Jlu490
go.nature.com/3Jlu490
Pancreatic cancer relies on opposing signalling pathways to drive its cellular diversity
Communication between epithelial and mesenchymal cells in pancreatic cancer leads to a poor prognosis. The molecular basis for this signalling has now been revealed.
go.nature.com
October 22, 2025 at 11:33 AM
The molecular basis for signalling between epithelial and mesenchymal cells in pancreatic cancer has now been revealed
go.nature.com/3Jlu490
go.nature.com/3Jlu490
Check out:
The phenotype and related gene expressions of macrophages in adipose tissue of T2D mice following MSCs infusion
Key point:
Mesenchymal stem cells induces an M2-like state in macrophages in adipose tissue.
www.sciencedirect.com/science/arti...
#immunology #macrophages #science #elsevier
The phenotype and related gene expressions of macrophages in adipose tissue of T2D mice following MSCs infusion
Key point:
Mesenchymal stem cells induces an M2-like state in macrophages in adipose tissue.
www.sciencedirect.com/science/arti...
#immunology #macrophages #science #elsevier
The phenotype and related gene expressions of macrophages in adipose tissue of T2D mice following MSCs infusion
Infusion of mesenchymal stem cells (MSCs) induces polarization of M2 macrophages in adipose tissue of type 2 diabetes (T2D) mice. Studies have shown t…
www.sciencedirect.com
October 14, 2025 at 1:00 PM
Check out:
The phenotype and related gene expressions of macrophages in adipose tissue of T2D mice following MSCs infusion
Key point:
Mesenchymal stem cells induces an M2-like state in macrophages in adipose tissue.
www.sciencedirect.com/science/arti...
#immunology #macrophages #science #elsevier
The phenotype and related gene expressions of macrophages in adipose tissue of T2D mice following MSCs infusion
Key point:
Mesenchymal stem cells induces an M2-like state in macrophages in adipose tissue.
www.sciencedirect.com/science/arti...
#immunology #macrophages #science #elsevier
Reposted by Mattia Laffranchi
What is RNA velocity in situ? ChatGPT kept getting it wrong...
So I made this video explaining how RNA velocity in situ infers gene expression dynamics by distinguishing nuclear vs. cytoplasmic expression in spatial transcriptomics data: youtu.be/z9Oxf1hvum0
#AcademicSky
So I made this video explaining how RNA velocity in situ infers gene expression dynamics by distinguishing nuclear vs. cytoplasmic expression in spatial transcriptomics data: youtu.be/z9Oxf1hvum0
#AcademicSky
RNA velocity in situ infers gene expression dynamics using spatial transcriptomics data
YouTube video by Prof. Jean Fan
youtu.be
October 13, 2025 at 7:09 PM
What is RNA velocity in situ? ChatGPT kept getting it wrong...
So I made this video explaining how RNA velocity in situ infers gene expression dynamics by distinguishing nuclear vs. cytoplasmic expression in spatial transcriptomics data: youtu.be/z9Oxf1hvum0
#AcademicSky
So I made this video explaining how RNA velocity in situ infers gene expression dynamics by distinguishing nuclear vs. cytoplasmic expression in spatial transcriptomics data: youtu.be/z9Oxf1hvum0
#AcademicSky
Reposted by Mattia Laffranchi
Amazing to have our work finally out!!! 😍🤩😍
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
www.nature.com
September 29, 2025 at 6:38 PM
Amazing to have our work finally out!!! 😍🤩😍
Check out:
Single-cell transcriptome analysis of macrophage subpopulations contributing to chemotherapy resistance in ovarian cancer
Key points:
macrophaged increased their frequency post-chemotherapy in ovarian cancers
www.sciencedirect.com/science/arti...
#Immunology #Immunobiology #Elsevier
Single-cell transcriptome analysis of macrophage subpopulations contributing to chemotherapy resistance in ovarian cancer
Key points:
macrophaged increased their frequency post-chemotherapy in ovarian cancers
www.sciencedirect.com/science/arti...
#Immunology #Immunobiology #Elsevier
September 30, 2025 at 1:11 PM
Check out:
Single-cell transcriptome analysis of macrophage subpopulations contributing to chemotherapy resistance in ovarian cancer
Key points:
macrophaged increased their frequency post-chemotherapy in ovarian cancers
www.sciencedirect.com/science/arti...
#Immunology #Immunobiology #Elsevier
Single-cell transcriptome analysis of macrophage subpopulations contributing to chemotherapy resistance in ovarian cancer
Key points:
macrophaged increased their frequency post-chemotherapy in ovarian cancers
www.sciencedirect.com/science/arti...
#Immunology #Immunobiology #Elsevier
Still relevant in Immunology:
Natural and trained innate immunity against Mycobacterium tuberculosis
www.sciencedirect.com/science/arti...
Key points:
M. Tuberculosis and BCG vaccine creates trained immune memory via TLR7/9 signaling.
#Tubercolosis #Vaccine #Immunology #Immunobiology #Elsevier
Natural and trained innate immunity against Mycobacterium tuberculosis
www.sciencedirect.com/science/arti...
Key points:
M. Tuberculosis and BCG vaccine creates trained immune memory via TLR7/9 signaling.
#Tubercolosis #Vaccine #Immunology #Immunobiology #Elsevier
September 26, 2025 at 11:53 AM
Still relevant in Immunology:
Natural and trained innate immunity against Mycobacterium tuberculosis
www.sciencedirect.com/science/arti...
Key points:
M. Tuberculosis and BCG vaccine creates trained immune memory via TLR7/9 signaling.
#Tubercolosis #Vaccine #Immunology #Immunobiology #Elsevier
Natural and trained innate immunity against Mycobacterium tuberculosis
www.sciencedirect.com/science/arti...
Key points:
M. Tuberculosis and BCG vaccine creates trained immune memory via TLR7/9 signaling.
#Tubercolosis #Vaccine #Immunology #Immunobiology #Elsevier
Check out one of our latest review on Chemerin (RARRES2) and it's roles in the regulation of immune responses on Journal of Leukocyte Biology.
doi.org/10.1093/jleu...
#science #immunology #review #chemerin #immunesystem
doi.org/10.1093/jleu...
#science #immunology #review #chemerin #immunesystem
September 18, 2025 at 2:09 PM
Check out one of our latest review on Chemerin (RARRES2) and it's roles in the regulation of immune responses on Journal of Leukocyte Biology.
doi.org/10.1093/jleu...
#science #immunology #review #chemerin #immunesystem
doi.org/10.1093/jleu...
#science #immunology #review #chemerin #immunesystem
Still relevant in Immunology:
Human macrophage polarization in vitro: Maturation and activation methods compared
Key points:
Macrophage polarization is highly dependent on environmental factors.
www.sciencedirect.com/science/arti...
#Science #Immunology #Macrophage #Immunobiology #Elsevier
Human macrophage polarization in vitro: Maturation and activation methods compared
Key points:
Macrophage polarization is highly dependent on environmental factors.
www.sciencedirect.com/science/arti...
#Science #Immunology #Macrophage #Immunobiology #Elsevier
September 15, 2025 at 8:12 PM
Still relevant in Immunology:
Human macrophage polarization in vitro: Maturation and activation methods compared
Key points:
Macrophage polarization is highly dependent on environmental factors.
www.sciencedirect.com/science/arti...
#Science #Immunology #Macrophage #Immunobiology #Elsevier
Human macrophage polarization in vitro: Maturation and activation methods compared
Key points:
Macrophage polarization is highly dependent on environmental factors.
www.sciencedirect.com/science/arti...
#Science #Immunology #Macrophage #Immunobiology #Elsevier