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Reposted by Sara Wickstrom

@NicoliLab @nicolilab.bsky.social · 2d

So excited to announce lab alumni Dr. Helen Mengze He and Liana Boraas work at @yalecvrc.bsky.social in collaboration with the Kaelyn Sumigray lab @yaleschoolofmed.bsky.social is published today in @natcomms.nature.com and highlighted in Yale News! medicine.yale.edu/news-article...

Unlocking the Skin’s Natural Healing Power

Researchers show that embryonic skin stem cells rely on a specialized mechanism to resist injury. The findings could lead to new strategies for repairing wounds

medicine.yale.edu

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Reposted by Sara Wickstrom

James Briscoe @jamesbriscoe.bsky.social · 3d

The @crick.ac.uk is recruiting Early Career Group Leaders

- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology

Deadline 27 Nov

www.crick.ac.uk/careers-stud...

Early career group leaders

We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.

www.crick.ac.uk

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Reposted by Sara Wickstrom

Ralf H. Adams @ralfhadams.bsky.social · 2d

A recent preprint (Yang et al., doi.org/10.1101/2025...) challenges an article from my lab published in 2024 (Koh et al. 2024, PMID: 39537918). We strongly dispute their claims (please see our comment on bioRXiv).

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Degeneration and Impaired Resilience of Skull Bone and Hematopoietic Bone Marrow

Bone marrow health is central to transplantations, blood formation, and cancer progression. However, the bone marrow niche deteriorates with age, impairing haematopoietic stem cell function. Contrary ...

doi.org

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Reposted by Sara Wickstrom

Centro Andaluz de Biología del Desarrollo @cabd-upo-csic.bsky.social · 2d

Amazing talk today at #CABDseminars by @sarawickstrom.bsky.social! Sara explained work understanding mechanical regulation of cell states. She was hosted by @dariloops.bsky.social & @jrmarmor.bsky.social. Thanks for coming Dr. Wickstrom!

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Sara Wickstrom @sarawickstrom.bsky.social · 3d

Terribly sad news. Jochen was a pioneer in cell mechanics, a great colleague and a wonderful person. He will be missed.

Max Planck Institute for the Science of Light (MPL) @mpi-scienceoflight.bsky.social · 4d

With deep sadness, we share that Prof. Jochen Guck, Director at the Max Planck Institute for the Science of Light passed away on October 3. His visionary work bridged physics and medicine. We have lost a brilliant scientist and dear friend.

mpl.mpg.de/news/article...
@fau.de

📸 Stephan Spangenberg

Professor Jochen Guck, Director at the Max Planck Institute for the Science of Light (MPL), He headed the division “Cell Physics” at MPL and the Max-Planck-Zentrum für Physik und Medizin (MPZPM).

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Sara Wickstrom @sarawickstrom.bsky.social · 4d

Amazing 🤩

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Reposted by Sara Wickstrom

Centro Andaluz de Biología del Desarrollo @cabd-upo-csic.bsky.social · 7d

#CABDseminars

"Mechanical regulation of cell states" by Sara Wickström @sarawickstrom.bsky.social, @mpi-muenster.bsky.social

🗓️October 10th
⏰ 12 pm
📍Rosalind Franklin auditorium, CABD

Co-hosted by @dariloops.bsky.social & @jrmarmor.bsky.social

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Reposted by Sara Wickstrom

Journal of Cell Biology @jcb.org · 10d

Join @jcb.org Scientific Editor Gabriele Stephan at the EMBO | EMBL Symposium “Cell biology of the nucleus” during the lunchtime Meet the Editor talk Nov. 19. www.embl.org/about/info/c... #EESNucleus @events.embl.org

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Reposted by Sara Wickstrom

MwahahahahahadScientist @mads100tist.bsky.social · 13d

It's online! In this series of perspectives @dev-journal.bsky.social, yours truly talks about the exciting open questions and many things to do in the field of dev bio and neuroscience #DevBio🧪 #PIsOfTomorrow journals.biologists.com/dev/article/...

Pathway to Independence: a forecast for the future of developmental biology

ABSTRACT. In 2022, Development launched its Pathway to Independence (PI) programme, aimed at supporting postdocs as they transition to their first independent position. In 2025, we welcome our third c...

journals.biologists.com

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Reposted by Sara Wickstrom

Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · 8d

Elegant new study in our journal by @sarawickstrom.bsky.social @katemiro.bsky.social & co!

Nature Cell Biology @natcellbio.nature.com · 8d

💫NEW: @sarawickstrom.bsky.social @katemiro.bsky.social & co show that mechano-osmotic changes in the #nucleus induce general #transcriptional repression and prime #chromatin for cell fate transitions by relieving repression of specific differentiation genes. #pluripotency
bit.ly/3VMcyNZ

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

bit.ly

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Reposted by Sara Wickstrom

Nature Cell Biology @natcellbio.nature.com · 8d

💫NEW: @sarawickstrom.bsky.social @katemiro.bsky.social & co show that mechano-osmotic changes in the #nucleus induce general #transcriptional repression and prime #chromatin for cell fate transitions by relieving repression of specific differentiation genes. #pluripotency
bit.ly/3VMcyNZ

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

bit.ly

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Sara Wickstrom @sarawickstrom.bsky.social · 11d

Thank you Leo!

Sara Wickstrom @sarawickstrom.bsky.social · 11d

Thank you Elias!

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Sara Wickstrom @sarawickstrom.bsky.social · 12d

Thank you for highlighting our paper Daryl! We are very proud of this one too 😊

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Reposted by Sara Wickstrom

Daryl Jason Verzosa David @djdavid.bsky.social · 12d

Third paper to highlight!
Here, Lisa Manning, @sarawickstrom.bsky.social, &c olleagues show contractility, pressure, signalling cooperating in vertebrate development, w/thorough combination of expertise in cell biology, signalling, & biophysics.

(Open Access) www.nature.com/articles/s41...

Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture - Nature Cell Biology

Villeneuve et al. report coordination of contractile forces during mammalian hair follicle development, with actomyosin contractility and mechanical forces from the epidermis and underlying tissue regulating placode invagination and Sox9 expression.

www.nature.com

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Sara Wickstrom @sarawickstrom.bsky.social · 12d

Thank you Jorge! Nice discussions today 😊

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Reposted by Sara Wickstrom

Journal of Cell Science @jcellsci.bsky.social · 13d

We're still accepting submissions for our next special issue:
Cell Biology of the Nucleus
Guest edited by @abbybuch.bsky.social and Megan King @luskinglab.bsky.social.
Submission deadline: 3 November
journals.biologists.com/jcs/pages/nu...

#cellbiology #nucleus #notforprofit #freetopublish

Promotional graphic for a special issue of Journal of Cell Science titled 'Cell Biology of the Nucleus.' Guest Editor: Abby Buchwalter. Submission deadline: 3 November 2025. The image features a stylized cell with a bright pink, heart-shaped nucleus on a black background. Text includes a call for papers.

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Sara Wickstrom @sarawickstrom.bsky.social · 13d

Thank you Christian!

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Sara Wickstrom @sarawickstrom.bsky.social · 13d

Thank you Carmelo!

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Reposted by Sara Wickstrom

Carmelo Ferrai @carmeloferrai.bsky.social · 13d

Nice work from the labs of @katemiro.bsky.social @sarawickstrom.bsky.social
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells

www.nature.com/articles/s41...

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

www.nature.com

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Sara Wickstrom @sarawickstrom.bsky.social · 13d

Thank you Adrien!

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Reposted by Sara Wickstrom

Hallou Lab @halloulab.bsky.social · 13d

A landmark study by @sarawickstrom.bsky.social @katemiro.bsky.social and colleagues elucidating the relative contribution of GF and nuclear mechanics on cell fate decisions🤩 !! Many congratulations on this 'tour de force' 👏🎉 (pun on words intended 😉!) !!

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Reposted by Sara Wickstrom

Kaitlin McCreery @mccreery.bsky.social · 13d

Our paper is out in Nature Cell Biology! 🚀 Growth factors, mechanical forces, and osmotic stress work together to guide stem cell differentiation. Delighted to see these discoveries out in the world 🔥

Sara Wickstrom @sarawickstrom.bsky.social · 13d

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

www.nature.com

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Sara Wickstrom @sarawickstrom.bsky.social · 13d

Thank you Francesca!

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Reposted by Sara Wickstrom

Waggoner Lab @labwaggoner.bsky.social · 13d

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells @natcellbio.nature.com @sarawickstrom.bsky.social @akistubb.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...

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