After pressure from consumer advocates, the Trump administration is reconsidering a Biden-era rule banning hard-to-cancel subscription practices.

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The Trump administration’s plan to move special education out of the Department of Education threatens our progress in meeting the needs of vulnerable students.

Our Partnership We are thrilled to announce a partnership with the Publications division of the American Chemical Society (ACS) and ACS Ventures, a world leader

Previous high-throughput evaluations of CRISPR activities for a large number of target and guide RNA sequences were based on measuring insertion–deletion frequencies rather than cleavage efficiencies. Here we develop two high-throughput in vitro methods, Cut-seq1 and Cut-seq2, to evaluate Cas9 cleavage efficiency for tens of thousands, or even hundreds of thousands, of guide RNA–target pairs. These methods reveal low correlations between in vitro cleavage efficiencies and insertion–deletion frequencies in cells, yet high concordances in protospacer adjacent motif compatibility. Using the resulting large datasets of in vitro cleavage efficiencies, we develop DeepCut, a set of deep learning models that can identify optimized single-guide RNAs that can selectively cleave specific sequences, even in the presence of similar noise sequences. Using these optimized single-guide RNAs, we develop a method, CLOVE-seq (which stands for cleavage for large-scale optimized variant enrichment sequenci

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Prison mindfulness involves practices to enhance mental well-being and emotional resilience among inmates. Techniques such as meditation, breathing exercises, and guided imagery help individuals manag...

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ALT: a cat is hanging on a clothes line with the words hang in there above it .

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