Lars Henning
@larshenningmd.bsky.social
80% gynecological oncologist Västerås 🇸🇪. 20% HTA-unit Camtö Örebro Hospital. Views my own. Too dumb and lazy for doing research but interested how to evaluate medical research&evidence.
Words matter. Dislike lifscience like QoL&D engl, swed, germ
Words matter. Dislike lifscience like QoL&D engl, swed, germ
Pinned
Lars Henning
@larshenningmd.bsky.social
· Dec 22
vardgivare.regionorebrolan.se/rapport-om-l...
Skrev i senaste "Rapport om läkemedel" från Läkemedelskommitén Örebro om Camtös systematiska översikt över torkat svinsköldkörtelextrakt mot hypotyreos och en kartläggning av dess förskrivning i Sverige. Så snygg illustrerat. Tacksam för kritisk läsning.
Skrev i senaste "Rapport om läkemedel" från Läkemedelskommitén Örebro om Camtös systematiska översikt över torkat svinsköldkörtelextrakt mot hypotyreos och en kartläggning av dess förskrivning i Sverige. Så snygg illustrerat. Tacksam för kritisk läsning.
New expression of concerrn in @bmj.com possibly causing waves of concern among Swedish scientists who earn their careers by harvesting the formidable Swedish registries. When its not ok anymore to assume causal effects in observational trials where will be the fun left?
www.bmj.com/content/391/...
www.bmj.com/content/391/...
www.bmj.com
November 26, 2025 at 7:35 PM
New expression of concerrn in @bmj.com possibly causing waves of concern among Swedish scientists who earn their careers by harvesting the formidable Swedish registries. When its not ok anymore to assume causal effects in observational trials where will be the fun left?
www.bmj.com/content/391/...
www.bmj.com/content/391/...
In my opinion the authors of any systematical review should not have such a tragicomical lengthy conflict of interest section like in this case
Presented today at #KidneyWk ✅:
📚Effects of Sodium Glucose Cotransporter 2 Inhibitors by Diabetes Status and Level of Albuminuria: A Meta- Analysis, from @jama.com.
🔗Free to read online:
ja.ma/4ooJqJ9
📚Effects of Sodium Glucose Cotransporter 2 Inhibitors by Diabetes Status and Level of Albuminuria: A Meta- Analysis, from @jama.com.
🔗Free to read online:
ja.ma/4ooJqJ9
November 26, 2025 at 3:01 PM
In my opinion the authors of any systematical review should not have such a tragicomical lengthy conflict of interest section like in this case
"A massive Swedish study examined hormonal birth control risks. But the nuances of such studies get lost on social media."
Comment: nuances were lost also in traditional media-outlets and the initial press-release by Uppsala University
Comment: nuances were lost also in traditional media-outlets and the initial press-release by Uppsala University
A Swedish study found hormonal birth control is safe overall but shows a small breast cancer risk increase during use. TikTok claims it causes cancer as dangerous as smoking. Originally published by @kffhealthnews.org
Misinformation About Birth Control and Breast Cancer Swirls
A massive Swedish study examined hormonal birth control risks. But the nuances of such studies get lost on social media.
f.mtr.cool
November 24, 2025 at 5:18 PM
"A massive Swedish study examined hormonal birth control risks. But the nuances of such studies get lost on social media."
Comment: nuances were lost also in traditional media-outlets and the initial press-release by Uppsala University
Comment: nuances were lost also in traditional media-outlets and the initial press-release by Uppsala University
Superintresting and learnfull blogg on HPV-vaccination which illustrated clearly how challenging triangulation for longterm clinical effects with meaningful surrogate endpoints are. My greatest respect for not using the Danish ø a single time
We've had to wait a long time to get to this point! With this new pair of Cochrane systematic reviews, the weight of the evidence has tipped very heavily in favor of HPV vaccination.
My new post @plos.org absolutelymaybe.plos.org/2025/11/24/t...
#Vaccines
My new post @plos.org absolutelymaybe.plos.org/2025/11/24/t...
#Vaccines
This Evidence Fundamentally Shifts the Debate About the HPV Vaccine - Absolutely Maybe
We’ve had to wait a long time to get to this point. If cervical cancer develops after HPV infection, it will take…
absolutelymaybe.plos.org
November 24, 2025 at 1:29 PM
Superintresting and learnfull blogg on HPV-vaccination which illustrated clearly how challenging triangulation for longterm clinical effects with meaningful surrogate endpoints are. My greatest respect for not using the Danish ø a single time
Reposted by Lars Henning
We've had to wait a long time to get to this point! With this new pair of Cochrane systematic reviews, the weight of the evidence has tipped very heavily in favor of HPV vaccination.
My new post @plos.org absolutelymaybe.plos.org/2025/11/24/t...
#Vaccines
My new post @plos.org absolutelymaybe.plos.org/2025/11/24/t...
#Vaccines
This Evidence Fundamentally Shifts the Debate About the HPV Vaccine - Absolutely Maybe
We’ve had to wait a long time to get to this point. If cervical cancer develops after HPV infection, it will take…
absolutelymaybe.plos.org
November 24, 2025 at 10:24 AM
We've had to wait a long time to get to this point! With this new pair of Cochrane systematic reviews, the weight of the evidence has tipped very heavily in favor of HPV vaccination.
My new post @plos.org absolutelymaybe.plos.org/2025/11/24/t...
#Vaccines
My new post @plos.org absolutelymaybe.plos.org/2025/11/24/t...
#Vaccines
This is the kind of paper which is unethical to have behind paywall as it is directed to cancerpatients and their families. Reading might decrease unnecessary anxiety and stress and might improve quality of life and intimacy with loved ones while on chemotherapy. Recommended read.
November 21, 2025 at 10:04 AM
This is the kind of paper which is unethical to have behind paywall as it is directed to cancerpatients and their families. Reading might decrease unnecessary anxiety and stress and might improve quality of life and intimacy with loved ones while on chemotherapy. Recommended read.
www.dagensmedicin.se/alla-nyheter...
En av våra cancerpatienter får idag utan krångel en blodtransfusion i hemtrakten i Fagersta. Jag blev nästan gråtfärdig. Många take home messages här i artikeln:
- fördel med små enheter och eget ansvar
-Alltid bra att utgå från patientens behov & få jobb gjort
En av våra cancerpatienter får idag utan krångel en blodtransfusion i hemtrakten i Fagersta. Jag blev nästan gråtfärdig. Många take home messages här i artikeln:
- fördel med små enheter och eget ansvar
-Alltid bra att utgå från patientens behov & få jobb gjort
”Vi pratar inte pengar” – modellen som gjort Fagersta till ett föredöme i nära vård
När andra fastnar i ekonomi gjorde Fagersta tvärtom: de slutade prata pengar och började samarbeta. Resultatet är ett närvårdsteam som på bara tre år gjort nära vård till vardag – och förändrat patien...
www.dagensmedicin.se
November 21, 2025 at 8:17 AM
www.dagensmedicin.se/alla-nyheter...
En av våra cancerpatienter får idag utan krångel en blodtransfusion i hemtrakten i Fagersta. Jag blev nästan gråtfärdig. Många take home messages här i artikeln:
- fördel med små enheter och eget ansvar
-Alltid bra att utgå från patientens behov & få jobb gjort
En av våra cancerpatienter får idag utan krångel en blodtransfusion i hemtrakten i Fagersta. Jag blev nästan gråtfärdig. Många take home messages här i artikeln:
- fördel med små enheter och eget ansvar
-Alltid bra att utgå från patientens behov & få jobb gjort
Reposted by Lars Henning
This is a problem for scientific communication. A total lack of causation can never be proven for anything. You cannot prove that playing cello in your underwear doesn't cause autism. These charlatans exploit that.
This is completely disgusting. Today, the CDC updated their vaccine safety page. It now says:
“The claim "vaccines do not cause autism" is not an evidence-based claim because studies have not ruled out the possibility that infant vaccines cause autism”.
“The claim "vaccines do not cause autism" is not an evidence-based claim because studies have not ruled out the possibility that infant vaccines cause autism”.
November 20, 2025 at 6:30 AM
This is a problem for scientific communication. A total lack of causation can never be proven for anything. You cannot prove that playing cello in your underwear doesn't cause autism. These charlatans exploit that.
To fail in critical assessment of the published scientifical litterature (which implies to identify the shitty garbage part of published research) costs life
CDC has overhauled its website to assert that “the claim ‘vaccines do not cause autism’ is not an evidence-based claim”
November 20, 2025 at 5:53 AM
To fail in critical assessment of the published scientifical litterature (which implies to identify the shitty garbage part of published research) costs life
Its bad that this important patient-centered article is not open-access. The only advice i give to my patients on chemotherapy (not backed by evidence) is that they might avoid to kiss a person with fever. And that they should try to gather some cool moments of gold while on this toxic treatment.
“While you are on chemotherapy …” Myths:
- Avoid large social gatherings
- Wash clothes w body fluids STAT
- Use a separate toilet
- Avoid all EtOH
- Avoid certain foods, coffee
--> lack evidence, cause harm academic.oup.com/jnci/article... great article from @csoncol.bsky.social #oncology
- Avoid large social gatherings
- Wash clothes w body fluids STAT
- Use a separate toilet
- Avoid all EtOH
- Avoid certain foods, coffee
--> lack evidence, cause harm academic.oup.com/jnci/article... great article from @csoncol.bsky.social #oncology
“While you are on chemotherapy …”: common recommendations that lack evidence and may cause harm
Abstract. Patients on chemotherapy often use multiple resources to obtain information on wide-ranging issues, including prognosis, treatments, diet, exerci
academic.oup.com
November 18, 2025 at 5:28 AM
Its bad that this important patient-centered article is not open-access. The only advice i give to my patients on chemotherapy (not backed by evidence) is that they might avoid to kiss a person with fever. And that they should try to gather some cool moments of gold while on this toxic treatment.
Reposted by Lars Henning
Are methodological and causal inference errors creating a false impression that the gut microbiome causes autism? In this strong analysis, Mitchell, Dahly, and Bishop question the evidence.
They show that triangulation in science requires multiple robust lines of research.
They show that triangulation in science requires multiple robust lines of research.
The link between the gut #microbiome and autism is not backed by science, researchers say.
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
November 14, 2025 at 12:49 PM
Are methodological and causal inference errors creating a false impression that the gut microbiome causes autism? In this strong analysis, Mitchell, Dahly, and Bishop question the evidence.
They show that triangulation in science requires multiple robust lines of research.
They show that triangulation in science requires multiple robust lines of research.
9th of december free 2-hour introduction online workshop on the INSPECT-SR tool for assessing trustworthiness of randomised controlled trials (RCTs. 👇
November 6, 2025 at 6:02 PM
9th of december free 2-hour introduction online workshop on the INSPECT-SR tool for assessing trustworthiness of randomised controlled trials (RCTs. 👇
Detection for fabricated or unlikely data in RCT's should be mandatory for HTA-units as well 👇
i agree. Problem is that peer review is not geared up for detection of fabricated data. Sadly I think we need to be more alert to this. Inclusion of raw data v helpful in this case - and the discrepancies in age hit you as soon as you open the file. But deposited data should be .csv! @bmj.com
November 3, 2025 at 11:28 AM
Detection for fabricated or unlikely data in RCT's should be mandatory for HTA-units as well 👇
Reposted by Lars Henning
10/ Protecting every child protects the world. 🌍
That’s what vaccine equity means — a safer, fairer future for all.
Learn more:
🔹 The Lancet: tinyurl.com/3vbkwrfx
🔹 Nature: tinyurl.com/yc3v84uj
🔹 Gavi: gavi.org
#GlobalHealth
That’s what vaccine equity means — a safer, fairer future for all.
Learn more:
🔹 The Lancet: tinyurl.com/3vbkwrfx
🔹 Nature: tinyurl.com/yc3v84uj
🔹 Gavi: gavi.org
#GlobalHealth
November 2, 2025 at 12:07 PM
10/ Protecting every child protects the world. 🌍
That’s what vaccine equity means — a safer, fairer future for all.
Learn more:
🔹 The Lancet: tinyurl.com/3vbkwrfx
🔹 Nature: tinyurl.com/yc3v84uj
🔹 Gavi: gavi.org
#GlobalHealth
That’s what vaccine equity means — a safer, fairer future for all.
Learn more:
🔹 The Lancet: tinyurl.com/3vbkwrfx
🔹 Nature: tinyurl.com/yc3v84uj
🔹 Gavi: gavi.org
#GlobalHealth
Reposted by Lars Henning
Who did this?!
November 1, 2025 at 8:38 PM
Who did this?!
Good study which contributes to informed decision making of women when choosing contraceptives. But also an example of failed communication of research findings in the 🇸🇪 media. A school-book example imo where it should be forbidden to use relative risks and mandatory with absolute risk.
Both combined and progestin-only contraceptives are linked to increased breast cancer risk, with greater risk observed for progestin-only, particularly desogestrel-containing products. ja.ma/47lXKLe
November 2, 2025 at 8:44 AM
Good study which contributes to informed decision making of women when choosing contraceptives. But also an example of failed communication of research findings in the 🇸🇪 media. A school-book example imo where it should be forbidden to use relative risks and mandatory with absolute risk.
Reposted by Lars Henning
Evidence synthesis for decision making: navigating the chaos of the real world | Online
🗓️ 6 November
This webinar will discuss some of the challenges in evidence synthesis when the available evidence may not answer all the questions.
🔗 Register here: universityofgalway-ie.zoom.us/webinar/regi...
🗓️ 6 November
This webinar will discuss some of the challenges in evidence synthesis when the available evidence may not answer all the questions.
🔗 Register here: universityofgalway-ie.zoom.us/webinar/regi...
universityofgalway-ie.zoom.us
October 31, 2025 at 3:07 PM
Evidence synthesis for decision making: navigating the chaos of the real world | Online
🗓️ 6 November
This webinar will discuss some of the challenges in evidence synthesis when the available evidence may not answer all the questions.
🔗 Register here: universityofgalway-ie.zoom.us/webinar/regi...
🗓️ 6 November
This webinar will discuss some of the challenges in evidence synthesis when the available evidence may not answer all the questions.
🔗 Register here: universityofgalway-ie.zoom.us/webinar/regi...
Good example of nice description of disadvantages with multidisciplinary conferences in cancer-care and bad solutions (AI as the rescue). My 2 cents: centralization has gone too far. Invest in oncologists close to patients and listen to them and you'll do better decisions www.bmj.com/content/391/...
Cancer decision making needs a radical rethink
Long meetings involving dozens of clinicians can delay patient care and leave no room for service improvement. It’s time for a fresh approach, say Tom Roques and colleagues
For 30 years, multidiscip...
www.bmj.com
October 31, 2025 at 3:09 PM
Good example of nice description of disadvantages with multidisciplinary conferences in cancer-care and bad solutions (AI as the rescue). My 2 cents: centralization has gone too far. Invest in oncologists close to patients and listen to them and you'll do better decisions www.bmj.com/content/391/...
Debatt-artikel efter HTA-enhet Camtös rapport om exploderande CT-användning. Camtö uppmärksammade i rapporten att det saknas organiserad statistik om användning av CT där man var tvungen att använda framtagen data från ett företag
”Ökningen av CT behöver stoppas”
www.svd.se/a/5EAgP6/ove...
”Ökningen av CT behöver stoppas”
www.svd.se/a/5EAgP6/ove...
”Ökningen av CT behöver stoppas”
DEBATT. Överläkare: Sjukvården är fast i en farlig spiral där krav på perfektion, produktion och emellanåt omöjliga förutsättningar betalas med ett ökande antal CT-undersökningar.
www.svd.se
October 31, 2025 at 6:02 AM
Debatt-artikel efter HTA-enhet Camtös rapport om exploderande CT-användning. Camtö uppmärksammade i rapporten att det saknas organiserad statistik om användning av CT där man var tvungen att använda framtagen data från ett företag
”Ökningen av CT behöver stoppas”
www.svd.se/a/5EAgP6/ove...
”Ökningen av CT behöver stoppas”
www.svd.se/a/5EAgP6/ove...
Reposted by Lars Henning
This is an excellent point that generalizes.
Researchers often defend suboptimal practices by referring to future studies with better designs.
But: Why would anybody run those studies when you can just throw a bunch of variables into a regression and make sweeping "preliminary" claims?
Researchers often defend suboptimal practices by referring to future studies with better designs.
But: Why would anybody run those studies when you can just throw a bunch of variables into a regression and make sweeping "preliminary" claims?
October 28, 2025 at 11:22 AM
This is an excellent point that generalizes.
Researchers often defend suboptimal practices by referring to future studies with better designs.
But: Why would anybody run those studies when you can just throw a bunch of variables into a regression and make sweeping "preliminary" claims?
Researchers often defend suboptimal practices by referring to future studies with better designs.
But: Why would anybody run those studies when you can just throw a bunch of variables into a regression and make sweeping "preliminary" claims?
Sociologen @rolandpaulsen.bsky.social med mycket intressant berättelse om testosteron-industrins bakgrund och idéhistorie inklusive hänvisning till HTA-enheten CAMTÖ's debattartikel och ny boktips om överdiagnos
www.dn.se/kultur/rolan...
www.dn.se/kultur/rolan...
Roland Paulsen: Jag mätte mina testosteronhalter – resultatet var chockerande
Alla från Trump till Andrew Tate skryter med sina höga testosteronhalter. En dag började Roland Paulsen undra om han själv kanske behövde tillskott.
www.dn.se
October 26, 2025 at 11:04 AM
Sociologen @rolandpaulsen.bsky.social med mycket intressant berättelse om testosteron-industrins bakgrund och idéhistorie inklusive hänvisning till HTA-enheten CAMTÖ's debattartikel och ny boktips om överdiagnos
www.dn.se/kultur/rolan...
www.dn.se/kultur/rolan...
Dyra sprutan kan skydda mot demens
www.svd.se/a/OowPbb/bal...
Fascinerande artikel som ställer frågan om inte en välgjord observationsstudie som innefattar ett naturligt experiment skall vara tillräckligt för att introducera bältrosvaccination för äldre i svenska vaccinationsprogrammet.
www.svd.se/a/OowPbb/bal...
Fascinerande artikel som ställer frågan om inte en välgjord observationsstudie som innefattar ett naturligt experiment skall vara tillräckligt för att introducera bältrosvaccination för äldre i svenska vaccinationsprogrammet.
Dyra sprutan kan skydda mot demens
Vaccin mot bältros tycks minska risken för demens, enligt flera studier. Därför bör de dyra sprutorna nu införas i det svenska vaccinationsprogrammet, anser forskare.
www.svd.se
October 22, 2025 at 2:22 PM
Dyra sprutan kan skydda mot demens
www.svd.se/a/OowPbb/bal...
Fascinerande artikel som ställer frågan om inte en välgjord observationsstudie som innefattar ett naturligt experiment skall vara tillräckligt för att introducera bältrosvaccination för äldre i svenska vaccinationsprogrammet.
www.svd.se/a/OowPbb/bal...
Fascinerande artikel som ställer frågan om inte en välgjord observationsstudie som innefattar ett naturligt experiment skall vara tillräckligt för att introducera bältrosvaccination för äldre i svenska vaccinationsprogrammet.
Unfortunately sold out for now. But hopefully more free online workshops in the future
Free online workshop for assessing trustworthiness of RCTs
Introductory online INSPECT-SR workshop. November 6th, 12-2pm UK-time. Free, places limited. BOOK: www.trybooking.com/uk/events/la...
October 22, 2025 at 1:14 PM
Unfortunately sold out for now. But hopefully more free online workshops in the future
Still painful not to be able to read Cochrane Reviews during the first year in full. Much more painful that I wasted resources for far too many years with my misguided non-evidence routine to give blood transfusion to my cancer patients with Hb<100. #choosewisely
A Cochrane review found that, for most people, waiting for for their haemoglobin drop to lower levels before giving a transfusion was safe and means fewer transfusions in general.
🔗 www.cochranelibrary.com/cdsr/doi/10....
🔗 www.cochranelibrary.com/cdsr/doi/10....
October 21, 2025 at 10:37 AM
Still painful not to be able to read Cochrane Reviews during the first year in full. Much more painful that I wasted resources for far too many years with my misguided non-evidence routine to give blood transfusion to my cancer patients with Hb<100. #choosewisely
Reposted by Lars Henning
New blogpost on my concerns about Wellcome LEAP new $50m program on autism/microbiome links. deevybee.blogspot.com/2025/10/a-le...
#autism #microbiome #biomarkers #diagnostic
#autism #microbiome #biomarkers #diagnostic
A LEAP into the future, or off a cliff: Wellcome LEAP's new $50M program
A few days ago, I saw this post on LinkedIn: How does the gut microbiome shape early brain development? That’s what FORM, a new $50 million...
deevybee.blogspot.com
October 20, 2025 at 1:53 PM
New blogpost on my concerns about Wellcome LEAP new $50m program on autism/microbiome links. deevybee.blogspot.com/2025/10/a-le...
#autism #microbiome #biomarkers #diagnostic
#autism #microbiome #biomarkers #diagnostic