Jan Lammerding - Lab
@lammerdinglab.bsky.social
We study lamins and nuclear mechanobiology. Meinig School of Biomedical Engineering. Weill Institute for Cell and Molecular Biology. Cornell University. https://lammerding.wicmb.cornell.edu/
Motivational video for #MigrationMovieMonday. A persistent 4T1 breast cancer cell squeezing itself through a tight constriction despite undergoing repetitive nuclear envelope rupture. Credit: Kristen Nedza @weillinstitute.bsky.social
November 25, 2025 at 1:36 AM
Motivational video for #MigrationMovieMonday. A persistent 4T1 breast cancer cell squeezing itself through a tight constriction despite undergoing repetitive nuclear envelope rupture. Credit: Kristen Nedza @weillinstitute.bsky.social
Reposted by Jan Lammerding - Lab
Thanks to @katemiro.bsky.social , Megan King, Verena Ruprecht & @lammerdinglab.bsky.social for organising the very first meeting on the “Mechanobiology of the Nucleus” #MBNSRC @faseborg.bsky.social and for the invitation to present our discoveries. The conference was fantastic!
End of an incredible meeting — Mechanobiology of the Cell Nucleus #MBNSRC.
So proud of my PhD student @leamayeur.bsky.social for winning the Best Early Career Researcher Presentation Award! 🏆👏
So proud of my PhD student @leamayeur.bsky.social for winning the Best Early Career Researcher Presentation Award! 🏆👏
November 13, 2025 at 2:23 PM
Thanks to @katemiro.bsky.social , Megan King, Verena Ruprecht & @lammerdinglab.bsky.social for organising the very first meeting on the “Mechanobiology of the Nucleus” #MBNSRC @faseborg.bsky.social and for the invitation to present our discoveries. The conference was fantastic!
It’s been a pleasure working with @apdaria.bsky.social, Julie Heffler, and the Prosser Lab on this study, supported by the Leducq Foundation and the National Institutes of Health (NIH). This research is one step to get us closer to an effective treatment for cardiac #laminopathies and #LMNA-DCM.
It is finally out! Updated with exciting in-vivo microtubule disruption results to protect Lmna deficient nuclei from damage. My final postdoc project with Prosser Lab and a great collaboration with @lammerdinglab.bsky.social, Shenoy Lab, and Jain lab.
Research | Amiad Pavlov, Heffler et al. demonstrate that stress transmitted to the cardiomyocyte nucleus by the microtubule cage drives LMNA-associated cardiomyopathy and may represent a promising therapeutic target.
doi.org/10.1038/s441...
rdcu.be/eOeTA
doi.org/10.1038/s441...
rdcu.be/eOeTA
November 6, 2025 at 1:34 PM
It’s been a pleasure working with @apdaria.bsky.social, Julie Heffler, and the Prosser Lab on this study, supported by the Leducq Foundation and the National Institutes of Health (NIH). This research is one step to get us closer to an effective treatment for cardiac #laminopathies and #LMNA-DCM.
How do LMNA mutations cause dilated cardiomyopathy (DCM) and other #laminopathies? In our latest preprint (doi.org/10.1101/2024...), led by the amazing Noam Zuela-Sopilniak and Julien Morival, we show that cardiomyocyte-specific lamin A/C depletion causes severe DCM, consistent with other studies.
September 18, 2025 at 6:12 PM
How do LMNA mutations cause dilated cardiomyopathy (DCM) and other #laminopathies? In our latest preprint (doi.org/10.1101/2024...), led by the amazing Noam Zuela-Sopilniak and Julien Morival, we show that cardiomyocyte-specific lamin A/C depletion causes severe DCM, consistent with other studies.
Reposted by Jan Lammerding - Lab
Odell, J et al. (@lammerdinglab.bsky.social lab) A-type lamins anchor emerin at the inner nuclear membrane via two independent binding sites. bioRxiv posted 2 September 2025 doi:10.1101/2025.09.01.673543. www.biorxiv.org/content/10.1...
A-type lamins anchor emerin at the inner nuclear membrane via two independent binding sites
Lamins form a dense meshwork at the inner surface of the inner nuclear membrane (INM), where they interact with other nuclear envelope proteins such as emerin. Emerin is an integral membrane protein t...
www.biorxiv.org
September 3, 2025 at 11:31 AM
Odell, J et al. (@lammerdinglab.bsky.social lab) A-type lamins anchor emerin at the inner nuclear membrane via two independent binding sites. bioRxiv posted 2 September 2025 doi:10.1101/2025.09.01.673543. www.biorxiv.org/content/10.1...
Final call to register and submit abstracts for the @faseborg.bsky.social conference on the Mechanobiology of the Cell Nucleus (#MBNSRC) to be considered for platform presentations. The conference takes place in Melbourne, FL, Oct. 26-30, 2025. See more info at: events.faseb.org/event/Mechan...
August 29, 2025 at 10:37 PM
Final call to register and submit abstracts for the @faseborg.bsky.social conference on the Mechanobiology of the Cell Nucleus (#MBNSRC) to be considered for platform presentations. The conference takes place in Melbourne, FL, Oct. 26-30, 2025. See more info at: events.faseb.org/event/Mechan...
Reposted by Jan Lammerding - Lab
Spread the word - we at @stanford-chemh.bsky.social are searching to fill a new junior faculty at the interface of molecular and computational science. See link below!
Open faculty position!
We're seeking applicants for a tenure-track faculty position at the junior level (Assistant or untenured Associate Professor) with research programs that exist at the interface between molecular science and computation. Apply here: stanford.io/45MF3Qa
We're seeking applicants for a tenure-track faculty position at the junior level (Assistant or untenured Associate Professor) with research programs that exist at the interface between molecular science and computation. Apply here: stanford.io/45MF3Qa
August 27, 2025 at 3:27 AM
Spread the word - we at @stanford-chemh.bsky.social are searching to fill a new junior faculty at the interface of molecular and computational science. See link below!
Reposted by Jan Lammerding - Lab
FOMO no more: NOMO and Calmin extend #mechanobiology to the ER. Julie Heffler and Jan Lammerding @LammerdingLab.bsky.social discuss recent studies from the @schliekerlab.bsky.social (doi.org/10.1083/jcb....) & @hennelab.bsky.social (doi.org/10.1016/j.ce...), in Spotlight: rupress.org/jcb/article/...
August 25, 2025 at 7:02 PM
FOMO no more: NOMO and Calmin extend #mechanobiology to the ER. Julie Heffler and Jan Lammerding @LammerdingLab.bsky.social discuss recent studies from the @schliekerlab.bsky.social (doi.org/10.1083/jcb....) & @hennelab.bsky.social (doi.org/10.1016/j.ce...), in Spotlight: rupress.org/jcb/article/...
Interested in #mechanobiology of the cell nucleus? The submission deadline for the first ever FASEB Science Research Conference on the Mechanobiology of the Nucleus is August 31, 2025. Submit your abstract to be considered for a platform presentation.
#MBNSRC
events.faseb.org/event/Mechan...
#MBNSRC
events.faseb.org/event/Mechan...
August 19, 2025 at 7:43 PM
Interested in #mechanobiology of the cell nucleus? The submission deadline for the first ever FASEB Science Research Conference on the Mechanobiology of the Nucleus is August 31, 2025. Submit your abstract to be considered for a platform presentation.
#MBNSRC
events.faseb.org/event/Mechan...
#MBNSRC
events.faseb.org/event/Mechan...
Last chance to register and submit an abstract to be considered for a platform presentation. If you are interested in nuclear #mechano Ta
Looking forward to meeting "old" & new friends at the FASEB Science Research Conference on the Mechanobiology of the Nucleus #MBNSRC.
Submit your abstract by Aug, 31!
Submit your abstract by Aug, 31!
Interested in nuclear #mechanobiology? Join us for the first ever FASEB Science Research Conference on the Mechanobiology of the Nucleus #MBNSRC.
Find more information and register at: events.faseb.org/event/Mechan...
Submit abstracts by August 31, 2025. Please share and see you in October!
Find more information and register at: events.faseb.org/event/Mechan...
Submit abstracts by August 31, 2025. Please share and see you in October!
August 19, 2025 at 4:41 PM
Last chance to register and submit an abstract to be considered for a platform presentation. If you are interested in nuclear #mechano Ta
Reposted by Jan Lammerding - Lab
Heffler and @LammerdingLab.bsky.social discuss recent studies from the @schliekerlab.bsky.social (doi.org/10.1083/jcb....) and @hennelab.bsky.social (doi.org/10.1016/j.ce...) that identify two proteins serving as crucial mechanical elements in the endoplasmic reticulum. rupress.org/jcb/article/...
August 18, 2025 at 6:15 PM
Heffler and @LammerdingLab.bsky.social discuss recent studies from the @schliekerlab.bsky.social (doi.org/10.1083/jcb....) and @hennelab.bsky.social (doi.org/10.1016/j.ce...) that identify two proteins serving as crucial mechanical elements in the endoplasmic reticulum. rupress.org/jcb/article/...
Please submit your abstracts by August 31st to be considered for a platform presentation! We look forward to an exciting and stimulating meeting! Please share!
A Nuclear Mechanobiology meeting is a dream come true!!! Please join us!
Interested in nuclear #mechanobiology? Join us for the first ever FASEB Science Research Conference on the Mechanobiology of the Nucleus #MBNSRC.
Find more information and register at: events.faseb.org/event/Mechan...
Submit abstracts by August 31, 2025. Please share and see you in October!
Find more information and register at: events.faseb.org/event/Mechan...
Submit abstracts by August 31, 2025. Please share and see you in October!
August 14, 2025 at 4:38 AM
Please submit your abstracts by August 31st to be considered for a platform presentation! We look forward to an exciting and stimulating meeting! Please share!
Reposted by Jan Lammerding - Lab
Happy #FluorescenceFriday! Our #CellLineOfTheWeek is MLC-2a - illuminating sarcomeric thick filaments! 💪🧫
Our high-quality stem cell lines & plasmids are available for just the cost of shipping to reduce the barriers to discovery.
📦 Dist. by @coriellinstitute.bsky.social & @addgene.bsky.social.
Our high-quality stem cell lines & plasmids are available for just the cost of shipping to reduce the barriers to discovery.
📦 Dist. by @coriellinstitute.bsky.social & @addgene.bsky.social.
August 8, 2025 at 9:20 PM
Happy #FluorescenceFriday! Our #CellLineOfTheWeek is MLC-2a - illuminating sarcomeric thick filaments! 💪🧫
Our high-quality stem cell lines & plasmids are available for just the cost of shipping to reduce the barriers to discovery.
📦 Dist. by @coriellinstitute.bsky.social & @addgene.bsky.social.
Our high-quality stem cell lines & plasmids are available for just the cost of shipping to reduce the barriers to discovery.
📦 Dist. by @coriellinstitute.bsky.social & @addgene.bsky.social.
Reposted by Jan Lammerding - Lab
The Anne West lab at Duke is hiring a postdoc to work on nuclear cell biology in neurogenesis. Please help me spread the word! Applications to [email protected].
July 27, 2025 at 8:27 PM
The Anne West lab at Duke is hiring a postdoc to work on nuclear cell biology in neurogenesis. Please help me spread the word! Applications to [email protected].
What allows lamins A and C to confer much stronger mechanical stability to the nuclei than lamin B? We show that even though all lamins can protect the nucleus from small cell intrinsic forces, only lamin A/C protect the nucleus from large deformations: www.biorxiv.org/content/10.1...
1/n
1/n
July 26, 2025 at 7:35 PM
What allows lamins A and C to confer much stronger mechanical stability to the nuclei than lamin B? We show that even though all lamins can protect the nucleus from small cell intrinsic forces, only lamin A/C protect the nucleus from large deformations: www.biorxiv.org/content/10.1...
1/n
1/n
Reposted by Jan Lammerding - Lab
Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...
The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate - Nature Cell Biology
Marin et al. report the role of lamin proteins and the lamin B receptor (LBR) in chromatin positioning at the nuclear periphery. Knockout of all lamins and LBR in mouse embryonic stem cells leads to h...
www.nature.com
July 22, 2025 at 5:10 PM
Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...
Reposted by Jan Lammerding - Lab
Join us for the first Mechanobiology of the Nucleus conference supported by @faseborg.bsky.social. Co-organized with @lammerdinglab.bsky.social, @katemiro.bsky.social and Verena Ruprecht, the amazing program is here:
events.faseb.org/event/Mechan...
Opportunities for talks! Abstracts by Aug. 31st.
events.faseb.org/event/Mechan...
Opportunities for talks! Abstracts by Aug. 31st.
July 21, 2025 at 1:14 AM
Join us for the first Mechanobiology of the Nucleus conference supported by @faseborg.bsky.social. Co-organized with @lammerdinglab.bsky.social, @katemiro.bsky.social and Verena Ruprecht, the amazing program is here:
events.faseb.org/event/Mechan...
Opportunities for talks! Abstracts by Aug. 31st.
events.faseb.org/event/Mechan...
Opportunities for talks! Abstracts by Aug. 31st.
If you know anyone with Emery-Dreifuss Muscular Dystrophy (#EDMD) or want to support research on this disease, a patient family we have been working with for many years has started a new foundation, cureEDMD, to raise awareness for this devastating disease: www.cureedmd.org
Please share widely!
Please share widely!
cureEDMD
cureEDMD is a patient and family-led, scientist-supported foundation to advance research into a treatment or cure for Emery-Dreifuss Muscular Dystrophy (EDMD)
www.cureedmd.org
July 18, 2025 at 4:14 PM
If you know anyone with Emery-Dreifuss Muscular Dystrophy (#EDMD) or want to support research on this disease, a patient family we have been working with for many years has started a new foundation, cureEDMD, to raise awareness for this devastating disease: www.cureedmd.org
Please share widely!
Please share widely!
Reposted by Jan Lammerding - Lab
Excited for our next special issue and looking forward to working with Abby Buchwalter (@abbybuch.bsky.social) and Megan King (@luskinglab.bsky.social)! Working on the cell biology of the nucleus? Send your papers our way!
#notforprofit
#notforprofit
Call for papers: Cell Biology of the Nucleus
We invite you to submit your latest research to our special issue: Cell Biology of the Nucleus, guest edited by Abby Buchwalter @abbybuch.bsky.social, working alongside Megan King @luskinglab.bsky.social.
journals.biologists.com/jcs/pages/nu...
We invite you to submit your latest research to our special issue: Cell Biology of the Nucleus, guest edited by Abby Buchwalter @abbybuch.bsky.social, working alongside Megan King @luskinglab.bsky.social.
journals.biologists.com/jcs/pages/nu...
July 16, 2025 at 3:55 PM
Excited for our next special issue and looking forward to working with Abby Buchwalter (@abbybuch.bsky.social) and Megan King (@luskinglab.bsky.social)! Working on the cell biology of the nucleus? Send your papers our way!
#notforprofit
#notforprofit
Interested in nuclear #mechanobiology? Join us for the first ever FASEB Science Research Conference on the Mechanobiology of the Nucleus #MBNSRC.
Find more information and register at: events.faseb.org/event/Mechan...
Submit abstracts by August 31, 2025. Please share and see you in October!
Find more information and register at: events.faseb.org/event/Mechan...
Submit abstracts by August 31, 2025. Please share and see you in October!
July 16, 2025 at 6:35 PM
Interested in nuclear #mechanobiology? Join us for the first ever FASEB Science Research Conference on the Mechanobiology of the Nucleus #MBNSRC.
Find more information and register at: events.faseb.org/event/Mechan...
Submit abstracts by August 31, 2025. Please share and see you in October!
Find more information and register at: events.faseb.org/event/Mechan...
Submit abstracts by August 31, 2025. Please share and see you in October!
Reposted by Jan Lammerding - Lab
I'm a current Harvard graduate student and I found out today that I had my NSF GRFP terminated without notification. I was awarded this individual research fellowship before even choosing Harvard as my graduate school
May 22, 2025 at 9:38 PM
I'm a current Harvard graduate student and I found out today that I had my NSF GRFP terminated without notification. I was awarded this individual research fellowship before even choosing Harvard as my graduate school
Reposted by Jan Lammerding - Lab
The entire nation should protesting this utterly unwarranted, unprecedented, & probably illegal on-going attack on a university. It's right out of the authoritarian playbook. It's an assault on possibility free speech, free thought, & dissent.
Fascism is coming small step by small step, not at once.
Fascism is coming small step by small step, not at once.
https://www.pbs.org/newshour/education/trump-administration-bars-harvard-from-enrolling-foreign-students-including-current-ones “This means Harvard can no longer enroll foreign students and existing foreign students must transfer or lose their legal status” #harvard #highered #uspolitics
Trump administration bars Harvard from enrolling foreign students, including current ones
The Trump administration revoked Harvard University's ability to enroll international students in its escalating battle with the Ivy League school, saying thousands of current students must transfer to other schools or leave the country.
www.pbs.org
May 23, 2025 at 1:41 AM
The entire nation should protesting this utterly unwarranted, unprecedented, & probably illegal on-going attack on a university. It's right out of the authoritarian playbook. It's an assault on possibility free speech, free thought, & dissent.
Fascism is coming small step by small step, not at once.
Fascism is coming small step by small step, not at once.
Reposted by Jan Lammerding - Lab
"We need the whole country to appreciate that by investing in university research and educating the next generation of explorers and innovators, the country has reaped, and will continue to reap, tremendous rewards in new cures, treatments, and inventions, and in new industries, companies, and jobs"
May 23, 2025 at 2:07 AM
"We need the whole country to appreciate that by investing in university research and educating the next generation of explorers and innovators, the country has reaped, and will continue to reap, tremendous rewards in new cures, treatments, and inventions, and in new industries, companies, and jobs"
How do altered levels of lamins and other nuclear envelope proteins contribute to cancer metastasis, and what role does #mechanobiology play here? Learn more in our recent review by fantastic Sarah Henretta, now out in NPJ - Biological Physics and Mechanics, open access: doi.org/10.1038/s443...
Nuclear envelope proteins, mechanotransduction, and their contribution to breast cancer progression - npj Biological Physics and Mechanics
npj Biological Physics and Mechanics - Nuclear envelope proteins, mechanotransduction, and their contribution to breast cancer progression
doi.org
May 12, 2025 at 7:25 AM
How do altered levels of lamins and other nuclear envelope proteins contribute to cancer metastasis, and what role does #mechanobiology play here? Learn more in our recent review by fantastic Sarah Henretta, now out in NPJ - Biological Physics and Mechanics, open access: doi.org/10.1038/s443...
Reposted by Jan Lammerding - Lab
New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇
April 11, 2025 at 9:04 AM
New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇