Nature Reviews Molecular Cell Biology, Published online: 06 November 2025; doi:10.1038/s41580-025-00914-4RNA-binding proteins (RBPs) are essential for gene regulation. Recent data reveal that small biomolecules (SBMs) such as sugars, nucleotides, metabolites and drugs bind to RBPs and regulate their function. This Review discusses the landscape of SBM-binding RBPs, the molecular basis of their interactions and their relevance to human diseases.

Dates 17-19 November 2025 To foster international participation, this course will be held online

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

A biophysical model uses knockdown or overexpression data to infer splicing factor activity.

The Helmholtz Institute for RNA-based Infection Researchopens a call for

Estell and Łazowski et al. show that Integrator and Restrictor form distinct pathways for early attenuation of RNA polymerase II: Integrator acts at the promoter-proximal pause site, whereas Restrictor acts over a downstream “restriction zone.” For transcription to proceed, CDK7/9 oppose Integrator, while U1 snRNP counteracts both Integrator and Restrictor.

Understanding how bacteria survive extreme conditions is key to tackling challenges in health, food safety, and industry. This study reveals a previously unexplored layer of control in Bacillus subtil...

Long non-coding RNAs are abundant in the brain, where they are proposed to regulate numerous processes. In this Review, Mattick and colleagues describe our current understanding of their mechanisms of...

The advent of system-wide proteomic approaches has largely expanded the number of RNA-binding proteins (RBPs). This review discusses how recent discoveries are transforming our understanding of biolog...