Marinos Kallikourdis, PhD
@kallikourdis.bsky.social
NatSci/Immunol(Cambridge). AssocProf of Pathology, Head of Adaptive Immunity Lab@Humanitas, Milan. Developing cardio-immunotherapies.
Reposted by Marinos Kallikourdis, PhD
A wonderful memory shared by Shohei Hori on a Japanese TV special about S. Sakaguchi & Tregs: the 1999 Arrabida meeting on dominant tolerance organized by Antonio Coutinho, back when Tregs were not yet mainstream.
The full documentary (30mns) is available in English👇
www3.nhk.or.jp/nhkworld/en/...
The full documentary (30mns) is available in English👇
www3.nhk.or.jp/nhkworld/en/...
December 12, 2025 at 8:12 AM
A wonderful memory shared by Shohei Hori on a Japanese TV special about S. Sakaguchi & Tregs: the 1999 Arrabida meeting on dominant tolerance organized by Antonio Coutinho, back when Tregs were not yet mainstream.
The full documentary (30mns) is available in English👇
www3.nhk.or.jp/nhkworld/en/...
The full documentary (30mns) is available in English👇
www3.nhk.or.jp/nhkworld/en/...
On the occasion of the Nobel prize to Sakaguchi and colleagues, Nature has published a list of the laureates' works, as well as a list of noteworthy studies stemming from the prize-winning work. No 5 of this list (Related Research) brings me heaps of joy and gratitude. www.nature.com/collections/...
Nobel Prize in Physiology or Medicine 2025
The 2025 Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries ...
www.nature.com
October 14, 2025 at 5:22 PM
On the occasion of the Nobel prize to Sakaguchi and colleagues, Nature has published a list of the laureates' works, as well as a list of noteworthy studies stemming from the prize-winning work. No 5 of this list (Related Research) brings me heaps of joy and gratitude. www.nature.com/collections/...
I've had Sakaguchi papers on my desk since '99, when I was warned against studying cells (Treg) that may not exist. 26 years on, we've shown you need them to reproduce and we may bring them to Heart clinics. A joyous overdue toast to Sakaguchi's steadfast building of the foundations of our science!
A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine
October 6, 2025 at 7:21 PM
I've had Sakaguchi papers on my desk since '99, when I was warned against studying cells (Treg) that may not exist. 26 years on, we've shown you need them to reproduce and we may bring them to Heart clinics. A joyous overdue toast to Sakaguchi's steadfast building of the foundations of our science!
Reposted by Marinos Kallikourdis, PhD
A long-awaited consensus statement on inflammation and heart disease
"We have thus entered an era when the evidence linking inflammation with ASCVD is no longer exploratory but is
compelling and clinically actionable."
@jaccjournals.bsky.social open-access
www.jacc.org/doi/10.1016/...
"We have thus entered an era when the evidence linking inflammation with ASCVD is no longer exploratory but is
compelling and clinically actionable."
@jaccjournals.bsky.social open-access
www.jacc.org/doi/10.1016/...
September 29, 2025 at 2:18 PM
A long-awaited consensus statement on inflammation and heart disease
"We have thus entered an era when the evidence linking inflammation with ASCVD is no longer exploratory but is
compelling and clinically actionable."
@jaccjournals.bsky.social open-access
www.jacc.org/doi/10.1016/...
"We have thus entered an era when the evidence linking inflammation with ASCVD is no longer exploratory but is
compelling and clinically actionable."
@jaccjournals.bsky.social open-access
www.jacc.org/doi/10.1016/...
Reposted by Marinos Kallikourdis, PhD
'(...) deciphering the interactions between ab-mediated immunity & viral evolution will be key. In this perspective, we explore these dynamic relationships & highlight research priorities that may guide the dev. of more effective strategies to mitigate the impact of emerging infectious diseases.'
Immunological drivers of zoonotic virus emergence, evolution, and endemicity
In this perspective, Andersen and colleagues examine how host immunity shapes the
emergence, evolution, and persistence of novel and emerging viruses. They highlight
the role of antibody-driven select...
www.cell.com
April 3, 2025 at 4:33 AM
'(...) deciphering the interactions between ab-mediated immunity & viral evolution will be key. In this perspective, we explore these dynamic relationships & highlight research priorities that may guide the dev. of more effective strategies to mitigate the impact of emerging infectious diseases.'
We don't make the journal cover often (indeed this is only the second time ever). We don't even publish that often. But this paper took very many years of work, from very many people, and I am wholeheartedly grateful to each and every one of them.
March 21, 2025 at 4:32 PM
We don't make the journal cover often (indeed this is only the second time ever). We don't even publish that often. But this paper took very many years of work, from very many people, and I am wholeheartedly grateful to each and every one of them.
A comprehensive collection of insights and ideas on #aging and how to treat its associated diseases. Honoured to have been involved, with many thanks to @stelloslab.bsky.social for the herculean feat of coordination.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Roadmap for alleviating the manifestations of ageing in the cardiovascular system - Nature Reviews Cardiology
In this Roadmap, Stellos and colleagues discuss the mechanisms of cardiovascular system ageing and how the ageing of blood, vessels and heart relates to the decline in organ function, and highlight po...
www.nature.com
March 21, 2025 at 4:29 PM
A comprehensive collection of insights and ideas on #aging and how to treat its associated diseases. Honoured to have been involved, with many thanks to @stelloslab.bsky.social for the herculean feat of coordination.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Happy to share our latest paper in JITC, exploring the “bottom of the iceberg” of tumor immunotherapy myocarditis with MRI. Defining this is important for survivors, as we wait for prognosis and therapy tools. Many thanks to all onco/cardio/radio/immunologists involved: jitc.bmj.com/content/13/3...
Cardiac MRI study of adverse events in patients treated with immune checkpoint inhibitors: a prospective cohort study of cardiac adverse events
Immune checkpoint inhibitors (ICIs) revolutionized cancer therapy, yet require management of immune-related adverse events (irAEs). Fulminant myocarditis is a rare irAE, but lower-severity cardiac eve...
jitc.bmj.com
March 21, 2025 at 4:27 PM
Happy to share our latest paper in JITC, exploring the “bottom of the iceberg” of tumor immunotherapy myocarditis with MRI. Defining this is important for survivors, as we wait for prognosis and therapy tools. Many thanks to all onco/cardio/radio/immunologists involved: jitc.bmj.com/content/13/3...