Engineered T cells that have been used to treat ulcerative colitis, rheumatoid arthritis and lupus show promising results.

The studies may still hold clues to the powers and limits of GLP-1 drugs

A “journey” is something you choose. No one chooses chronic illness.

Fragmented Neanderthal bones discovered in a cave in Belgium show that one group cannibalized the women and children of another group.

Approximately 30% of long COVID patients still experience neurological symptoms (brain fog, pain, chronic fatigue) more than 4 months after the onset of COVID-19. This condition, known as neurological...

Strong evidence suggests that food allergies are caused by a lack of exposure to food allergens—not by exposure to toxins

Scientific Reports - Highly selective cannibalism in the Late Pleistocene of Northern Europe reveals Neandertals were targeted prey

NASA-funded planetary science institute previously scrubbed hundreds of records from its archive

While every self-aware doctor knows no one is an expert on everything, the average person turning to the internet cannot distinguish evidence from gloss

This week’s Current Climate newsletter also looks at Tesla’s engineering exodus and helping the electric truck market expand

A report released Monday by the infant and maternal health nonprofit March of Dimes says that only about 75% of babies last year were born to mothers who started prenatal care in the first trimester o...

Background: All of the major antigenic changes in influenza A(H3N2) viruses since 1968 have involved mutations at just nine amino acid positions, called cluster transition sites, surrounding the receptor binding region of the hemagglutinin surface protein. During the northern hemisphere (NH) 2024–2025 influenza season, A(H3N2) variants emerged with multiple parallel substitutions affecting cluster transition sites 135, 145, 158 and/or 189, with implications for the 2025–2026 season. Methods: Using >24,000 global A(H3) sequences between September 2024 and August 2025, we assess the nature and frequency of amino acid mutations among emerging NH and southern hemisphere (SH) A(H3N2) variants relative to the 2024–2025 subclade J and updated 2025–2026 subclade J.2 vaccine reference strains. We contextualize based upon historic amino acid variation among >210,000 global A(H3) sequences since 1968 and publicly available antigenic characterization data relative to 2024–2025 and 2025–2026 vaccine reference strains Results: Virtually all circulating A(H3N2) viruses in 2024–2025 were subclade J.2. In Europe, about one-third had cluster transition site mutations, mostly T135A with S145N. In North America, more than two-thirds had cluster transition site mutations, including T135K or S145N, with late-season increase in doubly mutated J.2.3 (N158K + K189R) and J.2.5 (S145N + N158K) subclades. The SH 2025 season showed increase in J.2.3 and emergence of J.2.4 (T135K + K189R) including a further drifted J.2.4.1 variant with additional N158D and other mutations, recently renamed subclade K. A substantial proportion of J.2.3 and J.2.4 viruses are antigenically distinct from the 2025–2026 influenza vaccine. Conclusion: Influenza A(H3N2) variants with a combination of cluster transition site mutations emerged during the NH 2024–2025 season. A further drifted and vaccine-mismatched variant now called subclade K arose during the SH 2025 season and is projected to predominate among A(H3N2) viruses for the NH 2025–2026 season. While mismatched vaccines may still provide protection, enhanced genetic, antigenic and epidemiological (eg, vaccine effectiveness) monitoring are warranted to inform risk assessment and response.

A retreat from investments in drugs and vaccines leaves U.S. less prepared for the next viral scourge, experts warn

DNA methylation loss at transposable elements (TEs) can affect neighboring genes and be epigenetically inherited in plants, yet the determinants and importance of this additional system of inheritance...

New research suggests the visibility of a few successful women may make people believe that sufficient equality has already been achieved, even when it hasn’t.

Evidence for a new independent lifestyle factor linked to healthy aging

Funds will allow gut, lymph node, and blood samples collected from trial participants to be maximally analyzed for signs of SARS-CoV-2...

The short documentary “Rovina’s Choice” tells the story of what goes when aid goes.