Dr Jacinta Kalisch-Smith
@jkalism.bsky.social
BHF Intermediate Fellow, Group Leader
Investigating placental and cardiac vascular development in pregnancy pathologies - miscarriage, congenital heart defects, fetal growth restriction.
kalischsmithlab.org
IDRM, University of Oxford 🇬🇧
PhD UQ 🇦🇺
Investigating placental and cardiac vascular development in pregnancy pathologies - miscarriage, congenital heart defects, fetal growth restriction.
kalischsmithlab.org
IDRM, University of Oxford 🇬🇧
PhD UQ 🇦🇺
Pinned
Feto-placental blood vessel development
Summary: This Review contains an overview of placental vascular development and pathologies in mice and humans and highlights key remaining questions in the field.
journals.biologists.com
Very happy to share I've written a review on placental vascular formation in mice and humans, now published in @dev-journal.bsky.social.
journals.biologists.com/dev/article/...
@idrm.ox.ac.uk Funded by the @thebhf.bsky.social
journals.biologists.com/dev/article/...
@idrm.ox.ac.uk Funded by the @thebhf.bsky.social
Reposted by Dr Jacinta Kalisch-Smith
Collaborative science is just so much fun! From our brilliant collaboration with Liz Robertson from @dunnschool.bsky.social; embryology, single cell omics and computational biology deliver new insights into the intricacies of blood and endothelial development. www.sciencedirect.com/science/arti...
June 24, 2025 at 4:04 PM
Collaborative science is just so much fun! From our brilliant collaboration with Liz Robertson from @dunnschool.bsky.social; embryology, single cell omics and computational biology deliver new insights into the intricacies of blood and endothelial development. www.sciencedirect.com/science/arti...
Reposted by Dr Jacinta Kalisch-Smith
🧪 Job alert 🔊 we are hiring a Research Assistant - join the Simões Group at DPAG-IDRM @ox.ac.uk supporting #cardiovascular development and regeneration research, working with #zebrafish and #human stem cell systems: my.corehr.com/pls/uoxrecru... @oxforddpag.bsky.social @idrm.ox.ac.uk (1/4)
Job Details
my.corehr.com
July 7, 2025 at 2:43 PM
🧪 Job alert 🔊 we are hiring a Research Assistant - join the Simões Group at DPAG-IDRM @ox.ac.uk supporting #cardiovascular development and regeneration research, working with #zebrafish and #human stem cell systems: my.corehr.com/pls/uoxrecru... @oxforddpag.bsky.social @idrm.ox.ac.uk (1/4)
Reposted by Dr Jacinta Kalisch-Smith
Exciting news! Dr Jacinta Kalisch-Smith, @jkalism.bsky.social, has been awarded a BHF fellowship to explore how placental blood vessels support fetal growth and development.
Her research could change how we detect and prevent complications during pregnancy.
🔗 Read more: shorturl.at/OVzqq
Her research could change how we detect and prevent complications during pregnancy.
🔗 Read more: shorturl.at/OVzqq
June 9, 2025 at 8:59 AM
Exciting news! Dr Jacinta Kalisch-Smith, @jkalism.bsky.social, has been awarded a BHF fellowship to explore how placental blood vessels support fetal growth and development.
Her research could change how we detect and prevent complications during pregnancy.
🔗 Read more: shorturl.at/OVzqq
Her research could change how we detect and prevent complications during pregnancy.
🔗 Read more: shorturl.at/OVzqq
Reposted by Dr Jacinta Kalisch-Smith
Feto-placental blood vessel development
In this Review, Jacinta Kalisch-Smith @jkalism.bsky.social gives an overview of placental vascular development and pathologies in mice and humans and highlights key remaining questions in the field:
doi.org/10.1242/dev....
In this Review, Jacinta Kalisch-Smith @jkalism.bsky.social gives an overview of placental vascular development and pathologies in mice and humans and highlights key remaining questions in the field:
doi.org/10.1242/dev....
June 6, 2025 at 8:51 AM
Feto-placental blood vessel development
In this Review, Jacinta Kalisch-Smith @jkalism.bsky.social gives an overview of placental vascular development and pathologies in mice and humans and highlights key remaining questions in the field:
doi.org/10.1242/dev....
In this Review, Jacinta Kalisch-Smith @jkalism.bsky.social gives an overview of placental vascular development and pathologies in mice and humans and highlights key remaining questions in the field:
doi.org/10.1242/dev....
Reposted by Dr Jacinta Kalisch-Smith
Epigenetic regulation of placental vascularization - now published in Developmental Cell (www.sciencedirect.com/science/arti...). Congratulations & thanks to Stephanie Gehrs for fantastic work and paving the way of the www.augustinlab.de into the world of vascular epigenetics. There’s more to come!
January 14, 2025 at 7:52 PM
Epigenetic regulation of placental vascularization - now published in Developmental Cell (www.sciencedirect.com/science/arti...). Congratulations & thanks to Stephanie Gehrs for fantastic work and paving the way of the www.augustinlab.de into the world of vascular epigenetics. There’s more to come!
Very happy to share I've written a review on placental vascular formation in mice and humans, now published in @dev-journal.bsky.social.
journals.biologists.com/dev/article/...
@idrm.ox.ac.uk Funded by the @thebhf.bsky.social
journals.biologists.com/dev/article/...
@idrm.ox.ac.uk Funded by the @thebhf.bsky.social
Feto-placental blood vessel development
Summary: This Review contains an overview of placental vascular development and pathologies in mice and humans and highlights key remaining questions in the field.
journals.biologists.com
June 2, 2025 at 10:24 AM
Very happy to share I've written a review on placental vascular formation in mice and humans, now published in @dev-journal.bsky.social.
journals.biologists.com/dev/article/...
@idrm.ox.ac.uk Funded by the @thebhf.bsky.social
journals.biologists.com/dev/article/...
@idrm.ox.ac.uk Funded by the @thebhf.bsky.social
Reposted by Dr Jacinta Kalisch-Smith
I had a some great news this week, being awarded an independent @thebhf.bsky.social fellowship. Thanks to the support from @idrm.ox.ac.uk @oxforddpag.bsky.social @ox.ac.uk colleagues past and present. Looking forward to the next few years investigating placental vascular development.
🎉 Congratulations to Jacinta Kalisch-Smith who has just been awarded a 5 year Intermediate Fellowship from the British Heart Foundation.
Her fellowship will study how placental blood vessels develop to understand the cause of neonatal heart conditions from early pregnancy @oxforddpag.bsky.social
Her fellowship will study how placental blood vessels develop to understand the cause of neonatal heart conditions from early pregnancy @oxforddpag.bsky.social
March 28, 2025 at 4:46 PM
I had a some great news this week, being awarded an independent @thebhf.bsky.social fellowship. Thanks to the support from @idrm.ox.ac.uk @oxforddpag.bsky.social @ox.ac.uk colleagues past and present. Looking forward to the next few years investigating placental vascular development.
Reposted by Dr Jacinta Kalisch-Smith
✨Excited to share our work revisiting the developmental origins of mammalian lymphatic endothelial cells.✨
A summary of our key findings using scRNA-seq, snMultiome-seq and imaging to show the direct specification of mesenchymal progenitors to LECs🧵 #blutorial #blabstract
tinyurl.com/LECspec
A summary of our key findings using scRNA-seq, snMultiome-seq and imaging to show the direct specification of mesenchymal progenitors to LECs🧵 #blutorial #blabstract
tinyurl.com/LECspec
Direct specification of lymphatic endothelium from mesenchymal progenitors - Nature Cardiovascular Research
Lupu, Grainger, Kirschnick et al. show that, contrary to prevailing belief, the initial specification of mammalian lymphatic endothelial cells primarily occurs from previously unidentified mesenchymal...
tinyurl.com
January 13, 2025 at 2:31 PM
✨Excited to share our work revisiting the developmental origins of mammalian lymphatic endothelial cells.✨
A summary of our key findings using scRNA-seq, snMultiome-seq and imaging to show the direct specification of mesenchymal progenitors to LECs🧵 #blutorial #blabstract
tinyurl.com/LECspec
A summary of our key findings using scRNA-seq, snMultiome-seq and imaging to show the direct specification of mesenchymal progenitors to LECs🧵 #blutorial #blabstract
tinyurl.com/LECspec
Reposted by Dr Jacinta Kalisch-Smith
Very happy to share our work on lymphatic endothelial cell specification, which was published in Nature Cardiovascular Research this week.
January 22, 2025 at 4:14 PM
Very happy to share our work on lymphatic endothelial cell specification, which was published in Nature Cardiovascular Research this week.
Reposted by Dr Jacinta Kalisch-Smith
Here in the UK, the HFEA is recommending changing the 14-day rule on human embryo research to allow culture up to 28 days. This will open up new avenues of research into previously inaccessible stages of development, and potentially provide new understanding of the causes of early pregnancy failure.
Limit on human embryo research should be extended to 28 days, says UK regulator
Experts say increasing law from 14 days could lead to breakthroughs in understand of miscarriages
www.theguardian.com
December 11, 2024 at 8:53 AM
Here in the UK, the HFEA is recommending changing the 14-day rule on human embryo research to allow culture up to 28 days. This will open up new avenues of research into previously inaccessible stages of development, and potentially provide new understanding of the causes of early pregnancy failure.
Reposted by Dr Jacinta Kalisch-Smith
Side-hustle activated. Stoked to have this popular science piece out in Aeon Magazine:
aeon.co/essays/after...
aeon.co/essays/after...
After 3,000 years of science, the embryo is very different | Aeon Essays
For 3,000 years, humans have struggled to understand the embryo. Now there is a revolution underway
aeon.co
November 13, 2024 at 9:47 PM
Side-hustle activated. Stoked to have this popular science piece out in Aeon Magazine:
aeon.co/essays/after...
aeon.co/essays/after...
Sorry to hear this Tom, hope someone can help you get some feedback. I certainly wouldn't have progressed without it.
...So when the @royalsociety.org says "due to the high number of applications we are unable to provide feedback", it sits badly. What little down time we have sunk into an application and the funder cant even say if it was on the right track, feels like a kick in the teeth to young researchers. 3/3
December 11, 2024 at 7:37 PM
Sorry to hear this Tom, hope someone can help you get some feedback. I certainly wouldn't have progressed without it.
Reposted by Dr Jacinta Kalisch-Smith
Nice to see our latest review published in
@natrevmcb.bsky.social today – a collaborative exploration of mammalian extraembryonic development with @cwhanna.bsky.social for an invaluable epigenetic focus. @srinivas-lab.bsky.social
www.nature.com/articles/s41...
@natrevmcb.bsky.social today – a collaborative exploration of mammalian extraembryonic development with @cwhanna.bsky.social for an invaluable epigenetic focus. @srinivas-lab.bsky.social
www.nature.com/articles/s41...
Origin, fate and function of extraembryonic tissues during mammalian development - Nature Reviews Molecular Cell Biology
During mammalian embryogenesis, extraembryonic tissues are required for the patterning and morphogenesis of the embryo. This Review discusses how signalling networks and epigenetic modifications regul...
www.nature.com
December 4, 2024 at 4:03 PM
Nice to see our latest review published in
@natrevmcb.bsky.social today – a collaborative exploration of mammalian extraembryonic development with @cwhanna.bsky.social for an invaluable epigenetic focus. @srinivas-lab.bsky.social
www.nature.com/articles/s41...
@natrevmcb.bsky.social today – a collaborative exploration of mammalian extraembryonic development with @cwhanna.bsky.social for an invaluable epigenetic focus. @srinivas-lab.bsky.social
www.nature.com/articles/s41...