Filipa Simões
@simoesfilipa.bsky.social
Development and Regeneration of the Heart | Cardio-Immuno Genomics | Group Leader University of Oxford IDRM-DPAG | playing with zebrafish & cardiac organoids | academic mama of 2 children & 1 dog | curiosity led
Pinned
Immune-mediated cardiac development and regeneration
The complex interplay between the immune and cardiovascular systems during development, homeostasis and regeneration represents a rapidly evolving fie…
www.sciencedirect.com
Just published! Our Review on how immune cells masterfully orchestrate heart development and regeneration. Beyond fighting pathogens, they're actually building & repairing your heart! Learn how cutting-edge technologies are driving therapeutic opportunities here www.sciencedirect.com/science/arti...
Reposted by Filipa Simões
With two giants of the sci publishing world who birthed biorxiv & medrxiv
December 8, 2025 at 9:23 PM
With two giants of the sci publishing world who birthed biorxiv & medrxiv
Reposted by Filipa Simões
Do your samples move out of view? Tired of manually adjusting the stage? Introducing DySTrack developed by @zimengwu33.bsky.social and Jonas Hartmann from UCL, a tool that can be integrated into modern microscopes to automate the tracking of moving samples. #MicroscopyMonday doi.org/10.64898/202...
December 8, 2025 at 9:31 PM
Do your samples move out of view? Tired of manually adjusting the stage? Introducing DySTrack developed by @zimengwu33.bsky.social and Jonas Hartmann from UCL, a tool that can be integrated into modern microscopes to automate the tracking of moving samples. #MicroscopyMonday doi.org/10.64898/202...
Reposted by Filipa Simões
A genetic therapy has reversed aggressive & incurable blood cancers in ~64% of patients in a trial.
The treatment involves editing the DNA in white blood cells to transform them into a cancer-fighting "living drug".
🧪🩸🧬 #medsky
www.bbc.co.uk/news/article...
The treatment involves editing the DNA in white blood cells to transform them into a cancer-fighting "living drug".
🧪🩸🧬 #medsky
www.bbc.co.uk/news/article...
Blood cancer therapy reverses incurable leukaemia in some patients
Seven out of 11 patients with incurable cancer who had the treatment appear to be cancer-free.
www.bbc.co.uk
December 9, 2025 at 9:21 AM
A genetic therapy has reversed aggressive & incurable blood cancers in ~64% of patients in a trial.
The treatment involves editing the DNA in white blood cells to transform them into a cancer-fighting "living drug".
🧪🩸🧬 #medsky
www.bbc.co.uk/news/article...
The treatment involves editing the DNA in white blood cells to transform them into a cancer-fighting "living drug".
🧪🩸🧬 #medsky
www.bbc.co.uk/news/article...
Reposted by Filipa Simões
The inaugural conference on #assembloids and complex cell-cell interactions starting tonight at @cshlnews.bsky.social ! Amazing energy and inspiring opening keynote by Ruslan Medzhitov.
December 9, 2025 at 6:52 AM
The inaugural conference on #assembloids and complex cell-cell interactions starting tonight at @cshlnews.bsky.social ! Amazing energy and inspiring opening keynote by Ruslan Medzhitov.
Reposted by Filipa Simões
Sign up now for EMBO Workshop "#LimbDevelopment and #regeneration: Quantitative, ecological and diversification studies" in #Tokyo, JP, 23–27 March 2026.
Registration by 23 Jan 2026
Abstract submission by 15 Dec 2025
https://meetings.embo.org/event/26-limb-dev
#EMBOLimbDev #GeneSky #EMBOevents 🧪
Registration by 23 Jan 2026
Abstract submission by 15 Dec 2025
https://meetings.embo.org/event/26-limb-dev
#EMBOLimbDev #GeneSky #EMBOevents 🧪
December 9, 2025 at 7:25 AM
Sign up now for EMBO Workshop "#LimbDevelopment and #regeneration: Quantitative, ecological and diversification studies" in #Tokyo, JP, 23–27 March 2026.
Registration by 23 Jan 2026
Abstract submission by 15 Dec 2025
https://meetings.embo.org/event/26-limb-dev
#EMBOLimbDev #GeneSky #EMBOevents 🧪
Registration by 23 Jan 2026
Abstract submission by 15 Dec 2025
https://meetings.embo.org/event/26-limb-dev
#EMBOLimbDev #GeneSky #EMBOevents 🧪
Reposted by Filipa Simões
✨New preprint!
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
December 9, 2025 at 7:52 AM
✨New preprint!
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
Reposted by Filipa Simões
🔬 Call to create junior research groups at the Institut Pasteur
Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies
📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD
Apply now 📝 research.pasteur.fr/en/call/crea...
#JobOpportunity #Research
Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies
📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD
Apply now 📝 research.pasteur.fr/en/call/crea...
#JobOpportunity #Research
Creation of new junior research groups at the Institut Pasteur - Call for applications 2026 - Research
The Institut Pasteur is launching an international call to recruit new junior research group leaders leveraging cutting-edge transdisciplinary approaches to exploring infectious diseases, host-microbe...
research.pasteur.fr
December 8, 2025 at 8:53 AM
🔬 Call to create junior research groups at the Institut Pasteur
Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies
📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD
Apply now 📝 research.pasteur.fr/en/call/crea...
#JobOpportunity #Research
Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies
📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD
Apply now 📝 research.pasteur.fr/en/call/crea...
#JobOpportunity #Research
Reposted by Filipa Simões
There’s an art to writing a grant proposal so that your creativity is on full display. Maria Leptin - president of the ERC - talks about it on the new episode of the Night Science Podcast.
December 9, 2025 at 4:36 AM
There’s an art to writing a grant proposal so that your creativity is on full display. Maria Leptin - president of the ERC - talks about it on the new episode of the Night Science Podcast.
Reposted by Filipa Simões
NEWS: Battle in the Gut at IF Oxford 2025
In October, researchers from @rdm.ox.ac.uk engaged with the public, asking "How much do you know about what’s going on in your gut?". Children created their own salmonella using Play-Doh and adults played Micropoly.
In October, researchers from @rdm.ox.ac.uk engaged with the public, asking "How much do you know about what’s going on in your gut?". Children created their own salmonella using Play-Doh and adults played Micropoly.
Battle in the Gut at IF Oxford 2025
In October 2025, researchers from the MRC Translational Immune Discovery Unit led activities on researching gut bacteria at Oxford Science + Ideas Festival.
www.medsci.ox.ac.uk
December 9, 2025 at 9:01 AM
NEWS: Battle in the Gut at IF Oxford 2025
In October, researchers from @rdm.ox.ac.uk engaged with the public, asking "How much do you know about what’s going on in your gut?". Children created their own salmonella using Play-Doh and adults played Micropoly.
In October, researchers from @rdm.ox.ac.uk engaged with the public, asking "How much do you know about what’s going on in your gut?". Children created their own salmonella using Play-Doh and adults played Micropoly.
Reposted by Filipa Simões
Great day with these certified knuckleheads that are absolutely the best (and future) of their fields 🧪 @ethanewe.bsky.social @marliesoomen.bsky.social @giuliapaci.bsky.social @amjeve.bsky.social @maxfarnworth.bsky.social @anzymiller.bsky.social Martina and Toshi
December 8, 2025 at 8:41 PM
Great day with these certified knuckleheads that are absolutely the best (and future) of their fields 🧪 @ethanewe.bsky.social @marliesoomen.bsky.social @giuliapaci.bsky.social @amjeve.bsky.social @maxfarnworth.bsky.social @anzymiller.bsky.social Martina and Toshi
Reposted by Filipa Simões
📢 You won't want to miss our next episode with Dr. @hansclevers.bsky.social!
Learn about his return to the @hubrechtinstitute.bsky.social and his experience running the Institute of Human Biology at Roche: https://bit.ly/48sIRIV
Learn about his return to the @hubrechtinstitute.bsky.social and his experience running the Institute of Human Biology at Roche: https://bit.ly/48sIRIV
December 8, 2025 at 9:13 PM
📢 You won't want to miss our next episode with Dr. @hansclevers.bsky.social!
Learn about his return to the @hubrechtinstitute.bsky.social and his experience running the Institute of Human Biology at Roche: https://bit.ly/48sIRIV
Learn about his return to the @hubrechtinstitute.bsky.social and his experience running the Institute of Human Biology at Roche: https://bit.ly/48sIRIV
Reposted by Filipa Simões
Very happy to see this piece on the Tunicate Ciona published. Grateful to @alexandrejan.bsky.social and @chiaracastelletti.bsky.social for the Illustrations, and to @natmethods.nature.com for the opportunity to showcase our ever emerging model organism www.nature.com/articles/s41...
The tunicate Ciona - Nature Methods
The ascidian tunicate Ciona, one of the closest relatives of the vertebrates, inhabits shallow temperate waters in the worldwide ocean. A unique combination of simple stereotyped embryogenesis, regula...
www.nature.com
December 8, 2025 at 6:33 PM
Very happy to see this piece on the Tunicate Ciona published. Grateful to @alexandrejan.bsky.social and @chiaracastelletti.bsky.social for the Illustrations, and to @natmethods.nature.com for the opportunity to showcase our ever emerging model organism www.nature.com/articles/s41...
Reposted by Filipa Simões
@fenaochs.bsky.social
Can you please add me to your 3D chromatin starter pack. Thanks for starting it :)
Can you please add me to your 3D chromatin starter pack. Thanks for starting it :)
December 6, 2025 at 6:26 PM
@fenaochs.bsky.social
Can you please add me to your 3D chromatin starter pack. Thanks for starting it :)
Can you please add me to your 3D chromatin starter pack. Thanks for starting it :)
Reposted by Filipa Simões
Can't believe my postdoc paper is finally out. Christmas came early this year, holy moly 🎄
Molecular basis for de novo thymus regeneration in a vertebrate, the axolotl | Science Immunology www.science.org/doi/10.1126/...
Molecular basis for de novo thymus regeneration in a vertebrate, the axolotl | Science Immunology www.science.org/doi/10.1126/...
Molecular basis for de novo thymus regeneration in a vertebrate, the axolotl
The molecular, cellular, and functional restoration of the axolotl thymus after de novo regeneration is described.
www.science.org
December 5, 2025 at 9:17 PM
Can't believe my postdoc paper is finally out. Christmas came early this year, holy moly 🎄
Molecular basis for de novo thymus regeneration in a vertebrate, the axolotl | Science Immunology www.science.org/doi/10.1126/...
Molecular basis for de novo thymus regeneration in a vertebrate, the axolotl | Science Immunology www.science.org/doi/10.1126/...
Reposted by Filipa Simões
Have we lost some of the academic magic in the US? A true privilege to give the Sherrington Prize Lecture at Oxford. A wonderful audience, a fantastic dinner at Merton College, and even the Merton Choir. Special for me since Sherrington coined proprioception and interoception.
December 4, 2025 at 11:48 PM
Have we lost some of the academic magic in the US? A true privilege to give the Sherrington Prize Lecture at Oxford. A wonderful audience, a fantastic dinner at Merton College, and even the Merton Choir. Special for me since Sherrington coined proprioception and interoception.
Reposted by Filipa Simões
We have just published a tribute to John Gurdon, reflecting on his scientific legacy and the profound influence he had on generations of developmental biologists.
The piece is available open access in Nature Communications:
www.nature.com/articles/s41...
The piece is available open access in Nature Communications:
www.nature.com/articles/s41...
Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon - Nature Communications
Nature Communications - Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon
www.nature.com
December 5, 2025 at 8:05 AM
We have just published a tribute to John Gurdon, reflecting on his scientific legacy and the profound influence he had on generations of developmental biologists.
The piece is available open access in Nature Communications:
www.nature.com/articles/s41...
The piece is available open access in Nature Communications:
www.nature.com/articles/s41...
Reposted by Filipa Simões
BBC News - Top UK scientist says research visa restrictions endanger economy
www.bbc.com/news/article...
www.bbc.com/news/article...
Top UK scientist says research visa restrictions endanger economy
Prof Sir Paul Nurse says the UK is "shooting itself in the foot" with its visa system for researchers.
www.bbc.com
December 5, 2025 at 6:35 AM
BBC News - Top UK scientist says research visa restrictions endanger economy
www.bbc.com/news/article...
www.bbc.com/news/article...
Reposted by Filipa Simões
Applications are open for @dev-journal.bsky.social 2026 Pathway to Independence (PI) programme, supporting postdocs applying for group leader positions:
Mentoring
Profile raising
Leadership training
Network building
Spread the word...
www.biologists.com/grants/devel...
Mentoring
Profile raising
Leadership training
Network building
Spread the word...
www.biologists.com/grants/devel...
Development's Pathway to Independence Programme
Our grants support and encourage the sharing of knowledge throughout the community by facilitating international collaboration, event attendance and the organisation of scientific meetings, conference...
www.biologists.com
December 3, 2025 at 6:56 AM
Applications are open for @dev-journal.bsky.social 2026 Pathway to Independence (PI) programme, supporting postdocs applying for group leader positions:
Mentoring
Profile raising
Leadership training
Network building
Spread the word...
www.biologists.com/grants/devel...
Mentoring
Profile raising
Leadership training
Network building
Spread the word...
www.biologists.com/grants/devel...
Reposted by Filipa Simões
🧠 Applications for the International Neuroscience Doctoral Programme (INDP) @champalimaudf.bsky.social open until 31 January 2026.
☀️ Join our vibrant and international research community in sunny Lisbon!
🔗 fchampalimaud.org/champalimaud...
☀️ Join our vibrant and international research community in sunny Lisbon!
🔗 fchampalimaud.org/champalimaud...
December 3, 2025 at 6:33 PM
🧠 Applications for the International Neuroscience Doctoral Programme (INDP) @champalimaudf.bsky.social open until 31 January 2026.
☀️ Join our vibrant and international research community in sunny Lisbon!
🔗 fchampalimaud.org/champalimaud...
☀️ Join our vibrant and international research community in sunny Lisbon!
🔗 fchampalimaud.org/champalimaud...
Reposted by Filipa Simões
Sir Charles Sherrington Prize Lecture
Today at 4.00 pm in the Blakemore Lecture Theatre, Sherrington Building (University cards required to gain access)
Today at 4.00 pm in the Blakemore Lecture Theatre, Sherrington Building (University cards required to gain access)
December 4, 2025 at 9:38 AM
Sir Charles Sherrington Prize Lecture
Today at 4.00 pm in the Blakemore Lecture Theatre, Sherrington Building (University cards required to gain access)
Today at 4.00 pm in the Blakemore Lecture Theatre, Sherrington Building (University cards required to gain access)
Reposted by Filipa Simões
Excited to share the final piece of my postdoctoral work from the Joyner Lab, exploring the regenerative potential of the adult cerebellar astroglia in collaboration with @ricardkoche. 🧠
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
The regenerative potential of adult Nestin+ cerebellar astroglia is limited compared to in neonates
There is a crucial need for strategies that stimulate repair in the adult brain. The neonatal mouse cerebellum can regenerate via the adaptive reprogramming of nestin (Nes)-expressing progenitors (NEP...
www.biorxiv.org
December 3, 2025 at 6:00 PM
Excited to share the final piece of my postdoctoral work from the Joyner Lab, exploring the regenerative potential of the adult cerebellar astroglia in collaboration with @ricardkoche. 🧠
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Filipa Simões
We are excited to share our new preprint:
SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids.
www.biorxiv.org/content/10.64898/2025.12.01.691499v1
SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids.
www.biorxiv.org/content/10.64898/2025.12.01.691499v1
December 3, 2025 at 6:53 PM
We are excited to share our new preprint:
SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids.
www.biorxiv.org/content/10.64898/2025.12.01.691499v1
SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids.
www.biorxiv.org/content/10.64898/2025.12.01.691499v1
Don’t miss out on this opportunity- come and join us at the Oxford Organoid Hub working under the MRC-BHF REACT programme! If you love in vitro 3D models, the ❤️ and regenerative therapies, this is for you - apply by 18 Dec @oxforddpag.bsky.social @idrm.ox.ac.uk @rdm.ox.ac.uk
Some good news, myself and @simoesfilipa.bsky.social are advertising for a post-doctoral researcher to join us at the Oxford Organoid hub: tinyurl.com/OOHJob
Come and join us to develop novel human organoid systems as part of the MRC/BHF CRE in advanced cardiac therapies.
Come and join us to develop novel human organoid systems as part of the MRC/BHF CRE in advanced cardiac therapies.
November 30, 2025 at 11:02 PM
Don’t miss out on this opportunity- come and join us at the Oxford Organoid Hub working under the MRC-BHF REACT programme! If you love in vitro 3D models, the ❤️ and regenerative therapies, this is for you - apply by 18 Dec @oxforddpag.bsky.social @idrm.ox.ac.uk @rdm.ox.ac.uk
Reposted by Filipa Simões
A joy to present at the Oxford @thebhf.bsky.social Centre of Research Excellence annual symposium. Great discussions and a great opportunity to show some of the research happening around the Oxford Organoid Hub. @rdm.ox.ac.uk @simoesfilipa.bsky.social @idrm.ox.ac.uk
November 28, 2025 at 6:18 PM
A joy to present at the Oxford @thebhf.bsky.social Centre of Research Excellence annual symposium. Great discussions and a great opportunity to show some of the research happening around the Oxford Organoid Hub. @rdm.ox.ac.uk @simoesfilipa.bsky.social @idrm.ox.ac.uk
@shifaant.bsky.social @srinivas-lab.bsky.social peaking into the chick heart - love it!!
This week's scientific video, created by Dr Shifaan Thowfeequ from the Shankar Srinivas lab, is titled “Chasing the wave – in search of the origins of the first heartbeat.” The video captures the mechanical and chemical dynamics of an embryonic chick heart as it first forms and starts to beat.
November 28, 2025 at 8:36 AM
@shifaant.bsky.social @srinivas-lab.bsky.social peaking into the chick heart - love it!!