Jia Luo, MD
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jia-luo.bsky.social
Jia Luo, MD
@jia-luo.bsky.social
1.2K followers 150 following 110 posts
Thoracic medical oncologist and cancer researcher at Dana-Farber/ Harvard Cancer Center
// Prev MSKCC Fellow, OHSU IM & Chief Res, Stanford Med, and UW-Madison
https://t.co/Y9HwVQ1jyq
Posts Replies Media Videos
Reposted by Jia Luo, MD
theaacr.bsky.social
Alexander Drilon, Jolanta Grembecka, Jessica Jiyeong Lin, and Jia Luo will discuss "Translating Discoveries Toward New Therapies" in a plenary session at the AACR Conference on Fusion-Positive Cancers (January 13-15, 2026; Philadelphia). Learn more:
buff.ly/3jO4l4j
#AACRfusion26 @jia-luo.bsky.social
November 4, 2025 at 6:44 PM
Reposted by Jia Luo, MD
danafarber.bsky.social
@stolaney1.bsky.social addresses a full house during the #ESMO25 presidential discussion on Reshaping Density – Transforming Outcomes in High-Risk HER2+ Breast Cancer.
October 18, 2025 at 3:37 PM
Reposted by Jia Luo, MD
danafarbernews.bsky.social
Lung cancer research at #ESMO25: Chemotherapy combo boosts overall survival in patients with EGFR-mutant non-small cell lung cancer. @danafarber.bsky.social's Dr. Pasi Jänne presents the complete data from phase 3 FLAURA2 study.

Press release ➡️bit.ly/47oV0hd
Dr. Pasi Jänne of Dana-Farber Cancer Institutes presents at #ESMO25.
October 17, 2025 at 2:05 PM
Reposted by Jia Luo, MD
bloodgenes.bsky.social
www.nih.gov/news-events/...
Secretary Kennedy Swears in Dr. Anthony Letai as Director of the National Cancer Institute
Dr. Letai will serve as NCI’s 18th director.
www.nih.gov
September 29, 2025 at 9:37 PM
jia-luo.bsky.social
What a great throwback!

Brings me back to middle school computer lab when - as the cool kids - we were using this little known search called "google" on our bright boxy blue iMacs when the standard at the time was Ask Jeeves
September 27, 2025 at 5:29 PM
Reposted by Jia Luo, MD
carlzimmer.com
A deep dive into the destruction of US cancer research by @jonathanmahler.bsky.social “It’s an absolutely unmitigated disaster,” a former top official at NIH told him. “It will take decades to recover from this, if we ever do.” Gift link: nyti.ms/48iH3Cr
nyti.ms
September 14, 2025 at 2:44 PM
jia-luo.bsky.social
What a fantastic IASLC WCLC25!

Congrats to star resident (onc-to-be!) Dr Huang &

We had a superb global multi-D discussion on ground glass/semisolid lung nodules - packed room in our last session of the day!

TY chairs Drs Naidoo Opitz Malapelle & Noemi - feeling inspired 🙏
@iaslc.bsky.social
September 10, 2025 at 3:40 AM
Reposted by Jia Luo, MD
paulsaxmd.bsky.social
For us ID doctors, the CDC has been a rock. Data, guidelines, surveillance, travel advice -- all there, vetted by experts, referenced, reliable. Perfect? No. But watching its dismantling now breaks my heart. Some thoughts: blogs.jwatch.org/hiv-id-obser...
Watching the Chaos at the CDC -- with Sadness and Alarm
Throughout my career as an infectious diseases doctor, the CDC has been a rock-solid source. Need reliable data on an outbreak? The CDC. Need thoughtful, evidence-based guidelines? The CDC. Need an au...
blogs.jwatch.org
August 30, 2025 at 5:30 AM
jia-luo.bsky.social
🩻 Look forward to our interactive multidisciplinary lung nodules session @ IASLC WCLC 2025 meeting next week, September 6-9 in Barcelona

It's been fantastic to plan our program with this group of experts spanning the 🗺️, meeting 6am (PT) - 11pm (AEST)!
wclc.iaslc.org #lcsm @iaslc.bsky.social #WCLC25
August 29, 2025 at 6:36 PM
Reposted by Jia Luo, MD
ejohnwherry.bsky.social
vimeo.com/1103907156/4...
A World Without Academic Medicine 2025
This is "A World Without Academic Medicine 2025" by AAMC on Vimeo, the home for high quality videos and the people who love them.
vimeo.com
August 15, 2025 at 4:26 PM
Reposted by Jia Luo, MD
jeremymberg.bsky.social
New report from AAMC about clinical trials, other grants, and training

www.aamc.org/about-us/mis...
Clinical trials and research training stalled as billions in NIH funds sit idle
Billions in NIH research funds remain unspent, stalling clinical trials, halting grants, and disrupting training for future scientists.
www.aamc.org
August 15, 2025 at 5:22 PM
Reposted by Jia Luo, MD
danafarber.bsky.social
Please join us in congratulating Alice Shaw, MD, PhD, on being named our next Chair of the Department of Medical Oncology.

Learn more: bit.ly/45wiiQ6
Alice T. Shaw named Chair of Department of Medical Oncology at Dana-Farber Cancer Institute | Dana-Farber Cancer Institute
Alice T. Shaw, MD, PhD, was named Chair of the Department of Medical Oncology at Dana-Farber Cancer Institute, in an announcement today.
bit.ly
August 12, 2025 at 1:45 PM
jia-luo.bsky.social
Fantastic to interview Dr. William Pao about his book "Breakthrough" with Dr. Jänne

So inspiring for us to hear stories about resiliency and learning from failure in research to develop transformational medicines

Special thanks to Sitara & the Chen-Huang Center #lcsm @danafarber.bsky.social
Photos of the Endowed Lecture interview with Dr Wiliam Pao, including Drs Luo, Jänne, Rotow, Barbie, Sitara and the in person crowd
August 12, 2025 at 7:58 PM
jia-luo.bsky.social
Excited to host drug developer extraordinaire Dr. William Pao at Dana-Farber

Dr. Jänne and I will interview Dr. Pao tomorrow (Tuesday, August 12) about his book, Breakthrough, "a triumphant read about overcoming disease"

www.simonandschuster.com/books/Breakt... @danafarbernews.bsky.social
August 11, 2025 at 2:44 PM
jia-luo.bsky.social
🩺 In NEJM, our interactive case on a common CC - evaluation of a patient with new pulmonary symptoms www.nejm.org/doi/full/10....

Congrats to star fellow Dr Joanne I. Hsu for leading & wonderful to learn from expert multi-D colleagues @anandvaidya17.bsky.social @harvardmed.bsky.social @nejm.org
nejm.org NEJM.org @nejm.org · Jul 28
A 59-year-old woman presented to the emergency department with a 1-week history of profound fatigue, nonproductive cough, confusion, and decreased oral intake. The night before presentation, she began to have chills and night sweats. Learn more and test your skills: nej.md/4mcUHuL
Interactive Medical Case A Case of Crackles An illustration of the patient coughing in bed and her husband caring for her
August 8, 2025 at 2:08 PM
jia-luo.bsky.social
Celebrating endings and new beginnings - it has been fantastic to have Dr Paoloni on our research team during his awarded American-Italian Cancer Foundation Research Fellowship grant!

@danafarber.bsky.social @danafarbernews.bsky.social #lcsm
Research group dinner. From left to right: Dr Paoloni, Huang, Sara Walton, Justin Kim, Dr Luo, and Dr Pecci Dr Paoloni (center) with Drs French and Luo
August 4, 2025 at 2:08 PM
Reposted by Jia Luo, MD
jeremymberg.bsky.social
New STAT story about multi-year funding.

www.statnews.com/2025/07/29/n...
NIH is shrinking the number of research projects it funds due to a new Trump policy
NIH plans to shrink the share of grant applications it will award for the remainder of the fiscal year, in some cases by more than half.
www.statnews.com
July 29, 2025 at 11:40 AM
jia-luo.bsky.social
1/ In Clinical Cancer Research, we examined underdiagnosis of NUT carcinoma, an aggressive squamous lung, head and neck cancer, and found >75% are missed on standard of care testing (DNA panel NGS)

🫁 🗣️ doi.org/10.1158/1078... #medsky #oncsky #meded #lcsm #lungcancer @theaacr.bsky.social

🧵A thread:
Molecular characterization of NUT carcinoma: a report from the NUT carcinoma registry Abstract Purpose: NUT carcinoma (NC) is an underdiagnosed, poorly differentiated squamous cell cancer with a median survival of 6.7 months. Defined by NUTM1 fusions, NC enhances oncogene transcription, including MYC. We investigated the ability of standard next-generation sequencing (NGS) to identify NUTM1 fusions and describe additional molecular features of NC. Experimental Design: This study included 116 NC patients whose tumors underwent broad-panel NGS (>80 genes) of DNA, ctDNA, and/or RNA fusion sequencing between 2013-2024. NGS reports and medical records were manually reviewed. Results: Of 116 patients (median age 38, 40.5% female), 84.5% had DNA, 12.1% had ctDNA, and 51.7% had RNA fusion testing. In a subset of 100 patients with DNA/ctDNA testing, 92.9% (n=79/85) had <10 pack-years/never-smoking history, and 58.8% (n=47/80) had a BRD4::NUTM1 fusion. Median TMB was 1.0 mut/Mb (range 0.0-16.0; n=71 known), and 19.7% (n=13/66) had PD-L1 expression ≥1%. DNA, ctDNA, RNA fusion, NUT IHC, and NUTM1 FISH detected NC fusions in 21.6%, 21.4%, 83.9%, 100.0%, and 91.9% of tests, respectively. Co-occurring pathogenic mutations included oncogenes PIK3CA, RET, FGFR3, and tumor suppressors ATM and BRCA1 (n=1 each). Secondary genes altered in >5% of NCs included LRP1B (10.4%), MLL2/KMT2D (8.0%), and FAT1 (5.5%); common pathways with mutated genes were epigenetic (57.0%), cell cycle (26.0%), and DNA repair (24.0%). Conclusions: Standard DNA NGS detects less than a quarter of NUT carcinomas; RNA-based fusion testing, or NUT IHC/NUTM1 FISH, should be routine for suspected NC. NCs are enriched in co-occurring epigenetic, cell cycle, and DNA repair alterations, warranting further evaluation.
July 28, 2025 at 11:22 AM
Reposted by Jia Luo, MD
jia-luo.bsky.social
🌟 Some great colleagues, including Dr Julia Rotow, and I will be discussing the latest practice changing data in oncology @ Best of ASCO Boston July 26-27!

Program and registration horizoncme.com/best-of-asco...

#oncsky @ascocancer.bsky.social @danafarbernews.bsky.social @danafarber.bsky.social
This two-day conference is an Official Annual Meeting Review of ASCO25, featuring expert faculty who will review findings, discuss potential impacts on the current standard of care, and apply the results within the clinical context of a patient case.
May 19, 2025 at 9:52 PM
jia-luo.bsky.social
Encouraging news from the US FDA - a fast track designation - for our patients with NUT carcinoma!

It's been incredible team science from the preclinical, to the iterative FIH translation, to our ongoing NIH-funded NCI CTEP/ETCTN clinical trial #oncsky #lcsm
July 25, 2025 at 6:37 PM
Reposted by Jia Luo, MD
nanditagarud.bsky.social
I am seeking a postdoc for my group at UCLA. We work at the intersection of population genetics x microbiome (garud.eeb.ucla.edu). If interested, please message me!
Garud Lab
garud.eeb.ucla.edu
July 22, 2025 at 5:51 PM
Reposted by Jia Luo, MD
nature.com
These members of the NIH Council of Councils are voicing serious concerns about NIH grant terminations, restructure, and budget cuts

go.nature.com/46Vr8t2
Protect the integrity of the US National Institutes of Health
Letter to the Editor
go.nature.com
July 23, 2025 at 12:03 PM
jia-luo.bsky.social
Outstanding commencement speech by Sandra Oh fit for these times on living with discomfort. Well worth the watch.

youtu.be/P7TYeFy0JtA?...
2025 Commencement Address by Sandra Oh
YouTube video by Dartmouth
youtu.be
July 19, 2025 at 1:47 PM
jia-luo.bsky.social
🗺️ 🫁 Thrilled to work with and learn from this multi-D international panel of lung cancer experts

We’ve got a fantastic interactive discussion on pulmonary nodules planned - Tues Sept 9 @ IASLC #WCLC25 in Barcelona

Join us! / Register: wclc.iaslc.org

@iaslc.bsky.social #lcsm #medsky
Zoom picture of multidisciplinary panel of experts on lung cancers
July 16, 2025 at 2:11 PM
jia-luo.bsky.social
Celebrating a win - when a fantastic CRC in your group achieves their dream of going to medical school!
Coffee with mentees
July 9, 2025 at 2:52 PM