Vijay G. Sankaran
@bloodgenes.bsky.social
Pediatric Hematologist/Oncologist, Geneticist, Stem Cell Biologist
bloodgenes.org
bloodgenes.org
Reposted by Vijay G. Sankaran
A big advance, folks, for off-the-shelf, universal, engineered (base-edited) T cells achieving complete response vs incurable leukemia in several patients
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
December 8, 2025 at 10:10 PM
A big advance, folks, for off-the-shelf, universal, engineered (base-edited) T cells achieving complete response vs incurable leukemia in several patients
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Amazing talk from Nancy Speck, who is the 2025 recipient of the E. Donnall Thomas Lecture and Award from @ash.hematology.org!!! Congratulations, Nancy! #ASH25
December 8, 2025 at 2:50 PM
Amazing talk from Nancy Speck, who is the 2025 recipient of the E. Donnall Thomas Lecture and Award from @ash.hematology.org!!! Congratulations, Nancy! #ASH25
Reposted by Vijay G. Sankaran
Congratulations to Dr. Jorge Di Paola for winning the 2025 ASH Mentor Award and Dr. Diane Krause for winning the ASH Advancing Inclusive Excellence Award!
@ash.hematology.org President Dr. Avalos was honored to present these at #ASH25
@ash.hematology.org President Dr. Avalos was honored to present these at #ASH25
December 7, 2025 at 8:14 PM
Congratulations to Dr. Jorge Di Paola for winning the 2025 ASH Mentor Award and Dr. Diane Krause for winning the ASH Advancing Inclusive Excellence Award!
@ash.hematology.org President Dr. Avalos was honored to present these at #ASH25
@ash.hematology.org President Dr. Avalos was honored to present these at #ASH25
Wow!! 🔥🔥 CDK4/6 inhibition prevents selection of #ClonalHematopoiesis with DNA-damage repair mutations after chemotherapy! Awesome presentation from Irenaeus Chan from @kellybolton.bsky.social lab! #ASH25
December 7, 2025 at 8:28 PM
Wow!! 🔥🔥 CDK4/6 inhibition prevents selection of #ClonalHematopoiesis with DNA-damage repair mutations after chemotherapy! Awesome presentation from Irenaeus Chan from @kellybolton.bsky.social lab! #ASH25
Really enjoyed the fantastic session we had yesterday on applications of AI in hematology at #ASH25 with @wondermixtape.bsky.social,
Sanam Loghavi, and @kdpsingh.bsky.social!
Sanam Loghavi, and @kdpsingh.bsky.social!
December 7, 2025 at 12:00 PM
Really enjoyed the fantastic session we had yesterday on applications of AI in hematology at #ASH25 with @wondermixtape.bsky.social,
Sanam Loghavi, and @kdpsingh.bsky.social!
Sanam Loghavi, and @kdpsingh.bsky.social!
Reposted by Vijay G. Sankaran
Please encourage undergraduates with an interest in biomedical research to apply!
Deadline is December 22. $15,000 stipend for the 9 week @hhmi-science.bsky.social Cech Fellows Program.
Deadline is December 22. $15,000 stipend for the 9 week @hhmi-science.bsky.social Cech Fellows Program.
@hhmi.org Summer Undergraduate Research Experience - #CechFellows named in honor of Prof Tom Cech
Deadline to apply: 12/22/2025
Spend 9 weeks in a paid, mentored biomedical research experience in an HHMI lab. See you next summer!!!
www.hhmi.org/programs/cec...
Deadline to apply: 12/22/2025
Spend 9 weeks in a paid, mentored biomedical research experience in an HHMI lab. See you next summer!!!
www.hhmi.org/programs/cec...
Summer Undergraduate Research Experience | HHMI
The Cech Fellows Program is a paid, nine-week summer research experience empowering the next generation of scientific leaders.
www.hhmi.org
December 5, 2025 at 5:27 AM
Please encourage undergraduates with an interest in biomedical research to apply!
Deadline is December 22. $15,000 stipend for the 9 week @hhmi-science.bsky.social Cech Fellows Program.
Deadline is December 22. $15,000 stipend for the 9 week @hhmi-science.bsky.social Cech Fellows Program.
Reposted by Vijay G. Sankaran
Practice changing plenary #ASH25‼️
Iron is hypothesized to feed infxn & IV iron often avoided in that setting.
>85k people hospitalized w/5 most common bacterial infxns, compared those who recvd IV iron to those who did not.
🩸greater hemoglobin increase
🩸lower mortality at 14 & 90 days
Iron is hypothesized to feed infxn & IV iron often avoided in that setting.
>85k people hospitalized w/5 most common bacterial infxns, compared those who recvd IV iron to those who did not.
🩸greater hemoglobin increase
🩸lower mortality at 14 & 90 days
December 6, 2025 at 6:46 PM
Practice changing plenary #ASH25‼️
Iron is hypothesized to feed infxn & IV iron often avoided in that setting.
>85k people hospitalized w/5 most common bacterial infxns, compared those who recvd IV iron to those who did not.
🩸greater hemoglobin increase
🩸lower mortality at 14 & 90 days
Iron is hypothesized to feed infxn & IV iron often avoided in that setting.
>85k people hospitalized w/5 most common bacterial infxns, compared those who recvd IV iron to those who did not.
🩸greater hemoglobin increase
🩸lower mortality at 14 & 90 days
Reposted by Vijay G. Sankaran
The NIH grant cuts in 2025
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
December 2, 2025 at 3:16 PM
The NIH grant cuts in 2025
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
Reposted by Vijay G. Sankaran
Gift link for NY Times article on cuts at NIH and NSF:
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
The U.S. Is Funding Fewer Grants in Every Area of Science and Medicine (Gift Article)
A quiet policy change means the government is making fewer bets on long-term science.
www.nytimes.com
December 2, 2025 at 3:51 PM
Gift link for NY Times article on cuts at NIH and NSF:
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
Reposted by Vijay G. Sankaran
New lab preprint! ERCC6L2 disease is a recessive bone marrow failure syndrome caused by mutations in the putative DNA helicase ERCC6L2. Using mouse genetics, biochemistry and AF3 we uncover ERCC6L2-MRI as a KU-regulatory complex stimulating NHEJ at staggered DSBs: www.biorxiv.org/content/10.1...
The ERCC6L2-MRI-KU complex coordinates NHEJ at staggered DNA double-strand breaks
ERCC6L2 disease is a recessive bone marrow failure (BMF) syndrome caused by mutations in the SNF2-like putative DNA helicase ERCC6L2. While implicated in DNA replication, double strand break (DSB) rep...
www.biorxiv.org
December 1, 2025 at 9:28 PM
New lab preprint! ERCC6L2 disease is a recessive bone marrow failure syndrome caused by mutations in the putative DNA helicase ERCC6L2. Using mouse genetics, biochemistry and AF3 we uncover ERCC6L2-MRI as a KU-regulatory complex stimulating NHEJ at staggered DSBs: www.biorxiv.org/content/10.1...
How did the devastation of the atomic bombings 80 years ago ultimately help give rise to bone marrow transplantation and modern #stemcell biology? Our historical commentary with Jonas Gudera in @natcellbio.nature.com explores these unappreciated connections: www.nature.com/articles/s41...
December 1, 2025 at 2:10 PM
How did the devastation of the atomic bombings 80 years ago ultimately help give rise to bone marrow transplantation and modern #stemcell biology? Our historical commentary with Jonas Gudera in @natcellbio.nature.com explores these unappreciated connections: www.nature.com/articles/s41...
Reposted by Vijay G. Sankaran
In this Nature Medicine paper, we draw from our experiences in evaluating and implementing #genomics in Australia, Canada, England, Hong Kong and the US
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Determining the value of genomics in healthcare - Nature Medicine
Assessing the value of genomics is key to informing evidence-based policies; this Review outlines how current approaches to health technology assessment, implementation and data management can be adap...
www.nature.com
November 27, 2025 at 11:22 PM
In this Nature Medicine paper, we draw from our experiences in evaluating and implementing #genomics in Australia, Canada, England, Hong Kong and the US
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Vijay G. Sankaran
Massive single-cell study by Kanai et al (www.medrxiv.org/content/10.1...):
- Once statistical power is high, constrained genes have more (though weaker) eQTLs.
- Chromatin-QTLs near constrained genes have "normal" effect sizes, colocalize more with disease, but exhibit attenuated peak-gene effects.
- Once statistical power is high, constrained genes have more (though weaker) eQTLs.
- Chromatin-QTLs near constrained genes have "normal" effect sizes, colocalize more with disease, but exhibit attenuated peak-gene effects.
November 30, 2025 at 5:06 PM
Massive single-cell study by Kanai et al (www.medrxiv.org/content/10.1...):
- Once statistical power is high, constrained genes have more (though weaker) eQTLs.
- Chromatin-QTLs near constrained genes have "normal" effect sizes, colocalize more with disease, but exhibit attenuated peak-gene effects.
- Once statistical power is high, constrained genes have more (though weaker) eQTLs.
- Chromatin-QTLs near constrained genes have "normal" effect sizes, colocalize more with disease, but exhibit attenuated peak-gene effects.
Grateful to Isabella Alves & @cterminiphd.bsky.social for writing this fantastic N&V in @natcellbio.nature.com: www.nature.com/articles/s41...
Nicely covers our 📰 led by della Volpe & co: www.nature.com/articles/s41...
Nicely covers our 📰 led by della Volpe & co: www.nature.com/articles/s41...
December 1, 2025 at 1:10 AM
Grateful to Isabella Alves & @cterminiphd.bsky.social for writing this fantastic N&V in @natcellbio.nature.com: www.nature.com/articles/s41...
Nicely covers our 📰 led by della Volpe & co: www.nature.com/articles/s41...
Nicely covers our 📰 led by della Volpe & co: www.nature.com/articles/s41...
Reposted by Vijay G. Sankaran
🩸 Dr. Lucrezia della Volpe and a team in Dr. Vijay Sankaran's lab (@bloodgenes.bsky.social) discovered that ferroptosis is a key barrier to HSC survival during ex vivo culture.
Read their @natcellbio.nature.com paper: https://go.nature.com/4ib4Ln6
Listen to the discussion: https://bit.ly/48dmghX
Read their @natcellbio.nature.com paper: https://go.nature.com/4ib4Ln6
Listen to the discussion: https://bit.ly/48dmghX
November 27, 2025 at 4:53 PM
🩸 Dr. Lucrezia della Volpe and a team in Dr. Vijay Sankaran's lab (@bloodgenes.bsky.social) discovered that ferroptosis is a key barrier to HSC survival during ex vivo culture.
Read their @natcellbio.nature.com paper: https://go.nature.com/4ib4Ln6
Listen to the discussion: https://bit.ly/48dmghX
Read their @natcellbio.nature.com paper: https://go.nature.com/4ib4Ln6
Listen to the discussion: https://bit.ly/48dmghX
Reposted by Vijay G. Sankaran
The US government support of cancer research via NCI
has been severely cut.
And of June 2025, "There were 181 individual terminated NCI funded grants, with a total award amount of $640,867, 956."
jamanetwork.com/journals/jam...
has been severely cut.
And of June 2025, "There were 181 individual terminated NCI funded grants, with a total award amount of $640,867, 956."
jamanetwork.com/journals/jam...
Disrupted Federal Funding for Extramural Cancer Research
This cross-sectional study assesses the scale and scope of terminated cancer research grants from the National Cancer Institute.
jamanetwork.com
November 26, 2025 at 4:59 PM
The US government support of cancer research via NCI
has been severely cut.
And of June 2025, "There were 181 individual terminated NCI funded grants, with a total award amount of $640,867, 956."
jamanetwork.com/journals/jam...
has been severely cut.
And of June 2025, "There were 181 individual terminated NCI funded grants, with a total award amount of $640,867, 956."
jamanetwork.com/journals/jam...
Reposted by Vijay G. Sankaran
Excited to share a preprint of my PhD project looking at interactions between SNPs and polygenic scores in the UK Biobank!
A thread... 🧵
www.medrxiv.org/content/10.1...
A thread... 🧵
www.medrxiv.org/content/10.1...
Interactions with polygenic background impact quantitative traits in the UK Biobank
Association studies have linked many genetic variants to a variety of phenotypes but under-standing the biological mechanisms underlying these signals remains a major challenge. Since genes operate wi...
www.medrxiv.org
November 24, 2025 at 5:13 PM
Excited to share a preprint of my PhD project looking at interactions between SNPs and polygenic scores in the UK Biobank!
A thread... 🧵
www.medrxiv.org/content/10.1...
A thread... 🧵
www.medrxiv.org/content/10.1...
If you have not read this moving and courageous essay from Tatiana Schlossberg in the @newyorker.com, please check it out. You may be wondering why inv(3) leukemia is so deadly? Here is a brief 🧵 (1/n)
Tatiana Schlossberg, the daughter of Caroline Kennedy, had just given birth when she was diagnosed with a rare form of leukemia. She writes about her fear of adding another tragedy to her family’s life. https://newyorkermag.visitlink.me/CLpbsb
November 24, 2025 at 2:40 PM
If you have not read this moving and courageous essay from Tatiana Schlossberg in the @newyorker.com, please check it out. You may be wondering why inv(3) leukemia is so deadly? Here is a brief 🧵 (1/n)
Reposted by Vijay G. Sankaran
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
The missing heritability question is now (mostly) answered
Not with a bang but with a whimper
theinfinitesimal.substack.com
November 21, 2025 at 10:34 PM
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
Reposted by Vijay G. Sankaran
Your bloodstream is a battlefield and a delivery service, all at once! 🩸🧪
Quinten Geldhof, also known as Microhobbyist, takes you into a drop of blood to explain how red blood cells lack a nucleus so they can carry more oxygen throughout your body.
Watch the video here:
Quinten Geldhof, also known as Microhobbyist, takes you into a drop of blood to explain how red blood cells lack a nucleus so they can carry more oxygen throughout your body.
Watch the video here:
Blood Under A Microscope: An Ecosystem That Keeps You Alive
YouTube video by Museum of Science
www.youtube.com
November 20, 2025 at 9:17 PM
Your bloodstream is a battlefield and a delivery service, all at once! 🩸🧪
Quinten Geldhof, also known as Microhobbyist, takes you into a drop of blood to explain how red blood cells lack a nucleus so they can carry more oxygen throughout your body.
Watch the video here:
Quinten Geldhof, also known as Microhobbyist, takes you into a drop of blood to explain how red blood cells lack a nucleus so they can carry more oxygen throughout your body.
Watch the video here:
Reposted by Vijay G. Sankaran
New discovery in ulcerative colitis: a bacterial toxin that kills macrophages and increases inflammation, which could be the foundation for a new treatment
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
A bacterial toxin disarms gut defenses against inflammation
Macrophage-toxic bacteria from patients with ulcerative colitis worsen gut inflammation in mice
science.org
November 20, 2025 at 7:25 PM
New discovery in ulcerative colitis: a bacterial toxin that kills macrophages and increases inflammation, which could be the foundation for a new treatment
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
Ferroptosis and 🩸 stem cell biology have a lot to say to each other... Hoping this work inspires #ferroptosis researchers to explore HSCs and #hematopoiesis researchers to lean into ferroptosis 🤝
Excited to share our new study, led by @dellaVolpe_L, now out in @natcellbio.nature.com! Blocking #ferroptosis enhances human 🩸 stem cell expansion, with implications for transplantation and gene therapy. www.nature.com/articles/s41...
November 19, 2025 at 10:07 PM
Ferroptosis and 🩸 stem cell biology have a lot to say to each other... Hoping this work inspires #ferroptosis researchers to explore HSCs and #hematopoiesis researchers to lean into ferroptosis 🤝
Excited to share our new study, led by @dellaVolpe_L, now out in @natcellbio.nature.com! Blocking #ferroptosis enhances human 🩸 stem cell expansion, with implications for transplantation and gene therapy. www.nature.com/articles/s41...
November 18, 2025 at 5:49 PM
Excited to share our new study, led by @dellaVolpe_L, now out in @natcellbio.nature.com! Blocking #ferroptosis enhances human 🩸 stem cell expansion, with implications for transplantation and gene therapy. www.nature.com/articles/s41...