Anja Groth
@groth-anja.bsky.social
Group leader at the Danish Cancer Institute and Professor at University of Copenhagen #NNFCPR. Interested in epigenetics, genome maintenance, aging & cancer, creativity & innovation, society in general. Opinions are my own.
Chromatin fatigue: DNA repair alters the chromatin environment and introduces heritable variation in gene expression in a larger region around the lesion! Amazing achievement by @sbantele.bsky.social and Jiri Lukas published in @science.org 🙌 Happy we could contribute. See 👇
𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
Repair of DNA double-strand breaks leaves heritable impairment to genome function
Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...
tinyurl.com
November 12, 2025 at 3:55 AM
Chromatin fatigue: DNA repair alters the chromatin environment and introduces heritable variation in gene expression in a larger region around the lesion! Amazing achievement by @sbantele.bsky.social and Jiri Lukas published in @science.org 🙌 Happy we could contribute. See 👇
Reposted by Anja Groth
📢 Don't miss @groth-anja.bsky.social from the Danish Cancer Institute, who will present her research at the #Embryo2026 🧬
"How cells copy their epigenome"
Register until Oct 31! 👇
www.molgen.mpg.de/embryo2026
Supported by the Weizmann Institute of Science
"How cells copy their epigenome"
Register until Oct 31! 👇
www.molgen.mpg.de/embryo2026
Supported by the Weizmann Institute of Science
October 29, 2025 at 12:22 PM
📢 Don't miss @groth-anja.bsky.social from the Danish Cancer Institute, who will present her research at the #Embryo2026 🧬
"How cells copy their epigenome"
Register until Oct 31! 👇
www.molgen.mpg.de/embryo2026
Supported by the Weizmann Institute of Science
"How cells copy their epigenome"
Register until Oct 31! 👇
www.molgen.mpg.de/embryo2026
Supported by the Weizmann Institute of Science
Reposted by Anja Groth
🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
July 28, 2025 at 9:10 AM
🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
Reposted by Anja Groth
Yadav, Jadhav, @hanasedlackova.bsky.social et al present a novel cell-permeable biotin-HaloTag ligand. The reported ligand expands the HaloTag toolbox by enabling in vivo labeling & providing capabilities for efficient affinity capture of protein variants from live cells rupress.org/jcb/article/...
July 16, 2025 at 4:15 PM
Yadav, Jadhav, @hanasedlackova.bsky.social et al present a novel cell-permeable biotin-HaloTag ligand. The reported ligand expands the HaloTag toolbox by enabling in vivo labeling & providing capabilities for efficient affinity capture of protein variants from live cells rupress.org/jcb/article/...
Reposted by Anja Groth
We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease - Nature Reviews Molecular Cell Biology
Transposable elements (TEs) comprise nearly half of the human genome. This Review discusses transcriptional and post-transcriptional mechanisms that repress TE activity, how TEs escape this suppressio...
www.nature.com
June 30, 2025 at 1:12 PM
We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Anja Groth
Check out this new review (with animations, natch) of mechanisms of licensing origins of DNA replication - a wonderful (and continuing!) collaboration with Bruce Stillman @cshlnews.bsky.social and John Diffley @crick.ac.uk! www.nature.com/articles/s41...
July 2, 2025 at 5:01 PM
Check out this new review (with animations, natch) of mechanisms of licensing origins of DNA replication - a wonderful (and continuing!) collaboration with Bruce Stillman @cshlnews.bsky.social and John Diffley @crick.ac.uk! www.nature.com/articles/s41...
Reposted by Anja Groth
Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages.
ki.se/en/about-ki/...
ki.se/en/about-ki/...
Call for 20 Assistant Professor positions
Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...
ki.se
June 25, 2025 at 2:56 PM
Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages.
ki.se/en/about-ki/...
ki.se/en/about-ki/...
Reposted by Anja Groth
Postdoc positions open in my lab (Francis Crick Institute) to study
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
June 20, 2025 at 9:38 AM
Postdoc positions open in my lab (Francis Crick Institute) to study
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
Reposted by Anja Groth
Latest #CDlab paper online now:
Cohesin supercoils DNA during loop extrusion
www.cell.com/cell-reports...
This extensive study was led by Jan Michael Peters at Vienna; our lab contributed mostly modeling of plasmid supercoiling (@romanbarth.bsky.social) and single-molecule data (Richard Janissen).
Cohesin supercoils DNA during loop extrusion
www.cell.com/cell-reports...
This extensive study was led by Jan Michael Peters at Vienna; our lab contributed mostly modeling of plasmid supercoiling (@romanbarth.bsky.social) and single-molecule data (Richard Janissen).
June 16, 2025 at 12:01 PM
Latest #CDlab paper online now:
Cohesin supercoils DNA during loop extrusion
www.cell.com/cell-reports...
This extensive study was led by Jan Michael Peters at Vienna; our lab contributed mostly modeling of plasmid supercoiling (@romanbarth.bsky.social) and single-molecule data (Richard Janissen).
Cohesin supercoils DNA during loop extrusion
www.cell.com/cell-reports...
This extensive study was led by Jan Michael Peters at Vienna; our lab contributed mostly modeling of plasmid supercoiling (@romanbarth.bsky.social) and single-molecule data (Richard Janissen).
Reposted by Anja Groth
Please join us celebrate the 5th year birthday of Social DNAing! Dr. Chapman will take the stage in the coming week. Sign up at cancer.columbia.edu/research/progr…
June 15, 2025 at 1:57 AM
Please join us celebrate the 5th year birthday of Social DNAing! Dr. Chapman will take the stage in the coming week. Sign up at cancer.columbia.edu/research/progr…
Reposted by Anja Groth
Are you @ the late stages of your postdoc ? Want to pursue a PI career ?
Then this 👇👇 is for you ! Apply for a spot @ our Talent Forum
www.helmholtz-munich.de/en/stem-cell...
Peer-networking / Career orientation and more !!!
Please distribute :) 🙂
Then this 👇👇 is for you ! Apply for a spot @ our Talent Forum
www.helmholtz-munich.de/en/stem-cell...
Peer-networking / Career orientation and more !!!
Please distribute :) 🙂
June 12, 2025 at 12:58 PM
Are you @ the late stages of your postdoc ? Want to pursue a PI career ?
Then this 👇👇 is for you ! Apply for a spot @ our Talent Forum
www.helmholtz-munich.de/en/stem-cell...
Peer-networking / Career orientation and more !!!
Please distribute :) 🙂
Then this 👇👇 is for you ! Apply for a spot @ our Talent Forum
www.helmholtz-munich.de/en/stem-cell...
Peer-networking / Career orientation and more !!!
Please distribute :) 🙂
Amazing accomplishment 👏👏 congrats Hiten and team 🎉
Hey there,
Our latest paper is out in Cell.
We made a knockout collection in a human fungal pathogen, performed over 140 screens, and developed 6 follow up stories.
Phenotypic landscape of an invasive fungal pathogen reveals its unique biology
Share link:
authors.elsevier.com/c/1lFMiL7PXu...
Our latest paper is out in Cell.
We made a knockout collection in a human fungal pathogen, performed over 140 screens, and developed 6 follow up stories.
Phenotypic landscape of an invasive fungal pathogen reveals its unique biology
Share link:
authors.elsevier.com/c/1lFMiL7PXu...
authors.elsevier.com
June 12, 2025 at 9:54 AM
Amazing accomplishment 👏👏 congrats Hiten and team 🎉
Excellent advice!!
#NextGenSci asked young scientists to write a rule that all principal investigators should be required to follow to improve the experience of young scientists in their lab.
Check out their answers on #NationalHigherEducationDay: scim.ag/45zsFEr
Check out their answers on #NationalHigherEducationDay: scim.ag/45zsFEr
June 6, 2025 at 8:29 PM
Excellent advice!!
Reposted by Anja Groth
From theory to practice — explore #computational approaches and #AI developments at EMBO Practical Course "Integrative modelling of biomolecular interactions" in Izmir, Türkiye, 28 September–3 October 2025
Deadline: 15 June
meetings.embo.org/event/25-bio...
#EMBObiomolInteractions #EMBOevents 🧪
Deadline: 15 June
meetings.embo.org/event/25-bio...
#EMBObiomolInteractions #EMBOevents 🧪
Integrative modelling of biomolecular interactions
Experimental structural studies of interactions can be costly, low-throughput, and challenging. Therefore, computational methods aiming to model protein complexes are particularly valuable. The accur…
meetings.embo.org
June 5, 2025 at 6:02 AM
From theory to practice — explore #computational approaches and #AI developments at EMBO Practical Course "Integrative modelling of biomolecular interactions" in Izmir, Türkiye, 28 September–3 October 2025
Deadline: 15 June
meetings.embo.org/event/25-bio...
#EMBObiomolInteractions #EMBOevents 🧪
Deadline: 15 June
meetings.embo.org/event/25-bio...
#EMBObiomolInteractions #EMBOevents 🧪
Reposted by Anja Groth
URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
My lab studies bacterial infections. We spend a lot of time looking at (or for) species-specific genetic and genomic databases for hosts and microbes. FlyBase is the best of all—there is literally no comparison. Its existence is under threat. Please donate.
www.philanthropy.cam.ac.uk/give-to-camb...
www.philanthropy.cam.ac.uk/give-to-camb...
Drosophila Genetic Database
The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...
www.philanthropy.cam.ac.uk
June 3, 2025 at 5:20 PM
URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
Reposted by Anja Groth
⏰🚨FINAL DEADLINE APPROACHING
#BGFP25 's extended reg deadline is closing on 02 June 2025. This is your last chance to register and confirm your place at this fantastic conference 🧬!
Join us in sunny Portugal this July and register now: bit.ly/3AnsVZF
#BGFP25 's extended reg deadline is closing on 02 June 2025. This is your last chance to register and confirm your place at this fantastic conference 🧬!
Join us in sunny Portugal this July and register now: bit.ly/3AnsVZF
May 28, 2025 at 9:47 AM
⏰🚨FINAL DEADLINE APPROACHING
#BGFP25 's extended reg deadline is closing on 02 June 2025. This is your last chance to register and confirm your place at this fantastic conference 🧬!
Join us in sunny Portugal this July and register now: bit.ly/3AnsVZF
#BGFP25 's extended reg deadline is closing on 02 June 2025. This is your last chance to register and confirm your place at this fantastic conference 🧬!
Join us in sunny Portugal this July and register now: bit.ly/3AnsVZF
Reposted by Anja Groth
📢 Next speaker in our '3D Regulatory Genome' series: Dr. Alvaro Rada Iglesias (@radaiglesiaslab.bsky.social) presenting innovative enhancer research using transgenic mouse stem cells!
Moderated by @stefanschoenfelder.bsky.social
Register: us02web.zoom.us/webinar/regi...
#Genomics #VirtualSeminar
Moderated by @stefanschoenfelder.bsky.social
Register: us02web.zoom.us/webinar/regi...
#Genomics #VirtualSeminar
May 28, 2025 at 2:17 PM
📢 Next speaker in our '3D Regulatory Genome' series: Dr. Alvaro Rada Iglesias (@radaiglesiaslab.bsky.social) presenting innovative enhancer research using transgenic mouse stem cells!
Moderated by @stefanschoenfelder.bsky.social
Register: us02web.zoom.us/webinar/regi...
#Genomics #VirtualSeminar
Moderated by @stefanschoenfelder.bsky.social
Register: us02web.zoom.us/webinar/regi...
#Genomics #VirtualSeminar
Reposted by Anja Groth
One more appointment with great science in a few days, one click away 👇
May 28, 2025 at 7:55 PM
One more appointment with great science in a few days, one click away 👇
Reposted by Anja Groth
💫NEW: @jzylicz.bsky.social & co show that dimethyl α-ketoglutarate enhances the production and functional maturation of human #trophectoderm - like cells from embryonic #StemCells by regulating histone acetyltransferase activity and the pluripotency network.
bit.ly/3EGflmL
bit.ly/3EGflmL
α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells - Nature Cell Biology
Van Nerum et al. show that dimethyl α-ketoglutarate enhances the production and functional maturation of human trophectoderm-like cells from embryonic stem cells by regulating histone acetyltransferas...
bit.ly
May 9, 2025 at 7:54 PM
💫NEW: @jzylicz.bsky.social & co show that dimethyl α-ketoglutarate enhances the production and functional maturation of human #trophectoderm - like cells from embryonic #StemCells by regulating histone acetyltransferase activity and the pluripotency network.
bit.ly/3EGflmL
bit.ly/3EGflmL
Reposted by Anja Groth
Get to know Tuncay Baubec, former EMBO Young Investigator and EMBO Postdoctoral Fellow, who studied in #Austria, started his own group at University of Zurich and is now Professor at @utrechtuniversity.bsky.social: www.embo.org/people/the-f... 🧪 #LifeSciences #research #opportunities
The freedom to choose your own research focus – People – EMBO
Meet Tuncay Baubec, Professor at Utrecht University | Former EMBO Young Investigator and EMBO Postdoctoral Fellow
www.embo.org
May 8, 2025 at 11:11 AM
Get to know Tuncay Baubec, former EMBO Young Investigator and EMBO Postdoctoral Fellow, who studied in #Austria, started his own group at University of Zurich and is now Professor at @utrechtuniversity.bsky.social: www.embo.org/people/the-f... 🧪 #LifeSciences #research #opportunities
Reposted by Anja Groth
Exciting science ahead! Hope to see many of you online on Tuesday 6th (just connect, no registration needed)
The Genome Integrity Webinar Series continues on Tuesday, May 6th at 5PM (Rome) / 11AM (New York) with an exciting discussion on DNA damage response and repair @kajastelab.bsky.social
Join via Zoom: uniroma1.zoom.us/j/95149984403
Join via Zoom: uniroma1.zoom.us/j/95149984403
May 1, 2025 at 2:50 PM
Exciting science ahead! Hope to see many of you online on Tuesday 6th (just connect, no registration needed)
Reposted by Anja Groth
Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....
Always on the Move: Overview on Chromatin Dynamics within Nuclear Processes
Our genome is organized into chromatin, a dynamic and modular structure made of nucleosomes. Chromatin organization controls access to the DNA sequence, playing a fundamental role in cell identity and...
doi.org
May 4, 2025 at 7:39 AM
Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....
Reposted by Anja Groth
Comprehensive mapping of protein-protein interactions in the Drosophila piRNA pathway reveals how adaptive evolution contributes to rapid diversification of this genome-defense mechanism
Peter Andersen @germline.bsky.social and collaborators
www.embopress.org/doi/full/10....
Peter Andersen @germline.bsky.social and collaborators
www.embopress.org/doi/full/10....
April 25, 2025 at 10:42 AM
Comprehensive mapping of protein-protein interactions in the Drosophila piRNA pathway reveals how adaptive evolution contributes to rapid diversification of this genome-defense mechanism
Peter Andersen @germline.bsky.social and collaborators
www.embopress.org/doi/full/10....
Peter Andersen @germline.bsky.social and collaborators
www.embopress.org/doi/full/10....
Reposted by Anja Groth
Co-organized by EMBL, EMBO and EMBO Press, the EMBL Science and Society Conference "In science we trust?" will explore the importance of public trust in science and the role we all play in shaping its future. 🧪 Register by 5 May: www.embl.org/about/info/c... #LifeSciences @embl.org @embopress.org
In science we trust?
EMBL Science and Society Conference
www.embl.org
April 23, 2025 at 9:12 AM
Co-organized by EMBL, EMBO and EMBO Press, the EMBL Science and Society Conference "In science we trust?" will explore the importance of public trust in science and the role we all play in shaping its future. 🧪 Register by 5 May: www.embl.org/about/info/c... #LifeSciences @embl.org @embopress.org
Reposted by Anja Groth
Cell scientist to watch – Hana Polasek-Sedlackova @hanasedlackova.bsky.social
In this interview, we learn about Hana’s career, her insights on collaborative research and her engineering hobby.
journals.biologists.com/jcs/article/...
In this interview, we learn about Hana’s career, her insights on collaborative research and her engineering hobby.
journals.biologists.com/jcs/article/...
April 21, 2025 at 2:02 PM
Cell scientist to watch – Hana Polasek-Sedlackova @hanasedlackova.bsky.social
In this interview, we learn about Hana’s career, her insights on collaborative research and her engineering hobby.
journals.biologists.com/jcs/article/...
In this interview, we learn about Hana’s career, her insights on collaborative research and her engineering hobby.
journals.biologists.com/jcs/article/...