Granton Jindal
@grantonjindal.bsky.social
Assistant Project Scientist at UC San Diego studying dev bio and genomics
Pinned
Granton Jindal
@grantonjindal.bsky.social
· Nov 11
Hello Bluesky!
My name is Granton Jindal and I'm currently an Assistant Project Scientist at UC San Diego studying developmental biology and genomics.
With this account, I will mostly repost things I find interesting in developmental biology and genomics!
My name is Granton Jindal and I'm currently an Assistant Project Scientist at UC San Diego studying developmental biology and genomics.
With this account, I will mostly repost things I find interesting in developmental biology and genomics!
Reposted by Granton Jindal
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
The missing heritability question is now (mostly) answered
Not with a bang but with a whimper
theinfinitesimal.substack.com
November 21, 2025 at 10:34 PM
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
Reposted by Granton Jindal
#KnowYourZDM or ‘Know Your Zebrafish Disease Model’ features ways the miniature fish is helping doctors and researchers fight human diseases. Stay tuned for more on this series!
#KnowYourZDM: In 2019, a 10-year-old patient w/ a life-threatening lymphatic disorder was losing hope. Zebrafish to the rescue! Scientists created zebrafish with the same gene mutation and found a melanoma drug that fixed the fish. Then, doctors used the same drug on the patient to save his life! 🧪
November 20, 2025 at 7:26 PM
#KnowYourZDM or ‘Know Your Zebrafish Disease Model’ features ways the miniature fish is helping doctors and researchers fight human diseases. Stay tuned for more on this series!
Reposted by Granton Jindal
SAVE THE DATE! Stoked to organize the 2026 Santa Cruz Developmental Biology Meeting with @rashmi-priya.bsky.social, @lowelab.bsky.social, and Shelbi Russell. Come learn about Biomedicine, Biomechanics, and the Biosphere, August 24-28, 2026. Registration dates, etc., coming soon! Please RT
November 19, 2025 at 8:23 PM
SAVE THE DATE! Stoked to organize the 2026 Santa Cruz Developmental Biology Meeting with @rashmi-priya.bsky.social, @lowelab.bsky.social, and Shelbi Russell. Come learn about Biomedicine, Biomechanics, and the Biosphere, August 24-28, 2026. Registration dates, etc., coming soon! Please RT
Reposted by Granton Jindal
Terrific new work on tendon growth by Heather Dingwall @dingwallaby.bsky.social and @jennagalloway.bsky.social in collaboration with my lab. Congrats Heather and all authors! journals.plos.org/plosgenetics...
Dynamic transcriptional and epigenetic changes define postnatal tendon growth
Author summary Tendons provide essential connections within our musculoskeletal system, transmitting the force from muscle to bone to enable movement. Concomitant with skeletal growth, tendon developm...
journals.plos.org
November 19, 2025 at 11:57 AM
Terrific new work on tendon growth by Heather Dingwall @dingwallaby.bsky.social and @jennagalloway.bsky.social in collaboration with my lab. Congrats Heather and all authors! journals.plos.org/plosgenetics...
Reposted by Granton Jindal
What the Frog's Eye Tells the Frog's Brain 🐸👁️🧠https://ieeexplore.ieee.org/document/4065609 - A little embarrassed to admit I've just read this classic paper for the first time and I'm glad I did! 😊
November 17, 2025 at 2:54 PM
What the Frog's Eye Tells the Frog's Brain 🐸👁️🧠https://ieeexplore.ieee.org/document/4065609 - A little embarrassed to admit I've just read this classic paper for the first time and I'm glad I did! 😊
Reposted by Granton Jindal
Re-upping this with a Bluetorial in a shameless act of self-promotion. 1/n
Cell cycle-driven transcriptome maturation confers multilineage competence to cardiopharyngeal progenitors
Wei Wang, @lionlchristiaen.bsky.social and colleagues
www.embopress.org/doi/full/10....
Wei Wang, @lionlchristiaen.bsky.social and colleagues
www.embopress.org/doi/full/10....
November 15, 2025 at 8:15 AM
Re-upping this with a Bluetorial in a shameless act of self-promotion. 1/n
Reposted by Granton Jindal
I am grateful to my current lab members Jonas and Noah who have more than pitched in, and helped make the analysis available for all to navigate online: christiaenlab-sars.com/scRNA-seq-da...
Christiaen Lab - SARS Atlas Datasets
christiaenlab-sars.com
November 15, 2025 at 10:11 AM
I am grateful to my current lab members Jonas and Noah who have more than pitched in, and helped make the analysis available for all to navigate online: christiaenlab-sars.com/scRNA-seq-da...
Reposted by Granton Jindal
November 13, 2025 at 7:23 PM
Reposted by Granton Jindal
Hiding in plain sight - how close are we to mapping ALL 🧬enhancers🧬 in the genome?
Our new paper by Mannion et al. takes a systematic look at "hidden enhancers" and why they remain so hard to find. With @mosterwalder.bsky.social, @jlopezrios.bsky.social & many more
www.nature.com/articles/s41...
Our new paper by Mannion et al. takes a systematic look at "hidden enhancers" and why they remain so hard to find. With @mosterwalder.bsky.social, @jlopezrios.bsky.social & many more
www.nature.com/articles/s41...
August 8, 2025 at 6:10 PM
Hiding in plain sight - how close are we to mapping ALL 🧬enhancers🧬 in the genome?
Our new paper by Mannion et al. takes a systematic look at "hidden enhancers" and why they remain so hard to find. With @mosterwalder.bsky.social, @jlopezrios.bsky.social & many more
www.nature.com/articles/s41...
Our new paper by Mannion et al. takes a systematic look at "hidden enhancers" and why they remain so hard to find. With @mosterwalder.bsky.social, @jlopezrios.bsky.social & many more
www.nature.com/articles/s41...
Reposted by Granton Jindal
Most neurodevelopmental disorders are caused by having 1 functional gene copy. Using SCN2A, we show that upregulating the functional copy rescues neuronal phenotypes. Amazing work with @neurobender.bsky.social led by Serena Tamura, Andrew Nelson, Perry Spratt & others.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CRISPR activation for SCN2A-related neurodevelopmental disorders | Nature
www.nature.com
September 17, 2025 at 3:13 PM
Most neurodevelopmental disorders are caused by having 1 functional gene copy. Using SCN2A, we show that upregulating the functional copy rescues neuronal phenotypes. Amazing work with @neurobender.bsky.social led by Serena Tamura, Andrew Nelson, Perry Spratt & others.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Granton Jindal
✨ New hashtag series: #ZebrafishJokes, where we share our fintastic fish puns. Second take:
What do you call a zebrafish with a medical degree?
A fishician.
What do you call a zebrafish with a medical degree?
A fishician.
November 11, 2025 at 7:51 PM
✨ New hashtag series: #ZebrafishJokes, where we share our fintastic fish puns. Second take:
What do you call a zebrafish with a medical degree?
A fishician.
What do you call a zebrafish with a medical degree?
A fishician.
Reposted by Granton Jindal
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
November 10, 2025 at 11:11 AM
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
Reposted by Granton Jindal
#GI2025 Ilias Georgakopoulos-Soares presents "Quadrupia - a comprehensive catalog of G-quadruplexes across genomes from the tree of life". Now published in Genome Research @genomeresearch.bsky.social Read full text here ➡️ tinyurl.com/Genome-Res-2...
November 6, 2025 at 10:41 PM
#GI2025 Ilias Georgakopoulos-Soares presents "Quadrupia - a comprehensive catalog of G-quadruplexes across genomes from the tree of life". Now published in Genome Research @genomeresearch.bsky.social Read full text here ➡️ tinyurl.com/Genome-Res-2...
Reposted by Granton Jindal
I'd only dabbled with napari, but needed to use it for a paper we're writing. This is a quick post about getting started: from installation to a folder full of thousands of processed images, with gotchas along the way.
quantixed.org/2025/11/04/a...
quantixed.org/2025/11/04/a...
Adventures in Code VII: getting started with napari – quantixed
quantixed.org
November 4, 2025 at 10:00 AM
I'd only dabbled with napari, but needed to use it for a paper we're writing. This is a quick post about getting started: from installation to a folder full of thousands of processed images, with gotchas along the way.
quantixed.org/2025/11/04/a...
quantixed.org/2025/11/04/a...
Reposted by Granton Jindal
We are thrilled to see this out in @jcellsci.bsky.social an in the special issue on Cilia. Cfap298 - which we call Kurly - is the mutant that keeps on giving us surprises! In this paper, a mutation generated by CRISPR, that deletes two aa and changes a third, specifically affects cilia motility.
Marvin Cortez, Cullen Young, Rebecca Burdine @rburdine1.bsky.social and colleagues identify a conserved domain in Cfap298 that governs left–right symmetry breaking in vertebrates.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
November 3, 2025 at 6:33 PM
We are thrilled to see this out in @jcellsci.bsky.social an in the special issue on Cilia. Cfap298 - which we call Kurly - is the mutant that keeps on giving us surprises! In this paper, a mutation generated by CRISPR, that deletes two aa and changes a third, specifically affects cilia motility.
Reposted by Granton Jindal
Must read! Nice examples why basic science is important and how we all benefit from it
www.nature.com/articles/d41...
www.nature.com/articles/d41...
7 basic science discoveries that changed the world
Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government.
www.nature.com
November 2, 2025 at 9:53 PM
Must read! Nice examples why basic science is important and how we all benefit from it
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Granton Jindal
A fun little side project I've been working on with @stepadenisov.bsky.social , Mato Lagator, and Andreas Wagner: "Strong promoters are mutationally robust". Briefly...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Strong promoters are mutationally robust
Mutational robustness is the persistence of a phenotype upon mutation. It facilitates molecular evolution and has been characterized in a variety of biological systems, but studies of prokaryotic prom...
www.biorxiv.org
October 21, 2025 at 8:02 AM
A fun little side project I've been working on with @stepadenisov.bsky.social , Mato Lagator, and Andreas Wagner: "Strong promoters are mutationally robust". Briefly...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Granton Jindal
One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Massively parallel interrogation of the fitness of natural variants in ancient signaling pathways reveals pervasive local adaptation
The nature of standing genetic variation remains a central debate in population genetics, with differing perspectives on whether common variants are almost always neutral as suggested by neutral and n...
www.biorxiv.org
October 22, 2025 at 5:46 PM
One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Granton Jindal
50 years ago, King & Wilson published a foundational paper that underlies the cis-regulatory paradigm (CRP) of #DevoEvo #EvoDevo, i.e., that *almost* all morphological evolution is driven by mutations in regulatory elements, rather than proteins, and it all arose from simple misunderstanding 🧪 🧵
October 29, 2025 at 12:35 AM
Reposted by Granton Jindal
New paper alert! Rare DNA changes in the SETBP1 gene are linked to speech problems & diverse syndromes affecting brain development. Work led by ace postdoc @maggiemkwong.bsky.social uncovered impact of different gene variants, coupling clinical/speech evaluation to molecular & cellular readouts.🧬🗣️🔬🧪
SETBP1 variants outside the degron disrupt DNA-binding, transcription and neuronal differentiation capacity to cause a heterogeneous neurodevelopmental disorder - Nature Communications
Different types of SETBP1 variants cause variable developmental syndromes with only partial clinical and functional overlaps. Here, the authors report that SETBP1 variants outside the degron region impair DNA-binding, transcription, and neuronal differentiation capacity and morphologies.
www.nature.com
October 10, 2025 at 5:36 PM
New paper alert! Rare DNA changes in the SETBP1 gene are linked to speech problems & diverse syndromes affecting brain development. Work led by ace postdoc @maggiemkwong.bsky.social uncovered impact of different gene variants, coupling clinical/speech evaluation to molecular & cellular readouts.🧬🗣️🔬🧪
Reposted by Granton Jindal
The most important paper in evolutionary biology I'd never heard of:
1/
www.sciencedirect.com/science/arti...
1/
www.sciencedirect.com/science/arti...
October 6, 2025 at 2:00 PM
The most important paper in evolutionary biology I'd never heard of:
1/
www.sciencedirect.com/science/arti...
1/
www.sciencedirect.com/science/arti...
Reposted by Granton Jindal
I'm very pleased to announce the official publication of our lab's paper "DNA mutagenesis driven by transcription factor competition with mismatch repair" in today's issue of Cell! www.cell.com/cell/abstrac...
DNA mutagenesis driven by transcription factor competition with mismatch repair
Competition between transcription factors and mismatch repair machinery drives localized
hypermutation at regulatory elements, with implications for cancer and genome evolution.
www.cell.com
October 2, 2025 at 11:37 PM
I'm very pleased to announce the official publication of our lab's paper "DNA mutagenesis driven by transcription factor competition with mismatch repair" in today's issue of Cell! www.cell.com/cell/abstrac...
Reposted by Granton Jindal
New week, new tool: Find our Protein Domain Designer tool to generate publication-ready protein domain diagrams here: domaindesigner.farnunglab.com
September 29, 2025 at 3:01 PM
New week, new tool: Find our Protein Domain Designer tool to generate publication-ready protein domain diagrams here: domaindesigner.farnunglab.com
Reposted by Granton Jindal
Nature rarely invents, but recycles all the time..,
More on the ancient foundation of animal development. Coyle & King illustrate how core regulatory modules were present in our pre-animal ancestors. The key was not invention, but recycling & new protein interactions. #CellBiology #multicellularity #protistsOnSky
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 8, 2025 at 11:29 AM
Nature rarely invents, but recycles all the time..,
Reposted by Granton Jindal
❄️ Common shrews shrink their brains in winter.
🧠 The process is reversible and occurs because brain cells shrink, rather than die off. As a result, neuronal numbers stay constant and preserve brain function.
I can defo relate to seasonal brain shrinkage.
🧪🦊🌍
Paper: www.cell.com/current-biol...
🧠 The process is reversible and occurs because brain cells shrink, rather than die off. As a result, neuronal numbers stay constant and preserve brain function.
I can defo relate to seasonal brain shrinkage.
🧪🦊🌍
Paper: www.cell.com/current-biol...
September 4, 2025 at 3:23 PM
❄️ Common shrews shrink their brains in winter.
🧠 The process is reversible and occurs because brain cells shrink, rather than die off. As a result, neuronal numbers stay constant and preserve brain function.
I can defo relate to seasonal brain shrinkage.
🧪🦊🌍
Paper: www.cell.com/current-biol...
🧠 The process is reversible and occurs because brain cells shrink, rather than die off. As a result, neuronal numbers stay constant and preserve brain function.
I can defo relate to seasonal brain shrinkage.
🧪🦊🌍
Paper: www.cell.com/current-biol...